Chk
Chk (Checkpoint Kinase) inhibitors target the Chk1 and Chk2 kinases, which are key regulators of the DNA damage response and cell cycle checkpoints. These kinases halt cell cycle progression in response to DNA damage, allowing time for repair. Inhibiting Chk kinases can prevent cell cycle arrest, forcing damaged cells to proceed through the cycle and ultimately undergo apoptosis. Chk inhibitors are particularly valuable in cancer research, where they can sensitize tumor cells to DNA-damaging agents. At CymitQuimica, we provide a variety of high-quality Chk inhibitors to support your research in DNA damage response, cell cycle regulation, and oncology.
Found 47 products of "Chk"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Formula:C18H19BrClN7O2Purity:99.29%Color and Shape:SoildMolecular weight:480.75CCT241533 dihydrochloride
CAS:Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Formula:C23H29Cl2FN4O4Color and Shape:SolidMolecular weight:515.41Chk1-IN-6
CAS:Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
Formula:C16H18F3N7Color and Shape:SolidMolecular weight:365.364PROTAC Chk1 degrader-1
CAS:Compound PROTAC-2, also known as PROTAC Chk1 degrader-1, is a potent degrader of Chk1, exhibiting a DC50 of 1.33 μM. It is utilized in cancer research [1].Formula:C43H44N14O9Color and Shape:SolidMolecular weight:900.9WAY-230563
CAS:WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cellsFormula:C17H12N2O2SPurity:98.40%Color and Shape:SolidMolecular weight:308.35CBP501 Affinity Peptide
CAS:CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].Formula:C68H119N21O25SColor and Shape:SolidMolecular weight:1662.86CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Formula:C19H19N7O2Color and Shape:SolidMolecular weight:377.16002Zimistobart
CAS:Zimistobart (BMS-986315) is a fully human IgG1 antibody that targets and binds to NKG2A. It is applicable in research for non-small cell lung cancer (NSCLC). For an isotype control, refer to HumanIgG1kappa, Isotype Control.Color and Shape:LiquidCHK1-IN-9
CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.GDC-0425
CAS:GDC-0425 (RG-7602), an oral selective ChK1 inhibitor, targets multiple cancers.Formula:C18H19N5OColor and Shape:SolidMolecular weight:321.38PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Formula:C20H12N2O3Purity:98.02%Color and Shape:SolidMolecular weight:328.32CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Formula:C20H24N8O2Purity:99.17%Color and Shape:SolidMolecular weight:408.46GDC-0575 dihydrochloride
CAS:GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.Formula:C16H22BrCl2N5OColor and Shape:SolidMolecular weight:451.19GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Formula:C16H21BrClN5OPurity:97.85%Color and Shape:SolidMolecular weight:414.73Ref: TM-T27407
1mg43.00€2mg55.00€5mg80.00€10mg103.00€25mg177.00€50mg255.00€100mg356.00€200mg520.00€1mL*10mM (DMSO)93.00€CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Formula:C16H16F3N7OPurity:98.28% - 99.93%Color and Shape:SolidMolecular weight:379.34Ref: TM-T7080
1mg37.00€2mg49.00€5mg79.00€10mg113.00€25mg213.00€50mg350.00€100mg523.00€1mL*10mM (DMSO)87.00€GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Formula:C16H20BrN5OPurity:≥95%Color and Shape:SolidMolecular weight:378.27ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Formula:C19H12F2N4Purity:99.39%Color and Shape:SolidMolecular weight:334.32Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.
Formula:C18H22BrN5O3Purity:98.86% - 99.87%Color and Shape:SolidMolecular weight:436.3LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formula:C19H23N7O2Purity:99.77%Color and Shape:SolidMolecular weight:381.43M2I-1
CAS:M2I-1 inhibits Mad2 binding to Cdc20, disrupting SAC-related PPI and Mad2 dynamics, blocks Mad2-F-Mbp1 in FP assays.Formula:C19H24N4O4SPurity:99.02% - >99.99%Color and Shape:SolidMolecular weight:404.48
