HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Found 169 products of "HSP"
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MK2-IN-1 hydrochloride
CAS:<p>MK2-IN-1 hydrochloride (MK 25) selectively inhibits MK2 with IC50 of 0.11 μM, non-ATP competitive.</p>Formula:C27H26Cl2N4O2Purity:97.32%Color and Shape:SolidMolecular weight:509.43XL888
CAS:<p>XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.</p>Formula:C29H37N5O3Purity:99.18%Color and Shape:SolidMolecular weight:503.64HM03 trihydrochloride
CAS:<p>HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.</p>Formula:C26H30Cl4N4O2Color and Shape:SolidMolecular weight:572.35Tanespimycin
CAS:<p>Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!</p>Formula:C31H43N3O8Purity:99.07% - 99.83%Color and Shape:Dark Purple SolidMolecular weight:585.69VER49009
CAS:<p>VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).</p>Formula:C19H18ClN3O4Purity:98.95% - >99.99%Color and Shape:SolidMolecular weight:387.82MitoBloCK-10
CAS:<p>MitoBloCK-10 inhibits Tim44-Hsp70 binding; first to reduce PAM complex activity.</p>Formula:C12H8FN3O3SPurity:99.51%Color and Shape:SolidMolecular weight:293.27HSP70-IN-1
CAS:<p>HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).</p>Formula:C24H28N6O2SPurity:99.91%Color and Shape:SolidMolecular weight:464.58HM03
CAS:<p>HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.</p>Formula:C26H27ClN4O2Purity:97.15%Color and Shape:SolidMolecular weight:462.97VER-50589
CAS:<p>VER-50589 is a potent HSP90 inhibitor.</p>Formula:C19H17ClN2O5Purity:99.96% - >99.99%Color and Shape:SolidMolecular weight:388.8MK2-IN-1
CAS:<p>MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.</p>Formula:C27H25ClN4O2Color and Shape:SolidMolecular weight:472.97MKT-077
CAS:<p>MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.</p>Formula:C21H22ClN3OS2Purity:98.2%Color and Shape:SolidMolecular weight:432HSP27 inhibitor J2
CAS:<p>HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of</p>Formula:C13H12O4SPurity:99.51%Color and Shape:SolidMolecular weight:264.3ML346
CAS:<p>ML346 is a novel activator of Hsp70.</p>Formula:C14H12N2O4Purity:97.32% - 99.36%Color and Shape:SolidMolecular weight:272.262-hexyl-4-Pentynoic Acid
CAS:<p>2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.</p>Formula:C11H18O2Purity:98%Color and Shape:SolidMolecular weight:182.26Luminespib
CAS:<p>Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C26H31N3O5Purity:98% - 99.25%Color and Shape:SolidMolecular weight:465.54Onalespib
CAS:<p>Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.</p>Formula:C24H31N3O3Purity:98.05% - 99.66%Color and Shape:SolidMolecular weight:409.52Rocaglamide
CAS:<p>Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.</p>Formula:C29H31NO7Purity:95.32% - 99.67%Color and Shape:SolidMolecular weight:505.56Alvespimycin hydrochloride
CAS:<p>Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.</p>Formula:C32H48N4O8·HClPurity:99.94%Color and Shape:SolidMolecular weight:653.21PF-04929113 Mesylate
CAS:<p>PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37</p>Formula:C26H34F3N5O7SPurity:99% - 99.46%Color and Shape:SolidMolecular weight:617.63JG-98
CAS:<p>JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).</p>Formula:C24H21Cl2N3OS3Purity:99.13%Color and Shape:SolidMolecular weight:534.53Teprenone
CAS:<p>Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).</p>Formula:C23H38OPurity:99.1% - 99.96%Color and Shape:SolidMolecular weight:330.55DDO-5936
CAS:<p>DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.</p>Formula:C25H29N5O4SPurity:99.81%Color and Shape:SolidMolecular weight:495.59NVP-HSP990
CAS:<p>NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).</p>Formula:C20H18FN5O2Purity:98.03% - 99.32%Color and Shape:SolidMolecular weight:379.39L-Alanyl-L-glutamine
CAS:<p>L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.</p>Formula:C8H15N3O4Purity:99.71% - 99.97%Color and Shape:SolidMolecular weight:217.22PF04929113
CAS:<p>PF04929113 (SNX-5422), a synthetic small molecule Hsp90 inhibitor, offers potent efficacy orally for various cancers.</p>Formula:C25H30F3N5O4Purity:99.04%Color and Shape:SolidMolecular weight:521.53Eupalinolide A
CAS:<p>Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.</p>Formula:C24H30O9Purity:98.82% - 99.22%Color and Shape:SolidMolecular weight:462.49Grp94 Inhibitor-1
CAS:<p>Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).</p>Formula:C22H28N2O2Purity:97.02%Color and Shape:SolidMolecular weight:352.47Paeoniflorin
CAS:<p>Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.</p>Formula:C23H28O11Purity:96.9% - 97.43%Color and Shape:White Fine PowderMolecular weight:480.46Gedunin
CAS:<p>Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.</p>Formula:C28H34O7Purity:99.64% - 99.68%Color and Shape:SolidMolecular weight:482.57Ganetespib
CAS:<p>Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.</p>Formula:C20H20N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:364.4TRC051384
CAS:<p>TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.</p>Formula:C25H31N5O4Purity:98.79%Color and Shape:SolidMolecular weight:465.54KRIBB11
CAS:<p>KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.</p>Formula:C13H12N6O2Purity:97.25% - 99.91%Color and Shape:SolidMolecular weight:284.27Pimitespib
CAS:<p>Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).</p>Formula:C25H26N8OPurity:99.22% - 99.49%Color and Shape:SolidMolecular weight:454.53VER-49009
CAS:<p>VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).</p>Formula:C19H18ClN3O4Purity:99.36% - 99.99%Color and Shape:SolidMolecular weight:387.82TRC051384 HCl
CAS:<p>TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.</p>Formula:C25H32ClN5O4Purity:97.55%Color and Shape:SolidMolecular weight:502.01BIIB021
CAS:<p>BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).</p>Formula:C14H15ClN6OPurity:98% - 99.82%Color and Shape:SolidMolecular weight:318.76Geldanamycin
CAS:<p>Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.</p>Formula:C29H40N2O9Purity:97.59% - 99.27%Color and Shape:Yellow To Orange PowderMolecular weight:560.64Feretoside
CAS:<p>Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).</p>Formula:C17H24O11Purity:99.85%Color and Shape:SolidMolecular weight:404.37HA15
CAS:<p>HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.</p>Formula:C23H22N4O3S2Purity:99.77% - 99.86%Color and Shape:SolidMolecular weight:466.58Palmitic acid
CAS:<p>Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.</p>Formula:C16H32O2Purity:99.17% - 99.67%Color and Shape:White Crystalline Scales SolidMolecular weight:256.42KNK437
CAS:<p>KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).</p>Formula:C13H11NO4Purity:98.90%Color and Shape:SolidMolecular weight:245.23DTHIB
CAS:<p>DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.</p>Formula:C13H9ClFN3O3Purity:98.86% - 99.29%Color and Shape:SolidMolecular weight:309.68Apoptozole
CAS:<p>Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.</p>Formula:C33H25F6N3O3Purity:99.75%Color and Shape:SolidMolecular weight:625.56Azadiradione
CAS:<p>Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica</p>Formula:C28H34O5Purity:99.52%Color and Shape:SolidMolecular weight:450.57HSF1A
CAS:<p>HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.</p>Formula:C21H19N3O2S2Purity:98.89%Color and Shape:SolidMolecular weight:409.52YUM70
CAS:<p>YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.</p>Formula:C21H19ClN2O4Purity:97.25%Color and Shape:SolidMolecular weight:398.84KBU2046
CAS:<p>KBU2046: oral anti-metastasis compound, enhances survival, targets chaperone complexes, not a typical HSP90 inhibitor.</p>Formula:C15H11FO2Purity:99.89%Color and Shape:SolidMolecular weight:242.24VER-82576
CAS:<p>VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.</p>Formula:C21H23Cl2N5O2SPurity:97.31% - 99.85%Color and Shape:SolidMolecular weight:480.41VER-155008
CAS:<p>VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.</p>Formula:C25H23Cl2N7O4Purity:97.03% - 99.55%Color and Shape:SolidMolecular weight:556.4PU-H54
CAS:<p>PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.</p>Formula:C18H19N5SPurity:99.13%Color and Shape:SolidMolecular weight:337.44
