GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(939 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.945 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(148 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor Endotelina(76 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(31 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(165 produtos)
- Hedgehog/Smoothened(44 produtos)
- Receptor de Histamina(358 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
- PAFR(11 produtos)
- PKA(48 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5352 produtos de "GPCR/Proteína-G"
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Pancreatic Polypeptide (human) acetate
<p>Pancreatic Polypeptide (human) acetate is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.</p>Pureza:97.26%Cor e Forma:LiquidPeso molecular:N/APACAP 1-38 acetate
<p>PACAP 1-38 acetate, a PACAP analog, targets PACAP type I (IC50=4nM) and VIP2 receptors (IC50=1nM), not VIP1.</p>Pureza:98.16%Cor e Forma:LiquidPeso molecular:N/AML382
CAS:<p>ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM).</p>Fórmula:C18H20N2O4SPureza:99.79%Cor e Forma:SolidPeso molecular:360.43Samelisant dihydrochloride
CAS:<p>SUVN-G3031: H3 receptor antagonist; may treat cognitive issues, ADHD, epilepsy, sleep, obesity, schizophrenia, eating disorders, pain.</p>Fórmula:C21H33Cl2N3O3Cor e Forma:SolidPeso molecular:446.41GUANABENZ
CAS:<p>GUANABENZ is a Central alpha-2 Adrenergic Agonist. The mechanism of action of guanabenz is as an Adrenergic alpha2-Agonist.</p>Fórmula:C8H8Cl2N4Pureza:98.31%Cor e Forma:White Solid From Acetonitrile SolidPeso molecular:231.08MK 212 hydrochloride
CAS:<p>MK 212 hydrochloride is a 5-HT2C receptor agonist</p>Fórmula:C8H11ClN4·HClPureza:99.88%Cor e Forma:SolidPeso molecular:235.12Detomidine hydrochloride
CAS:<p>Detomidine hydrochloride (MPV-253 AII) produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.</p>Fórmula:C12H14N2·HClPureza:99.97%Cor e Forma:SolidPeso molecular:222.71MCL0020
CAS:<p>MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, reverses stress-induced anorexia but has no effect on food intake in free-feeding rats.</p>Fórmula:C34H39N7O4Pureza:99.18%Cor e Forma:SolidPeso molecular:609.72Indacaterol
CAS:<p>Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.</p>Fórmula:C24H28N2O3Pureza:99.96%Cor e Forma:SolidPeso molecular:392.49SAX-187
CAS:<p>SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor.</p>Fórmula:C15H13ClN4O2S2Pureza:97.82% - 98%Cor e Forma:SolidPeso molecular:380.87Trimethobenzamide hydrochloride
CAS:<p>Trimethobenzamide hydrochloride (Ro 2-9578) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.</p>Fórmula:C21H29ClN2O5Pureza:99.52%Cor e Forma:SolidPeso molecular:424.92ZK 756326
CAS:<p>ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.</p>Fórmula:C21H28N2O3Pureza:99.43%Cor e Forma:SolidPeso molecular:356.46Lixisenatide acetate (320367-13-3 free base)
CAS:<p>Lixisenatide acetate is a receptor agonist similar to glucagon-like peptide-1 (glp-1) for the treatment of type 2 diabetes mellitus (T2DM).</p>Fórmula:C215H347N61O65S·6C2H4O2Pureza:98% - 99.9%Cor e Forma:SolidPeso molecular:5218.88Hydroxyzine
CAS:<p>Hydroxyzine (Hydroxyzine free base) is an antagonist of histamine H1-receptor.</p>Fórmula:C21H27ClN2O2Pureza:99.54% - ≥95%Cor e Forma:Oil SolidPeso molecular:374.9MF-766
CAS:<p>MF-766: potent, selective oral EP4 antagonist, Ki=0.23 nM, IC50=1.4 nM; shifts to 1.8 nM with 10% HS. Useful in cancer, inflammation studies.</p>Fórmula:C27H21F3N2O3Pureza:99.54% - 99.59%Cor e Forma:SolidPeso molecular:478.46N-Desmethylclozapine
CAS:<p>N-Desmethylclozapine: 5-HT2C antagonist (IC50: 7.1 nM), dopamine D4 antagonist, δ-opioid agonist.</p>Fórmula:C17H17ClN4Pureza:97.25% - 99.83%Cor e Forma:Yellow Crystalline SolidPeso molecular:312.8Bindarit
CAS:<p>Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.Cost-effective and quality-assured.</p>Fórmula:C19H20N2O3Pureza:98.35% - 98.55%Cor e Forma:SolidPeso molecular:324.37Ranitidine
CAS:<p>Ranitidine (HSDB 3925) is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors).</p>Fórmula:C13H22N4O3SPureza:99.52%Cor e Forma:Solid SolidPeso molecular:314.40Orexin B, rat, mouse Acetate
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.Fórmula:C128H219N45O36SPureza:94.61%Cor e Forma:SolidPeso molecular:2996.45S1RA hydrochloride
CAS:<p>S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki ></p>Fórmula:C20H24ClN3O2Pureza:98% - 99.84%Cor e Forma:SolidPeso molecular:373.87Epinastine hydrochloride
CAS:<p>Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.</p>Fórmula:C16H15N3·HClPureza:99.26% - 99.62%Cor e Forma:White SolidPeso molecular:285.77Vortioxetine
CAS:<p>Vortioxetine (Lu AA 21004) is a serotonergic antidepressant used for major depression disorders.</p>Fórmula:C18H22N2SPureza:99.34% - 99.34%Cor e Forma:SolidPeso molecular:298.45Olcegepant
CAS:<p>Olcegepant (BIBN-4096) is an effective and selective non-peptide calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (IC50 of 0.03 nM and Ki of 14.4</p>Fórmula:C38H47Br2N9O5Pureza:96.08% - 97.24%Cor e Forma:SolidPeso molecular:869.65Raclopride
CAS:<p>Raclopride is a selective antagonist of dopamine D2/D3 receptor.</p>Fórmula:C15H20Cl2N2O3Pureza:99.17%Cor e Forma:SolidPeso molecular:347.24L-745870 trihydrochloride
CAS:<p>L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.</p>Fórmula:C18H22Cl4N4Pureza:97.52%Cor e Forma:SolidPeso molecular:436.21JNJ-7777120
CAS:<p>JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist, exhibits >1000-fold selectivity over the other histamin receptors.</p>Fórmula:C14H16ClN3OPureza:99.83% - 99.96%Cor e Forma:SolidPeso molecular:277.75Zacopride hydrochloride
CAS:<p>Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.</p>Fórmula:C15H20ClN3O2·HClPureza:98.32%Cor e Forma:SolidPeso molecular:346.26CGP71683 hydrochloride
CAS:<p>CGP71683 hydrochloride: NPY5 receptor antagonist, Ki=1.3 nM; inactive at Y1 (Ki >4000 nM) and Y2 (Ki=200 nM).</p>Fórmula:C26H30ClN5O2SPureza:99.92%Cor e Forma:SolidPeso molecular:512.07β-MSH (1-22) (human) acetate
Beta-MSH (1-22) (human) acetate (Beta-MSH (1-22) (human) acetate (17908-57-5 Free base)) , is an endogenous melanocortin-4 receptor (MC4-R) agonist.Fórmula:C120H178N34O37SPureza:99.64%Cor e Forma:SolidPeso molecular:2720.97Pancreatic Polypeptide, rat acetate
<p>Pancreatic Polypeptide, rat acetate is an agonist of NPY receptor, with high affinity at NPYR4.</p>Pureza:97.53%Cor e Forma:SolidPeso molecular:N/AL-745870 hydrochloride
CAS:<p>L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor</p>Fórmula:C18H20Cl2N4Pureza:97.36%Cor e Forma:SolidPeso molecular:363.28KH7
CAS:<p>KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific.</p>Fórmula:C17H15BrN4O2SPureza:98.43%Cor e Forma:SolidPeso molecular:419.31-(1-Naphthyl) piperazine hydrochloride
CAS:<p>1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) is a serotonergic ligand which could bind nonselectively with multiple</p>Fórmula:C14H17ClN2Pureza:98.27%Cor e Forma:SolidPeso molecular:248.75Reboxetine
CAS:<p>Reboxetine (Norebox) is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD.</p>Fórmula:C19H23NO3Pureza:98%Cor e Forma:SolidPeso molecular:313.39Vericiguat
CAS:<p>Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator.</p>Fórmula:C19H16F2N8O2Pureza:98.86% - 99.93%Cor e Forma:SolidPeso molecular:426.38RS-127445 hydrochloride
CAS:<p>RS-127445 hydrochloride (MT 500) is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5).</p>Fórmula:C17H17ClFN3Pureza:99.48%Cor e Forma:SolidPeso molecular:317.79JNJ-31020028
CAS:<p>JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity (pIC50=8.07, human; pIC50=8.22, rat).</p>Fórmula:C34H36FN5O2Pureza:95.92% - 99.65%Cor e Forma:SolidPeso molecular:565.68Syk Inhibitor II dihydrochloride
CAS:<p>Syk inhibitor II selectively blocks Syk (IC50 = 41 nM), impacting platelet function and inflammation, with lower potency against other kinases.</p>Fórmula:C14H17Cl2F3N6OPureza:98.53%Cor e Forma:SolidPeso molecular:413.22Vortioxetine hydrobromide
CAS:<p>Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33</p>Fórmula:C18H22N2S·HBrPureza:98.85% - 99.98%Cor e Forma:SolidPeso molecular:379.36Lys-[Des-Arg9]Bradykinin,TFA
<p>Lys-[Des-Arg9]Bradykinin,TFA is Endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2</p>Fórmula:C54H75F6N13O15Pureza:97.35%Cor e Forma:SolidPeso molecular:1260.24BRL-15572 dihydrochloride
CAS:<p>BRL-15572 dihydrochloride: 5-HT1D antagonist, pKi 7.9, also binds 5-HT1A/2B, 60x selective over 5-HT1B.</p>Fórmula:C25H27ClN2O·2HClPureza:99.74%Cor e Forma:SolidPeso molecular:479.87Mosapride
CAS:<p>Mosapride (AS-4370) is a selective 5HT4 agonist</p>Fórmula:C21H25ClFN3O3Pureza:99.56%Cor e Forma:White To Off-White Crystalline SolidPeso molecular:421.89Betahistine dihydrochloride
CAS:<p>Betahistine dihydrochloride (Betahistine 2HCl) is a histamine analog and H1 receptor agonist that serves as a vasodilator.</p>Fórmula:C8H14Cl2N2Pureza:99.34% - 99.88%Cor e Forma:White To Light Yellow Crystalline PowderPeso molecular:209.12Fipamezole HCl
CAS:<p>Fipamezole HCl, a α2-adrenoceptor antagonist, is used potentially for the treatment of dyskinesia associated with Parkinson's disease.</p>Fórmula:C14H16ClFN2Cor e Forma:SolidPeso molecular:266.74Eltoprazine
CAS:<p>Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.</p>Fórmula:C12H16N2O2Cor e Forma:SolidPeso molecular:220.27Neuropeptide S (Rat) acetate
<p>Neuropeptide S (Rat) acetate is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor.</p>Fórmula:C97H164N34O29Pureza:95.36%Cor e Forma:SolidPeso molecular:2270.59MK-1064
CAS:<p>MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).</p>Fórmula:C24H20ClN5O3Pureza:99.19% - 99.82%Cor e Forma:SolidPeso molecular:461.9Amperozide
CAS:<p>Amperozide (FG 5606), an atypical antipsychotic, antagonizes 5-HT2A and modulates dopamine activity for schizophrenia treatment.</p>Fórmula:C23H29F2N3OPureza:99.68%Cor e Forma:SolidPeso molecular:401.49Bromodiphenhydramine
CAS:<p>Ambodryl, an antihistamine effective against many bacteria, aids in skin allergy studies.</p>Fórmula:C17H20BrNOCor e Forma:SolidPeso molecular:334.25REV 5901
CAS:<p>REV 5901: oral leukotriene receptor antagonist and 5-lipoxygenase inhibitor with Ki of 0.7 μM, researched for asthma.</p>Fórmula:C22H25NO2Cor e Forma:SolidPeso molecular:335.44
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