CAS 70288-86-7

Ivermectin

Description:

Ivermectin is a broad-spectrum antiparasitic agent primarily used in veterinary medicine and human health for the treatment of various parasitic infections. It belongs to the class of macrocyclic lactones and is derived from the bacterium Streptomyces avermitilis. The compound exhibits a complex structure characterized by a large lactone ring and multiple stereocenters, contributing to its biological activity. Ivermectin works by binding to glutamate-gated chloride channels in the nerve and muscle cells of parasites, leading to paralysis and death of the organism. It is effective against a range of parasites, including those causing river blindness, lymphatic filariasis, and scabies. Ivermectin is generally well-tolerated, with a favorable safety profile, although side effects can occur, particularly in cases of high parasitic load. Its use has expanded beyond traditional applications, with ongoing research exploring its potential antiviral properties. The compound is typically administered orally or topically, depending on the type of infection being treated.

Formula: Unspecified

InChI: InChI=1/C48H74O14.C47H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38;1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3;11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b13-12+,27-15+,32-14+;12-11+,26-14+,31-13+/t25?,26-,28-,30-,31-,33+,34?,35-,36-,37-,38?,39-,40+,41-,42-,43+,44-,45+,47+,48+;25-,27-,29-,30-,32+,33?,34-,35-,36-,37?,38-,39+,40-,41+,42-,43-,44+,46+,47+/m00/s1

Synonyms:

• 22,23-Dihydroavermectin
• 22,23-Dihydroavermectin B1
• 22,23-Dihydroavermectin B₁
• Bagomectina
• Bimectin
• Bovinet
• Cardomec
• Cardotek 30
• Cardotek Plus
• Cevamec
• Equimec
• Equimec Paste
• Equimectrin
• Equirat Gold
• Eqvalan
• Heartgard
• Heartgard 30
• Hyvermectin
• Ivectin
• Ivermec
• Ivermectin B1a-ivermectin B1b mixture
• Ivermectin Injection
• Ivermectina
• Ivermectine
• Iversalt
• Ivertin
• Ivomec
• Ivomec Gold
• Ivosint
• Jetamec
• L 640471
• Mectizan
• Mk 933
• Mk-0933
• Mukhnet I
• Noramectin
• Noromectin
• Oramec
• Oramectin
• Pandex
• Phoenectin
• Solantra
• Soolantra
• Stromectol
• Uvemec
• Vermic
• Vetmec
• Virbamec LA
• Zimecterin

Ivermectin

CAS: 70288-86-7

Formula: C₄₈H₇₄O₁₄

Purity: >93.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 875.11

Ref: 3B-I0819

Ivermectin

CAS: 70288-86-7

It is used as a positive allosteric modulator of the 7 neuronal nicotinic acetylcholine receptor. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar p

Formula: C₉₅H₁₄₆O₂₈

Color and Shape: Powder, White to pale cream

Molecular weight: 1736.19

Ref: 02-J62777

Ivermectin

CAS: 70288-86-7

Ivermectin

Formula: C₄₈H₇₄O₁₄

Purity: 87.6%

Color and Shape: White To Off-White

Molecular weight: 874.50786

Ref: 47-864

IVERMECTIN RS

CAS: 70288-86-7

IVERMECTIN RS

Ref: 41-ICRS73066

IVERMECTIN CRS

CAS: 70288-86-7

IVERMECTIN CRS

Formula: C₉₅H₁₄₆O₂₈

Color and Shape: Powder

Ref: 41-I8000010

Ivermectin

CAS: 70288-86-7

Lactones, nesoi

Formula: H₂B₁a(C₄₈H₇₄O₁₄)H₂B₁b(C₄₇H₇₂O₁₄)

Color and Shape: White Light Yellow Crystalline Powder

Ref: 45-1354309

Ivermectin

CAS: 70288-86-7

Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.

Formula: C₄₈H₇₄O₁₄

Purity: 94.11% - 99.71%

Color and Shape: Solid

Molecular weight: 875.09

Ref: TM-T1131

Ivermectin (Mixture of B1a and B1b)

CAS: 70288-86-7

Formula: C₄₈H₇₄O₁₄B₁aC₄₇H₇₂O₁₄B₁b

Molecular weight: 875.11 (B1a) 861.08 (B1b)

Ref: 4Z-I-077001

Ivermectin

CAS: 70288-86-7

Formula: C₄₈H₇₄O₁₄(H₂B₁a)

Purity: ≥ 95.0% (dry basis, H2B1a + H2B1b)

Color and Shape: White to light-yellow crystalline powder

Molecular weight: 875.11 (H2B1a)

Ref: 7W-GA9725

Ivermectine 100 µg/mL in Acetonitrile

CAS: 70288-86-7

Formula: C₄₈H₇₄O₁₄·C₄₇H₇₂O₁₄

Color and Shape: Single Solution

Molecular weight: 1736.16

Ref: 04-XA14488000AL

LC PestiMix 4 10 µg/mL in Acetonitrile

CAS: 103055-07-8, 10311-84-9, 103112-35-2, 113614-08-7, 114-26-1, 114369-43-6, 1172134-12-1, 117428-22-5, 117704-25-3, 120983-64-4, 1216-44-0, 122836-35-5, 123997-26-2, 125225-28-7, 126833-17-8, 129558-76-5, 129630-19-9, 13067-93-1, 13141-86-1, 131983-72-7, 135590-91-9, 13684-63-4, 137641-05-5, 14255-72-2, 142891-20-1, 143807-66-3, 149961-52-4, 163520-33-0, 165108-07-6, 179101-81-6, 189278-12-4, 19044-88-3, 203313-25-1, 220899-03-6, 2274-67-1, 229977-93-9, 2303-17-5, 23031-36-9, 2314-09-2, 24353-61-5, 2439-01-2, 24691-80-3, 2600-69-3, 2655-15-4, 26644-46-2, 30558-43-1, 31251-03-3, 33399-00-7, 35256-85-0, 35575-96-3, 3761-41-9, 38083-17-9, 39184-27-5, 39184-59-3, 40487-42-1, 42509-80-8, 50512-35-1, 50563-36-5, 51218-49-6, 5131-24-8, 54406-48-3, 555-37-3, 56425-91-3, 581809-46-3, 60-51-5, 60207-31-0, 60238-56-4, 6132-17-8, 6552-21-2, 69581-33-5, 70124-77-5, 70288-86-7, 71751-41-2, 7292-16-2, 76674-21-0, 78-34-2, 79622-59-6, 81406-37-3, 83121-18-0, 83657-24-3, 86-50-0, 86479-06-3, 87237-48-7, 87674-68-8, 95617-09-7, 98730-04-2, 98886-44-3, 99607-70-2

Color and Shape: Mixture

Ref: 04-A50000804AL

Ivermectine

Controlled Product

CAS: 70288-86-7

Formula: C₄₈H₇₄O₁₄·C₄₇H₇₂O₁₄

Color and Shape: Neat

Molecular weight: 1736.16

Ref: 04-CA14488000

PharmaVetResiMix 1 Avermectins-v6 10 µg/mL in Methanol

Controlled Product

CAS: 113507-06-5, 117704-25-3, 123997-26-2, 155569-91-8, 70288-86-7, 71751-41-2

Color and Shape: Mixture

Ref: 04-A30000031ME

Smart Solutions™ v59 PharmaVetResiMix Kit 1

CAS: 100-90-3, 113507-06-5, 115550-35-1, 117704-25-3, 119478-55-6, 122-11-2, 1220-83-3, 123997-26-2, 127-71-9, 127-79-7, 144-82-1, 144-83-2, 14698-29-4, 148-79-8, 149676-40-4, 155569-91-8, 19562-30-2, 20559-55-1, 2447-57-6, 28657-80-9, 31430-15-6, 31431-39-7, 389-08-2, 42835-25-6, 43210-67-9, 515-64-0, 51940-44-4, 53716-50-0, 54029-12-8, 54965-21-8, 57-67-0, 57-68-1, 58306-30-2, 59-40-5, 63-74-1, 651-06-9, 68-35-9, 68786-66-3, 70288-86-7, 70458-96-7, 71751-41-2, 72-14-0, 723-46-6, 729-99-7, 74011-58-8, 75184-71-3, 79660-72-3, 80-08-0, 80-32-0, 80-35-3, 80983-34-2, 82419-36-1, 85721-33-1, 88254-99-3, 91296-86-5, 91296-87-6, 93106-60-6, 948-71-0, 98079-52-8

Color and Shape: Mixture

Ref: 04-K30000030

GB 23200.121-2021 Pesticide Mixture 8 50 µg/mL in Acetonitrile:Methanol

Controlled Product

CAS: 101205-02-1, 107534-96-3, 111479-05-1, 111988-49-9, 117428-22-5, 119446-68-3, 121-21-1, 129630-19-9, 131860-33-8, 133855-98-8, 134098-61-6, 135186-78-6, 143390-89-0, 148477-71-8, 153233-91-1, 153719-23-4, 19666-30-9, 2312-35-8, 238410-11-2, 283594-90-1, 28434-01-7, 39300-45-3, 39515-41-8, 40596-69-8, 50512-35-1, 51-03-6, 51338-27-3, 51630-58-1, 52645-53-1, 52918-63-5, 55179-31-2, 55219-65-3, 69806-50-4, 70288-86-7, 76578-14-8, 77501-63-4, 77501-90-7, 80844-07-1, 82657-04-3, 83-79-4, 83657-24-3, 850881-70-8, 88671-89-0, 935545-74-7, 94361-06-5, 95737-68-1

Color and Shape: Mixture

Ref: 04-A50000728MC

Ivermectin-d2

Controlled Product

CAS: 70288-86-7

Applications Isotope labelled Ivermectin, is the labeled analogue of Ivermectin (I940800), which is a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980), Campbell, W.C., et al.: Science, 221, 823 (1983), Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988), Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995), ; Caly, L., et al.: Antivir. Res., 178

Formula: C₄₈H₇₂D₂O₁₄

Color and Shape: Neat

Molecular weight: 877.11

Ref: TR-I940802

Ivermectin

Controlled Product

CAS: 70288-86-7

Applications Semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Anthelmintic (Onchocerca).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);

Formula: C₄₈H₇₄O₁₄·C₄₇H₇₂O₁₄

Color and Shape: White To Off-White

Molecular weight: 1736.16

Ref: TR-I940800

Ivermectin - Bio-X ™

CAS: 70288-86-7

Naturally produced by the soil bacterium Streptomyces avermitili, Ivermectin is clinically used in the treatment of parasitosis in both humans and animals. Ivermectin is commercially available as a mixture of 80% 22, 23-dihydroavermectin B1a and 20% 22, 23-dihydroavermectin B1b. In 2020, research indicated that it was a good antiviral agent in the treatment of SARS-CoV-2 and a new mechanism of action has been suggested. Ivermectin would act on importin α/β heterodimer and affect nuclear transport and the translocation of viral proteins.

Formula: C₄₈H₇₄O₁₄

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 875.09 g/mol

Ref: 3D-BI166167

Ivermectin

CAS: 70288-86-7

Naturally produced by the soil bacterium Streptomyces avermitili, it is clinically used in the treatment of parasitosis in both humans and animals. Ivermectin is commercially available as a mixture of 80% 22, 23-dihydroavermectin B1a and 20% 22, 23-dihydroavermectin B1b. In 2020, Ivermectin indicated that it was a good antiviral agent in the treatment of SARS-CoV-2 and a new mechanism of action has been suggested. Ivermectin would act on importin α/β heterodimer and affect nuclear transport and the translocation of viral proteins.

Formula: C₄₈H₇₄O₁₄

Purity: Min. 90 Area-%

Color and Shape: White Yellow Powder

Molecular weight: 875.09 g/mol

Ref: 3D-FI24744

Ivermectin (IVM), 95-102%

CAS: 70288-86-7

Formula: C₄₈H₇₄O₁₄

Purity: min. 95 - 102%

Color and Shape: White to off-white, Crystalline powder

Molecular weight: 875.10

Ref: SR-18443