Chk
Chk (Checkpoint Kinase) inhibitors target the Chk1 and Chk2 kinases, which are key regulators of the DNA damage response and cell cycle checkpoints. These kinases halt cell cycle progression in response to DNA damage, allowing time for repair. Inhibiting Chk kinases can prevent cell cycle arrest, forcing damaged cells to proceed through the cycle and ultimately undergo apoptosis. Chk inhibitors are particularly valuable in cancer research, where they can sensitize tumor cells to DNA-damaging agents. At CymitQuimica, we provide a variety of high-quality Chk inhibitors to support your research in DNA damage response, cell cycle regulation, and oncology.
Found 46 products of "Chk"
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Monalizumab
CAS:Monalizumab, a humanized antibody, enhances NK cell function by inhibiting NKG2A; used in HNSCC studies.Purity:95% - >95.0% (SDS-PAGE); 100% (SEC-HPLC)Color and Shape:LiquidMolecular weight:147 kDa (average)CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Formula:C18H19BrClN7O2Purity:99.29%Color and Shape:SoildMolecular weight:480.75Zimistobart
CAS:Zimistobart (BMS-986315) is a fully human IgG1 antibody that targets and binds to NKG2A. It is applicable in research for non-small cell lung cancer (NSCLC). For an isotype control, refer to HumanIgG1kappa, Isotype Control.Color and Shape:LiquidCHK1-IN-9
CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.WAY-230563
CAS:WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cellsFormula:C17H12N2O2SPurity:98.40%Color and Shape:SolidMolecular weight:308.35CCT241533 dihydrochloride
CAS:Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Formula:C23H29Cl2FN4O4Color and Shape:SolidMolecular weight:515.41Chk1-IN-6
CAS:<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Formula:C16H18F3N7Color and Shape:SolidMolecular weight:365.364CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Formula:C19H19N7O2Color and Shape:SolidMolecular weight:377.16002CBP501 Affinity Peptide
CAS:CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].Formula:C68H119N21O25SColor and Shape:SolidMolecular weight:1662.86GDC-0425
CAS:GDC-0425 (RG-7602), an oral selective ChK1 inhibitor, targets multiple cancers.Formula:C18H19N5OColor and Shape:SolidMolecular weight:321.38PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Formula:C20H12N2O3Purity:98.02%Color and Shape:SolidMolecular weight:328.32CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Formula:C20H24N8O2Purity:99.17%Color and Shape:SolidMolecular weight:408.46GDC-0575 dihydrochloride
CAS:GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.Formula:C16H22BrCl2N5OColor and Shape:SolidMolecular weight:451.19CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Formula:C16H16F3N7OPurity:98.28% - 99.93%Color and Shape:SolidMolecular weight:379.34Ref: TM-T7080
1mg39.00€2mg51.00€5mg84.00€10mg119.00€25mg225.00€50mg369.00€100mg552.00€1mL*10mM (DMSO)92.00€Rabusertib
CAS:<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Formula:C18H22BrN5O3Purity:98.86% - 99.87%Color and Shape:SolidMolecular weight:436.3SAR-020106
CAS:SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.Formula:C19H19ClN6OPurity:97.78%Color and Shape:SolidMolecular weight:382.85ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Formula:C19H12F2N4Purity:99.39%Color and Shape:SolidMolecular weight:334.32AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Formula:C17H19FN4O2SPurity:98.96% - 99.19%Color and Shape:SolidMolecular weight:362.42Ref: TM-T6093
1mg38.00€2mg49.00€5mg81.00€10mg96.00€25mg177.00€50mg280.00€100mg449.00€1mL*10mM (DMSO)88.00€LY2880070
CAS:LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formula:C19H23N7O2Purity:99.77%Color and Shape:SolidMolecular weight:381.43M2I-1
CAS:M2I-1 inhibits Mad2 binding to Cdc20, disrupting SAC-related PPI and Mad2 dynamics, blocks Mad2-F-Mbp1 in FP assays.Formula:C19H24N4O4SPurity:99.02% - >99.99%Color and Shape:SolidMolecular weight:404.48GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Formula:C16H20BrN5OPurity:≥95%Color and Shape:SolidMolecular weight:378.27GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Formula:C16H21BrClN5OPurity:97.85%Color and Shape:SolidMolecular weight:414.73Ref: TM-T27407
1mg46.00€2mg58.00€5mg85.00€10mg108.00€25mg187.00€50mg269.00€100mg376.00€200mg548.00€1mL*10mM (DMSO)87.00€AZD7762 HCl
CAS:AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.Formula:C17H20ClFN4O2SPurity:98%Color and Shape:SolidMolecular weight:398.88SC-203885
CAS:SC-203885 is a checkpoint kinase 2 inhibitor.Formula:C15H13N5O2Purity:98%Color and Shape:SolidMolecular weight:295.3VRX-0466617
CAS:VRX-0466617 is a novel selective Chk2 inhibitor.Formula:C19H20BrN5O2SColor and Shape:SolidMolecular weight:462.36TCS 2312
CAS:checkpoint kinase 1 (chk1) inhibitorFormula:C25H24N4O2Purity:98%Color and Shape:SolidMolecular weight:412.48PV-1115
CAS:PV-1115 is an effective and highly selective inhibitor of the Chk2.Formula:C20H19N7O3Purity:98%Color and Shape:SolidMolecular weight:405.41NSC 109555 ditosylate
CAS:Chk2 inhibitor,ATP-competitiveFormula:C26H32N10O4SPurity:98%Color and Shape:SolidMolecular weight:580.66PV-1019
CAS:PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.Formula:C18H17N7O3Color and Shape:SolidMolecular weight:379.37CCT245737(S)
CAS:CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.Formula:C16H16F3N7OColor and Shape:SolidMolecular weight:379.34M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Formula:C31H30F3N7O2Purity:98.95%Color and Shape:SolidMolecular weight:589.61CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Formula:C20H23N9OPurity:98.78%Color and Shape:SolidMolecular weight:405.46Ref: TM-T10791
1mg172.00€2mg245.00€5mg393.00€10mg590.00€25mg917.00€50mg1,216.00€100mg1,663.00€200mg2,242.00€1mL*10mM (DMSO)445.00€NR2F6 modulator-1
CAS:NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.Formula:C23H17NO5SPurity:98.31%Color and Shape:SolidMolecular weight:419.45Ref: TM-T62204
1mg92.00€5mg188.00€10mg283.00€25mg530.00€50mg742.00€100mg1,035.00€1mL*10mM (DMSO)215.00€MU-380
CAS:MU-380 is an effective and selective inhibitor of CHK1.Formula:C15H15BrF3N7Color and Shape:SolidMolecular weight:430.23CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H27FN4O4Purity:98%Color and Shape:SolidMolecular weight:442.48VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Formula:C31H34N6O3Purity:98%Color and Shape:SolidMolecular weight:538.64PD-321852
CAS:PD-321852, a Chk1 inhibitor, boosts gemcitabine's effect in pancreatic cancer cells, varying from minimal in Panc1 to >30-fold in MiaPaCa2.Formula:C24H19Cl2N3O3Color and Shape:SolidMolecular weight:468.33CCT241533 hydrochloride
CAS:CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H28ClFN4O4Purity:97.13%Color and Shape:SolidMolecular weight:478.95Ref: TM-T10718L
1mg73.00€2mg96.00€5mg159.00€10mg240.00€25mg515.00€50mg852.00€100mg1,264.00€500mg2,547.00€1mL*10mM (DMSO)170.00€CHK1-IN-2
CAS:CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Formula:C20H22N4OSPurity:98%Color and Shape:SolidMolecular weight:366.48CHK-IN-1
CAS:CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Formula:C18H19ClFN5OSPurity:>99.99%Color and Shape:SolidMolecular weight:407.89BBI-355
CAS:BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.Formula:C19H19N7O2Color and Shape:SolidMolecular weight:377.40CHK1-IN-11
CAS:CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.Formula:C20H22N8O2Color and Shape:SolidMolecular weight:406.44CHK1-IN-4
CAS:CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.Formula:C18H18BrN7O2Purity:98%Color and Shape:SolidMolecular weight:444.29CHK1 inhibitor
CAS:CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Formula:C17H21BrN4OPurity:98%Color and Shape:SolidMolecular weight:377.28Chk1-IN-5
CAS:Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.Formula:C18H18FN7O2Color and Shape:SolidMolecular weight:383.38PHI-101
CAS:<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Formula:C19H19FN4O2SPurity:99.4%Color and Shape:SolidMolecular weight:386.44
