CAS 68844-77-9: Astemizole

Description: Astemizole is an antihistamine that was primarily used to treat allergic conditions such as hay fever and urticaria. It belongs to the class of selective H1 receptor antagonists and is characterized by its long duration of action. Astemizole is a lipophilic compound, which allows it to cross the blood-brain barrier, potentially leading to central nervous system effects. Its chemical structure features a piperidine ring and a substituted phenyl group, contributing to its pharmacological properties. However, astemizole has been associated with serious cardiac side effects, particularly arrhythmias, due to its ability to prolong the QT interval. This risk led to its withdrawal from many markets in the late 1990s. Despite its efficacy in alleviating allergic symptoms, the safety concerns surrounding its use have limited its application in clinical practice. As a result, astemizole is no longer widely prescribed, and alternative antihistamines with better safety profiles have become more prevalent.

Formula: C₂₈H₃₁FN₄O

InChI: InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)

InChI key: InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N

SMILES: FC1=CC=C(C=C1)CN2C(=NC=3C=CC=CC32)NC4CCN(CCC5=CC=C(OC)C=C5)CC4

Synonyms:

• 1-((4-fluorophenyl)-methyl)-N-(1-(2-(4-methoxyphenyl)ethyl)-4-piperidinyl)-1H-benzimidazol-2-amine
• 1-(4-Fluorobenzyl)-2-(1-(4-methoxyphenethyl)piperidin-4-yl)aminobenzimidazole
• 1-(4-fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine
• 1H-Benzimidazol-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-
• Astemisan
• Astemizol
• Hismanal
• Histamen
• Histaminos
• Histazol
• Kelp
• Laridal
• Metodik
• Novo-Nastizol A
• Nsc 329963
• Paralergin
• R 42512
• R 43512
• Retolen
• Stemiz
• Waruzol
• Astemizole

Astemizole, 99+%

CAS: 68844-77-9

Astemizole, is used as a potent and selective H1-receptor antagonist that displays antihistamine and antimalarial …

• Formula: C₂₈H₃₁FN₄O
• Purity: 99+%
• Molecular weight: 458.58

Astemizole

CAS: 68844-77-9

Astemizole (Laridal) is a long-acting antihistamine for allergies like rhinitis and asthma, with fewer anticholinergic …

• Formula: C₂₈H₃₁FN₄O
• Purity: 98.24% - 99.67%
• Color and Shape: White Crystals Solid
• Molecular weight: 458.57

1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine

CAS: 68844-77-9

• Formula: C₂₈H₃₁FN₄O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 458.5703432000001

Astemizole

CAS: 68844-77-9

• Purity: 98.24%
• Molecular weight: 458.57g/mol

Astemizole

CAS: 68844-77-9

• Molecular weight: 458.57g/mol

Astemizole

CAS: 68844-77-9

• Formula: C₂₈H₃₁FN₄O
• Molecular weight: 458.58

Astemizole

CAS: 68844-77-9

• Formula: C₂₈H₃₁FN₄O
• Color and Shape: White To Off-White
• Molecular weight: 458.57

Astemizole

CAS: 68844-77-9

• Formula: C₂₈H₃₁FN₄O
• Molecular weight: 458.57

Astemizole

CAS: 68844-77-9

Applications Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin …

• Formula: C₂₈H₃₁FN₄O
• Color and Shape: White To Off-White
• Molecular weight: 458.57

Astemizole

CAS: 68844-77-9

Histamine-1 receptor antagonist; hERG K+ channel blocker

• Formula: C₂₈H₃₁FN₄O
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 458.57 g/mol

Astemizole - Bio-X ™

CAS: 68844-77-9

Astemizole is an antihistamine drug used to treat allergy symptoms. This drug is a histamine-1 …

• Formula: C₂₈H₃₁FN₄O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 458.57 g/mol

Astemizole-d5

CAS: 68844-77-9

• Formula: C₂₈D₅H₂₆FN₄O
• Color and Shape: Neat
• Molecular weight: 463.601