HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Found 176 products for "HSP".
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Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formula:C22H30N6O2SPurity:98.98%Color and Shape:White SolidMolecular weight:442.58VER-155008
CAS:VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.Formula:C25H23Cl2N7O4Purity:97.03% - 99.55%Color and Shape:SolidMolecular weight:556.4Ref: TM-T7010
2mg44.00€5mg65.00€1mL*10mM (DMSO)80.00€10mg88.00€25mg155.00€50mg268.00€100mg442.00€200mg620.00€DDO-5936
CAS:DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.Formula:C25H29N5O4SPurity:99.81%Color and Shape:SolidMolecular weight:495.59Ref: TM-T9202
1mg34.00€5mg75.00€1mL*10mM (DMSO)84.00€10mg119.00€25mg250.00€50mg369.00€100mg525.00€200mg710.00€NVP-HSP990
CAS:NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).Formula:C20H18FN5O2Purity:98.03% - 99.32%Color and Shape:White SolidMolecular weight:379.39ML346
CAS:ML346 is a novel activator of Hsp70.Formula:C14H12N2O4Purity:97.32% - 99.36%Color and Shape:Red SolidMolecular weight:272.26Ref: TM-T3594
1mg38.00€2mg50.00€5mg80.00€1mL*10mM (DMSO)80.00€10mg109.00€25mg168.00€50mg259.00€100mg405.00€500mg888.00€Dihydroberberine
CAS:Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Formula:C20H19NO4Purity:99.86%Color and Shape:Yellow SolidMolecular weight:337.37Ganetespib
CAS:Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.Formula:C20H20N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:364.4Ref: TM-T2309
5mg63.00€1mL*10mM (DMSO)71.00€10mg93.00€25mg126.00€50mg158.00€100mg236.00€200mg401.00€500mg665.00€JG-98
CAS:JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).Formula:C24H21Cl2N3OS3Purity:99.13%Color and Shape:Yellow SolidMolecular weight:534.53Eupalinolide A
CAS:Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Formula:C24H30O9Purity:98.82% - 99.22%Color and Shape:SolidMolecular weight:462.49Grp94 Inhibitor-1
CAS:Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).Formula:C22H28N2O2Purity:97.02% - 98.83%Color and Shape:White SolidMolecular weight:352.47HM03 trihydrochloride
CAS:HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.Formula:C26H30Cl4N4O2Color and Shape:SolidMolecular weight:572.35KW-2478
CAS:KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.Formula:C30H42N2O9Purity:98.68% - 99.52%Color and Shape:SolidMolecular weight:574.66Ref: TM-T6558
1mg52.00€2mg77.00€5mg113.00€1mL*10mM (DMSO)145.00€10mg177.00€25mg299.00€50mg447.00€100mg627.00€MitoBloCK-10
CAS:MitoBloCK-10 inhibits Tim44-Hsp70 binding; first to reduce PAM complex activity.Formula:C12H8FN3O3SPurity:99.51%Color and Shape:SolidMolecular weight:293.27Ref: TM-T8741
500µg46.00€1mg66.00€1mL*10mM (DMSO)136.00€5mg144.00€10mg205.00€25mg349.00€50mg500.00€100mg700.00€200mg954.00€Shepherdin 79-87 acetate
Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.Formula:C43H68N12O14SPurity:98.08%Color and Shape:SolidMolecular weight:1009.14Pimitespib
CAS:Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).Formula:C25H26N8OPurity:99.22% - 99.49%Color and Shape:White SolidMolecular weight:454.53Paeoniflorin
CAS:Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.Formula:C23H28O11Purity:96.9% - 97.43%Color and Shape:White Fine PowderMolecular weight:480.46Iroxanadine hydrochloride
CAS:Iroxanadine hydrochloride is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H21ClN4OColor and Shape:SolidMolecular weight:296.8Tanespimycin
CAS:Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!Formula:C31H43N3O8Purity:98.24% - 99.83%Color and Shape:Purple SolidMolecular weight:585.69Gedunin
CAS:Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Formula:C28H34O7Purity:99.64% - 99.68%Color and Shape:SolidMolecular weight:482.57Ref: TM-T21883
1mg371.00€5mg1,108.00€1mL*10mM (DMSO)1,215.00€10mg1,513.00€25mg2,242.00€50mg3,025.00€100mg4,078.00€p5 Ligand for Dnak and DnaJ acetate
p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40).Formula:C46H85N15O13SPurity:96.33%Color and Shape:White SolidMolecular weight:1088.32VER49009
CAS:VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).Formula:C19H18ClN3O4Purity:99.24% - >99.99%Color and Shape:White SolidMolecular weight:387.82Ref: TM-T2268
1mg57.00€2mg80.00€1mL*10mM (DMSO)90.00€5mg105.00€10mg164.00€25mg268.00€50mg447.00€100mg610.00€KBU2046
CAS:KBU2046: oral anti-metastasis compound, enhances survival, targets chaperone complexes, not a typical HSP90 inhibitor.Formula:C15H11FO2Purity:99.89%Color and Shape:White SolidMolecular weight:242.24Ref: TM-T15646
2mg33.00€5mg50.00€1mL*10mM (DMSO)50.00€10mg71.00€25mg133.00€50mg200.00€100mg304.00€200mg425.00€YUM70
CAS:YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Formula:C21H19ClN2O4Purity:97.25%Color and Shape:White SolidMolecular weight:398.84Ref: TM-T8901
1mg46.00€1mL*10mM (DMSO)90.00€5mg92.00€10mg128.00€25mg250.00€50mg369.00€100mg525.00€200mg710.00€HSF1A
CAS:HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Formula:C21H19N3O2S2Purity:98.89%Color and Shape:SolidMolecular weight:409.52Ref: TM-T4125
1mg52.00€2mg94.00€1mL*10mM (DMSO)123.00€5mg132.00€10mg195.00€25mg439.00€50mg642.00€100mg888.00€Azadiradione
CAS:Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indicaFormula:C28H34O5Purity:99.52%Color and Shape:SolidMolecular weight:450.57Ref: TM-TN6729
1mg124.00€5mg271.00€1mL*10mM (DMSO)334.00€10mg489.00€25mg735.00€50mg1,018.00€100mg1,378.00€Geldanamycin
CAS:Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.Formula:C29H40N2O9Purity:97.59% - 99.27%Color and Shape:Yellow To Orange PowderMolecular weight:560.64L-Alanyl-L-glutamine
CAS:L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.Formula:C8H15N3O4Purity:99.71% - 99.97%Color and Shape:White SolidMolecular weight:217.22MK2-IN-1
CAS:MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.Formula:C27H25ClN4O2Color and Shape:SolidMolecular weight:472.97DTHIB
CAS:DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.Formula:C13H9ClFN3O3Purity:98.86% - 99.29%Color and Shape:SolidMolecular weight:309.68Ref: TM-T8858
1mg34.00€5mg66.00€1mL*10mM (DMSO)73.00€10mg99.00€25mg200.00€50mg319.00€100mg512.00€500mg1,071.00€PU-H54
CAS:PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.Formula:C18H19N5SPurity:99.13%Color and Shape:SolidMolecular weight:337.44TRC051384
CAS:TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.Formula:C25H31N5O4Purity:98.79%Color and Shape:SolidMolecular weight:465.54Ref: TM-T3527
1mg34.00€5mg75.00€1mL*10mM (DMSO)77.00€10mg105.00€25mg200.00€50mg281.00€100mg409.00€200mg590.00€TRC051384 HCl
CAS:TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Formula:C25H32ClN5O4Purity:97.55%Color and Shape:Yellow SolidMolecular weight:502.01BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Formula:C14H15ClN6OPurity:98% - 99.82%Color and Shape:SolidMolecular weight:318.76MKT-077
CAS:MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Formula:C21H22ClN3OS2Purity:98.2%Color and Shape:SolidMolecular weight:432Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formula:C8H7NO2SPurity:99.33% - 99.79%Color and Shape:SolidMolecular weight:181.21XL888
CAS:XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.Formula:C29H37N5O3Purity:99.18%Color and Shape:SolidMolecular weight:503.64HSP70-IN-1
CAS:HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).Formula:C24H28N6O2SPurity:99.91%Color and Shape:SolidMolecular weight:464.58Ref: TM-T3487
1mg90.00€5mg215.00€1mL*10mM (DMSO)219.00€10mg334.00€25mg587.00€50mg802.00€100mg1,108.00€MK2-IN-1 hydrochloride
CAS:MK2-IN-1 hydrochloride (MK 25) selectively inhibits MK2 with IC50 of 0.11 μM, non-ATP competitive.Formula:C27H26Cl2N4O2Purity:97.32%Color and Shape:SolidMolecular weight:509.43KNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Formula:C13H11NO4Purity:98.90%Color and Shape:SolidMolecular weight:245.23Ref: TM-T2444
2mg38.00€5mg54.00€1mL*10mM (DMSO)59.00€10mg77.00€25mg149.00€50mg220.00€100mg331.00€200mg530.00€Palmitic acid
CAS:Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.Formula:C16H32O2Purity:99.17% - 99.67%Color and Shape:White SolidMolecular weight:256.42HSP27 inhibitor J2
CAS:HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function ofFormula:C13H12O4SPurity:99.51%Color and Shape:SolidMolecular weight:264.3Ref: TM-T7265
1mg123.00€2mg175.00€5mg295.00€1mL*10mM (DMSO)432.00€10mg447.00€25mg713.00€50mg1,009.00€100mg1,341.00€VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Formula:C21H23Cl2N5O2SPurity:97.31% - 99.85%Color and Shape:SolidMolecular weight:480.41KRIBB11
CAS:KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.Formula:C13H12N6O2Purity:97.25% - 99.91%Color and Shape:SolidMolecular weight:284.27Ref: TM-T3652
5mg49.00€1mL*10mM (DMSO)50.00€10mg73.00€25mg150.00€50mg249.00€100mg484.00€200mg680.00€500mg1,035.00€VER-49009
CAS:VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).Formula:C19H18ClN3O4Purity:99.36% - 99.99%Color and Shape:SolidMolecular weight:387.82Ref: TM-T3454
2mg43.00€1mL*10mM (DMSO)50.00€5mg60.00€10mg96.00€25mg156.00€50mg245.00€100mg335.00€200mg475.00€HM03
CAS:HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.Formula:C26H27ClN4O2Purity:97.15%Color and Shape:SolidMolecular weight:462.972-hexyl-4-Pentynoic Acid
CAS:2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.Formula:C11H18O2Purity:98%Color and Shape:SolidMolecular weight:182.26Luminespib
CAS:Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.Formula:C26H31N3O5Purity:98% - 99.25%Color and Shape:SolidMolecular weight:465.54Ref: TM-T1989
5mg54.00€1mL*10mM (DMSO)59.00€10mg77.00€25mg138.00€50mg210.00€100mg344.00€200mg512.00€500mg825.00€Onalespib
CAS:Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.Formula:C24H31N3O3Purity:99.01% - 99.66%Color and Shape:SolidMolecular weight:409.52HA15
CAS:HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.Formula:C23H22N4O3S2Purity:99.77% - 99.86%Color and Shape:SolidMolecular weight:466.58Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formula:C29H31NO7Purity:95.32% - 99.67%Color and Shape:SolidMolecular weight:505.56Ref: TM-TQ0131
500µg155.00€1mg187.00€5mg410.00€1mL*10mM (DMSO)449.00€10mg710.00€25mg1,381.00€50mg2,352.00€
