ROCK
ROCK (Rho-associated protein kinase) inhibitors target ROCK kinases, which are involved in the regulation of the cytoskeleton, cell shape, and motility. ROCK plays a significant role in the control of cell division, particularly in processes such as cytokinesis. Inhibiting ROCK can lead to changes in cell cycle dynamics, cell motility, and apoptosis, making these inhibitors valuable in cancer research, neurobiology, and cardiovascular studies. At CymitQuimica, we provide a selection of high-quality ROCK inhibitors to support your research in cell biology, cytoskeletal dynamics, and disease mechanisms.
Found 70 products of "ROCK"
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ROCK inhibitor-2
CAS:<p>ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).</p>Formula:C21H20N2O2Purity:99.85%Color and Shape:SolidMolecular weight:332.4Netarsudil Dihydrochloride
CAS:<p>Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.</p>Formula:C28H29Cl2N3O3Purity:99.94% - 99.98%Color and Shape:SolidMolecular weight:526.45Y-33075 dihydrochloride
CAS:<p>Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).</p>Formula:C16H18Cl2N4OPurity:98.88% - 99.89%Color and Shape:SolidMolecular weight:353.25CMPD101
CAS:<p>CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).</p>Formula:C24H21F3N6OPurity:99.01% - 99.04%Color and Shape:SolidMolecular weight:466.46Akt/ROCK-IN-1
<p>Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively.</p>Formula:C21H19BrF2N4O2SPurity:98%Color and Shape:SolidMolecular weight:509.37RhoA-ROCK-IN-1
<p>RhoA-ROCK-IN-1 (Compound b19) is an inhibitor of the RhoA/ROCK pathway. It significantly inhibits cell proliferation, migration, and invasion, while promoting cell apoptosis (apoptosis). RhoA-ROCK-IN-1 exhibits strong anticancer activities by inhibiting the RhoA/ROCK pathway.</p>Formula:C24H23N3O4SColor and Shape:SolidMolecular weight:449.52WAY-656935
CAS:<p>WAY-656935 inhibits ROCK.</p>Formula:C20H28ClN3O3SPurity:98.1%Color and Shape:SolidMolecular weight:425.97LX-7101 hydrochloride
CAS:<p>LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.</p>Formula:C23H29N7O3xHClPurity:98.96%Color and Shape:SolidMolecular weight:487.99GKI-1 HCl
<p>GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.</p>Formula:C15H13Cl2N3Purity:98.51%Color and Shape:SoildMolecular weight:306.19ROCK2-IN-9
<p>ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.</p>Formula:C28H30N8O2Color and Shape:SolidMolecular weight:510.59Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formula:C14H17N3O2SPurity:99.79% - 99.84%Color and Shape:SolidMolecular weight:291.37Ripasudil free base
CAS:<p>Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.</p>Formula:C15H18FN3O2SPurity:98%Color and Shape:SolidMolecular weight:323.39Verosudil
CAS:<p>Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.</p>Formula:C17H17N3O2SPurity:99.72%Color and Shape:SolidMolecular weight:327.4GSK269962A hydrochloride
CAS:<p>GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.</p>Formula:C29H31ClN8O5Color and Shape:SolidMolecular weight:607.06Cotosudil
CAS:<p>Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.</p>Formula:C16H21N3O2SPurity:98.41%Color and Shape:SolidMolecular weight:319.42Belumosudil mesylate
CAS:<p>Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.</p>Formula:C27H28N6O5SPurity:98.73%Color and Shape:SolidMolecular weight:548.61GSK180736A
CAS:<p>GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).</p>Formula:C19H16FN5O2Purity:98.38% - 98.98%Color and Shape:SolidMolecular weight:365.36Thiazovivin
CAS:<p>Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.</p>Formula:C15H13N5OSPurity:98.00%Color and Shape:SolidMolecular weight:311.36CCG-222740
CAS:<p>CCG-222740 is an inhibitor of Rho/MRTF pathway</p>Formula:C23H19ClF2N2O3Purity:98.76%Color and Shape:SolidMolecular weight:444.86RKI-1447
CAS:<p>RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.</p>Formula:C16H14N4O2SPurity:98% - 99.73%Color and Shape:SolidMolecular weight:326.37Tofacitinib
CAS:<p>Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of rheumatoid arthritis. Cost effective and quality assured.</p>Formula:C16H20N6OPurity:99% - >99.99%Color and Shape:SolidMolecular weight:312.37HA-100
CAS:<p>HA-100 is an inhibitor of protein kinase</p>Formula:C13H15N3O2SPurity:99.44%Color and Shape:Pale Yellow Crystalline SolidMolecular weight:277.34RKI1313
CAS:<p>RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion</p>Formula:C17H16N4O2SPurity:99.53% - ≥95%Color and Shape:SolidMolecular weight:340.4Hydroxyfasudil
CAS:<p>Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).</p>Formula:C14H17N3O3SPurity:98.13%Color and Shape:SolidMolecular weight:307.37GSK429286A
CAS:<p>GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).</p>Formula:C21H16F4N4O2Purity:97.68% - 98.49%Color and Shape:SolidMolecular weight:432.37SAR407899 hydrochloride
CAS:<p>SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and</p>Formula:C14H17ClN2O2Purity:99.15%Color and Shape:SolidMolecular weight:280.75URMC-099
CAS:<p>URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.</p>Formula:C27H27N5Purity:99.32% - 99.98%Color and Shape:SolidMolecular weight:421.54SAR407899
CAS:<p>SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.</p>Formula:C14H16N2O2Purity:99.42%Color and Shape:SolidMolecular weight:244.29CKI-7
CAS:<p>CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.</p>Formula:C11H14Cl3N3O2SPurity:>99.99%Color and Shape:SolidMolecular weight:358.67AT13148
CAS:<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Formula:C17H16ClN3OPurity:98.04% - ≥95%Color and Shape:SolidMolecular weight:313.78ROCK-IN-2
CAS:<p>ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.</p>Formula:C18H13ClF2N6OPurity:97.29%Color and Shape:SolidMolecular weight:402.79Narciclasine
CAS:<p>Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.</p>Formula:C14H13NO7Purity:98.16% - 99.58%Color and Shape:SolidMolecular weight:307.26ZINC00881524
CAS:<p>ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.</p>Formula:C21H20N2O3SPurity:99.48%Color and Shape:SolidMolecular weight:380.46Fasudil hydrochloride
CAS:<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Formula:C14H18ClN3O2SPurity:99.54% - ≥95%Color and Shape:White SolidMolecular weight:327.83Afuresertib hydrochloride
CAS:<p>Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)</p>Formula:C18H18Cl3FN4OSPurity:99.96%Color and Shape:SolidMolecular weight:463.8Hydroxyfasudil Hydrochloride
CAS:<p>Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).</p>Formula:C14H18ClN3O3SPurity:98.05%Color and Shape:SolidMolecular weight:343.83Y-27632
CAS:<p>Y-27632 (Y-27632) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II.</p>Formula:C14H21N3OPurity:99.53% - 99.87%Color and Shape:SolidMolecular weight:247.34Belumosudil
CAS:<p>Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).</p>Formula:C26H24N6O2Purity:97.64% - 98.59%Color and Shape:SolidMolecular weight:452.51Y-27632 dihydrochloride
CAS:<p>View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.</p>Formula:C14H21N3O·2HClPurity:97.96% - 99.98%Color and Shape:SolidMolecular weight:320.26BDP5290
CAS:<p>BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)</p>Formula:C17H18ClN7OPurity:97.22%Color and Shape:SolidMolecular weight:371.82Afuresertib
CAS:<p>Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic</p>Formula:C18H17Cl2FN4OSPurity:97.51% - 99.51%Color and Shape:SolidMolecular weight:427.32SR-3677
CAS:<p>SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).</p>Formula:C22H24N4O4Purity:98.46%Color and Shape:SolidMolecular weight:408.45GSK269962A
CAS:<p>GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.</p>Formula:C29H30N8O5Purity:99.14% - 99.71%Color and Shape:SolidMolecular weight:570.6GSK-25
CAS:<p>GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.</p>Formula:C24H16Cl2F2N6OPurity:98.59%Color and Shape:SolidMolecular weight:513.33Netarsudil mesylate
CAS:<p>Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.</p>Formula:C30H35N3O9S2Purity:99.7%Color and Shape:SolidMolecular weight:645.74CAY10746
CAS:<p>CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.</p>Formula:C26H23N3O5Purity:99.04%Color and Shape:SolidMolecular weight:457.48H-1152
CAS:<p>H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).</p>Formula:C16H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:319.42SB-772077B dihydrochloride
CAS:<p>SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).</p>Formula:C15H20Cl2N8O2Purity:98%Color and Shape:SolidMolecular weight:415.28Y-33075
CAS:<p>Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.</p>Formula:C16H16N4OPurity:98%Color and Shape:SolidMolecular weight:280.32CID-5056270
CAS:<p>CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma</p>Formula:C17H13N3O3SPurity:99.6%Color and Shape:SolidMolecular weight:339.37
