CAS 50-27-1

Estriol

Description:

Estriol, with the CAS number 50-27-1, is a naturally occurring estrogen and one of the three main estrogens produced by the human body, alongside estradiol and estrone. It is primarily synthesized in the placenta during pregnancy and plays a crucial role in maintaining pregnancy and fetal development. Estriol is characterized by its relatively weak estrogenic activity compared to estradiol and estrone, making it less potent in stimulating estrogen receptors. Chemically, it is a steroid hormone with a molecular formula of C18H24O3, featuring a phenolic structure that contributes to its biological activity. Estriol is often used in hormone replacement therapy, particularly for menopausal symptoms, and is also studied for its potential protective effects against certain hormone-related cancers. Its pharmacokinetics involve rapid metabolism and excretion, primarily through the liver. Due to its specific role in reproductive health, estriol levels are monitored during pregnancy and can be indicative of fetal well-being.

Formula: C₁₈H₂₄O₃

InChI: InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1

InChI key: InChIKey=PROQIPRRNZUXQM-ZXXIGWHRSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(C[C@@H](O)[C@@H]2O)[H]

Synonyms:

• (16Alpha,17Beta)-Estra-1,3,5(10)-Triene-3,16,17-Triol
• (16α,17β)-Estra-1,3,5(10)-triene-3,16,17-triol
• (8R,13S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
• 1,3,5 (10)-Estratriene-3, 16α, 17β-triol
• 1,3,5(10)-Estratriene-3,16a,17b-triol
• 13β-Methyl-1,3,5(10)-gonatriene-3,16α,17β-triol
• 16α,17β-Estriol
• 16α-Estriol
• 16α-Hydroxyestradiol
• 3,16α,17β-Estriol
• 3,16α,17β-Trihydroxyestra-1,3,5(10)-triene
• Aacifemine
• Colpogyn
• Destriol
• ESTRA-1,3,5(10)-TRIENE-3,16α,17β-TRIOL
• Estra-1,3,5(10)-triene-3,16,17-triol, (16α,17β)-
• Estra-1,3,5(10)-triene-3,16alpha,17beta-triol
• Estratriol
• Estriel
• Follicular hormone hydrate
• Gynasan
• Holin V
• Hormomed
• Incurin
• Klimax E
• Klimoral
• Nsc 12169
• OE3
• OE₃
• Oekolp
• Oestriol
• Ortho-Gynest
• Ovesterin
• Ovestin
• Ovestrion
• Ovo-Vinces
• Theelol
• Tridestrin
• Trihydroxyestrin
• Triovex

Estriol

CAS: 50-27-1

Formula: C₁₈H₂₄O₃

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 288.39

Ref: 3B-E0218

Estriol 1.0 mg/ml in Methanol

CAS: 50-27-1

Color and Shape: Colourless

Ref: 61-AMP0130.00-01

Estriol

CAS: 50-27-1

Color and Shape: Neat

Ref: 61-FOR0130.00

ESTRIOL FOR SYSTEM SUITABILITY CRS

CAS: 50-27-1

ESTRIOL FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001971

Estriol

CAS: 50-27-1

Estriol

Formula: C₁₈H₂₄O₃

Purity: 99.3%

Color and Shape: White To Off-White

Molecular weight: 288.17254

Ref: 47-752

Estriol impurity standard

CAS: 50-27-1

Estriol impurity standard

Color and Shape: Off-White

Ref: 47-753

ESTRIOL CRS

CAS: 50-27-1

ESTRIOL CRS

Ref: 41-E1680000

Estriol

CAS: 50-27-1

Estrogens and progestins

Formula: C₁₈H₂₄O₃

Color and Shape: White Crystalline Powder Crystals

Molecular weight: 288.17254

Ref: 45-1254508

(1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol

CAS: 50-27-1

Formula: C₁₈H₂₄O₃

Purity: %

Color and Shape: Solid

Molecular weight: 288.3814

Ref: IN-DA003AAT

Estriol

CAS: 50-27-1

Estriol is a major estrogen metabolite with hydroxyl groups at C3, 16-alpha, and 17-beta; it's abundant in pregnancy urine.

Formula: C₁₈H₂₄O₃

Purity: 97.97% - 98.55%

Color and Shape: Leaflets From Alcohol Solid

Molecular weight: 288.38

Ref: TM-T1571

Estriol

CAS: 50-27-1

Formula: C₁₈H₂₄O₃

Purity: ≤ 2.0%

Color and Shape: White to off-white powder

Molecular weight: 288.38

Ref: 7W-GP3903

Estriol

CAS: 50-27-1

Estriol

Purity: 98.5%

Molecular weight: 288.38g/mol

Ref: 54-OR1024871

Estriol

CAS: 50-27-1

Estriol

Purity: ≥95%

Molecular weight: 288.38g/mol

Ref: 54-BUP14727

Estriol

CAS: 50-27-1

Formula: C₁₈H₂₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 288.39

Ref: 4Z-E-351

16α-Hydroxy-17β-estradiol-2,4,17-d3

CAS: 50-27-1, 79037-36-8

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 291.40

Ref: 3U-D5384

16α-Hydroxy-17β-estradiol-2,4-d2

CAS: 50-27-1, 53866-32-3

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 290.40

Ref: 3U-D5279

Estriol 100 µg/mL in Acetonitrile

Controlled Product

CAS: 50-27-1

Formula: C₁₈H₂₄O₃

Color and Shape: Single Solution

Molecular weight: 288.38

Ref: 04-XA13213200AL

Estriol

Controlled Product

CAS: 50-27-1

Formula: C₁₈H₂₄O₃

Color and Shape: Neat

Molecular weight: 288.38

Ref: 86-MM0130.00

GB 31660.2-2019 Antibiotics Mixture 168 30-100 µg/mL in Methanol

Controlled Product

CAS: 140-66-9, 25154-52-3, 50-27-1, 50-28-2, 53-16-7, 56-53-1, 57-63-6, 80-05-7

Color and Shape: Mixture

Ref: 04-A50000168ME

Estriol

Controlled Product

CAS: 50-27-1

Formula: C₁₈H₂₄O₃

Color and Shape: Neat

Molecular weight: 288.38

Ref: 04-C13213200

Estriol RS

CAS: 50-27-1

Color and Shape: White Solid Crystalline Powder

Ref: 2K-1022000021

Estriol

Controlled Product

CAS: 50-27-1

Applications A metabolite of Estradiol (E888000). An estrogenic metabolite considerably less potent than the hormone Estradiol (E888000).
References Marrian, et al.: Biochem. J., 23,1090 (1929), Huffman, et al.: J. Biol. Chem., 169, 167 (1947),

Formula: C₁₈H₂₄O₃

Color and Shape: White To Off-White

Molecular weight: 288.38

Ref: TR-E888960

Estriol

Controlled Product

CAS: 50-27-1

Estriol is a steroidal estrogen, which is a naturally occurring hormone primarily sourced from the placenta during pregnancy. Its mode of action involves binding to estrogen receptors, thereby exerting its effects as part of the broader group of estrogens. Estriol has a relatively lower affinity for estrogen receptors compared to estradiol, contributing to its unique pharmacological profile.In scientific research and clinical settings, Estriol is employed in hormone replacement therapy, especially in postmenopausal women, due to its milder estrogenic effects and lower associated risks compared to other estrogens. It is also studied for its potential benefits in urogynecological health, such as the treatment of menopausal symptoms like vaginal atrophy. Furthermore, its application is under investigation for autoimmune conditions such as multiple sclerosis, given its immunomodulatory properties. Ongoing research aims to delineate the therapeutic potential and safety profile of Estriol in various clinical contexts.

Formula: C₁₈H₂₄O₃

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 288.38 g/mol

Ref: 3D-FE22836

Estriol

CAS: 50-27-1

Formula: C₁₈H₂₄O₃

Purity: 98+%

Molecular weight: 288.387

Ref: 10-F373692