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Angiogenesis

Angiogenesis

Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.

Subcategories of "Angiogenesis"

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Found 1414 products of "Angiogenesis"

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  • EGFR-IN-146
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    EGFR-IN-146

    CAS:
    <p>EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.</p>
    Formula:C20H16N4
    Color and Shape:Solid
    Molecular weight:312.368

    Ref: TM-T206146

  • ALKBH5-IN-3
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    ALKBH5-IN-3

    CAS:
    <p>ALKBH5-IN-3 (Compound 20m) is an efficacious and selective inhibitor of ALKBH5, exhibiting an IC50 value of 21 nM. It effectively stabilizes ALKBH5 in HepG2 cells and enhances m6A levels in intact cells.</p>
    Formula:C11H7F3N2O3
    Color and Shape:Solid
    Molecular weight:272.18

    Ref: TM-T201322

  • MTX-216
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    MTX-216

    CAS:
    <p>MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.</p>
    Formula:C22H14Cl2FN5O2S
    Color and Shape:Solid
    Molecular weight:502.348

    Ref: TM-T206251

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    JAK-IN-19

    <p>JAK-IN-19 inhibits JAK (pIC50: 7.2, 7.7), less so for VEGFR2 (7.0) and Aurora B (5.8).</p>
    Formula:C26H36FN5O2
    Color and Shape:Solid
    Molecular weight:469.59

    Ref: TM-T63026

  • BMS-986143
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    BMS-986143

    CAS:
    <p>BMS-986143: oral BTK inhibitor, IC50=0.26 nM, potential for autoimmune research, also targets TEC, BLK, BMX, TXK, YES1, ITK.</p>
    Formula:C31H24Cl2N4O4
    Color and Shape:Solid
    Molecular weight:587.45

    Ref: TM-T39129

  • JAK3/BTK-IN-4
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    JAK3/BTK-IN-4

    CAS:
    <p>JAK3/BTK-IN-4, a dual inhibitor for JAK3/BTK, shows synergy in autoimmune disease treatment. (Patent WO2021147953A1, compound 003)</p>
    Formula:C21H25ClN8O
    Color and Shape:Solid
    Molecular weight:440.93

    Ref: TM-T62553

  • I194496
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    I194496

    CAS:
    <p>I194496 is an effective inhibitor of cystathionine γ-lyase (CSE) with an IC50 value of 0.79 mM. It inhibits the growth of human TNBC cells by dual targeting the PI3K/Akt and Ras/Raf/ERK pathways. Additionally, I194496 suppresses the metastasis of human TNBC cells by downregulating the Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways.</p>
    Formula:C28H23F2N5O5S
    Color and Shape:Solid
    Molecular weight:579.58

    Ref: TM-T201096

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    FLT3-IN-13

    <p>FLT3-IN-13 inhibits topoisomerase II/FLT3 in leukemia with IC50 of 2.26 μM, causes G2/M arrest, and promotes apoptosis.</p>
    Formula:C20H14N4O2
    Color and Shape:Solid
    Molecular weight:342.35

    Ref: TM-T61101

  • SYHA1815
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    SYHA1815

    CAS:
    <p>SYHA1815, an orally active RET inhibitor (IC50=0.9 nmol/L), demonstrates antitumor activity. It exhibits greater selectivity for RET over KDR (IC50=15.9 nmol/L). SYHA1815 operates by downregulating c-Myc, arresting the G1 cell cycle, and inhibiting RET-driven cell proliferation.</p>
    Formula:C27H26ClF4N5O
    Color and Shape:Solid
    Molecular weight:547.98

    Ref: TM-T200124

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    FLT3/ITD-IN-1

    <p>FLT3/ITD-IN-1 inhibits FLT3-ITD with IC50s: 38.2 nM (FLT3) and 144.1 nM (ITD), and fights acute myeloid leukemia.</p>
    Formula:C19H22N6O2
    Color and Shape:Solid
    Molecular weight:366.42

    Ref: TM-T61415

  • CLM3
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    CLM3

    CAS:
    <p>CLM3, a pyrazolopyrimidine derivative, functions as a multitargeted tyrosine kinase inhibitor. It exhibits antiproliferative and proapoptotic activities on endothelial and cancer cells, activities that are synergistically enhanced by SN38. The primary mechanism of action for CLM3 involves the inhibition of phosphorylation in tyrosine kinases such as VEGFR-2, EGFR, and RET, along with their associated signaling pathways.</p>
    Formula:C21H21N5
    Color and Shape:Solid
    Molecular weight:343.43

    Ref: TM-T200080

  • Multi-kinase inhibitor 3
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    Multi-kinase inhibitor 3

    CAS:
    <p>Multi-kinase inhibitor 3 (compound 12) is an orally active and effective multikinase (multikinase) inhibitor, demonstrating potent IC50 values against FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, and PDGFRβ, at 1.59, 1.23, 1.19, 0.59, 0.22, and 1.15 nM respectively. This compound exhibits anti-proliferative and anticancer activities.</p>
    Formula:C26H26N6O2
    Color and Shape:Solid
    Molecular weight:454.52

    Ref: TM-T200518

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    EGFR/HER2-IN-5

    <p>EGFR/HER2-IN-5: Irreversible, oral dual EGFR inhibitor, IC50 0.6 nM, targets L858R/T790M mutations, anti-tumor in vivo for lung cancer study.</p>
    Color and Shape:Solid

    Ref: TM-T64254

  • SILA-123
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    SILA-123

    CAS:
    <p>SILA-123, an inhibitor of FLT3 (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM), induces cell apoptosis by hindering the cell cycle progression at the G0/G1 phase through the suppression of FLT3 phosphorylation and its downstream signaling pathways. This compound is utilized in the study of acute myeloid leukemia.</p>
    Formula:C24H25N5O2
    Color and Shape:Solid
    Molecular weight:415.49

    Ref: TM-T200498

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    HER2-IN-9

    <p>HER2-IN-9, an oral HER2 inhibitor (IC50: 0.03 μM), hinders growth and spread of HER2+ breast cancer.</p>
    Formula:C19H14BrF3N2O
    Color and Shape:Solid
    Molecular weight:423.23

    Ref: TM-T62271

  • BML-265
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    BML-265

    CAS:
    <p>BML-265 is a potent inhibitor of EGFR tyrosine kinase (EGFR tyrosine kinase). It disrupts Golgi apparatus integrity in human cells and hinders the transport of secretory proteins across various substances. In contrast, BML-265 does not affect the integrity and transport of the Golgi apparatus in rodent cells.</p>
    Formula:C18H15N3O2
    Color and Shape:Solid
    Molecular weight:305.331

    Ref: TM-T204769

  • YSY01A
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    YSY01A

    CAS:
    <p>YSY01A is a proteasome inhibitor that suppresses cancer cell survival by inducing apoptosis (Apoptosis). It demonstrates IC50 values against various cell lines such as HEK293T, A549, MCF-7, MGC-803, and PC-3M with values of 51.01, 9.21, 5.21, 8.9, and 35.4 nM respectively. Additionally, YSY01A serves as a degrader of gp130 and JAK2, eliminating constitutive STAT3 signaling in human A549 lung cancer cells by downregulating gp130 and JAK2. YSY01A holds potential for research in cancer therapeutics.</p>
    Formula:C29H38BN5O5
    Color and Shape:Solid
    Molecular weight:547.45

    Ref: TM-T200778

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    VEGFR-2-IN-11

    <p>VEGFR-2-IN-11 is a potent inhibitor of VEGFR-2 (IC50: 60.27 nM) with an IC50 value of 60.27 nM, which induces apoptosis and has anticancer activity.</p>
    Formula:C29H22BrN5S
    Color and Shape:Solid
    Molecular weight:552.49

    Ref: TM-T63900

  • Multi-kinase inhibitor 4
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    Multi-kinase inhibitor 4

    CAS:
    <p>Multi-kinase inhibitor 4 (compound 14) serves as an orally effective inhibitor targeting FLT1, KDR, FLT3, FLT4, PDGFRα, and PDGFRβ, exhibiting IC50 values of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, and 0.89 nM respectively. This compound plays a crucial role in cancer research.</p>
    Formula:C25H24N6O2
    Color and Shape:Solid
    Molecular weight:440.50

    Ref: TM-T201144

  • ERBB agonist-1
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    ERBB agonist-1

    CAS:
    <p>ERBB agonist-1 (Compound EF-1) is an ERBB4 agonist that activates the ERBB4 signaling pathway by inducing ERBB4 receptor dimerization, with an EC50 of 10.5 μM. It promotes phosphorylation of Akt and ERK1/2, reduces collagen expression in cardiac fibroblasts, and inhibits H2O2-induced cardiomyocyte death and Ang II-induced cardiac hypertrophy. Furthermore, ERBB agonist-1 can prevent myocardial fibrosis and demonstrates cardioprotective effects in mouse models.</p>
    Formula:C24H25N3O2S
    Color and Shape:Solid
    Molecular weight:419.539

    Ref: TM-T204401