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PKC

PKC

PKC (Protein Kinase C) inhibitors target the PKC family of serine/threonine kinases, which are involved in a wide range of cellular processes, including cell cycle regulation, apoptosis, and differentiation. PKC plays a key role in signal transduction pathways that influence cell proliferation and survival. Inhibiting PKC can lead to changes in cell cycle progression, making these inhibitors valuable in research related to cancer, neurobiology, and cardiovascular diseases. At CymitQuimica, we provide a diverse selection of high-quality PKC inhibitors to support your research in signal transduction, cell cycle regulation, and therapeutic development.

Found 129 products for "PKC".

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  • CRT0066854 hydrochloride
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    CRT0066854 hydrochloride

    CAS:
    CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.
    Formula:C24H27Cl2N5S
    Purity:99.63%
    Color and Shape:Orange Solid
    Molecular weight:488.476

    Ref: TM-T10888

  • VTX-27
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    VTX-27

    CAS:
    VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).
    Formula:C20H24ClFN6O
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:418.9

    Ref: TM-T13314

  • (-)-Indolactam V
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    (-)-Indolactam V

    CAS:
    (-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.
    Formula:C17H23N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:301.38

    Ref: TM-T17299

  • TCS 21311
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    TCS 21311

    CAS:
    TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.
    Formula:C27H25F3N4O4
    Purity:99.39% - ≥98%
    Color and Shape:Solid
    Molecular weight:526.51

    Ref: TM-T17019

  • PKC-θ inhibitor 1
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    PKC-θ inhibitor 1

    CAS:
    PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)
    Formula:C17H15F3N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:348.32

    Ref: TM-T12496

  • PKC-IN-1
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    PKC-IN-1

    CAS:
    PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,
    Formula:C25H37FN8O2
    Purity:98% - 98.79%
    Color and Shape:White Solid
    Molecular weight:500.6121

    Ref: TM-T12494

  • YAP/TAZ-TEAD-IN-2
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    YAP/TAZ-TEAD-IN-2

    YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that disrupts the interaction between YAP/TAZ and TEAD. It inhibits the transcriptional activity of TEAD with an IC50 of 1.2 nM. Additionally, YAP/TAZ-TEAD-IN-2 suppresses the expression of target genes (Cyr61, CTGF, AXL, and Survivin) and the proliferation of breast cancer cells.
    Formula:C19H20N2O3S
    Color and Shape:Solid
    Molecular weight:356.44

    Ref: TM-T201766

  • CIDD-0072424
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    CIDD-0072424

    CAS:
    CIDD-0072424 is a selective inhibitor of protein kinase C-epsilon (PKCε) in the central nervous system, with a Ki of 54 nM. It demonstrates a dose-dependent reduction in ethanol consumption and preference.
    Formula:C24H29ClN4O2
    Molecular weight:440.97

    Ref: TM-T209822

  • AS2521780
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    AS2521780

    CAS:
    AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
    Formula:C30H41N7OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:547.76

    Ref: TM-T14328