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Sinalização PI3K/Akt/mTOR

Sinalização PI3K/Akt/mTOR

Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.

Subcategorias de "Sinalização PI3K/Akt/mTOR"

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Foram encontrados 1038 produtos de "Sinalização PI3K/Akt/mTOR"

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  • PD-161570
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    PD-161570

    CAS:
    <p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>
    Fórmula:C26H35Cl2N7O
    Pureza:99.92%
    Cor e Forma:Solid
    Peso molecular:532.51

    Ref: TM-T23127

  • Indirubin-3′-oxime
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    Indirubin-3′-oxime

    CAS:
    <p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>
    Fórmula:C16H11N3O2
    Pureza:98.34%
    Cor e Forma:Solid
    Peso molecular:277.28

    Ref: TM-T9138

  • Endoxifen (Z-isomer)
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    Endoxifen (Z-isomer)

    CAS:
    <p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>
    Fórmula:C25H27NO2
    Pureza:99.19% - 99.81%
    Cor e Forma:Solid
    Peso molecular:373.49

    Ref: TM-T2280

  • Avitinib
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    Avitinib

    CAS:
    <p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>
    Fórmula:C26H26FN7O2
    Pureza:99.81% - >99.99%
    Cor e Forma:Solid
    Peso molecular:487.53

    Ref: TM-T3024

  • Tyrphostin A9
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    Tyrphostin A9

    CAS:
    <p>Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor</p>
    Fórmula:C18H22N2O
    Pureza:98.21% - 99.87%
    Cor e Forma:Yellow Solid
    Peso molecular:282.38

    Ref: TM-T2479

  • AZ-5104
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    AZ-5104

    CAS:
    <p>AZ5104 is a potent EGFR inhibitor.</p>
    Fórmula:C27H31N7O2
    Pureza:98.40% - 99.59%
    Cor e Forma:Solid Powder
    Peso molecular:485.58

    Ref: TM-T2491

  • AMG 511
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    AMG 511

    CAS:
    <p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>
    Fórmula:C22H28FN9O3S
    Pureza:≥98%
    Cor e Forma:Solid
    Peso molecular:517.58

    Ref: TM-T14214

  • iMDK
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    iMDK

    CAS:
    <p>iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.</p>
    Fórmula:C21H13FN2O2S
    Pureza:99.99%
    Cor e Forma:Solid
    Peso molecular:376.4

    Ref: TM-T9460

  • GDC0084
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    GDC0084

    CAS:
    <p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>
    Fórmula:C18H22N8O2
    Pureza:99.72% - 99.87%
    Cor e Forma:Solid
    Peso molecular:382.42

    Ref: TM-T3705

  • AG490
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    AG490

    CAS:
    <p>AG490 inhibits EGFR (0.1 μM IC50), 135x &gt; selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>
    Fórmula:C17H14N2O3
    Pureza:98.6% - 99.39%
    Cor e Forma:Yellow Solid
    Peso molecular:294.3

    Ref: TM-T2600

  • Sapanisertib
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    Sapanisertib

    CAS:
    <p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>
    Fórmula:C15H15N7O
    Pureza:99.19% - >99.99%
    Cor e Forma:Solid
    Peso molecular:309.33

    Ref: TM-T1838

  • AEE788
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    AEE788

    CAS:
    <p>AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.</p>
    Fórmula:C27H32N6
    Pureza:98% - >99.99%
    Cor e Forma:Solid
    Peso molecular:440.58

    Ref: TM-T2116

  • DMNB
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    DMNB

    CAS:
    <p>DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.</p>
    Fórmula:C9H9NO5
    Pureza:97.87%
    Cor e Forma:Yellow Solid
    Peso molecular:211.17

    Ref: TM-T8637

  • Allitinib tosylate
    Targetmol
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    Allitinib tosylate

    CAS:
    <p>Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.</p>
    Fórmula:C31H26ClFN4O5S
    Pureza:98.46% - 98.68%
    Cor e Forma:Solid
    Peso molecular:621.08

    Ref: TM-T6331

  • (E/Z)-GSK-3β inhibitor 1
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    (E/Z)-GSK-3β inhibitor 1

    CAS:
    <p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>
    Fórmula:C14H10N2O
    Pureza:98.60%
    Cor e Forma:Solid
    Peso molecular:222.24

    Ref: TM-T9178

  • PIK-294
    Targetmol
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    PIK-294

    CAS:
    <p>PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).</p>
    Fórmula:C28H23N7O2
    Pureza:97.22% - >99.99%
    Cor e Forma:Solid
    Peso molecular:489.53

    Ref: TM-T2297

  • PI-3065
    Targetmol
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    PI-3065

    CAS:
    <p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>
    Fórmula:C27H31FN6OS
    Pureza:99.84% - ≥95%
    Cor e Forma:Solid
    Peso molecular:506.64

    Ref: TM-T2083

  • β-Hydroxyisovalerylshikonin
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    β-Hydroxyisovalerylshikonin

    CAS:
    <p>Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor</p>
    Fórmula:C21H24O7
    Pureza:98.16%
    Cor e Forma:Solid
    Peso molecular:388.41

    Ref: TM-TN1440

  • TBB
    Targetmol
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    TBB

    CAS:
    <p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>
    Fórmula:C6HBr4N3
    Pureza:98.51% - 99.45%
    Cor e Forma:Off-White Solid
    Peso molecular:434.71

    Ref: TM-T2695

  • Linperlisib
    Targetmol
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    Linperlisib

    CAS:
    <p>Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ</p>
    Fórmula:C28H37FN6O5S
    Pureza:99.01%
    Cor e Forma:Solid
    Peso molecular:588.69

    Ref: TM-T6330