GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(942 produtos)
- Receptor de adenosina(242 produtos)
- Receptor adrenérgico(2.949 produtos)
- Receptor de Bombesina(30 produtos)
- Receptor de Bradicinina(59 produtos)
- CXCR(149 produtos)
- CaSR(32 produtos)
- Receptor de Canabinóides(195 produtos)
- Receptor de Dopamina(410 produtos)
- Receptor Endotelina(75 produtos)
- Receptor GNRH(73 produtos)
- GPCR19(31 produtos)
- GRK(32 produtos)
- GTPase(21 produtos)
- Receptor Glucagon(166 produtos)
- Hedgehog/Smoothened(45 produtos)
- Receptor de Histamina(359 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(24 produtos)
- Receptor OX(40 produtos)
- Receptor opioide(298 produtos)
- PAFR(11 produtos)
- PKA(49 produtos)
- Receptor S1P(17 produtos)
- SGLT(30 produtos)
- Receptor Sigma(46 produtos)
Exibir 18 mais subcategorias
Foram encontrados 5378 produtos de "GPCR/Proteína-G"
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GV150013
CAS:<p>GV150013 is an antagonist of cholecystokinin-2 (CCK2) receptor.</p>Fórmula:C33H34N4O3Pureza:99.93%Cor e Forma:SolidPeso molecular:534.65Deriglidole
CAS:<p>Deriglidole (SL 86-0715), an alpha2 receptor inhibitor, blocks colistin/Idazoxan but not prazosin/α2-adrenergic receptors.</p>Fórmula:C16H21N3Pureza:97.31% - 98.23%Cor e Forma:SolidPeso molecular:255.36SB 216641 hydrochloride
CAS:<p>SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.</p>Fórmula:C28H31ClN4O4Pureza:98.06% - 99.23%Cor e Forma:SolidPeso molecular:523.02CGP-20712
CAS:<p>CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM.</p>Fórmula:C23H25F3N4O5Pureza:99.40% - 99.58%Cor e Forma:SolidPeso molecular:494.46GW 833972A
CAS:<p>GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.</p>Fórmula:C18H14Cl2F3N5OPureza:99.93%Cor e Forma:SoildPeso molecular:444.24Enerisant
CAS:<p>Enerisant (TS-091) is a histamine H3 receptor antagonist that promotes pro-cognitive effects and reverses scopolamine-induced cognitive deficits.</p>Fórmula:C22H30N4O3Pureza:99.7%Cor e Forma:SoildPeso molecular:398.50TAK-441
CAS:TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.Fórmula:C28H31F3N4O6Pureza:99.82%Cor e Forma:SolidPeso molecular:576.56Selvigaltin
CAS:<p>Selvigaltin (GB1211) is a Gal-3 inhibitor with potential anticancer activity. Selvigaltin is used in the study of cirrhosis and cancer.</p>Fórmula:C19H16BrF3N4O4SPureza:99.49%Cor e Forma:SolidPeso molecular:533.32Selatogrel
CAS:<p>Selatogrel (ACT-246475) is a P2Y12 receptor antagonist with antithrombotic activity and inhibits platelet aggregation.</p>Fórmula:C28H39N6O8PPureza:98.43%Cor e Forma:SolidPeso molecular:618.62Didesmethyl cariprazine
CAS:<p>Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.</p>Fórmula:C19H28Cl2N4OPureza:99.52%Cor e Forma:SolidPeso molecular:399.36(±)-Prenalterol
CAS:<p>(±)-Prenalterol (H 80/62) is an agonist of beta-2- and beta-1-adrenergic receptors and is used to study chronic congestive heart failure.</p>Fórmula:C12H19NO3Pureza:99.73%Cor e Forma:SolidPeso molecular:225.28ST-1006
CAS:<p>ST-1006: histamine H4 agonist, pKi 7.94, anti-inflammatory, anti-pruritic, promotes basophil migration.</p>Fórmula:C16H20Cl2N6Pureza:98.87% - 99.96%Cor e Forma:SolidPeso molecular:367.28Lotiglipron
CAS:<p>Lotiglipron (PF-07081532) is a GLP-1R agonist that lowers blood glucose and may be used in the study of type 2 diabetes mellitus (T2DM) and excess obesity.</p>Fórmula:C31H31ClN4O5Pureza:98.3%Cor e Forma:SolidPeso molecular:575.05K777
CAS:<p>K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).</p>Fórmula:C32H38N4O4SPureza:98.43% - 99.14%Cor e Forma:SolidPeso molecular:574.73WAY-639889
CAS:<p>WAY-639889 is a small molecule compound with selective and potent inhibitory effects on neuropeptide Y-5 receptors.</p>Fórmula:C25H27N5OPureza:99.73%Cor e Forma:SolidPeso molecular:413.51PSB-603
CAS:<p>PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.</p>Fórmula:C24H25ClN6O4SPureza:97.13%Cor e Forma:SolidPeso molecular:529.01PSB 1115
CAS:<p>PSB 1115 is an A2B receptor antagonist and can counteract the inhibitory effect of NECA.</p>Fórmula:C14H14N4O5SPureza:98.69% - >99.99%Cor e Forma:SolidPeso molecular:350.35INCB3344
CAS:<p>INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8</p>Fórmula:C29H34F3N3O6Pureza:98% - 98.2%Cor e Forma:SolidPeso molecular:577.59Lumateperone
CAS:<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Fórmula:C24H28FN3OPureza:99.68% - 99.91%Cor e Forma:SolidPeso molecular:393.5SB-616234-A
CAS:<p>SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.</p>Fórmula:C32H36ClN5O3Pureza:99.72%Cor e Forma:SolidPeso molecular:574.11SR 142948
CAS:<p>SR 142948 is a neurotensin (NT) receptor antagonist.</p>Fórmula:C39H51N5O6Pureza:98%Cor e Forma:SolidPeso molecular:685.85GLP-1R agonist 8
CAS:<p>GLP-1R agonist 8 is a potent agonist of GLP-1R (EC50 < 2 nM).</p>Fórmula:C33H32N4O5Cor e Forma:SolidPeso molecular:564.63GLP-1 receptor agonist 11
CAS:<p>GLP-1 Receptor Agonist 11 (compound 3) acts as an effective agonist for the GLP Receptor, finding use in research related to conditions like diabetes and non-alc. fatty liver disease [1].</p>Fórmula:C31H31ClFN3O4Cor e Forma:SolidPeso molecular:564.055-HT1A antagonist 1
<p>Compound 6f is a potent, selective 5-HT1A receptor blocker (Ki: 35 nM), useful in CNS disorder research.</p>Fórmula:C23H29ClN6O2Cor e Forma:SolidPeso molecular:456.97BRD50837
CAS:<p>BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).</p>Fórmula:C26H32ClN3O6SPureza:98%Cor e Forma:SolidPeso molecular:550.07A2A receptor antagonist 2
<p>A2A receptor antagonist 2 is a highly selective and potent antagonist of the adenosine A2Areceptor (IC50: 8.3 nM).</p>Fórmula:C25H28FN7O3Cor e Forma:SolidPeso molecular:493.53SAR-150640
CAS:SAR-150640, a selective β3-adrenergic receptor agonist, prevents an increase in MMP activity and production observed after LPS stimulation or in cases of chorioamnionitis.Fórmula:C25H35ClN2O7SCor e Forma:SolidPeso molecular:543.07Sulfinalol hydrochloride
CAS:<p>Sulfinalol hydrochloride is an orally active β-adrenoceptor (β-adrenoceptor) antagonist that exhibits direct vasodilatory activity. It is also classified as an antihypertensive agent.</p>Fórmula:C20H28ClNO4SCor e Forma:SolidPeso molecular:413.96Tipindole
CAS:<p>Tipindole is a serotonin antagonist utilized in research related to depression.</p>Fórmula:C16H20N2O2SCor e Forma:SolidPeso molecular:304.41RBM10-8
CAS:<p>RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.</p>Fórmula:C17H36NO5PCor e Forma:SolidPeso molecular:365.45MDA7
CAS:<p>MDA7 is a selective agonist of the cannabinoid receptor 2 (CB2), demonstrating an EC50 of 128 nM in human CB2 receptors and 67.4 nM in rat CB2 receptors. The compound exhibits good affinity for CB2 receptors, with Ki values of 422 nM for humans and 238 nM for rats. In rat models, MDA7 shows analgesic activity.</p>Fórmula:C22H25NO2Cor e Forma:SolidPeso molecular:335.439Protease-Activated Receptor-1 antagonist 2
<p>Selective, orally active PAR-1 antagonist with an IC50 of 7 nM, potential for cardiovascular disease studies.</p>Cor e Forma:SolidZafirlukast metabolite M1
CAS:<p>Zafirlukast metabolite M1 (compound 15) is an inhibitor used in the treatment of asthma and other allergic pulmonary conditions, effectively antagonizing leukotriene activity.</p>Fórmula:C25H25N3O4SCor e Forma:SolidPeso molecular:463.549AA 497 (Free Base)
CAS:<p>AA 497, a beta-2 agonist, causes relaxation and suppresses Ca spike frequency.</p>Fórmula:C14H21NO3Pureza:98%Cor e Forma:SolidPeso molecular:251.32EP4 receptor antagonist 7
CAS:<p>EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4, with an IC50 of 1.1 nM. This compound inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC50 of 0.9 nM. In RAW 264.7 macrophages, it reduces the expression of PGE2-induced IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C motif) ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase 1 (Arg1) mRNA. In the CT26 mouse colon cancer model, EP4 receptor antagonist 7, combined with an anti-PD-1 antibody, inhibits tumor growth and enhances CD8+ T cell infiltration into the tumor.</p>Fórmula:C24H18F3N3O3Cor e Forma:SolidPeso molecular:453.413Butopamine hydrochloride
CAS:<p>Butopamine hydrochloride is an orally active inotropic compound that is more effective at increasing heart rate compared to Dobutamine.</p>Fórmula:C18H24ClNO3Cor e Forma:SolidPeso molecular:337.84Tixanox sodium
CAS:Tixanox sodium effectively blocks histamine release in the lungs triggered by anti-IgE. It has also been demonstrated that when administered orally, Tixanox sodium can successfully counteract exercise-induced asthma.Fórmula:C15H9NaO5SCor e Forma:SolidPeso molecular:324.28AFP-07
CAS:<p>AFP-07 is a highly selective and potent agonist. It was used for the prostacyclin receptor.</p>Fórmula:C22H29F2NaO5Pureza:98%Cor e Forma:SolidPeso molecular:434.458 Hydroxy PIPAT oxalate
CAS:8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.Fórmula:C18H24INO5Cor e Forma:SolidPeso molecular:461.29AL 8810
CAS:<p>AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].</p>Fórmula:C24H31FO4Cor e Forma:SolidPeso molecular:402.5A3AR antagonist 5
CAS:<p>A3AR antagonist 5 (Compound 16) acts as a selective antagonist for the human adenosine A3 receptor (human adenosine A3 receptor), with an affinity expressed as a pC value of 4.542 μM.</p>Fórmula:C18H16N2O2SCor e Forma:SolidPeso molecular:324.40ZK118182 isopropyl ester
CAS:<p>ZK118182 isopropyl ester is a PG analog with potent DP-agonist activity (EC50 = 16.5 nM) and high affinity for the DP receptor (Ki = 74 nM).</p>Fórmula:C23H37ClO5Pureza:98%Cor e Forma:SolidPeso molecular:428.99S1PR1 agonist 2
CAS:<p>S1PR1 agonist 2 is potent for autoimmune research (from WO2021175225A1).</p>Fórmula:C25H25N5O4Cor e Forma:SolidPeso molecular:459.50D4R antagonis-2
<p>Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.</p>Fórmula:C21H23ClF2N2O2Cor e Forma:SolidPeso molecular:408.87(2R,3S)-Azelaprag
CAS:<p>(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist</p>Fórmula:C25H29N7O4SPureza:97.47% - >99.99%Cor e Forma:SoildPeso molecular:523.61Vibegron
CAS:<p>Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).</p>Fórmula:C26H28N4O3Cor e Forma:SolidPeso molecular:444.53GLP-1 receptor agonist 15
CAS:<p>GLP-1 receptor agonist 15 (Example 4) is a GLP receptor agonist with an EC50 of 0.74 nM. It exhibits an IC50 of 10.1 μM against the hERG potassium ion channel. This compound is applicable for research in the diabetes field.</p>Fórmula:C32H31ClFN3O5Cor e Forma:SolidPeso molecular:592.057PSB 36
CAS:<p>A1 adenosine receptor antagonist</p>Fórmula:C21H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:386.49Burapitant
CAS:<p>Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.</p>Fórmula:C31H35Cl2F6N3O3Pureza:>99.99% - >99.99%Cor e Forma:SolidPeso molecular:682.52TAK-661
CAS:<p>TAK-661 is an inhibitor of eosinophil chemotaxis (eosinophil chemotaxis) that significantly alleviates late-phase bronchoconstriction while inhibiting the proliferation of eosinophils in bronchoalveolar lavage (BAL) and their infiltration into the airway walls.</p>Fórmula:C13H21N5O3SCor e Forma:SolidPeso molecular:327.40
