PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 231 produtos de "PI3K"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Pictilisib dimethanesulfonate
CAS:Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) andFórmula:C25H35N7O9S4Pureza:99.63%Cor e Forma:SolidPeso molecular:705.85Parsaclisib
CAS:Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
Fórmula:C20H22ClFN6O2Pureza:98.59%Cor e Forma:SolidPeso molecular:432.88Tenalisib
CAS:Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Fórmula:C23H18FN5O2Pureza:99.71%Cor e Forma:SolidPeso molecular:415.42Ref: TM-T13119
1mg38,00€2mg49,00€5mg81,00€10mg111,00€25mg188,00€50mg304,00€100mg457,00€1mL*10mM (DMSO)88,00€P110δ-IN-1
CAS:P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).Fórmula:C31H40N8O3SPureza:99.75%Cor e Forma:SolidPeso molecular:604.77Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Fórmula:C21H27ClN2S2Pureza:99.55% - 99.957%Cor e Forma:White To Off-White SolidPeso molecular:407.04CGS 15943
CAS:CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.Fórmula:C13H8ClN5OPureza:97.4%Cor e Forma:SolidPeso molecular:285.69Ref: TM-T14944
2mg34,00€5mg50,00€10mg82,00€25mg147,00€50mg222,00€100mg334,00€200mg494,00€1mL*10mM (DMSO)55,00€PI4KIIIbeta-IN-9
CAS:PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Fórmula:C23H25N3O5S2Pureza:97.18%Cor e Forma:SolidPeso molecular:487.59Ref: TM-T12469
1mg80,00€5mg188,00€10mg283,00€25mg512,00€50mg715,00€100mg938,00€1mL*10mM (DMSO)A consultarInavolisib
CAS:Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.Cost-effective and quality-assured.Fórmula:C18H19F2N5O4Pureza:97.36% - 99.90%Cor e Forma:SolidPeso molecular:407.37Ref: TM-T15375
1mg88,00€5mg212,00€10mg373,00€25mg635,00€50mg1.035,00€100mg1.691,00€200mg2.262,00€1mL*10mM (DMSO)404,00€Sophocarpine monohydrate
CAS:Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Fórmula:C15H22N2OPureza:99.55%Cor e Forma:SolidPeso molecular:246.35NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Fórmula:C29H27F2N5O5S2Pureza:99.58%Cor e Forma:SolidPeso molecular:627.68Ref: TM-T16355
2mg39,00€5mg60,00€10mg87,00€25mg159,00€50mg231,00€100mg355,00€200mg505,00€1mL*10mM (DMSO)84,00€Safingol hydrochloride
CAS:Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.Fórmula:C18H40ClNO2Pureza:99.39% - 99.71%Cor e Forma:SoildPeso molecular:337.969IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Fórmula:C25H25N7O2Pureza:98.00%Cor e Forma:SolidPeso molecular:455.51Ref: TM-T15592
1mg44,00€2mg60,00€5mg99,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€1mL*10mM (DMSO)107,00€Recilisib
CAS:Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.Fórmula:C16H13ClO4SPureza:98.85% - 98.96%Cor e Forma:SolidPeso molecular:336.79Ref: TM-T13862
1mg43,00€2mg56,00€5mg93,00€10mg113,00€25mg177,00€50mg295,00€100mg477,00€200mg677,00€1mL*10mM (DMSO)100,00€PI4KIIIbeta-IN-10
CAS:PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Fórmula:C22H25N3O5S2Pureza:99.76%Cor e Forma:SolidPeso molecular:475.58Ref: TM-T12468
1mg75,00€5mg156,00€10mg241,00€25mg399,00€50mg532,00€100mg750,00€200mg1.009,00€1mL*10mM (DMSO)164,00€Copanlisib dihydrochloride
CAS:Copanlisib dihydrochloride: ATP-competitive PI3K inhibitor, potent for PI3Kα/δ/β/γ, antitumor, 2000x selectivity over other kinases except mTOR.Fórmula:C23H30Cl2N8O4Pureza:99.05% - 99.16%Cor e Forma:SolidPeso molecular:553.44GSK2292767 FA
GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.
Fórmula:C25H30N6O7SPureza:99.52%Cor e Forma:SoildPeso molecular:558.61Duvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Fórmula:C22H18Cl2N6OPureza:99.86% - 99.88%Cor e Forma:SoildPeso molecular:453.32Ref: TM-T11129L
1mg296,00€5mg718,00€10mg982,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€1mL*10mM (DMSO)895,00€Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Cor e Forma:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarPI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withCor e Forma:Odour SolidRef: TM-L1300
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarPI3K-IN-57
PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.Cor e Forma:Odour SolidPITCOIN4
PITCOIN4 is a Class II Alpha PI3K-C2α inhibitor with high selectivity, demonstrating nanomolar inhibition of PI3K-C2α and exhibiting over 100-fold selectivityPureza:98%Cor e Forma:Odour SolidSTX-478
CAS:STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumorFórmula:C16H12F5N5O2Pureza:98.31% - 99.78%Cor e Forma:SolidPeso molecular:401.29Ref: TM-T78211
1mg88,00€5mg187,00€10mg303,00€25mg540,00€50mg815,00€100mg1.216,00€1mL*10mM (DMSO)207,00€PI3Kδ-IN-14
PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of
Fórmula:C26H20ClFN8OPureza:98%Cor e Forma:SolidPeso molecular:514.94IHMT-PI3Kδ-372 S-isomer
CAS:IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.Fórmula:C26H23F2N7O2Pureza:99.97%Cor e Forma:SoildPeso molecular:503.5Ref: TM-T60196
1mg109,00€2mg163,00€5mg241,00€10mg354,00€25mg532,00€50mg745,00€100mg1.018,00€1mL*10mM (DMSO)294,00€Umbralisib R-enantiomer
CAS:Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Fórmula:C31H24F3N5O3Pureza:97.34%Cor e Forma:SolidPeso molecular:571.55Ref: TM-T13140
1mg187,00€5mg455,00€10mg655,00€25mg1.169,00€50mg1.510,00€100mg1.882,00€1mL*10mM (DMSO)560,00€FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Cor e Forma:LiquidWYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Fórmula:C28H32N8O3Pureza:99.93%Cor e Forma:SolidPeso molecular:528.61PI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)Fórmula:C50H46F4N8O8S2Pureza:98%Cor e Forma:SolidPeso molecular:1027.07PI3Kα-IN-12
PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values
Fórmula:C28H36F2N10O5S3Cor e Forma:SolidPeso molecular:726.84PI3K-IN-41
PI3K-IN-41 (compound 2), a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties, demonstrates potent PI3K inhibition following UV lightFórmula:C45H39F2N5O12SPureza:98%Cor e Forma:SolidPeso molecular:911.88IHMT-PI3K-315
IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.Fórmula:C22H20F2N6O4Cor e Forma:SolidPeso molecular:470.43PI5P4Ks-IN-2
CAS:PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.Fórmula:C22H23N5Pureza:98.97% - 99.35%Cor e Forma:SoildPeso molecular:357.45Ref: TM-T72032
1mg152,00€5mg319,00€10mg477,00€25mg803,00€50mg1.054,00€100mg1.378,00€1mL*10mM (DMSO)350,00€PI3K-IN-46
CAS:PI3K-IN-46 is a specific inhibitor of PI3Kγ.
Fórmula:C13H9N3OSPureza:97.51%Cor e Forma:SoildPeso molecular:255.3D-106669
CAS:D-106669 (comppun 150) is a potent inhibitor of PI3Kα, with an IC50 value of 0.129 μM, and plays a significant role in cancer research.Fórmula:C17H18N6OCor e Forma:SolidPeso molecular:322.36PI3Kδ-IN-18
Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1].Pureza:98%Cor e Forma:Odour SolidIHMT-PI3K-455
IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM forFórmula:C26H21F2N7O3Pureza:98%Cor e Forma:SolidPeso molecular:517.49BAY1082439
CAS:BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].Fórmula:C25H30N6O5Pureza:98%Cor e Forma:SolidPeso molecular:494.54GSK251
CAS:GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Fórmula:C29H37FN6O4SPureza:99.8%Cor e Forma:SolidPeso molecular:584.71ARUK2001607
CAS:ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Fórmula:C14H13N3O2S2Pureza:99.75%Cor e Forma:SoildPeso molecular:319.40PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Fórmula:C21H19ClN4O4Cor e Forma:SolidPeso molecular:426.853740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Fórmula:C143H226N43O41PS3Pureza:99.92%Cor e Forma:SoildPeso molecular:3330.79PROTAC PI3Kα degrader-1
PROTACPI3Kα degrader-1 is a PI3Kα-targeting PROTAC degrader (DC50= 0.08 μM) that demonstrates notable selectivity in degrading PI3Kα over the PI3Kβ, PI3Kγ, and PI3Kδ isoforms. It degrades PI3Kα effectively in a time- and concentration-dependent manner and significantly inhibits the phosphorylation of AKT at the Ser473 site. Additionally, PROTACPI3Kα degrader-1 exhibits significant in vivo anticancer efficacy in HGC-27 and DOHH2 xenograft models.Cor e Forma:Odour Solid(3S)-GSK-F1
CAS:(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.Fórmula:C27H18F5N5O4SPureza:99.04%Cor e Forma:SoildPeso molecular:603.52Ref: TM-T67837
1mg70,00€5mg133,00€10mg210,00€25mg371,00€50mg532,00€100mg837,00€1mL*10mM (DMSO)182,00€PROTAC PI3K/110β degrader-1
CAS:PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.Fórmula:C51H65N9O9SCor e Forma:SolidPeso molecular:980.18PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Fórmula:C20H15Cl2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:444.27PF-06843195
CAS:PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Fórmula:C20H25F3N8O4Pureza:98.01%Cor e Forma:SolidPeso molecular:498.46Alpelisib
CAS:Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.Fórmula:C19H22F3N5O2SPureza:98% - 99.73%Cor e Forma:SolidPeso molecular:441.47Ref: TM-T1921
2mg39,00€5mg55,00€10mg72,00€25mg87,00€50mg96,00€100mg154,00€500mg447,00€1mL*10mM (DMSO)60,00€Flupentixol dihydrochloride
CAS:Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.Fórmula:C23H27Cl2F3N2OSPureza:98.76% - >99.99%Cor e Forma:White Or Off-White SolidPeso molecular:507.43AS-605240
CAS:AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Fórmula:C12H7N3O2SPureza:97% - 99.91%Cor e Forma:SolidPeso molecular:257.27Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Fórmula:C23H30N8O3SPureza:98.28% - 99.64%Cor e Forma:SolidPeso molecular:498.6Brevianamide F
CAS:Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.
Fórmula:C16H17N3O2Pureza:97.30% - 98.82%Cor e Forma:SolidPeso molecular:283.33PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Fórmula:C16H14BrN5O4S·HClPureza:97.82%Cor e Forma:SolidPeso molecular:488.74Glaucocalyxin A
CAS:Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.
Fórmula:C20H28O4Pureza:99.55% - 99.80%Cor e Forma:SolidPeso molecular:332.43YS-49
CAS:YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).Fórmula:C20H20BrNO2Pureza:99.65%Cor e Forma:SolidPeso molecular:386.28Ref: TM-T13376
1mg48,00€2mg62,00€5mg90,00€10mg144,00€25mg274,00€50mg408,00€100mg590,00€500mg1.216,00€1mL*10mM (DMSO)97,00€NIBR-17
CAS:NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Fórmula:C18H20N8O2Pureza:97.79%Cor e Forma:SolidPeso molecular:380.4Rigosertib
CAS:Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.
Fórmula:C21H25NO8SPureza:99.53%Cor e Forma:SolidPeso molecular:451.49Erucic acid
CAS:Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).Fórmula:C22H42O2Pureza:99.64%Cor e Forma:Needles From Alcohol Liquid OthersolidPeso molecular:338.571-Deoxynojirimycin hydrochloride
CAS:1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.Fórmula:C6H14ClNO4Pureza:99.88%Cor e Forma:SolidPeso molecular:199.63AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Cor e Forma:SolidPeso molecular:380.4Ref: TM-T7122
1mg38,00€5mg84,00€10mg113,00€25mg177,00€50mg295,00€100mg447,00€200mg650,00€1mL*10mM (DMSO)93,00€VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Fórmula:C17H22N8OPureza:97.82% - 99.54%Cor e Forma:SolidPeso molecular:354.41Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Fórmula:C36H56O13Pureza:99.66% - 99.74%Cor e Forma:SolidPeso molecular:696.82Ref: TM-T5S1982
1mg35,00€5mg77,00€10mg106,00€25mg170,00€50mg253,00€100mg375,00€500mg892,00€1mL*10mM (DMSO)107,00€PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Fórmula:C22H24N2O3Pureza:98.92%Cor e Forma:SolidPeso molecular:364.44Ref: TM-T28416
1mg40,00€2mg57,00€5mg97,00€10mg156,00€25mg255,00€50mg368,00€100mg510,00€200mg700,00€1mL*10mM (DMSO)105,00€Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Fórmula:C25H17F2N5O3SPureza:98% - 99.8%Cor e Forma:SolidPeso molecular:505.5Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFórmula:C15H10O5Pureza:97.93%Cor e Forma:SolidPeso molecular:270.24PIK-294
CAS:PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).Fórmula:C28H23N7O2Pureza:97.22% - >99.99%Cor e Forma:SolidPeso molecular:489.53PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Fórmula:C19H16N4O3Pureza:97.79% - 99.3%Cor e Forma:SolidPeso molecular:348.36Eganelisib
CAS:Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)Fórmula:C30H24N8O2Pureza:98.92% - 99.28%Cor e Forma:SolidPeso molecular:528.56Euscaphic acid
CAS:Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 clustering.Fórmula:C30H48O5Pureza:98.93%Cor e Forma:SolidPeso molecular:488.7HS-173
CAS:HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).Fórmula:C21H18N4O4SPureza:99.33% - 99.64%Cor e Forma:SolidPeso molecular:422.46Ref: TM-T2308
2mg34,00€5mg52,00€10mg77,00€25mg128,00€50mg200,00€100mg296,00€200mg425,00€1mL*10mM (DMSO)52,00€Taurolithocholic acid sodium salt
CAS:Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, butFórmula:C26H44NNaO5SPureza:99.79% - 99.93%Cor e Forma:SolidPeso molecular:505.69ZSTK474
CAS:PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potentialFórmula:C19H21F2N7O2Pureza:98.29% - 99.95%Cor e Forma:White PowderPeso molecular:417.413-Methyladenine
CAS:3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).Fórmula:C6H7N5Pureza:98% - 99.51%Cor e Forma:SolidPeso molecular:149.15Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Fórmula:C21H22O11Pureza:98.63% - 99.54%Cor e Forma:SolidPeso molecular:450.39SKI V
CAS:SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),
Fórmula:C15H10O4Pureza:98.78%Cor e Forma:SolidPeso molecular:254.24Hederacolchiside A1
CAS:Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.Fórmula:C47H76O16Pureza:98.76% - 99.92%Cor e Forma:SolidPeso molecular:897.1Ref: TM-T2P2806
1mg48,00€5mg120,00€10mg170,00€25mg283,00€50mg430,00€100mg620,00€200mg870,00€1mL*10mM (DMSO)170,00€Vps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Fórmula:C17H17N7Pureza:98.39% - 98.43%Cor e Forma:SolidPeso molecular:319.36Ref: TM-T6945
1mg49,00€2mg67,00€5mg110,00€10mg192,00€25mg429,00€50mg628,00€100mg893,00€500mg1.791,00€1mL*10mM (DMSO)110,00€AMG 511
CAS:AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).Fórmula:C22H28FN9O3SPureza:≥98%Cor e Forma:SolidPeso molecular:517.58Idelalisib
CAS:Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Fórmula:C22H18FN7OPureza:98% - 99.39%Cor e Forma:SolidPeso molecular:415.42Ref: TM-T1894
5mg34,00€10mg48,00€25mg71,00€50mg88,00€100mg103,00€200mg133,00€500mg213,00€1mL*10mM (DMSO)50,00€iMDK
CAS:iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.Fórmula:C21H13FN2O2SPureza:99.99%Cor e Forma:SolidPeso molecular:376.4GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFórmula:C17H20N6O2SPureza:98%Cor e Forma:SolidPeso molecular:372.44NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Fórmula:C20H14F3N3SPureza:99.84% - 99.9%Cor e Forma:SolidPeso molecular:385.41Ref: TM-T3556
2mg35,00€5mg51,00€10mg75,00€25mg133,00€50mg225,00€100mg323,00€200mg447,00€1mL*10mM (DMSO)55,00€BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Fórmula:C28H25F3N6O2Pureza:95.74% - 99.78%Cor e Forma:SolidPeso molecular:534.53Ref: TM-T6072L
1mg47,00€2mg62,00€5mg92,00€10mg147,00€25mg295,00€50mg485,00€100mg737,00€1mL*10mM (DMSO)107,00€Fimepinostat
CAS:Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.Fórmula:C23H24N8O4SPureza:98.27% - 99.87%Cor e Forma:SolidPeso molecular:508.55Ref: TM-T2078
2mg47,00€5mg70,00€10mg97,00€25mg175,00€50mg311,00€100mg512,00€500mg1.093,00€1mL*10mM (DMSO)79,00€Rigosertib sodium
CAS:Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Fórmula:C21H24NNaO8SPureza:98% - 99.37%Cor e Forma:SolidPeso molecular:473.47TASP0415914
CAS:TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TFórmula:C13H17N5O3SPureza:98.14%Cor e Forma:SolidPeso molecular:323.37Ref: TM-T7879
1mg52,00€5mg111,00€10mg177,00€25mg299,00€50mg424,00€100mg587,00€200mg792,00€1mL*10mM (DMSO)127,00€Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Fórmula:C23H24O8Pureza:95.84% - 99.77%Cor e Forma:White SolidPeso molecular:428.43Ref: TM-T6283
1mg38,00€2mg49,00€5mg80,00€10mg119,00€25mg235,00€50mg406,00€100mg602,00€1mL*10mM (DMSO)88,00€Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Fórmula:C17H20F3N7O2Pureza:97.58% - 98.92%Cor e Forma:SolidPeso molecular:411.38PI3K-IN-1
CAS:PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Fórmula:C31H29N5O6SPureza:97.03% - 98%Cor e Forma:SolidPeso molecular:599.66PI-3065
CAS:PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Fórmula:C27H31FN6OSPureza:99.84% - ≥95%Cor e Forma:SolidPeso molecular:506.64AS-252424
CAS:AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.Fórmula:C14H8FNO4SPureza:99.06% - 99.09%Cor e Forma:SolidPeso molecular:305.28Ref: TM-T6208
1mg37,00€2mg52,00€5mg77,00€10mg128,00€25mg205,00€50mg309,00€100mg447,00€500mg973,00€1mL*10mM (DMSO)84,00€Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66% - 99.93%Cor e Forma:SolidPeso molecular:332.39PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Fórmula:C22H27N5O4Pureza:96.27% - ≥95%Cor e Forma:SolidPeso molecular:425.48Ref: TM-T6251
1mg34,00€2mg43,00€5mg63,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€1mL*10mM (DMSO)65,00€Oroxin B
CAS:Oroxin B (Hypocretin-2) has antioxidant activity.Fórmula:C27H30O15Pureza:98.22% - 99.87%Cor e Forma:SolidPeso molecular:594.52GDC0084
CAS:GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.
Fórmula:C18H22N8O2Pureza:99.72% - 99.87%Cor e Forma:SolidPeso molecular:382.42Copanlisib
CAS:Copanlisib (BAY 80-6946), a PI3K inhibitor, may block tumor growth and improve cancer treatment efficacy.Fórmula:C23H28N8O4Pureza:99% - 99.88%Cor e Forma:SolidPeso molecular:480.52PF-4989216
CAS:PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.Fórmula:C18H13FN6OSPureza:99.85%Cor e Forma:SolidPeso molecular:380.4Ref: TM-T6938
2mg39,00€5mg65,00€10mg101,00€25mg187,00€50mg329,00€100mg398,00€200mg565,00€1mL*10mM (DMSO)67,00€GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Fórmula:C21H28N8O3S2Pureza:98.88% - 99.55%Cor e Forma:SolidPeso molecular:504.63Ref: TM-T3692
1mg44,00€2mg57,00€5mg93,00€10mg138,00€25mg286,00€50mg447,00€100mg677,00€1mL*10mM (DMSO)92,00€Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
Fórmula:C21H25F3N6O2Pureza:99.88%Cor e Forma:SolidPeso molecular:450.461-Deoxynojirimycin
CAS:1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.Fórmula:C6H13NO4Pureza:99.65% - 99.98%Cor e Forma:White-Beige Solid CrystallinePeso molecular:163.17Ref: TM-T3675
2mg46,00€5mg62,00€10mg79,00€25mg147,00€50mg261,00€100mg339,00€500mg817,00€1mL*10mM (DMSO)60,00€Dihydrocapsaicin
CAS:Dihydrocapsaicin, similar to capsaicin, is an irritant found in Capsicum, used in "pure" capsaicin products at about 10%, activates VR1, and is an antioxidant.Fórmula:C18H29NO3Pureza:99.8% - ≥95%Cor e Forma:White CrystalPeso molecular:307.43
