p53
p53 inhibitors target the p53 protein, a tumor suppressor that plays a crucial role in regulating the cell cycle, DNA repair, and apoptosis. While p53 is often mutated or inactivated in cancer cells, its inhibition is sometimes necessary to protect healthy cells from apoptosis during certain treatments. On the other hand, restoring p53 function in tumors can lead to cancer cell apoptosis. Research into p53 inhibitors is complex and significant for both understanding cancer mechanisms and developing new therapies. At CymitQuimica, we provide a selection of high-quality p53 inhibitors and modulators to support your research in cancer biology, apoptosis, and therapeutic development.
Found 63 products of "p53"
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MT 63-78
CAS:MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM).
Formula:C21H14N2O2Purity:97.11%Color and Shape:SolidMolecular weight:326.35Etoposide
CAS:Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).
Formula:C29H32O13Purity:99.19% - 99.94%Color and Shape:Crystals From Methanol SolidMolecular weight:588.56Unesbulin
CAS:Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1).
Formula:C19H13F5N6Purity:98.71%Color and Shape:SolidMolecular weight:420.34Amifostine
CAS:Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Formula:C5H15N2O3PSPurity:99.59%Color and Shape:White SolidMolecular weight:214.22NSC-87877
CAS:NSC-87877 inhibits Shp2 (IC50=0.318μM), Shp1 (IC50=0.355μM), and DUSP26 phosphatases.Formula:C19H13N3O7S2Purity:97.35%Color and Shape:SolidMolecular weight:459.45Chlorambucil
CAS:Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.Formula:C14H19Cl2NO2Purity:97.37% - 98.45%Color and Shape:Off-White Slightly Granular Powder Melting Point 65-69°CMolecular weight:304.21Quinacrine dihydrochloride
CAS:Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplasticFormula:C23H30CLN3O·2HClPurity:98.24% - 99.80%Color and Shape:Yellow Crystals Or PowderMolecular weight:472.88Apoptosis Compound Library
A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;Color and Shape:Odour SolidRef: TM-L9000
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireTetrofosmin
CAS:Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.Formula:C18H40O4P2Color and Shape:SolidMolecular weight:382.46ReACp53 acetate
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.Formula:C110H210N52O26Purity:99.55%Color and Shape:SolidMolecular weight:2677.18Transcription Factor-Targeted Compound Library
Well-chosen xnum compounds with unique structures targeting transcription factor;Color and Shape:Odour SolidRef: TM-L1380
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquirep53 (17-26)
CAS:Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.Formula:C60H90N12O17Purity:98%Color and Shape:SolidMolecular weight:1251.43UNC 0631
CAS:UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).Formula:C37H61N7O2Purity:97.42%Color and Shape:SolidMolecular weight:635.93BMH-7 HCl
BMH-7 HCl is a p53 activator, showing anti-cancer activity by activating the p53 pathway.Formula:C20H22ClN5OPurity:99.62%Color and Shape:SolidMolecular weight:383.88HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Color and Shape:Lyophilized PowderMolecular weight:The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.Anti-p53 Antibody (9D896)
Anti-p53 Antibody (9D896) is an antibody targeting p53. Anti-p53 Antibody (9D896) can be used in ELISA, WB, IHC, IF.Color and Shape:Odour LiquidAnti-p53 Antibody (2H232)
Anti-p53 Antibody (2H232) is an antibody targeting p53. Anti-p53 Antibody (2H232) can be used in ELISA, IHC.Color and Shape:Odour LiquidAnti-p53 Antibody (3K688)
Anti-p53 Antibody (3K688) is a Rabbit antibody targeting p53. Anti-p53 Antibody (3K688) can be used in WB,ELISA,IP.Color and Shape:Odour LiquidAnti-p53 Antibody (9G129)
Anti-p53 Antibody (9G129) is a Rabbit antibody targeting p53. Anti-p53 Antibody (9G129) can be used in IHC-P,ICC/IF.Color and Shape:Odour LiquidAnti-p53 Antibody (9G324)
Anti-p53 Antibody (9G324) is an antibody targeting p53. Anti-p53 Antibody (9G324) can be used in ELISA, IF.Color and Shape:Odour LiquidAnti-Phospho-TP53 (Ser392) Antibody (7W136)
Anti-Phospho-TP53 (Ser392) Antibody (7W136) is an antibody targeting Phospho-TP53 (Ser392). Anti-Phospho-TP53 (Ser392) Antibody (7W136) can be used in ELISA, WB.Color and Shape:Odour LiquidAnti-p53 Antibody (1J151)
Anti-p53 Antibody (1J151) is a Mouse antibody targeting p53. Anti-p53 Antibody (1J151) can be used in ELISA(Cap).Color and Shape:Odour LiquidAnti-p53 Antibody (8M251)
Anti-p53 Antibody (8M251) is an antibody targeting p53. Anti-p53 Antibody (8M251) can be used in ELISA, WB, IHC, IF.Color and Shape:Odour LiquidAnti-Phospho-TP53 (Thr55) Antibody (8C690)
Anti-Phospho-TP53 (Thr55) Antibody (8C690) is an antibody targeting Phospho-TP53 (Thr55). Anti-Phospho-TP53 (Thr55) Antibody (8C690) can be used in ELISA, WB, IF.Color and Shape:Odour LiquidAnti-Phospho-TP53 (Ser33) Antibody (4K787)
Anti-Phospho-TP53 (Ser33) Antibody (4K787) is an antibody targeting Phospho-TP53 (Ser33). Anti-Phospho-TP53 (Ser33) Antibody (4K787) can be used in ELISA, IHC, IF.Color and Shape:Odour LiquidAnti-p53 Antibody (2V863)
Anti-p53 Antibody (2V863) is a Mouse antibody targeting p53. Anti-p53 Antibody (2V863) can be used in ELISA,ELISA(Det).Color and Shape:Odour LiquidAnti-Phospho-TP53 (Ser9) Antibody (4M602)
Anti-Phospho-TP53 (Ser9) Antibody (4M602) is an antibody targeting Phospho-TP53 (Ser9). Anti-Phospho-TP53 (Ser9) Antibody (4M602) can be used in ELISA, IF.Color and Shape:Odour LiquidAnti-p53 Antibody (8C308)
Anti-p53 Antibody (8C308) is an antibody targeting p53. Anti-p53 Antibody (8C308) can be used in ELISA, WB, IF, FCM.Color and Shape:Odour LiquidMethylstat
CAS:Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability.Formula:C28H31N3O6Purity:98.34% - 98.34%Color and Shape:SolidMolecular weight:505.56p53 Protein, Cynomolgus, Recombinant
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family.Color and Shape:Lyophilized PowderMolecular weight:43.7 kDa (predicted); 48 kDa (reducing conditions)HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi), Biotinylated
p53 is a tumor suppressor protein.Color and Shape:Lyophilized PowderMolecular weight:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Color and Shape:Lyophilized PowderMolecular weight:The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Color and Shape:Lyophilized PowderMolecular weight:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi), Biotinylated
p53 is a tumor suppressor protein.Color and Shape:Lyophilized PowderMolecular weight:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
p53 is a tumor suppressor protein.Color and Shape:Odour Lyophilized PowderHLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Color and Shape:Lyophilized PowderMolecular weight:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
p53 is a tumor suppressor protein.Color and Shape:Odour Lyophilized PowderProteasome inhibitor IX
CAS:Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).Formula:C20H21B2NO5Purity:99.77%Color and Shape:SolidMolecular weight:377.01LLY-507
CAS:LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.Formula:C36H42N6OPurity:99.58% - 99.93%Color and Shape:SolidMolecular weight:574.76Ref: TM-T6879
1mg44.00€2mg55.00€5mg85.00€10mg138.00€25mg304.00€50mg552.00€100mg787.00€1mL*10mM (DMSO)110.00€KCC-07
CAS:KCC-07: Selective, potent, brain-penetrant MBD2 inhibitor with anticancer effects, blocking MBD2-DNA binding and activating BAI1 signaling.Formula:C14H11N3OSPurity:98.86% - 99.01%Color and Shape:SolidMolecular weight:269.32Ref: TM-T8554
1mg35.00€5mg71.00€10mg112.00€25mg212.00€50mg335.00€100mg500.00€200mg712.00€1mL*10mM (DMSO)73.00€UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Formula:C36H59N7O2Purity:>99.99%Color and Shape:SolidMolecular weight:621.9Schisandrol B
CAS:Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.Formula:C23H28O7Purity:99.14% - 99.95%Color and Shape:SolidMolecular weight:416.46Ref: TM-T6S1917
5mg67.00€10mg90.00€25mg190.00€50mg286.00€100mg429.00€500mg982.00€1mL*10mM (DMSO)74.00€XL177A
CAS:XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Formula:C48H57ClN8O5Purity:98.75%Color and Shape:SolidMolecular weight:861.47BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Formula:C28H38N6O2Purity:98.58% - 99.64%Color and Shape:SolidMolecular weight:490.64Ref: TM-T7697
1mg38.00€5mg80.00€10mg111.00€25mg197.00€50mg295.00€100mg447.00€200mg607.00€1mL*10mM (DMSO)124.00€NSC-87877 disodium
CAS:NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2. NSC-87877 also inhibits EGF-induced Erk1/2 activation in HEK293 cells.Formula:C19H13N3O7S2·2NaPurity:97.89%Color and Shape:SolidMolecular weight:503.42(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formula:C20H16N2O5Purity:99.09% - 99.81%Color and Shape:SolidMolecular weight:364.35NSC348884
CAS:NSC348884, a nucleophosmin inhibitor, disrupts oligomers, induces apoptosis, and inhibits cancer cell growth (IC50: 1.7-4.0 μM).Formula:C38H40N10Purity:98.69% - 99.91%Color and Shape:SolidMolecular weight:636.79Ref: TM-T6909
2mg39.00€5mg58.00€10mg90.00€25mg172.00€50mg280.00€100mg405.00€500mg888.00€1mL*10mM (DMSO)80.00€Lumichrome
CAS:Lumichrome, a riboflavin metabolite, influences plant growth, ascidian metamorphosis, bacterial communication, and blocks riboflavin uptake.Formula:C12H10N4O2Purity:99.69% - 99.93%Color and Shape:SolidMolecular weight:242.23XI-006
CAS:NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.Formula:C11H13N5O4Purity:99.51%Color and Shape:SolidMolecular weight:279.25Ref: TM-T6610
1mg52.00€2mg77.00€5mg113.00€10mg177.00€25mg409.00€50mg605.00€100mg860.00€500mg1,728.00€1mL*10mM (DMSO)108.00€cjoc42
CAS:Cjoc42 blocks gankyrin to prevent p53 reduction, aiding cancer prevention and DNA damage response.Formula:C20H21N3O5SPurity:99.56%Color and Shape:SolidMolecular weight:415.46Ref: TM-T27029
1mg60.00€5mg133.00€10mg193.00€25mg349.00€50mg522.00€100mg730.00€200mg982.00€1mL*10mM (DMSO)152.00€Amifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Formula:C5H15N2O3PS·3H2OPurity:99.71% - 99.80%Color and Shape:SolidMolecular weight:268.27Leptomycin B
CAS:Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Formula:C33H48O6Purity:97.10% - 99.04%Color and Shape:White Crystalline SolidMolecular weight:540.73Ref: TM-T15735
1mg202.00€2mg341.00€5mg620.00€10mg882.00€25mg1,320.00€50mg1,776.00€100mg2,403.00€1mL*10mM (DMSO)283.00€BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Formula:C28H38N6O2·3HClPurity:99.41% - 99.95%Color and Shape:SolidMolecular weight:600.02Ref: TM-T1959
2mg50.00€5mg67.00€10mg102.00€25mg182.00€50mg259.00€100mg447.00€200mg607.00€1mL*10mM (DMSO)105.00€Theaflavin 3,3′-digallate
CAS:Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFormula:C43H32O20Purity:98.71% - 99.86%Color and Shape:SolidMolecular weight:868.70Ref: TM-T5429
1mg87.00€5mg169.00€10mg268.00€25mg462.00€50mg647.00€100mg873.00€200mg1,153.00€1mL*10mM (DMSO)268.00€Nutlin-3a
CAS:Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.Formula:C30H30Cl2N4O4Purity:95.62% - 99.71%Color and Shape:SolidMolecular weight:581.49Ref: TM-T6023
1mg50.00€2mg66.00€5mg90.00€10mg156.00€25mg254.00€50mg376.00€100mg557.00€1mL*10mM (DMSO)128.00€YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purity:99.47%Color and Shape:SolidMolecular weight:372.18Ref: TM-T9320
2mg38.00€5mg57.00€10mg93.00€25mg170.00€50mg289.00€100mg507.00€200mg655.00€500mg1,018.00€1mL*10mM (DMSO)63.00€NSC 66811
CAS:NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.Formula:C23H20N2OPurity:96.94%Color and Shape:SolidMolecular weight:340.42O6-Benzylguanine
CAS:O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.Formula:C12H11N5OPurity:98.9%Color and Shape:Solid CrystallineMolecular weight:241.25UNC0224
CAS:UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.Formula:C26H43N7O2Purity:99.80%Color and Shape:SolidMolecular weight:485.67NSC 146109 hydrochloride
CAS:NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.Formula:C17H17ClN2SPurity:99.28%Color and Shape:SolidMolecular weight:316.85UNC0321
CAS:UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.Formula:C27H45N7O3Purity:99.80%Color and Shape:SolidMolecular weight:515.69BML-259
CAS:BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Formula:C14H16N2OSPurity:99.84%Color and Shape:SolidMolecular weight:260.35Ref: TM-T36964
5mg50.00€10mg85.00€25mg169.00€50mg279.00€100mg487.00€500mg1,035.00€1mL*10mM (DMSO)52.00€PDK4-IN-1 hydrochloride
CAS:PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM).Formula:C22H20ClN3O2Purity:99.67%Color and Shape:SolidMolecular weight:393.87Ref: TM-T12412L
1mg70.00€5mg150.00€10mg215.00€25mg358.00€50mg515.00€100mg707.00€200mg1,009.00€1mL*10mM (DMSO)165.00€
