GPCR/Proteína-G
Os inibidores de GPCR/proteínas G são compostos que têm como alvo os receptores acoplados a proteínas G (GPCRs) e as proteínas G associadas, que desempenham papéis críticos na transmissão de sinais do exterior para o interior das células. Esses inibidores são essenciais para estudar as vias de sinalização mediadas por GPCRs, que estão envolvidas em numerosos processos fisiológicos, incluindo percepção sensorial, resposta imunológica e neurotransmissão. Os inibidores de GPCR também são importantes no desenvolvimento de medicamentos, pois muitos agentes terapêuticos têm como alvo esses receptores. Na CymitQuimica, oferecemos uma ampla gama de inibidores de GPCR/proteínas G de alta qualidade para apoiar sua pesquisa em farmacologia, biologia celular e áreas afins.
Subcategorias de "GPCR/Proteína-G"
- Receptor 5-HT(1.025 produtos)
- Receptor de adenosina(249 produtos)
- Receptor adrenérgico(3.018 produtos)
- Receptor de Bombesina(35 produtos)
- Receptor de Bradicinina(61 produtos)
- CXCR(158 produtos)
- CaSR(34 produtos)
- Receptor de Canabinóides(217 produtos)
- Colecistocinina(1 produtos)
- Receptor de Dopamina(445 produtos)
- Receptor Endotelina(86 produtos)
- Receptor GNRH(84 produtos)
- GPCR19(33 produtos)
- GRK(33 produtos)
- GTPase(23 produtos)
- Receptor Glucagon(194 produtos)
- Hedgehog/Smoothened(49 produtos)
- Receptor de Histamina(385 produtos)
- Receptor LPA(21 produtos)
- Receptor de Melatonina(26 produtos)
- Receptor OX(41 produtos)
- Receptor opioide(327 produtos)
- PAFR(14 produtos)
- PKA(60 produtos)
- Receptor S1P(18 produtos)
- SGLT(31 produtos)
- Receptor Sigma(46 produtos)
Exibir 19 mais subcategorias
Foram encontrados 5983 produtos de "GPCR/Proteína-G"
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CP-199330
CAS:CP-199330: non-toxic alternative to Zafirlukast & Pranlukast, blocks cysteyl LT1 receptors.Fórmula:C28H24ClF3N2O6SCor e Forma:SolidPeso molecular:609.01Serlopitant
CAS:Serlopitant is a selective antagonist of Neurokinin-1 (NK-1) receptor.Fórmula:C29H28F7NO2Cor e Forma:SolidPeso molecular:555.53INCB-9471 dihydrochloride
CAS:INCB-9471 HCl: a potent CCR5 antagonist, blocks monocyte migration & HIV-1.Fórmula:C30H42Cl2F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:632.59Sulfinalol hydrochloride
CAS:Sulfinalol hydrochloride is an orally active β-adrenoceptor (β-adrenoceptor) antagonist that exhibits direct vasodilatory activity. It is also classified as an antihypertensive agent.Fórmula:C20H28ClNO4SCor e Forma:SolidPeso molecular:413.96U91356
CAS:U91356 is an agonist of the dopamine receptors.Fórmula:C13H17N3OPureza:98%Cor e Forma:SolidPeso molecular:231.29(Rac)-BI 703704
CAS:(Rac)-BI 703704 is a potent activator of soluble guanylyl cyclase (sGC).Fórmula:C32H37N3O4SPureza:98%Cor e Forma:SolidPeso molecular:559.72Etoperidone
CAS:Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).Fórmula:C19H28ClN5OCor e Forma:SolidPeso molecular:377.91H3R antagonist 5
CAS:H3R antagonist 5 (Compound 1b) is a selective inverse agonist of the histamine H3 receptor that can penetrate the blood-brain barrier, with an IC50 of 0.54 nM. It is applicable for research related to the central nervous system.Fórmula:C23H32N2O4Cor e Forma:SolidPeso molecular:400.511MRGPRX1 agonist 3
Compound 1f, a potent MRGPRX1 agonist, has an EC50 of 0.22 μM, useful for neuropathic pain studies.Fórmula:C14H11FN2OSCor e Forma:SolidPeso molecular:274.31HU-308
CAS:HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.
Fórmula:C27H42O3Cor e Forma:SolidPeso molecular:414.62Histamine H3 antagonist-1
CAS:Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].
Fórmula:C24H28F3N3O2Cor e Forma:SolidPeso molecular:447.495-HT2A/5-HT2C inverse agonist 1
CAS:5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.Fórmula:C24H35N5O2Cor e Forma:SolidPeso molecular:425.57UMB24
CAS:UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.Fórmula:C17H21N3Cor e Forma:SolidPeso molecular:267.37CVT-5440
CAS:CVT-5440 is a selective, high-affinity (2B) adenosine receptor antagonist with good selectivity.Fórmula:C27H28N6O5Cor e Forma:SolidPeso molecular:516.55TAAR1 agonist 2
CAS:TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.Fórmula:C9H11NOCor e Forma:SolidPeso molecular:149.19(S)-Bucindolol
CAS:(S)-Bucindolol is an enantiomer of bucindolol, specifically a β1-adrenergic receptor antagonist. It is primarily utilized in research related to heart failure.Fórmula:C22H25N3O2Cor e Forma:SolidPeso molecular:363.45VA012
CAS:VA012 (compound 11) acts as a positive allosteric modulator (PAM) of the serotonin 5-HT2C receptor. It has been shown to reduce food intake and prevent weight gain during subchronic administration without causing central nervous system-related discomfort. VA012 is applicable in obesity research.Fórmula:C21H19N3Cor e Forma:SolidPeso molecular:313.40YGZ-331
CAS:YGZ-331, a sedative hypnotic, acts by elevating GABA levels as a derivative of the adenosine nucleoside NGBA. It functions through activating A1R and A2aR, and inhibiting the phosphorylation of CaMKII (pCaMKII), thereby exerting its calming effects. Additionally, YGZ-331 reduces spontaneous motor activity in mice.Fórmula:C19H23N5O4Cor e Forma:SolidPeso molecular:385.42Elsovaptan
CAS:Elsovaptan is an antagonist of the vasopressin receptor and is applicable for research in Alzheimer's disease.Fórmula:C19H20ClN5O2Cor e Forma:SolidPeso molecular:385.847TM38837
CAS:CB1 antagonist 4 is an inverse agonist of cannabinoid receptor 1 (CB1) with an IC50 of 0.4 nM. It can reduce body weight, improve plasma inflammatory markers, and enhance glucose homeostasis [1].
Fórmula:C27H20Cl2F3N7OCor e Forma:SolidPeso molecular:586.40
