Bcr-Abl
Bcr-Abl inhibitors are targeted therapies that inhibit the Bcr-Abl fusion protein, which is formed due to the Philadelphia chromosome translocation and is a driver of chronic myeloid leukemia (CML). This protein also influences angiogenesis, contributing to tumor progression. Bcr-Abl inhibitors are crucial in the treatment of CML and are being explored for their potential in inhibiting angiogenesis in various cancers. At CymitQuimica, we provide high-quality Bcr-Abl inhibitors to support your research in cancer biology, angiogenesis, and targeted therapy.
Found 129 products for "Bcr-Abl".
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EphB4-IN-1
CAS:EphB4-IN-1 is a selective tyrosine kinase inhibitor of EphB4, exhibiting an IC50 value range of 0.16-0.30 μM. It binds to the ATP-binding site of EphB4 in the DFG-in conformation, creating four stable intermolecular hydrogen bonds. Additionally, EphB4-IN-1 inhibits kinases such as Src, Abl1, Lck, and EGFR and prevents the autophosphorylation of EphB4. This compound is applicable in cancer research, including studies on non-small cell lung cancer.Formula:C18H18N4O2Molecular weight:322.36Dyrk1A-IN-17
CAS:Dyrk1A-IN-17 is an orally active multikinase inhibitor capable of crossing the blood-brain barrier. It reduces the hyperphosphorylation of α-synuclein by inhibiting four kinases: ABL1, DYRK1A, GSK3β, and LRRK2, while stabilizing microtubules. Dyrk1A-IN-17 is applicable in the research of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.Formula:C17H14ClN5Molecular weight:323.78BGB659
CAS:BGB659 is effective inhibitor of RAF.Formula:C29H29F3N4O3Purity:98%Color and Shape:SolidMolecular weight:538.56HG-7-86-01
CAS:HG-7-86-01 is a selective type II tyrosine kinase inhibitor with antiproliferative activity against mutant T315I- Bcr-Abl for chronic myeloid leukemia (CML).Formula:C28H21F3N6O2SPurity:99.07%Color and Shape:SolidMolecular weight:562.57Pro-Dasatinib
CAS:Pro-Dasatinib (compound 2j) is an amino acid analogue of Dasatinib and serves as a potent Src/Abl kinase inhibitor. It exhibits antiproliferative activity against K652 leukemia cancer cells, with an IC50 of 0.21 nM.Formula:C25H29ClN8O2SMolecular weight:541.07GLPG3312
CAS:GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, for SIK1, SIK2 and SIK3, anti-inflammatory and immunomodulatory .Formula:C23H21F2N5O3Purity:98.53%Color and Shape:White SolidMolecular weight:453.44Tyrosine kinase-IN-9
CAS:Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.Formula:C20H14ClN3O3Color and Shape:SolidMolecular weight:379.796PP487
CAS:PP487 is a dual tyrosine kinase/PI(3)K inhibitor, exhibiting IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].Formula:C14H14BrN5OColor and Shape:SolidMolecular weight:348.2HPK1-IN-61
CAS:HPK1-IN-61 (Compound 1) serves as an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with a Ki of 0.4 nM, and also inhibits Abl with an IC50 of less than 0.51 nM. Additionally, HPK1-IN-61 displays inhibitory activity against LCK, with an IC50 of 24 nM.Formula:C23H22N4O2Color and Shape:SolidMolecular weight:386.45
