Wee1
Wee1 inhibitors target the Wee1 kinase, a key regulator of the G2/M checkpoint in the cell cycle. Wee1 controls the timing of mitosis by inhibiting cyclin-dependent kinases (CDKs) to prevent premature entry into mitosis. Inhibiting Wee1 can lead to the abrogation of the G2/M checkpoint, forcing cells with damaged DNA to enter mitosis prematurely, often resulting in cell death. This makes Wee1 inhibitors particularly useful in cancer therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a selection of high-quality Wee1 inhibitors to support your research in cell cycle control, DNA damage response, and cancer treatment.
Found 14 products of "Wee1"
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WEE1-IN-6
CAS:WEE1-IN-6 (compound 110) is an orally active inhibitor of WEE1, displaying a DC50 value of ≤ 100 nM. This compound effectively inhibits cell proliferation [1].Formula:C45H52FN11O4Color and Shape:SolidMolecular weight:829.96PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Formula:C24H26FN5O2Color and Shape:SolidMolecular weight:435.49PKMYT1-IN-4
PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.Formula:C19H15F3N4O2Color and Shape:SolidMolecular weight:388.34ZN-c3
CAS:Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties. Cost-effective and quality-assured.
Formula:C29H34N8O2Purity:99.98%Color and Shape:SolidMolecular weight:526.63PD0166285
CAS:PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.Formula:C26H27Cl2N5O2Purity:99.23%Color and Shape:SolidMolecular weight:512.43WEE1-IN-3
CAS:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Formula:C28H31N7O2Purity:98.33%Color and Shape:SolidMolecular weight:497.59Ref: TM-T8916
1mg70.00€5mg156.00€10mg239.00€25mg419.00€50mg562.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)170.00€Adavosertib
CAS:Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Formula:C27H32N8O2Purity:98.65% - 99.86%Color and Shape:SolidMolecular weight:500.6Ref: TM-T2077
5mg46.00€10mg66.00€25mg81.00€50mg96.00€100mg110.00€200mg161.00€500mg260.00€1mL*10mM (DMSO)49.00€RP-6306
CAS:Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.
Formula:C18H20N4O2Purity:98.41% - 99.28%Color and Shape:SolidMolecular weight:324.38WEE1-IN-10
CAS:WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.Formula:C28H30Cl2N8OPurity:98.18%Color and Shape:SolidMolecular weight:565.5WEE1/PKMYT1-IN-1
CAS:WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.
Formula:C16H16N4O3Color and Shape:SolidMolecular weight:312.323WEE1-IN-11
CAS:WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Formula:C26H29FN8OS2Color and Shape:SolidMolecular weight:552.69PKMYT1-IN-2
CAS:PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].Formula:C22H19N5O2Color and Shape:SolidMolecular weight:385.42WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Formula:C30H31N5O3Color and Shape:SolidMolecular weight:509.6PKMYT1-IN-9
CAS:PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.Formula:C17H14FN5OColor and Shape:SolidMolecular weight:323.324
