CAS 70288-86-7: Ivermectin
Description:Ivermectin is a broad-spectrum antiparasitic agent primarily used in veterinary medicine and human health for the treatment of various parasitic infections. It belongs to the class of macrocyclic lactones and is derived from the bacterium Streptomyces avermitilis. The compound exhibits a complex structure characterized by a large lactone ring and multiple stereocenters, contributing to its biological activity. Ivermectin works by binding to glutamate-gated chloride channels in the nerve and muscle cells of parasites, leading to paralysis and death of the organism. It is effective against a range of parasites, including those causing river blindness, lymphatic filariasis, and scabies. Ivermectin is generally well-tolerated, with a favorable safety profile, although side effects can occur, particularly in cases of high parasitic load. Its use has expanded beyond traditional applications, with ongoing research exploring its potential antiviral properties. The compound is typically administered orally or topically, depending on the type of infection being treated.
Formula:Unspecified
InChI:InChI=1/C48H74O14.C47H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38;1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3;11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b13-12+,27-15+,32-14+;12-11+,26-14+,31-13+/t25?,26-,28-,30-,31-,33+,34?,35-,36-,37-,38?,39-,40+,41-,42-,43+,44-,45+,47+,48+;25-,27-,29-,30-,32+,33?,34-,35-,36-,37?,38-,39+,40-,41+,42-,43-,44+,46+,47+/m00/s1
- Synonyms:
- 22,23-Dihydroavermectin
- 22,23-Dihydroavermectin B1
- 22,23-Dihydroavermectin B<sub>1</sub>
- Bagomectina
- Bimectin
- Bovinet
- Cardomec
- Cardotek 30
- Cardotek Plus
- Cevamec
- See more synonyms
- Equimec
- Equimec Paste
- Equimectrin
- Equirat Gold
- Eqvalan
- Heartgard
- Heartgard 30
- Hyvermectin
- Ivectin
- Ivermec
- Ivermectin B1a-ivermectin B1b mixture
- Ivermectin Injection
- Ivermectina
- Ivermectine
- Iversalt
- Ivertin
- Ivomec
- Ivomec Gold
- Ivosint
- Jetamec
- L 640471
- Mectizan
- Mk 933
- Mk-0933
- Mukhnet I
- Noramectin
- Noromectin
- Oramec
- Oramectin
- Pandex
- Phoenectin
- Solantra
- Soolantra
- Stromectol
- Uvemec
- Vermic
- Vetmec
- Virbamec LA
- Zimecterin
- Ivermectin
