CymitQuimica logo
Wee1

Wee1

Wee1 inhibitors target the Wee1 kinase, a key regulator of the G2/M checkpoint in the cell cycle. Wee1 controls the timing of mitosis by inhibiting cyclin-dependent kinases (CDKs) to prevent premature entry into mitosis. Inhibiting Wee1 can lead to the abrogation of the G2/M checkpoint, forcing cells with damaged DNA to enter mitosis prematurely, often resulting in cell death. This makes Wee1 inhibitors particularly useful in cancer therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a selection of high-quality Wee1 inhibitors to support your research in cell cycle control, DNA damage response, and cancer treatment.

Found 15 products of "Wee1"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
  • CymitQuimica logo
    Targetmol
    + Info

    PKMYT1-IN-4

    <p>PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.</p>
    Formula:C19H15F3N4O2
    Color and Shape:Solid
    Molecular weight:388.34

    Ref: TM-T201136

  • CymitQuimica logo
    Targetmol
    + Info

    PKMYT1-IN-3

    <p>PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.</p>
    Formula:C24H26FN5O2
    Color and Shape:Solid
    Molecular weight:435.49

    Ref: TM-T200211

  • ZN-c3
    Targetmol
    + Info

    ZN-c3

    CAS:
    <p>Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties. Cost-effective and quality-assured.</p>
    Formula:C29H34N8O2
    Purity:99.98%
    Color and Shape:Solid
    Molecular weight:526.63

    Ref: TM-T9643

  • WEE1-IN-6
    Targetmol
    + Info

    WEE1-IN-6

    CAS:
    <p>WEE1-IN-6 (compound 110) is an orally active inhibitor of WEE1, displaying a DC50 value of ≤ 100 nM. This compound effectively inhibits cell proliferation [1].</p>
    Formula:C45H52FN11O4
    Color and Shape:Solid
    Molecular weight:829.96

    Ref: TM-T87631

  • PD 407824
    Targetmol
    + Info

    PD 407824

    CAS:
    <p>PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).</p>
    Formula:C20H12N2O3
    Purity:98.02%
    Color and Shape:Solid
    Molecular weight:328.32

    Ref: TM-T16446

  • WEE1-IN-3
    Targetmol
    + Info

    WEE1-IN-3

    CAS:
    <p>WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of &lt;10 nM. It treatment of cancer and other proliferative diseases.</p>
    Formula:C28H31N7O2
    Purity:98.33%
    Color and Shape:Solid
    Molecular weight:497.59

    Ref: TM-T8916

  • Adavosertib
    Targetmol
    + Info

    Adavosertib

    CAS:
    <p>Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.</p>
    Formula:C27H32N8O2
    Purity:98.65% - 99.86%
    Color and Shape:Solid
    Molecular weight:500.6

    Ref: TM-T2077

  • PD0166285
    Targetmol
    + Info

    PD0166285

    CAS:
    <p>PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.</p>
    Formula:C26H27Cl2N5O2
    Purity:99.23%
    Color and Shape:Solid
    Molecular weight:512.43

    Ref: TM-T6931

  • RP-6306
    Targetmol
    + Info

    RP-6306

    CAS:
    <p>Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.</p>
    Formula:C18H20N4O2
    Purity:98.41% - 99.28%
    Color and Shape:Solid
    Molecular weight:324.38

    Ref: TM-T60889

  • PKMYT1-IN-9
    Targetmol
    + Info

    PKMYT1-IN-9

    CAS:
    <p>PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.</p>
    Formula:C17H14FN5O
    Color and Shape:Solid
    Molecular weight:323.324

    Ref: TM-T206301

  • WEE1 degrader 1
    Targetmol
    + Info

    WEE1 degrader 1

    <p>WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.</p>
    Formula:C30H31N5O3
    Color and Shape:Solid
    Molecular weight:509.6

    Ref: TM-T201806

  • WEE1-IN-11
    Targetmol
    + Info

    WEE1-IN-11

    CAS:
    <p>WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.</p>
    Formula:C26H29FN8OS2
    Color and Shape:Solid
    Molecular weight:552.69

    Ref: TM-T200924

  • WEE1/PKMYT1-IN-1
    Targetmol
    + Info

    WEE1/PKMYT1-IN-1

    CAS:
    <p>WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.</p>
    Formula:C16H16N4O3
    Color and Shape:Solid
    Molecular weight:312.323

    Ref: TM-T204368

  • WEE1-IN-10
    Targetmol
    + Info

    WEE1-IN-10

    CAS:
    <p>WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.</p>
    Formula:C28H30Cl2N8O
    Purity:98.18%
    Color and Shape:Solid
    Molecular weight:565.5

    Ref: TM-T89365

  • PKMYT1-IN-2
    Targetmol
    + Info

    PKMYT1-IN-2

    CAS:
    <p>PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].</p>
    Formula:C22H19N5O2
    Color and Shape:Solid
    Molecular weight:385.42

    Ref: TM-T87219