Ferroptosis
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides and iron-dependent oxidative stress. Unlike apoptosis, ferroptosis is not driven by caspases but rather by the failure of cellular antioxidant defenses, leading to cell death. Ferroptosis inhibitors and inducers are critical for studying this unique cell death pathway, which is implicated in various diseases, including cancer, neurodegeneration, and ischemia-reperfusion injury. At CymitQuimica, we offer a wide range of high-quality ferroptosis modulators to support your research in cell death mechanisms, oxidative stress, and disease pathology.
Found 215 products of "Ferroptosis"
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Ferroptosis-IN-16
<p>Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.</p>Formula:C26H23N5OColor and Shape:SolidMolecular weight:421.49W1131 TFA
<p>W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.</p>Formula:C25H20F3N5O6Purity:98.1%Color and Shape:SolidMolecular weight:543.45PRLX-93936 HCL
CAS:<p>PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.</p>Formula:C21H26Cl2N4O2Purity:98.4% - 99.94%Color and Shape:SolidMolecular weight:437.3784-B10
CAS:<p>84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.</p>Formula:C25H22F3NO5Purity:99.76%Color and Shape:SolidMolecular weight:473.44CuATSM
CAS:<p>Cu/Zn-SOD1 enzyme scavenges radicals; mutations cause ALS. Cu-ATSM, crossing blood-brain barrier, targets hypoxic tissue, may aid ALS mice.</p>Formula:C8H14CuN6S2Color and Shape:SolidMolecular weight:321.92Idebenone
CAS:Formula:C19H30O5Purity:>98.0%(T)(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:338.44CuATSP
CAS:<p>CuATSP is a potent free radical trapping antioxidant (RTA) and ferroptosis inhibitor inhibit lipid peroxidation, for (ALS) and Parkinson's disease.</p>Formula:C18H18CuN6S2Purity:97.09%Color and Shape:SolidMolecular weight:446.05Cerivastatin sodium
CAS:<p>Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.</p>Formula:C26H33FNNaO5Purity:98.50% - 99.67%Color and Shape:SolidMolecular weight:481.53CCW16
CAS:<p>CCW16 is a covalent E3 ubiquitin ligase RNF4 ligand, cysteine reactivity, inducing ferroptosis in AML cells by activating ROS signalling.</p>Formula:C22H20ClNO3Purity:97%Color and Shape:SolidMolecular weight:381.85Chrysosplenetin
CAS:<p>Chrysosplenetin is a metabolic inhibitor of artemisinin.</p>Formula:C19H18O8Purity:97.43% - 98.4%Color and Shape:SolidMolecular weight:374.34L-Glutamic acid monosodium salt
CAS:<p>L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.</p>Formula:C5H8NO4·NaPurity:99.93%Color and Shape:White Solid CrystallineMolecular weight:169.11Piperlongumine
CAS:<p>Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.</p>Formula:C17H19NO5Purity:97.03% - 99.90%Color and Shape:SolidMolecular weight:317.34NADPH tetracyclohexanamine
CAS:<p>NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.</p>Formula:C45H82N11O17P3Purity:98.73% - 99.05%Color and Shape:SolidMolecular weight:1142.12L-BUTHIONINE-(S,R)-SULFOXIMINE
CAS:<p>L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase that induces oxidative stress by depleting GSH.</p>Formula:C8H18N2O3SPurity:97.07% - ≥98%Color and Shape:White Fine PowderMolecular weight:222.31ML-210
CAS:<p>ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor. ML-210 has antitumor activity and induces ferroptosis. Cost-effective and quality-assured.</p>Formula:C22H20Cl2N4O4Purity:97% - 99.03%Color and Shape:SolidMolecular weight:475.32Piperazine Erastin
CAS:<p>Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.</p>Formula:C35H41ClN6O4Purity:99.52%Color and Shape:SolidMolecular weight:645.19RSL3
CAS:<p>View and buy RSL3 from TargetMol.RSL3 is a VDAC-independent ferroptosis activator.Cited in 10 publications.</p>Formula:C23H21ClN2O5Purity:98% - 99.96%Color and Shape:SolidMolecular weight:440.88TBHQ
CAS:<p>TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.</p>Formula:C10H14O2Purity:99.17% - 99.53%Color and Shape:White Solid PowderMolecular weight:166.22Trolox
CAS:<p>Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.</p>Formula:C14H18O4Purity:98.90% - 99.90%Color and Shape:White To Fainly Beige Crystalline PowderMolecular weight:250.29Alogliptin
CAS:<p>Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9</p>Formula:C18H21N5O2Purity:99.63%Color and Shape:SolidMolecular weight:339.39Alogliptin Benzoate
CAS:<p>Alogliptin Benzoate, a potent DPP-4 inhibitor with >10,000-fold selectivity over DPP-8/9, may also curb TLR-4-induced inflammation.</p>Formula:C25H27N5O4Purity:99.94% - >99.99%Color and Shape:White PowderMolecular weight:461.51WITHAFERIN A
CAS:<p>WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/</p>Formula:C28H38O6Purity:97.41% - 99.99%Color and Shape:SolidMolecular weight:470.6Bardoxolone Methyl
CAS:<p>Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-</p>Formula:C32H43NO4Purity:97.81% - 99.09%Color and Shape:SolidMolecular weight:505.69Siramesine hydrochloride
CAS:<p>Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit</p>Formula:C30H32ClFN2OPurity:99.72% - >99.99%Color and Shape:SolidMolecular weight:491.04Necrostatin-1
CAS:<p>Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity.</p>Formula:C13H13N3OSPurity:99.25% - >99.99%Color and Shape:SolidMolecular weight:259.33JKE-1674
CAS:<p>JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210.Cost-effective and quality-assured.</p>Formula:C20H20Cl2N4O4Purity:98.02% - 98.4%Color and Shape:SolidMolecular weight:451.3Bay 11-7085
CAS:<p>Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).</p>Formula:C13H15NO2SPurity:99.76% - 99.94%Color and Shape:White SolidMolecular weight:249.33DL-Buthionine-(S,R)-sulfoximine
CAS:<p>DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.</p>Formula:C8H18N2O3SPurity:98% - 99.64%Color and Shape:White Fine PowderMolecular weight:222.31Coenzyme Q10
CAS:<p>Coenzyme Q10 (CoQ10) (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.</p>Formula:C59H90O4Purity:99.14% - 99.88%Color and Shape:DrypowderMolecular weight:863.34ML162
CAS:<p>ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity. Cost-effective and quality-assured.</p>Formula:C23H22Cl2N2O3SPurity:98.42% - 99.55%Color and Shape:SolidMolecular weight:477.4(E)-Ferulic acid
CAS:<p>(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of</p>Formula:C10H10O4Purity:99.63%Color and Shape:SolidMolecular weight:194.18D-glutamine
CAS:<p>D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.</p>Formula:C5H10N2O3Purity:99.99%Color and Shape:White Or Off-White PowderMolecular weight:146.14BAY 87-2243
CAS:<p>BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).</p>Formula:C26H26F3N7O2Purity:98% - 99.95%Color and Shape:SolidMolecular weight:525.53L-Buthionine-(S,R)-sulfoximine hydrochloride
<p>L-Buthionine-(S,R)-sulfoximine hydrochloride is a fast, irreversible γ-GCS inhibitor that depletes glutathione. IC50: 1.9-29 μM in various tumors.</p>Formula:C8H19ClN2O3SColor and Shape:SolidMolecular weight:258.77Liproxstatin-1 hydrochloride
CAS:<p>Liproxstatin-1 hydrochloride is a high-potency ferroptosis inhibitor capable of effectively preventing ferroptotic cell death, with an IC50 value of 22 nM [1].</p>Formula:C19H22Cl2N4Color and Shape:SolidMolecular weight:377.31Pioglitazone potassium
CAS:<p>Pioglitazone potassium is an oral PPARγ agonist with EC50 of 0.93 μM (human) and 0.99 μM (mouse), used in diabetes research.</p>Formula:C19H19KN2O3SColor and Shape:SolidMolecular weight:394.53CDDO-Im
CAS:<p>CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).</p>Formula:C34H43N3O3Purity:98.3% - 99.61%Color and Shape:SolidMolecular weight:541.72(-)-Epicatechin
CAS:<p>(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization</p>Formula:C15H14O6Purity:98.55% - 98.80%Color and Shape:SolidMolecular weight:290.27UAMC-3203 hydrochloride
CAS:<p>UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.</p>Formula:C25H38ClN5O2SPurity:99.62%Color and Shape:SolidMolecular weight:508.12Baicalein monohydrate
CAS:<p>Baicalein monohydrate blocks 12-lipoxygenase, curbs leukotrienes, lysosomal enzymes, Ca2+ dynamics, and fights arthritis.</p>Formula:C15H12O6Color and Shape:SolidMolecular weight:288.25Ferrostatin-1
CAS:<p>Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death, potently inhibits Erastin-induced iron death in HT-1080 cells. High-Quality, Low-Cost!</p>Formula:C15H22N2O2Purity:96.1% - 99.68%Color and Shape:SolidMolecular weight:262.35CIL56
CAS:<p>CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS).</p>Formula:C23H27N3O5S2Purity:99.46% - 99.91%Color and Shape:SolidMolecular weight:489.61Hemin
CAS:<p>Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.</p>Formula:C34H32ClFeN4O4Purity:97.169% - 99.59%Color and Shape:Dark Purple Crystalline PowderMolecular weight:651.94DihydroarteMisinic acid
CAS:<p>DihydroarteMisinic acid (Dihydro-Artmisinic Acid) is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal</p>Formula:C15H24O2Purity:99.06% - 99.17%Color and Shape:SolidMolecular weight:236.35Arteannuin B
CAS:<p>1. Arteannuin B has potent antimalarial activity.</p>Formula:C15H20O3Purity:98% - 99.8%Color and Shape:SolidMolecular weight:248.32Eprenetapopt
CAS:<p>Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells.</p>Formula:C10H17NO3Purity:98.75% - 99.57%Color and Shape:SolidMolecular weight:199.25DL-α-Tocopherol
CAS:<p>DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.</p>Formula:C29H50O2Purity:99.61% - 99.90%Color and Shape:Light Yellow Liquid ViscousMolecular weight:430.71SRS11-92
CAS:<p>SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1</p>Formula:C22H28N2O2Purity:98.58%Color and Shape:SolidMolecular weight:352.47Deferitrin
CAS:<p>Deferitrin (GT-56-252) is an iron chelator. It potentially for the treatment of thalassemia and iron overload.</p>Formula:C11H11NO4SPurity:98.71%Color and Shape:SolidMolecular weight:253.271R,3S-RSL 3
CAS:<p>1R,3S-RSL 3 is a harmala alkaloid.</p>Formula:C23H21ClN2O5Purity:99.51%Color and Shape:SolidMolecular weight:440.88
