gsk-3
Os inibidores da GSK-3 são compostos que alvo a Glicogênio Sintase Quinase 3 (GSK-3), uma enzima envolvida em numerosos processos celulares, incluindo o metabolismo do glicogênio, a transcrição genética e a proliferação celular. A GSK-3 está implicada em várias doenças, como diabetes, distúrbios neurodegenerativos e câncer. Os inibidores da GSK-3 são ferramentas importantes para explorar essas vias e desenvolver potenciais terapias. Na CymitQuimica, oferecemos inibidores da GSK-3 para apoiar sua pesquisa em doenças metabólicas, neurobiologia e oncologia.
Foram encontrados 109 produtos de "gsk-3"
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Cromolyn sodium
CAS:Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.Fórmula:C23H14Na2O11Pureza:99.4% - 99.95%Cor e Forma:Colorless Crystals From Ethanol + Ether White Crystalline PowderPeso molecular:512.33Indazole
CAS:Indazole, a heterocyclic compound, offers diverse biological activities.Fórmula:C7H6N2Pureza:99.59% - 99.85%Cor e Forma:White Or Beige Crystalline PowderPeso molecular:118.149-ING-41
CAS:9-ING-41 is a glycogen synthase kinase-3 inhibitor.Fórmula:C22H13FN2O5Pureza:99.32%Cor e Forma:SolidPeso molecular:404.35Ref: TM-T14066
1mg50,00€2mg66,00€5mg94,00€1mL*10mM (DMSO)110,00€10mg155,00€25mg309,00€50mg447,00€100mg667,00€BRD0705
CAS:BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Fórmula:C20H23N3OPureza:99.01%Cor e Forma:SolidPeso molecular:321.42GSK3β Inhibitor XI
CAS:GSK3β Inhibitor XI has GSK3β inhibitory effect.Fórmula:C18H15N5O3Cor e Forma:SolidPeso molecular:349.35GSK-3β inhibitor 24
GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.Fórmula:C26H18N4O3Cor e Forma:SolidPeso molecular:434.446GSK-3β inhibitor 1
CAS:GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.Fórmula:C14H10N2OPureza:99.40%Cor e Forma:SolidPeso molecular:222.24Ref: TM-T11467
1mg60,00€5mg130,00€1mL*10mM (DMSO)142,00€10mg200,00€25mg356,00€50mg537,00€100mg737,00€200mg973,00€CHIR-98023
CAS:CHIR-98023 is a bio-active chemical.Fórmula:C20H16Cl2N8O2Cor e Forma:SolidPeso molecular:471.30BMP agonist 1
BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.Fórmula:C21H16N2O6Cor e Forma:SolidPeso molecular:392.36Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Cor e Forma:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarFRATide
CAS:FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.Fórmula:C55H102N2O2Cor e Forma:SolidPeso molecular:823.4332B-(SP)
CAS:Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)Fórmula:C71H123N26O29PPureza:98%Cor e Forma:SolidPeso molecular:1835.87GSK-3β inhibitor 19
GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.Fórmula:C15H12N4O2SCor e Forma:SolidPeso molecular:312.35GSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Cor e Forma:Odour SolidMeBIO
CAS:MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.Fórmula:C17H12BrN3O2Pureza:99.64%Cor e Forma:SolidPeso molecular:370.2Ref: TM-T21966
1mg39,00€5mg74,00€1mL*10mM (DMSO)86,00€10mg117,00€25mg220,00€50mg354,00€100mg520,00€500mg1.130,00€GSK-3β inhibitor 23
GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.Fórmula:C18H13Cl2N5O2SCor e Forma:SolidPeso molecular:434.299GSK-3 Inhibitor 5
CAS:4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.
Fórmula:C9H6BrNOPureza:99.58%Cor e Forma:Off-White To Light Yellow Crystalline PowderPeso molecular:224.056-Me-ATP
CAS:6-Me-ATP, a modified ATP, binds well to GSK3 and donates phosphate for GSK3β phosphorylation.Fórmula:C11H18N5O13P3Cor e Forma:SolidPeso molecular:521.21GSK3β/mTOR modulator 1
GSK3β/mTOR modulator 1 (derivative 2) is an agent that modulates the GSK3β/mTOR signaling pathway. It is applicable in research related to acute lung injury (ALI) and inflammation.Fórmula:C19H28O5Cor e Forma:SolidPeso molecular:336.19367Phospho-Glycogen Synthase Peptide-2(substrate)
CAS:Phospho-Glycogen Synthase Peptide-2 is a GSK-3 substrate, useful for serine kinase affinity purification.Fórmula:C123H191N40O48PCor e Forma:SolidPeso molecular:3029.087
