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DYRK

DYRK

DYRK (Dual-specificity Tyrosine Phosphorylation-regulated Kinase) inhibitors are compounds that target the DYRK family of kinases, which are involved in cell cycle regulation, neuronal development, and apoptosis. DYRK kinases have dual specificity, meaning they can phosphorylate both tyrosine and serine/threonine residues. Inhibiting DYRK kinases can affect various cellular processes, including cell cycle progression and differentiation. DYRK inhibitors are important tools in research on cancer, neurodegenerative diseases, and cell signaling. At CymitQuimica, we offer a selection of high-quality DYRK inhibitors to support your research in cell cycle control, neurobiology, and therapeutic development.

Found 47 products for "DYRK".

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  • BT173
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    BT173

    CAS:
    BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.
    Formula:C18H12BrN3O2
    Purity:98.24%
    Color and Shape:Solid
    Molecular weight:382.211

    Ref: TM-T9953

  • GSK-626616
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    GSK-626616

    CAS:
    GSK-626616: strong, oral DYRK3 inhibitor (IC50: 0.7 nM), affects DYRK family, may treat anemia.
    Formula:C18H10Cl2N4OS
    Purity:98.27%
    Color and Shape:Solid
    Molecular weight:401.269

    Ref: TM-T15422

  • AZ-Dyrk1B-33
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    AZ-Dyrk1B-33

    CAS:
    AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.
    Formula:C19H16N4
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:300.3571

    Ref: TM-T14364

  • DYR684
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    DYR684

    CAS:
    DYR684 is a PROTAC designed to target the protein kinase DYRK1A, promoting its rapid, efficient, potent, and selective degradation in cellular assays.
    Formula:C58H58FN15O5
    Color and Shape:Solid
    Molecular weight:1064.18

    Ref: TM-T201046

  • GNF2133
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    GNF2133

    CAS:
    GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.
    Formula:C24H30N6O2
    Purity:98.51%
    Color and Shape:Solid
    Molecular weight:434.534

    Ref: TM-T40187

  • CymitQuimica logo
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    Dyrk1A-IN-7

    Dyrk1A-IN-7 (Compound 29) is a selective DYRK1A kinase inhibitor with notable kinase selectivity, exhibiting an IC50 value of 28 nM for DYRK1A and a Kd of 17.5 nM for CLK2. This selective inhibitor is applicable in research related to cancer, type II diabetes, and neurological disorders.
    Formula:C19H13F3N4O
    Color and Shape:Solid
    Molecular weight:370.10415

    Ref: TM-T209333

  • CymitQuimica logo
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    KTD-092

    KTD-092, a DYRK1A inhibitor, exhibits an IC50 of 22 nM against human DYRK1A. It is applicable in research related to Down syndrome (DS), Alzheimer's disease (AD), autism spectrum disorder (ASD), diabetes, and other neurodegenerative diseases.

    Ref: TM-T210988

  • Mirk-IN-1
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    Mirk-IN-1

    CAS:
    Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).
    Formula:C23H17Cl2N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.318

    Ref: TM-T16078

  • Protein kinase inhibitors 1 hydrochloride
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    Protein kinase inhibitors 1 hydrochloride

    CAS:
    Protein Kinase Inhibitors 1 Hydrochloride effectively inhibits HIPK2, demonstrating high potency with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2,
    Formula:C18H18ClN5O3S
    Color and Shape:Solid
    Molecular weight:419.885

    Ref: TM-T39860

  • 2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
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    2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi

    CAS:
    2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.
    Formula:C6H6N4O
    Purity:99.21% - 99.39%
    Color and Shape:Solid
    Molecular weight:150.138

    Ref: TM-T5445

  • GNF4877
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    GNF4877

    CAS:
    GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.
    Formula:C25H27FN6O4
    Purity:98.68% - 99.51%
    Color and Shape:Solid
    Molecular weight:494.5181

    Ref: TM-T11447

  • Harmine
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    Harmine

    CAS:
    Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.
    Formula:C13H12N2O
    Purity:98.29% - 99.92%
    Color and Shape:White Solid
    Molecular weight:212.2472

    Ref: TM-T1711

  • AZ191
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    AZ191

    CAS:
    AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor.
    Formula:C24H27N7O
    Purity:98.04% - 99.65%
    Color and Shape:Solid
    Molecular weight:429.52

    Ref: TM-T6257

  • LDN-192960 hydrochloride
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    LDN-192960 hydrochloride

    CAS:
    LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.
    Formula:C18H22Cl2N2O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:401.35

    Ref: TM-T11830

  • GNF2133 hydrochloride
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    GNF2133 hydrochloride

    CAS:
    GNF2133 hydrochloride: selective oral DYRK1A inhibitor (IC50: 0.0062 μM), boosts β-cell growth and insulin, potential for type 1 diabetes research.
    Formula:C24H31ClN6O2
    Color and Shape:Solid
    Molecular weight:471.0

    Ref: TM-T63040

  • Harmine hydrochloride
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    Harmine hydrochloride

    CAS:
    Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.
    Formula:C13H13ClN2O
    Purity:99.61% - >99.99%
    Color and Shape:Yellow Solid
    Molecular weight:248.708

    Ref: TM-T2811

  • Protein kinase inhibitors 1
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    Protein kinase inhibitors 1

    CAS:
    Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
    Formula:C18H17N5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:383.42

    Ref: TM-T4636

  • ILK-IN-3
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    ILK-IN-3

    CAS:
    ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.
    Formula:C10H12N6O
    Purity:99.69%
    Color and Shape:White Solid
    Molecular weight:232.2419

    Ref: TM-T8523

  • LDN-192960
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    LDN-192960

    CAS:
    LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
    Formula:C18H22Cl2N2O2S
    Purity:99.01% - 99.51%
    Color and Shape:Yellow Solid
    Molecular weight:401.35

    Ref: TM-TQ0111

  • ID-8
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    ID-8

    CAS:
    ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
    Formula:C16H14N2O4
    Purity:99.32%
    Color and Shape:White Solid
    Molecular weight:298.2934

    Ref: TM-T2431