Sinalização PI3K/Akt/mTOR
Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.
Subcategorias de "Sinalização PI3K/Akt/mTOR"
- AMPK(170 produtos)
- ATM/ATR(72 produtos)
- DNA-PK(49 produtos)
- EGFR(581 produtos)
- MELK(7 produtos)
- PDK(9 produtos)
- PI3K(231 produtos)
- S6 Quinase(6 produtos)
- gsk-3(109 produtos)
- mTOR(163 produtos)
Exibir 2 mais subcategorias
Foram encontrados 993 produtos de "Sinalização PI3K/Akt/mTOR"
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Rociletinib
CAS:Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplasticFórmula:C27H28F3N7O3Pureza:98.52% - 99.25%Cor e Forma:SolidPeso molecular:555.55Barecetamab
CAS:Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Pureza:97.1% (SDS-PAGE); 96.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 96.4% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:143.86 kDaSAR405 R enantiomer
CAS:SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is an inhibitor of PIK3C3/Vps34.Fórmula:C19H21ClF3N5O2Pureza:98.04%Cor e Forma:SolidPeso molecular:443.85Ref: TM-T12831
1mg46,00€5mg96,00€10mg149,00€25mg248,00€50mg359,00€100mg502,00€200mg683,00€1mL*10mM (DMSO)94,00€P110δ-IN-1
CAS:P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).Fórmula:C31H40N8O3SPureza:99.75%Cor e Forma:SolidPeso molecular:604.77NV-5138
CAS:NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.Fórmula:C7H13F2NO2Pureza:98% - ≥98%Cor e Forma:SolidPeso molecular:181.18Ref: TM-T12270
1mg94,00€5mg203,00€10mg326,00€25mg698,00€50mg1.108,00€100mg1.603,00€1mL*10mM (DMSO)166,00€STL127705
CAS:STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.Fórmula:C22H20FN5O4Pureza:99.53% - 99.81%Cor e Forma:SolidPeso molecular:437.42Ref: TM-T13017
1mg70,00€5mg150,00€10mg219,00€25mg369,00€50mg550,00€100mg722,00€1mL*10mM (DMSO)170,00€Gefitinib
CAS:Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations.Fórmula:C22H24ClFN4O3Pureza:99.92% - >99.99%Cor e Forma:Light-Yellow Crystalline PowderPeso molecular:446.90LCH-7749944
CAS:LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.Fórmula:C20H22N4O2Pureza:99.48%Cor e Forma:SolidPeso molecular:350.41Ref: TM-T11826
1mg50,00€5mg103,00€10mg156,00€25mg269,00€50mg403,00€100mg583,00€200mg785,00€1mL*10mM (DMSO)110,00€BLU-945
CAS:BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs).Cost-effective and quality-assured.Fórmula:C28H37FN6O3SPureza:99.11% - 99.16%Cor e Forma:SolidPeso molecular:556.7Ref: TM-T9754
1mg35,00€5mg75,00€10mg114,00€25mg222,00€50mg356,00€100mg557,00€200mg790,00€1mL*10mM (DMSO)241,00€Lapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Fórmula:C29H26ClFN4O4SPureza:99.00% - 99.81%Cor e Forma:PowderPeso molecular:581.06IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Fórmula:C25H25N7O2Pureza:98.00%Cor e Forma:SolidPeso molecular:455.51Ref: TM-T15592
1mg44,00€2mg60,00€5mg99,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€1mL*10mM (DMSO)107,00€PI4KIIIbeta-IN-10
CAS:PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Fórmula:C22H25N3O5S2Pureza:99.76%Cor e Forma:SolidPeso molecular:475.58Ref: TM-T12468
1mg75,00€5mg156,00€10mg241,00€25mg399,00€50mg532,00€100mg750,00€200mg1.009,00€1mL*10mM (DMSO)164,00€LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Fórmula:C24H18N2O3SPureza:99.34%Cor e Forma:SolidPeso molecular:414.48Ref: TM-T15789
5mg43,00€10mg71,00€25mg138,00€50mg231,00€100mg344,00€200mg505,00€1mL*10mM (DMSO)47,00€SN32976
CAS:SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.Fórmula:C24H33F2N9O4SPureza:98.06%Cor e Forma:SolidPeso molecular:581.64AV-412
CAS:AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).Fórmula:C41H44ClFN6O7S2Pureza:99.85% - 99.92%Cor e Forma:SolidPeso molecular:851.41Ref: TM-T10419
1mg42,00€2mg55,00€5mg90,00€10mg137,00€25mg240,00€50mg403,00€100mg582,00€1mL*10mM (DMSO)129,00€BRD0705
CAS:BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Fórmula:C20H23N3OPureza:99.01%Cor e Forma:SolidPeso molecular:321.42Ref: TM-T10606
1mg94,00€5mg173,00€10mg253,00€25mg374,00€50mg525,00€100mg702,00€1mL*10mM (DMSO)190,00€Allitinib
CAS:Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Fórmula:C24H18ClFN4O2Pureza:99.89% - 99.91%Cor e Forma:SolidPeso molecular:448.88Ref: TM-T14336
1mg50,00€5mg105,00€10mg172,00€25mg313,00€50mg467,00€100mg663,00€1mL*10mM (DMSO)128,00€Cromolyn sodium
CAS:Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.Fórmula:C23H14Na2O11Pureza:99.4% - 99.95%Cor e Forma:Colorless Crystals From Ethanol + Ether White Crystalline PowderPeso molecular:512.33HyT36
CAS:HyT36: hydrophobic tag that destabilizes fusion proteins & Her3 pseudokinase; treats cells with acute erht.Fórmula:C25H44ClNO3Pureza:99.02%Cor e Forma:SolidPeso molecular:442.07Ref: TM-T72075
1mg56,00€5mg119,00€10mg188,00€25mg393,00€50mg628,00€100mg908,00€1mL*10mM (DMSO)131,00€Intetumumab
CAS:Intetumumab (CNTO 95) is a fully humanized anti-α(v)-integrin monoclonal antibody that is a radiosensitizer for xenograft tumor-bearing mice.Pureza:97.6% (SDS-PAGE); 97.1% (SEC-HPLC) - 97.6% (SDS-PAGE); 97.1% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.56 kDaMevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Fórmula:C23H34O5Pureza:99.12%Cor e Forma:White-Yellowish To Yellow Powder Solid PowderPeso molecular:390.51Khellin
CAS:Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.Fórmula:C14H12O5Pureza:99.89% - 99.95%Cor e Forma:Light Yellow CrystallinePeso molecular:260.24Pyrotinib dimaleate
CAS:Pyrotinib dimaleate is a selective EGFR/HER2 dual inhibitor, respectively, for the treatment of HER2-positive breast cancer.Cost-effective and quality-assured.Fórmula:C40H39ClN6O11Pureza:97.27% - 99.52%Cor e Forma:SolidPeso molecular:815.22Ref: TM-T12594
1mg146,00€5mg434,00€10mg577,00€25mg897,00€50mg1.234,00€100mg1.665,00€1mL*10mM (DMSO)587,00€Epertinib hydrochloride
CAS:Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity.Fórmula:C30H28Cl2FN5O3Pureza:99.14%Cor e Forma:SolidPeso molecular:596.48Ref: TM-T11213
1mg87,00€5mg178,00€10mg295,00€25mg505,00€50mg715,00€100mg964,00€500mg1.935,00€1mL*10mM (DMSO)241,00€AZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Fórmula:C27H32ClN7O2Pureza:99.65%Cor e Forma:SolidPeso molecular:522.04Mutated EGFR-IN-1
CAS:Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activatingFórmula:C25H31N7OPureza:98.91%Cor e Forma:SolidPeso molecular:445.56Panitumumab
CAS:Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).Pureza:95% - 98.1% (SDS-PAGE); 99.4% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.31 kDaErlotinib
CAS:Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Fórmula:C22H23N3O4Pureza:98.19% - 99.98%Cor e Forma:White To Off-White PowderPeso molecular:393.44Erlotinib hydrochloride
CAS:Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Fórmula:C22H23N3O4·HClPureza:99.78% - 99.85%Cor e Forma:White Or Off-White PowderPeso molecular:429.909-ING-41
CAS:9-ING-41 is a glycogen synthase kinase-3 inhibitor.Fórmula:C22H13FN2O5Pureza:99.32%Cor e Forma:SolidPeso molecular:404.35Ref: TM-T14066
1mg50,00€2mg66,00€5mg94,00€10mg155,00€25mg309,00€50mg447,00€100mg667,00€1mL*10mM (DMSO)110,00€Lapatinib ditosylate monohydrate
CAS:Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.
Fórmula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPureza:98% - 99.41%Cor e Forma:Colourless To Light-Yellow CrystalPeso molecular:943.47Tenalisib
CAS:Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Fórmula:C23H18FN5O2Pureza:99.71%Cor e Forma:SolidPeso molecular:415.42Ref: TM-T13119
1mg35,00€2mg50,00€5mg77,00€10mg105,00€25mg178,00€50mg289,00€100mg434,00€1mL*10mM (DMSO)84,00€Indazole
CAS:Indazole, a heterocyclic compound, offers diverse biological activities.Fórmula:C7H6N2Pureza:99.59% - 99.85%Cor e Forma:White Or Beige Crystalline PowderPeso molecular:118.14Parsaclisib
CAS:Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
Fórmula:C20H22ClFN6O2Pureza:98.59%Cor e Forma:SolidPeso molecular:432.88MELK-IN-1
CAS:MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).Fórmula:C31H33N5O4Pureza:99.84%Cor e Forma:SolidPeso molecular:539.62NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Fórmula:C29H27F2N5O5S2Pureza:99.58%Cor e Forma:SolidPeso molecular:627.68Ref: TM-T16355
2mg39,00€5mg60,00€10mg87,00€25mg159,00€50mg231,00€100mg355,00€200mg505,00€1mL*10mM (DMSO)84,00€Lapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Fórmula:C29H26ClFN4O4S·2C7H8O3SPureza:99.41%Cor e Forma:Yellow SolidPeso molecular:925.46O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Fórmula:C21H22ClFN4O3Pureza:97.17%Cor e Forma:SolidPeso molecular:432.88Ref: TM-T16369
1mg52,00€5mg105,00€10mg167,00€25mg324,00€50mg518,00€100mg742,00€1mL*10mM (DMSO)114,00€Petosemtamab
CAS:Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.
Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:145.97 kDaPI4KIIIbeta-IN-9
CAS:PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Fórmula:C23H25N3O5S2Pureza:97.18%Cor e Forma:SolidPeso molecular:487.59Ref: TM-T12469
1mg75,00€5mg178,00€10mg268,00€25mg485,00€50mg677,00€100mg888,00€1mL*10mM (DMSO)197,00€Gancotamab
CAS:Gancotamab (MM-302) is a polyethylene glycolated liposome targeting HER2 with antitumor activity for the study of advanced HER2-positive breast cancer.Pureza:96.7% (SDS-PAGE); 98.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 98.4% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:25.79 kDaRMC-4529
CAS:RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.Fórmula:C90H139N13O23Cor e Forma:SolidPeso molecular:1771.17Varlitinib Tosylate
CAS:Varlitinib Tosylate is a selective and potent inhibitor of ErbB1(EGFR) and ErbB2(HER2).Fórmula:C36H35ClN6O8S3Pureza:98%Cor e Forma:SolidPeso molecular:811.34Lyso-Monosialoganglioside GM3
CAS:Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analog of Ganglioside GM3 with antitumor properties. It inhibits the increase in EGFR kinase activity induced by EGF in A431 epithelial cancer cells.Fórmula:C41H74N2O20Cor e Forma:SolidPeso molecular:915.028Anticancer agent 271
Anticanceragent 271 (compound 5C) exhibits antiproliferative activity against lung cancer (A549), colon cancer (Caco-2) cell lines, and human lung fibroblasts (WI38), with an IC50 value of 9.18 μM for A549 cells. This compound can downregulate PI3K and mTOR gene expression and is applicable in cancer research.Cor e Forma:Odour SolidMulti-target kinase inhibitor 4
Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.Cor e Forma:Odour SolidPI3K-IN-22
CAS:PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.Fórmula:C31H35F3N8O3Cor e Forma:SolidPeso molecular:624.66PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Fórmula:C21H19ClN4O4Cor e Forma:SolidPeso molecular:426.853HER2/neu (654-662) GP2
CAS:Phage display selected Affibody ligands for HER2/neu from a protein library based on a 58-residue Staphylococcal protein A Z domain.Fórmula:C42H77N9O11Pureza:98%Cor e Forma:SolidPeso molecular:884.11GSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Cor e Forma:Odour Solid
