GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
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Adenosine 3'-monophosphate (sodium salt hydrate)
<p>Adenosine 3'-monophosphate (sodium salt hydrate) (3'-AMP) is a nucleotide and cAMP-generating agonist that elevates cAMP levels in NG108-15 cells.</p>Fórmula:C10H15N5NaO8PCor e Forma:SolidPeso molecular:387.22CUR61414 hydrochloride
<p>CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.</p>Fórmula:C31H43ClN4O5Pureza:94.05%Cor e Forma:SolidPeso molecular:587.15Pellotine
CAS:<p>Pellotine is an alkaloid isolated from Lophophora. It acts as an inverse agonist of the 5-HT7 receptor (5-HT7 receptor), with an EC50 of 291 nM. Pellotine shows strong affinity for the 5-HT1DR and 5-HT6R, with Ki values of 117 nM and 170 nM, respectively. Additionally, Pellotine reduces intracellular cAMP levels, thereby decreasing neuronal excitability and neurotransmitter release.</p>Fórmula:C13H19NO3Cor e Forma:SolidPeso molecular:237.295ABT 724 trihydrochloride
CAS:<p>ABT-724 trihydrochloride: selective D4 agonist; EC50=12.4nM(human),14.3nM(rat),23.2nM(ferret); for erectile dysfunction research.</p>Fórmula:C17H22Cl3N5Pureza:99.91%Cor e Forma:SolidPeso molecular:402.75GR231118
CAS:<p>Potent NPY Y1 antagonist & Y4 agonist; inhibits rat appetite; binds to NPFF receptors (Ki: 43-73 nM).</p>Fórmula:C110H170N34O24Pureza:98%Cor e Forma:Lyophilized PowderPeso molecular:2352.77AG 045572
CAS:<p>AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is</p>Fórmula:C30H37NO5Pureza:99.96%Cor e Forma:SolidPeso molecular:491.62NF157
CAS:<p>NF157, a selective P2Y11 antagonist with pKi 7.35, lowers MMP-3/MMP-13, aiding OA treatment; IC50s: P2Y11 463 nM, P2Y1 1811 μM, P2Y2 170 μM.</p>Fórmula:C49H28F2N6Na6O23S6Pureza:98%Cor e Forma:SolidPeso molecular:1437.115(S)-15-methyl Prostaglandin E2
CAS:<p>15(S)-15-methyl PGE2: A stable PGE2 analog; strong antiulcer with double PGE2 affinity; excels PGE1 in uterine contraction.</p>Fórmula:C21H34O5Cor e Forma:SolidPeso molecular:366.49BMS-753426
CAS:<p>BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .</p>Fórmula:C25H33F3N6O2Cor e Forma:SolidPeso molecular:506.574CYN 154806
CAS:CYN 154806: potent sst2 antagonist; pIC50: 8.58 (sst2), 5.41 (sst1), 6.07 (sst3), 5.76 (sst4), 6.48 (sst5).Fórmula:C56H68N12O14S2Pureza:98%Cor e Forma:SolidPeso molecular:1197.34Palmitoyl tetrapeptide-20 TFA
Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide and acts as an agonist of α-MSH. It protects follicular melanocytes by boosting catalase expression and activating melanogenesis.Fórmula:C38H70N6O8·xC2HF3O2Lys-[Des-Arg9]Bradykinin
CAS:Selective bradykinin B1 agonist with Ki 0.12 nM; inactive at B2 (>30,000 nM). Lowers blood pressure, more potent than Des-Arg9-Bradykinin.Fórmula:C50H73N13O11Pureza:98%Cor e Forma:SolidPeso molecular:1032.21GB-6
CAS:<p>GB-6, a short linear peptide that selectively binds to the gastrin releasing peptide receptor (GRPR), shows potential as a high-contrast imaging probe due to</p>Fórmula:C32H45N11O8Pureza:98%Cor e Forma:SolidPeso molecular:711.77Relaxin H3 (human) TFA
Relaxin H3 (human) (TFA) is a relaxin peptide that exerts antifibrotic effects through the RXFP1 receptor.Fórmula:C237H374N70O69S6·xC2HF3O2Linaclotide acetate
CAS:<p>Linaclotide acetate, an oral guanylate cyclase C agonist with 14 amino acids, treats constipation-predominant IBS and chronic constipation.</p>Fórmula:C61H83N15O23S6Pureza:98%Cor e Forma:SolidPeso molecular:1586.79ELA-32(human)
CAS:<p>Potent apelin receptor agonist with IC50 = 0.27 nM; does not bind GPR15/GPR25. Boosts hESC self-renewal and angiogenesis.</p>Fórmula:C170H289N63O39S4Pureza:98%Cor e Forma:SolidPeso molecular:3967.8Succinate/succinate receptor antagonist 1
CAS:<p>Potent succinate receptor antagonist with IC50 of 20 μM; blocks gingival succinate signaling, may treat periodontal disease.</p>Fórmula:C17H15N3OPureza:99.53%Cor e Forma:SoildPeso molecular:277.32Nizatidine
CAS:<p>Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.</p>Fórmula:C12H21N5O2S2Pureza:99.43%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:331.46RAG8 peptide
RAG8 peptide is an antagonist of protease-activated receptor 4 (PAR 4), which inhibits late-stage platelet activation and reduces thrombosis without altering hemostasis or increasing bleeding risk. It is applicable in atherosclerosis research.Fórmula:C56H98N16O11Peso molecular:1170.7601[Ala11,D-Leu15]-Orexin B(human)
CAS:<p>OX2 receptor agonist with 400x selectivity vs OX1. EC50: 0.13 nM (OX2), 52 nM (OX1).</p>Fórmula:C120H206N44O35SPureza:98%Cor e Forma:SolidPeso molecular:2857.28VIP36
<p>VIP36 is an agonist of the cannabinoid type 1 receptor (CB1) with analgesic properties. It reduces the recruitment of inhibitory proteins, thereby exerting its pain-relieving effects, and is applicable in research related to chronic pain.</p>Fórmula:C27H35FN6O4Cor e Forma:SolidPeso molecular:526.603Picumeterol FA
<p>picumeterol FA is a potent and selective β2-adrenergic receptor agonist.</p>Fórmula:C22H31Cl2N3O4Pureza:99.8%Cor e Forma:SoildPeso molecular:472.4Cetirizine D8 dihydrochloride
CAS:<p>Cetirizine D8 dihydrochloride is a deuterated H1-antihistamine with long-acting effects.</p>Fórmula:C21H26Cl2N2O3Pureza:98%Cor e Forma:SolidPeso molecular:433.4GLP-1R agonist 19
CAS:<p>GLP-1R agonist 19 (M3190) is a potent, selective GLP-1 receptor agonist that demonstrates excellent plasma and liver microsomal stability, along with low hERG toxicity [1].</p>Fórmula:C94H136FN21O25Cor e Forma:SolidPeso molecular:1979.21(±)14(15)-EpETE
CAS:<p>(±)14(15)-EpETE is an intestinal microbial lipid metabolite that attenuates cisplatin chemotherapy-induced nausea in rats by inhibiting Substance P release.</p>Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.45α-helical CRF 9-41 acetate
<p>α-helical CRF 9-41 acetate is a competitive antagonist of CRF2 (KB = 100 nM) and a partial agonist of CRF1 (EC50 = 140 nM).</p>Pureza:96.60%Cor e Forma:SolidPeso molecular:#N/ARelaxin H3 (human)
CAS:<p>Relaxin H3 (human) is a relaxin peptide that exhibits antifibrotic effects through activation of RXFP1 [1].</p>Cor e Forma:SolidFemoxetine
CAS:<p>Femoxetine: antidepressant, enhances morphine, inhibits MAO-A/B, boosts mice's exercise capacity.</p>Fórmula:C20H25NO2Pureza:99.1% - 99.35%Cor e Forma:SolidPeso molecular:311.42Sphinganine 1-phosphate
CAS:<p>Sphinganine 1-phosphate has protects kidney and liver through activation of the S1P1 receptor in mice and acts as an agonist for S1P4 in Homo sapien.</p>Fórmula:C18H40NO5PCor e Forma:SolidPeso molecular:381.49Neurokinin A(4-10) TFA
<p>Neurokinin A (4-10) TFA is a tachykinin NK 2 receptor agonist [1] .</p>Fórmula:C36H55F3N8O12SCor e Forma:SolidPeso molecular:880.93Neuropeptide Y (human) free acid
CAS:<p>Neuropeptide Y (human) free acid is the deamidated form of Neuropeptide Y (human, rat, mouse). The amidation of the C-terminal tyrosine in Neuropeptide Y is essential for its function, while the non-amidated form cannot initiate G-protein signaling.</p>Fórmula:C189H284N54O58SPeso molecular:4270.06542Benzquinamide
CAS:<p>Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer</p>Fórmula:C22H32N2O5Pureza:94.86%Cor e Forma:SolidPeso molecular:404.5PG 106 acetate
<p>PG 106 acetate: Selective hMC3 receptor antagonist, IC50=210 nM; inactive on hMC5 and hMC4, EC50=9900 nM.</p>Fórmula:C53H73N13O11Pureza:98.24%Cor e Forma:SolidPeso molecular:1068.23Survodutide
CAS:<p>Survodutide (BI 456906) is a dual agonist of glucagon and glucagon-like peptide 1 (GLP-1) receptor (GLP Receptor) that reduces body weight in HbA1c16 diabetes.</p>Fórmula:C192H289N47O61Pureza:99.83%Cor e Forma:SolidPeso molecular:4229.0957Neuropeptide Y (2-36) (porcine)
CAS:<p>Porcine Neuropeptide Y (2-36) is 97.14% similar to rat/human, an agonist for Y5, Y2, Y1 receptors, used in obesity research.</p>Fórmula:C181H278N54O55Cor e Forma:SolidPeso molecular:4090.47d[Cha4]-AVP TFA
<p>d[Cha4]-AVP TFA: potent, selective V1b agonist, K i 1.2 nM, favors V1b over V1a, V2, oxytocin receptors.</p>Fórmula:C52H72F3N13O13S2Cor e Forma:SolidPeso molecular:1208.33Vedaprofen
CAS:<p>Vedaprofen (PM 150) is a COX-1 inhibitor with anti-inflammatory effects, blocking E. coli clamp at IC50 222 μM, Ki 131 μM.</p>Fórmula:C19H22O2Pureza:99.24% - 99.70%Cor e Forma:SolidPeso molecular:282.38Y1 receptor antagonist 1 formic
<p>H 409-22 isomer formic, a formate salt of Y1 receptor antagonist 1, is an antagonist of the neuropeptide Y1 receptor (neuropeptide Y1 receptor). This compound effectively blocks the actions of the receptor, playing a crucial role in modulating physiological responses.</p>Fórmula:C29H35N5O5Cor e Forma:SolidPeso molecular:533.62INCB3344 R-isomer
<p>INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.</p>Fórmula:C29H34F3N3O6Pureza:98%Cor e Forma:SolidPeso molecular:577.59PACAP-38 (16-38), human, mouse, rat
CAS:<p>PACAP-38 (16-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production</p>Fórmula:C123H215N39O28SPureza:98%Cor e Forma:SolidPeso molecular:2720.33Peptide YY (PYY) (3-36), porcine TFA
<p>Peptide YY (PYY) (3-36), porcine TFA, functions as a gut hormone that serves as a Y2 receptor agonist, effectively reducing appetite [1].</p>Fórmula:C176H272N52O54·C2HF3O2Cor e Forma:SolidPeso molecular:4094.44QWF
CAS:<p>Tripeptide SP antagonist (IC50: 90 μM); blocks SP-MRGPR X2 binding and mast cell degranulation; reduces 48/80-induced scratching in mice.</p>Fórmula:C38H43N5O8Pureza:98%Cor e Forma:SolidPeso molecular:697.78CCK (26-30) (sulfated)
CAS:<p>CCK (26-30) is a digestive and satiety-related peptide fragment inhibiting [125I]CCK-33 binding by 10% at 0.1 mM.</p>Fórmula:C33H41N7O12S2Cor e Forma:SolidPeso molecular:791.85mPGES-1/sEH-IN-1
<p>mPGES-1/sEH-IN-1 (compound 1f) is an sEH inhibitor with an IC50 value of 5 μM. It also exhibits antitumor activity by inhibiting mPGES-1, with an IC50 value of 25 µM.</p>Fórmula:C20H16F3N3O2Cor e Forma:SolidPeso molecular:387.355(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
CAS:<p>V1A receptor antagonist; blocks vasopressin & oxytocin, lowers Ca²⁺ levels (IC50: 5/30 nM); long-acting antivasopressor; anxiolytic in dorsal hippocampus.</p>Fórmula:C52H74N14O12S2Pureza:98%Cor e Forma:White Lyophilized PowderPeso molecular:1151.38Lys-[Hyp3]-Bradykinin
CAS:<p>Lys-[Hyp3]-Bradykinin, a human urine-derived kinin and bradykinin agonist, is used for inflammation research.</p>Fórmula:C56H85N17O13Cor e Forma:SolidPeso molecular:1204.38HS014
CAS:Potent MC4 antagonist; Ki: 3.16 nM (MC4), 108 (MC1), 54.4 (MC3), 694 (MC5). Boosts rat appetite, mouse pain, blocks IL-1β Fos in hypothalamus.Fórmula:C71H94N20O17S2Pureza:98%Cor e Forma:SolidPeso molecular:1563.77Cetirizine methyl ester
CAS:<p>Cetirizine methyl ester is a Cetirizine impurity, a long-acting, oral H1-antihistamine and hydroxyzine metabolite.</p>Fórmula:C22H27ClN2O3Cor e Forma:SolidPeso molecular:402.91GLP-1R agonist 20
<p>GLP-1R agonist 20 (Compound I-132) is an agonist of the glucagon-like peptide-1 receptor (GLP-1 receptor), with an EC50 value of 0.0162 nM.</p>Fórmula:C31H30Cl2F2N4O5Peso molecular:646.15613Edg-2 receptor inhibitor 1
CAS:<p>Edg-2 receptor inhibitor 1 (SAR-100842) is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM).</p>Fórmula:C27H27NO5Pureza:99.47%Cor e Forma:SolidPeso molecular:445.51
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