CAS 53-19-0

Mitotane

Description:

Mitotane, with the CAS number 53-19-0, is an organic compound primarily used in the treatment of adrenocortical carcinoma, a rare type of cancer affecting the adrenal glands. It is classified as an antineoplastic agent and functions by inhibiting adrenal steroidogenesis, leading to a reduction in cortisol production. Mitotane is known for its lipophilic nature, which allows it to accumulate in adipose tissue and the adrenal glands, enhancing its therapeutic effects. The compound has a relatively low solubility in water but is soluble in organic solvents. Its mechanism of action involves the destruction of adrenal cortical cells and the alteration of steroid hormone synthesis. Mitotane can have significant side effects, including adrenal insufficiency, gastrointestinal disturbances, and neurotoxicity, necessitating careful monitoring during treatment. Due to its potent effects and potential toxicity, it is typically administered under strict medical supervision. Overall, Mitotane represents a critical option in the management of specific adrenal tumors, highlighting the importance of targeted therapies in oncology.

Formula:C₁₄H₁₀Cl₄

InChI:InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H

InChI key:InChIKey=JWBOIMRXGHLCPP-UHFFFAOYSA-N

SMILES:C(C(Cl)Cl)(C1=C(Cl)C=CC=C1)C2=CC=C(Cl)C=C2

Synonyms:

1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichlor
1-(o-Chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane
1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
1-Chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene
2,2,O,P-Tetrachloroethylidenebisbenzene
2,4'-Dichlorodiphenyldichloroethane
2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane
2-(p-Chlorophenyl)-2-(o-chlorophenyl)-1,1-dichloroethane
Benzene, 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-
Cb 313
Chloditan
Chlodithane
Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-
Lysodren
Mitotan
Mitotane
Mitotano
Nsc 38721
Opeprim
o,p'-DDD
o,p'-Dichlorodiphenyldichloroethane
o,p'-TDE
See more synonyms

Purity (%)

100

products per page.Found 41 products.

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HJ 921-2017 Organochlorine Pesticides Mixture 109 100 µg/mL in Toluene:n-Hexane
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Color and Shape:Mixture
Ref: 04-A50000109TH
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PAH/PCB/Pesticides Mixture 322 100 µg/mL in Cyclohexane
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Color and Shape:Mixture
Ref: 04-A50000322CY
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IRSA Method 5090 Pesticide Mixture 100 µg/mL in Acetone
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CAS:
Formula:C₁₄H₁₀Cl₄
Color and Shape:Mixture
Molecular weight:320.04
Ref: 04-GA09000944AC
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162.00€
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Pesticide-Mix 1037 10 µg/mL in Cyclohexane
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Formula:C₁₄H₁₀Cl₄
Color and Shape:Mixture
Molecular weight:320.04
Ref: 04-LA18001037CY
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143.00€
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Pesticide Mix 5 10 µg/mL in Cyclohexane
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CAS:
Formula:C₁₄H₁₀Cl₄
Color and Shape:Mixture
Molecular weight:320.04
Ref: 04-L18000005CY
10ml
230.00€
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Pesticide-Mix 13 10 µg/mL in Cyclohexane
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CAS:
Formula:C₁₂H₄Cl₆
Color and Shape:Mixture
Molecular weight:360.88
Ref: 04-LA18000013CY
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Pesticide Mixture 200 100 µg/mL in Ethyl acetate
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Formula:C₁₄H₁₀Cl₄
Color and Shape:Mixture
Molecular weight:320.04
Ref: 04-GA09000200EA
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571.00€
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Pesticide-Mix 13 10 µg/mL in Toluene
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CAS:
Formula:C₁₂H₄Cl₆
Color and Shape:Mixture
Molecular weight:360.88
Ref: 04-LA18000013TO
1ml
348.00€
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Pesticide-Mix 71 10 µg/mL in Cyclohexane
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Formula:C₆HCl₄NO₂
Color and Shape:Mixture
Molecular weight:260.89
Ref: 04-L18000071CY
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820.00€
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2,4'-DDD 10 µg/mL in Cyclohexane
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CAS:
- 53-19-0
Formula:C₁₄H₁₀Cl₄
Color and Shape:Single Solution
Molecular weight:320.04
Ref: 04-L12030000CY
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58.00€
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2,4'-DDD 100 µg/mL in Cyclohexane
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CAS:
- 53-19-0
Formula:C₁₄H₁₀Cl₄
Color and Shape:Single Solution
Molecular weight:320.04
Ref: 04-XA12030000CY
1ml
56.00€
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HJ 699-2014 Organochlorine Pesticides Mixture 517 10 µg/mL in n-Hexane
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Color and Shape:Mixture
Ref: 04-A50000517HE
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Pesticide-Mix 20 10 µg/mL in Cyclohexane
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Formula:C₁₄H₁₀Cl₄
Color and Shape:Mixture
Molecular weight:320.04
Ref: 04-L18000020CY
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Organochlorine Pesticides Mixture 637 500 µg/mL in Hexane
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Color and Shape:Mixture
Ref: 04-A50000637HE
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188.00€
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Mitotane-d4
CAS:
- 53-19-0
Formula:C₁₄H₆D₄Cl₄
Molecular weight:324.06
Ref: 4Z-M-091001
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Mitotane
CAS:
- 53-19-0
Formula:C₁₄H₁₀Cl₄
Molecular weight:320.05
Ref: 4Z-M-091002
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Mitotane
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 53-19-0
Applications An Antineoplastic. Used as an adrenolytic agent.
References Das, S., and Thomas, P.: Endocrinology, 140, 1953 (1999), Andersen, A., et al.: Ther. Drug. Monit., 21, 355 (1999), Leblond, V.S., and Hontela, T.: Toxicol. Appl. Pharmacol., 157, 16 (1999)
Formula:C₁₄H₁₀Cl₄
Color and Shape:Neat
Molecular weight:320.04
Ref: TR-M372500
50mg
93.00€
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1g
95.00€
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10g
626.00€
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Mitotane
CAS:
- 53-19-0
Mitotane is a drug that inhibits the function of p-glycoprotein (P-gp), which is an important protein in the transport of drugs and other substances across cellular membranes. Mitotane has been shown to inhibit P-gp function and increase the uptake of mitoxantrone, doxorubicin, and daunorubicin by adrenocortical cells. Mitotane may be used to treat adrenocortical carcinoma by inhibiting tumor growth and preventing metastasis. This drug also has a cytostatic effect on adrenocortical cells, slowing or stopping cell division. It is thought that this inhibition may be caused by mitotane's ability to alter mitochondrial functions. The molecular pathogenesis of mitotane induced cytostasis is not well understood at this time, but it may involve a matrix effect on mitochondria. Mitotane can also be used as an adjuvant therapy for the diagnosis of adrenocortical carcin
Formula:C₁₄H₁₀Cl₄
Purity:Min. 98 Area-%
Color and Shape:White Off-White Powder
Molecular weight:320.04 g/mol
Ref: 3D-FM02907
10g
275.00€
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25g
478.00€
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50g
724.00€
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100g
1,024.00€
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250g
1,365.00€
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Mitotane - Bio-X ™
CAS:
- 53-19-0
This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.
Formula:C₁₄H₁₀Cl₄
Purity:Min. 95%
Color and Shape:Powder
Molecular weight:320.04 g/mol
Ref: 3D-BM300096
100mg
186.00€
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MITOTANE
CAS:
- 53-19-0
Purity:98%+(GC-MS);RG
Molecular weight:320.0299988
Ref: 10-F825704
1g
47.00€
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5g
127.00€
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25g
375.00€
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