CAS 68844-77-9

Astemizole

Description:

Astemizole is an antihistamine that was primarily used to treat allergic conditions such as hay fever and urticaria. It belongs to the class of selective H1 receptor antagonists and is characterized by its long duration of action. Astemizole is a lipophilic compound, which allows it to cross the blood-brain barrier, potentially leading to central nervous system effects. Its chemical structure features a piperidine ring and a substituted phenyl group, contributing to its pharmacological properties. However, astemizole has been associated with serious cardiac side effects, particularly arrhythmias, due to its ability to prolong the QT interval. This risk led to its withdrawal from many markets in the late 1990s. Despite its efficacy in alleviating allergic symptoms, the safety concerns surrounding its use have limited its application in clinical practice. As a result, astemizole is no longer widely prescribed, and alternative antihistamines with better safety profiles have become more prevalent.

Formula: C₂₈H₃₁FN₄O

InChI: InChI=1/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)

InChI key: InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N

SMILES: C(N1C=2C(N=C1NC3CCN(CCC4=CC=C(OC)C=C4)CC3)=CC=CC2)C5=CC=C(F)C=C5

Synonyms:

• 1-((4-fluorophenyl)-methyl)-N-(1-(2-(4-methoxyphenyl)ethyl)-4-piperidinyl)-1H-benzimidazol-2-amine
• 1-(4-Fluorobenzyl)-2-(1-(4-methoxyphenethyl)piperidin-4-yl)aminobenzimidazole
• 1-(4-fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine
• 1H-Benzimidazol-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-
• Astemisan
• Astemizol
• Hismanal
• Histamen
• Histaminos
• Histazol
• Kelp
• Laridal
• Metodik
• Novo-Nastizol A
• Nsc 329963
• Paralergin
• R 42512
• R 43512
• Retolen
• Stemiz
• Waruzol
• Astemizole
• hisamanal
• AsteMizole, BP
• MJD-30
• hestazol
• 1-[(4-fluorophenyl)Methyl]-N-{1-[2-(4-Methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-aMine
• astemizolum(inn-latin)
• 1-((4-fluorophenyl)methyl)-n-(1-(2-(4-methoxyphenyl)ethyl)-4-piperidinyl)-1h-b
• 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine
• Retolan：Waruzol
• metodih
• 1-(p-fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole
• novo-mastizola
• 1-(p-fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzim
• astemison
• benzimidazole,1-(p-fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)
• Astemizole (200 mg)
• r42512
• 1-(p-Fluorobenzyl)-2-((1-(b-methoxyphenethyl)-4-piperidyl)amino)benzimidazole
• astemizol(inn-spanish)
• idazole
• 1-(4-Fluorobenzyl)-2-[[1-(4-methoxyphenethyl)-4-piperidyl]amino]-1H-benzimidazole
• [1-(4-fluorobenzyl)benzimidazol-2-yl]-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidyl]amine
• 1h-benzimidazol-2-amine,1-((4-fluorophenyl)methyl)-n-(1-(2-(4-methoxyphenyl)et
• r45312
• hl)-4-piperidinyl)-

Astemizole, 99+%

CAS: 68844-77-9

Selective histamine H1 receptor antagonist

Formula: C₂₈H₃₁FN₄O

Purity: 99+%

Molecular weight: 458.58

Ref: 02-J60339

Astemizole

CAS: 68844-77-9

Astemizole (Laridal) is a long-acting antihistamine for allergies like rhinitis and asthma, with fewer anticholinergic effects.

Formula: C₂₈H₃₁FN₄O

Purity: 98.24% - 99.67%

Color and Shape: White Crystals Solid

Molecular weight: 458.57

Ref: TM-T1278

1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine

CAS: 68844-77-9

Formula: C₂₈H₃₁FN₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 458.5703

Ref: IN-DA003DSP

Astemizole

CAS: 68844-77-9

Astemizole

Purity: ≥98%

Molecular weight: 458.57g/mol

Ref: 54-BUP06781

Astemizole

CAS: 68844-77-9

Astemizole

Purity: 98%

Molecular weight: 458.57g/mol

Ref: 54-PC108732

Astemizole

CAS: 68844-77-9

Formula: C₂₈H₃₁FN₄O

Molecular weight: 458.58

Ref: 4Z-A-157003

Astemizole

CAS: 68844-77-9

Formula: C₂₈H₃₁FN₄O

Color and Shape: Neat

Molecular weight: 458.57

Ref: 04-C10308000

Astemizole

CAS: 68844-77-9

Formula: C₂₈H₃₁FN₄O

Molecular weight: 458.57

Ref: 7W-GP5099

Astemizole

Controlled Product

CAS: 68844-77-9

Applications Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic.
References Wauquier, A., et al.: Eur. J. Pharmacol., 72, 245 (1981), Laduron, P.M., et al.: Mol. Pharmacol., 21, 294 (1982), Richards, D.M., et al.: Drugs, 28, 38 (1984), Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1991), Ishikawa, M., et al.: Biol. Pharm. Bull., 23, 112 (2000),

Formula: C₂₈H₃₁FN₄O

Color and Shape: White To Off-White

Molecular weight: 458.57

Ref: TR-A790030

Astemizole

CAS: 68844-77-9

Histamine-1 receptor antagonist; hERG K+ channel blocker

Formula: C₂₈H₃₁FN₄O

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 458.57 g/mol

Ref: 3D-FA18002

Astemizole - Bio-X ™

CAS: 68844-77-9

Astemizole is an antihistamine drug used to treat allergy symptoms. This drug is a histamine-1 receptor antagonist and does not cross the blood-brain barrier. Its binding to histamine receptors suppresses flare ups and pruritus.

Formula: C₂₈H₃₁FN₄O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 458.57 g/mol

Ref: 3D-BA300024

Astemizole-d5

Controlled Product

CAS: 68844-77-9

Formula: C₂₈D₅H₂₆FN₄O

Color and Shape: Neat

Molecular weight: 463.601

Ref: TR-A790034