GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(939 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.945 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(148 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(407 produtos)
- Receptor Endotelina(76 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(31 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(165 produtos)
- Hedgehog/Smoothened(44 produtos)
- Receptor de Histamina(358 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(297 produtos)
- PAFR(11 produtos)
- PKA(48 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5352 produtos de "GPCR/Proteína-G"
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Ki16425
CAS:<p>Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.</p>Fórmula:C23H23ClN2O5SPureza:97.6% - 97.78%Cor e Forma:SolidPeso molecular:474.96Perospirone hydrochloride
CAS:<p>Perospirone hydrochloride (Perospirone HCl) is an atypical antipsychotic agent for the treatment of schizophrenia.</p>Fórmula:C23H31ClN4O2SPureza:99.37%Cor e Forma:White SolidPeso molecular:463Empagliflozin
CAS:<p>Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6.</p>Fórmula:C23H27ClO7Pureza:98% - 99.98%Cor e Forma:SolidPeso molecular:450.91JNJ-5207852
CAS:<p>JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.</p>Fórmula:C20H32N2OPureza:97.19%Cor e Forma:SolidPeso molecular:316.48Melatonin
CAS:<p>Melatonin (Melatonine) is a natural hormone that activates melatonin receptors. Melatonin regulates the biological clock. Cost-effective and quality-assured.</p>Fórmula:C13H16N2O2Pureza:98% - 99.89%Cor e Forma:Pale Yellow Leaflets From Benzene SolidPeso molecular:232.28Verucerfont
CAS:<p>Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .</p>Fórmula:C22H26N6O2Pureza:99.90%Cor e Forma:SolidPeso molecular:406.48tcY-NH2 TFA(327177-34-4 free base)
<p>tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.</p>Fórmula:C42H50F3N7O9Pureza:>99.99%Cor e Forma:SolidPeso molecular:853.9PD-168077 maleate
CAS:<p>PD-168077 maleate is a selective agonist of dopamine D4 receptor(Ki : 9 nM)</p>Fórmula:C24H26N4O5Pureza:99.13%Cor e Forma:SolidPeso molecular:450.498-Cyclopentyl-1,3-dimethylxanthine
CAS:<p>8-Cyclopentyl-1,3-dimethylxanthine (CPT) is a potent antagonist of adenosine A1 receptor.</p>Fórmula:C12H16N4O2Pureza:98.58% - >99.99%Cor e Forma:SolidPeso molecular:248.28CHEMBL241987
CAS:<p>CHEMBL241987 targets the Adenosine receptor A3 (human)</p>Fórmula:C16H11N3OPureza:99.81%Cor e Forma:SolidPeso molecular:261.28Avexitide
CAS:<p>Avexitide (Exendin-3 (9-39) amide) (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor.</p>Fórmula:C149H234N40O47SPureza:98% - 99.65%Cor e Forma:SolidPeso molecular:3369.76Methyldopa hydrate
CAS:<p>Methyldopa hydrate (MK-351 hydrate) is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension.</p>Fórmula:C10H13NO4H2OPureza:99.67%Cor e Forma:White SolidPeso molecular:238.24BAR 501 impurity
CAS:<p>BAR 501 impurity 在 BAR501 制剂中发现的一种杂质，可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。</p>Fórmula:C26H46O3Pureza:98.78%Cor e Forma:SolidPeso molecular:406.64AVN-101
CAS:<p>AVN-101 is a very potent 5-HT7 receptor antagonist.Cost-effective and quality-assured.</p>Fórmula:C21H25ClN2Pureza:99.61%Cor e Forma:SolidPeso molecular:340.89Canagliflozin
CAS:<p>Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor. Canagliflozin is used to treat type II diabetes mellitus. Cost-effective and quality-assured.</p>Fórmula:C24H25FO5SPureza:98.01% - >99.99%Cor e Forma:SolidPeso molecular:444.52Veralipride
CAS:<p>Veralipride ((±)-Veralipride) is an antagonist of D2 receptor.</p>Fórmula:C17H25N3O5SPureza:99.65%Cor e Forma:SolidPeso molecular:383.46Thrombin Receptor Activator for Peptide
<p>Thrombin Receptor Activator (TRAP) or Coagulation Factor II (1-5), used in CHD research.</p>Fórmula:C32H51F3N8O9Pureza:99.88%Cor e Forma:SolidPeso molecular:748.79HAEGTFT acetate(926018-95-3 free base)
<p>HAEGTFT acetate is the first N-terminal 1-7 residues of GLP-1 peptide.</p>Fórmula:C35H51N9O14Pureza:>99.99%Cor e Forma:SolidPeso molecular:821.84Linzagolix
CAS:<p>Linzagolix is a small-molecule, non-peptide, orally active gonadotropin-releasing hormone antagonist (GnRH antagonist) which is under development by Kissei</p>Fórmula:C22H15F3N2O7SPureza:99.33%Cor e Forma:SolidPeso molecular:508.42ACH-000143
CAS:<p>ACH-000143 是一种可口服的褪黑素受体激动剂，对 MT1 和 MT2 的EC50值分别为0.06 和0.32 nM。</p>Fórmula:C13H16ClN3O3Pureza:98.15%Cor e Forma:SolidPeso molecular:297.74Ablukast
CAS:<p>Ablukast (Ro 23-3544) is a leuktriene receptor antagonist. Ablukast acts as an anti-asthmatic.</p>Fórmula:C28H34O8Pureza:98.58%Cor e Forma:SolidPeso molecular:498.56GW842166X
CAS:<p>GW842166X: Potent CB2 agonist, EC50=63 nM, inactive at CB1, in Phase 2 trials.</p>Fórmula:C18H17Cl2F3N4O2Pureza:99.47%Cor e Forma:SolidPeso molecular:449.25SCH-23390 hydrochloride
CAS:<p>SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM).</p>Fórmula:C17H19Cl2NOPureza:98% - 99.83%Cor e Forma:SolidPeso molecular:324.24Clozapine N-Oxide
CAS:<p>View and buy CLOZAPINE N-OXIDE from TargetMol.Clozapine N-oxide is a major metabolite of clozapine also known as DREADDs, technology to modulate synthetic receptors in vivo.Cited in 2 publications.</p>Fórmula:C18H19ClN4OPureza:98.43% - 99.94%Cor e Forma:SolidPeso molecular:342.82OXA (17-33) acetate
<p>OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).</p>Fórmula:C79H125N23O22Pureza:98.52%Cor e Forma:SolidPeso molecular:1748.98MK-0557
CAS:<p>MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM).</p>Fórmula:C22H19FN4O3Pureza:99.88%Cor e Forma:SolidPeso molecular:406.412-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
<p>2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) is a potent and selective protease-activated receptor 2 (PAR2) agonist.</p>Fórmula:C38H64F3N11O10Pureza:>99.99%Cor e Forma:SolidPeso molecular:891.98Tetradecyl Phosphonate
CAS:<p>Tetradecyl Phosphonate 是溶血磷脂酸 1 (LPA1)、LPA2 和 LPA3 受体的泛拮抗剂。</p>Fórmula:C14H31O3PPureza:99.95%Cor e Forma:White To Off-White PowderPeso molecular:278.37Midodrine
CAS:<p>Midodrine ((±)-Midodrin), an adrenergic alpha-1 agonist, belongs to the class of medications known as vasopressors.</p>Fórmula:C12H18N2O4Pureza:99.89%Cor e Forma:SolidPeso molecular:254.28CGS 21680 Hydrochloride
CAS:<p>CGS 21680 Hydrochloride (CGS 21680 HCl)(IC50=22 nM), an adenosine receptor agonist, exhibits 140-fold potency in A2 receptor over A1 receptor.</p>Fórmula:C23H29N7O6·HClPureza:96.74% - 99.53%Cor e Forma:SolidPeso molecular:535.98DORA-22
CAS:<p>DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory</p>Fórmula:C23H22F2N4O2Pureza:97.67%Cor e Forma:SolidPeso molecular:424.44Pridopidine
CAS:<p>Pridopidine (FR310826), a low-affinity D2R antagonist, enhances motor skills and has neuroprotective effects in Huntington's R6/2 mice.</p>Fórmula:C15H23NO2SPureza:95.2% - 99.89%Cor e Forma:SolidPeso molecular:281.41AZ3451
CAS:<p>AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).</p>Fórmula:C30H27BrN4O3Pureza:98.12%Cor e Forma:SolidPeso molecular:571.46Peptide YY (PYY) (3-36), human
CAS:<p>Peptide YY (PYY) (3-36), human (Peptide YY (3-36)) is a gut hormone peptide. Peptide YY (PYY) (3-36), human acts as a Y2 receptor agonist to reduce appetite.</p>Fórmula:C176H272N52O54Pureza:97.76%Cor e Forma:SolidPeso molecular:3980.42Doxazosin
CAS:<p>Doxazosin (UK 33274) is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms.</p>Fórmula:C23H25N5O5Pureza:99.47% - 99.87%Cor e Forma:SolidPeso molecular:451.48ZM241385
CAS:<p>ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.</p>Fórmula:C16H15N7O2Pureza:97.02% - 99.69%Cor e Forma:SolidPeso molecular:337.34Vilazodone Hydrochloride
CAS:<p>Vilazodone Hydrochloride (EMD 68843) , a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the</p>Fórmula:C26H27N5O2·HClPureza:99.56% - >99.99%Cor e Forma:SolidPeso molecular:477.99Anisotropine Methylbromide
CAS:<p>Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.</p>Fórmula:C17H32BrNO2Pureza:99.73%Cor e Forma:Crystals From Acetone SolidPeso molecular:362.35ABT-702 dihydrochloride
CAS:<p>ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor.</p>Fórmula:C22H21BrCl2N6OPureza:98.42% - 98.98%Cor e Forma:SolidPeso molecular:536.25NNC-0640
CAS:<p>NNC-0640 is a negative allosteric modulator of Human Glucagon Receptor with an IC50 of 69.2 nM.</p>Fórmula:C29H31N7O4SPureza:97.04%Cor e Forma:SolidPeso molecular:573.67Cerlapirdine
CAS:<p>Cerlapirdine (PF-05212365), a 5-HT6 receptor antagonist, is in trials for Alzheimer's and schizophrenia cognition issues.</p>Fórmula:C22H23N3O3SPureza:98.77%Cor e Forma:SolidPeso molecular:409.5SCH442416
CAS:<p>SCH442416: selective A2A adenosine receptor antagonist; Ki: 0.048 nM (human), 0.5 nM (rat).</p>Fórmula:C20H19N7O2Pureza:99.58%Cor e Forma:SolidPeso molecular:389.41Hemokinin 1 (human) acetate(491851-53-7 free base)
<p>Hemokinin 1 acetate: Human SP homolog, NK1 agonist (IC50: NK1 1.8 nM), proliferates B-cells, antihypertensive.</p>Fórmula:C56H88N14O16SPureza:97.82%Cor e Forma:SolidPeso molecular:1245.45Galanin Receptor Ligand M35 TFA
<p>Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM).</p>Fórmula:C109H154N27F3O28Pureza:99.45%Cor e Forma:SolidPeso molecular:2347.62HT-2157
CAS:<p>HT-2157 (SNAP-37889) is a selective, high-affinity competitive antagonist of the galanin-3 receptor (Gal3), demonstrating effective inhibition of this target.</p>Fórmula:C21H13F3N2OPureza:98.33%Cor e Forma:SolidPeso molecular:366.34Desmopressin acetate (16679-58-6 free base)
CAS:<p>Desmopressin (16679-58-6), a synthetic vasopressin analog, treats nocturia, enuresis, and diabetes insipidus by reducing urine production.</p>Fórmula:C48H68N14O14S2Pureza:98.84% - >99.99%Cor e Forma:SolidPeso molecular:1129.26Tolnapersine
CAS:<p>Tolnapersine is a mixed dopamine agonist and alpha-adrenoceptor antagonist.</p>Fórmula:C21H26N2OPureza:98%Cor e Forma:SolidPeso molecular:322.44Bay 55-9837 acetate
<p>Bay 55-9837 acetate is a potent and highly selective VPAC2 agonist(Kd = 0.65 nM) and can be used in type 2 diabetes studies.</p>Pureza:98.27%Cor e Forma:LiquidPeso molecular:N/ANeuropeptide Y (29-64), amide, human acetate
<p>Neuropeptide Y (29-64), amide, human acetate is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.</p>Pureza:98.42%Cor e Forma:LiquidPeso molecular:N/APancreatic Polypeptide (human) acetate
<p>Pancreatic Polypeptide (human) acetate is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.</p>Pureza:97.26%Cor e Forma:LiquidPeso molecular:N/A
