Bcr-Abl
Bcr-Abl inhibitors are targeted therapies that inhibit the Bcr-Abl fusion protein, which is formed due to the Philadelphia chromosome translocation and is a driver of chronic myeloid leukemia (CML). This protein also influences angiogenesis, contributing to tumor progression. Bcr-Abl inhibitors are crucial in the treatment of CML and are being explored for their potential in inhibiting angiogenesis in various cancers. At CymitQuimica, we provide high-quality Bcr-Abl inhibitors to support your research in cancer biology, angiogenesis, and targeted therapy.
Found 117 products of "Bcr-Abl"
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Olverembatinib
CAS:Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM).Formula:C29H27F3N6OPurity:98.53% - >99.99%Color and Shape:SolidMolecular weight:532.56Ref: TM-T3071
1mg34.00€2mg43.00€5mg63.00€10mg95.00€25mg190.00€50mg304.00€100mg416.00€1mL*10mM (DMSO)73.00€NVP-BHG712
CAS:NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src andFormula:C26H20F3N7OPurity:97.32% - 98.63%Color and Shape:SolidMolecular weight:503.48Ref: TM-T6348
1mg34.00€5mg74.00€10mg105.00€25mg200.00€50mg371.00€100mg557.00€200mg790.00€1mL*10mM (DMSO)84.00€Agerafenib
CAS:Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.Formula:C24H22F3N5O5Purity:95.78% - 99.23%Color and Shape:SolidMolecular weight:517.46Ref: TM-T2070
1mg39.00€5mg93.00€10mg124.00€25mg219.00€50mg358.00€100mg530.00€200mg757.00€1mL*10mM (DMSO)90.00€GNF-2
CAS:GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.Formula:C18H13F3N4O2Purity:98.17% - ≥95%Color and Shape:SolidMolecular weight:374.32GMB-475
CAS:GMB-475, a PROTAC-based BCR-ABL1 inhibitor, tackles drug resistance by promoting VHL-mediated degradation.Formula:C43H46F3N7O7SPurity:98.78% - >99.99%Color and Shape:SolidMolecular weight:861.93Ref: TM-T8488
1mg50.00€2mg66.00€5mg99.00€10mg160.00€25mg281.00€50mg416.00€100mg600.00€200mg835.00€1mL*10mM (DMSO)152.00€KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formula:C20H20N4OPurity:98.43% - 99.69%Color and Shape:SolidMolecular weight:332.4BGG463
CAS:BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with an IC50 of 0.25 μM, 0.09 μM and 0.590 μM, respectively.Formula:C30H29F3N6O3Purity:98.21% - >99.99%Color and Shape:SolidMolecular weight:578.58Ref: TM-T4618
1mg58.00€2mg82.00€5mg113.00€10mg178.00€25mg333.00€50mg477.00€100mg692.00€1mL*10mM (DMSO)145.00€Asciminib
CAS:Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5–0.8nM).
Formula:C20H18ClF2N5O3Purity:98.82% - 99.70%Color and Shape:SolidMolecular weight:449.84Ref: TM-T5177
1mg63.00€2mg92.00€5mg127.00€10mg187.00€25mg305.00€50mg427.00€100mg630.00€500mg1,320.00€Imatinib
CAS:Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFormula:C29H31N7OPurity:99.42% - 99.94%Color and Shape:Off White PowderMolecular weight:493.6Vodobatinib
CAS:Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.Formula:C27H20ClN3O2Purity:99.06% - 99.55%Color and Shape:SolidMolecular weight:453.92Ref: TM-T8882
1mg34.00€5mg74.00€10mg110.00€25mg200.00€50mg323.00€100mg500.00€500mg1,209.00€1mL*10mM (DMSO)82.00€XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54Ref: TM-T17267
1mg52.00€2mg73.00€5mg94.00€10mg141.00€25mg244.00€50mg371.00€100mg552.00€1mL*10mM (DMSO)104.00€Bafetinib
CAS:Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.Formula:C30H31F3N8OPurity:94.16% - 99.68%Color and Shape:SolidMolecular weight:576.62Ref: TM-T6311
1mg34.00€2mg49.00€5mg74.00€10mg98.00€25mg150.00€50mg178.00€100mg333.00€200mg432.00€1mL*10mM (DMSO)95.00€GNF-5
CAS:GNF-5, non-ATP Bcr-Abl inhibitor (IC50: 0.22±0.1 uM, wild-type), improves upon GNF-2 with better pharmacokinetics.Formula:C20H17F3N4O3Purity:98% - 99.94%Color and Shape:SolidMolecular weight:418.37CZC-8004
CAS:CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.
Formula:C17H16FN5Purity:99.29%Color and Shape:SolidMolecular weight:309.34Adaphostin
CAS:Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.Formula:C24H27NO4Purity:98.29%Color and Shape:SolidMolecular weight:393.48Nilotinib monohydrochloride monohydrate
CAS:Nilotinib monohydrochloride monohydrate (Nilotinib (monohydrochloride monohydrate)) is significantly potent BCR-ABL against, is a second generation tyrosineFormula:C28H22F3N7O·HCl·H2OPurity:99.93%Color and Shape:SolidMolecular weight:583.99AST 487
CAS:AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.Formula:C26H30F3N7O2Purity:98.17% - 99.56%Color and Shape:SolidMolecular weight:529.56Ref: TM-T4053
1mg34.00€2mg49.00€5mg74.00€10mg113.00€25mg177.00€50mg334.00€100mg500.00€500mg1,099.00€1mL*10mM (DMSO)87.00€PD173955
CAS:PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR andFormula:C21H16Cl2N4OSPurity:98.52% - 98.99%Color and Shape:SolidMolecular weight:443.35Ref: TM-T3063
2mg35.00€5mg50.00€10mg92.00€25mg166.00€50mg248.00€100mg371.00€200mg530.00€1mL*10mM (DMSO)94.00€Bosutinib hydrate
CAS:Bosutinib hydrate (SKI-606 hydrate) is a kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of leukemia.Formula:C26H31Cl2N5O4Purity:99.87%Color and Shape:SolidMolecular weight:548.46c-ABL-IN-3
CAS:c-ABL-IN-3, from patent WO2021048567A1, is a potent c-Abl inhibitor for researching ALS, PD, and cancer.Formula:C17H11F3N4O3Color and Shape:SolidMolecular weight:376.29
