Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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DR2313
CAS:DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.Formula:C8H10N2OSPurity:98.65%Color and Shape:SolidMolecular weight:182.24JQKD82
CAS:JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.Formula:C27H40N4O5Purity:100.00%Color and Shape:SolidMolecular weight:500.63Pacritinib
CAS:Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Formula:C28H32N4O3Purity:99.25% - 99.49%Color and Shape:SolidMolecular weight:472.58CPI203
CAS:CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formula:C19H18ClN5OSPurity:99.13% - 99.77%Color and Shape:SolidMolecular weight:399.9YKL-06-061
CAS:YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.Formula:C30H37N7O2Purity:99.52% - 99.79%Color and Shape:SolidMolecular weight:527.66ZM-447439
CAS:ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Formula:C29H31N5O4Purity:99.11% - 99.59%Color and Shape:Pale Yellow SolidMolecular weight:513.59Isoxazole
CAS:Isoxazole (1,2-oxazole) is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.Formula:C3H3NOPurity:98% - 99.34%Color and Shape:Colorless LiquidMolecular weight:69.06Bisindolylmaleimide IV
CAS:Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)
Formula:C20H13N3O2Purity:98.83%Color and Shape:Dark Red SolidMolecular weight:327.34AZ6102
CAS:AZ6102: Potent TNKS1/2 inhibitor, 100x selective over PARPs, IC50 = 5 nM in DLD-1 Wnt pathway.Formula:C25H28N6OPurity:97.98% - 99.91%Color and Shape:SolidMolecular weight:428.53Birabresib
CAS:Birabresib (MK-8628) is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4Formula:C25H22ClN5O2SPurity:98.3% - 99.36%Color and Shape:SolidMolecular weight:491.99Ref: TM-T6032
2mg46.00€5mg70.00€10mg90.00€25mg142.00€50mg222.00€100mg375.00€200mg560.00€500mg893.00€1mL*10mM (DMSO)74.00€OAC1
CAS:OAC1 (BAS 00287861) activates Oct4, boosts iPSC efficiency, and speeds up reprogramming.Formula:C14H11N3OPurity:99.49% - 99.65%Color and Shape:SolidMolecular weight:237.26Ref: TM-T2040
1mg34.00€2mg47.00€5mg66.00€10mg92.00€25mg164.00€50mg299.00€100mg540.00€1mL*10mM (DMSO)66.00€JNJ-7706621
CAS:JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Formula:C15H12F2N6O3SPurity:99.1% - 99.85%Color and Shape:SolidMolecular weight:394.36Ref: TM-T6126
1mg48.00€5mg100.00€10mg155.00€25mg268.00€50mg432.00€100mg595.00€200mg833.00€1mL*10mM (DMSO)94.00€Fraxinellone
CAS:1.Formula:C14H16O3Purity:99.35% - 99.92%Color and Shape:SolidMolecular weight:232.27Ref: TM-T6S0071
2mg34.00€5mg50.00€10mg84.00€25mg152.00€50mg222.00€100mg334.00€200mg494.00€1mL*10mM (DMSO)81.00€A1874
CAS:A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
Formula:C58H62Cl3F2N9O7SPurity:99.52%Color and Shape:SolidMolecular weight:1173.59Apabetalone
CAS:Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary arteryFormula:C20H22N2O5Purity:98.08% - ≥98%Color and Shape:SolidMolecular weight:370.4I-BRD9
CAS:I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.Formula:C22H22F3N3O3S2Purity:98.16% - 99.51%Color and Shape:SolidMolecular weight:497.55Ref: TM-T6859
1mg38.00€2mg49.00€5mg71.00€10mg107.00€25mg205.00€50mg389.00€100mg577.00€1mL*10mM (DMSO)79.00€M1001
CAS:M1001 is a HIF-2α agonist.Formula:C17H17N3O2SPurity:98.83%Color and Shape:SolidMolecular weight:327.4Cerdulatinib
CAS:Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Formula:C20H27N7O3SPurity:98.74% - 99.49%Color and Shape:SolidMolecular weight:445.54Ref: TM-T2487
1mg42.00€2mg52.00€5mg74.00€10mg101.00€25mg175.00€50mg268.00€100mg409.00€200mg573.00€500mg888.00€1mL*10mM (DMSO)81.00€MRTX-1719
CAS:MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines.Cost-effective and quality-assured.Formula:C23H18ClFN6O2Purity:98.27% - 99.18%Color and Shape:SolidMolecular weight:464.88Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Formula:C20H13N5OPurity:97.03% - 98.69%Color and Shape:SolidMolecular weight:339.35Ref: TM-T5093
1mg85.00€2mg124.00€5mg173.00€10mg263.00€25mg464.00€50mg672.00€100mg945.00€1mL*10mM (DMSO)192.00€SGC-SMARCA-BRDVIII
CAS:SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM,Formula:C19H25N5O3Purity:99.54% - 99.92%Color and Shape:SolidMolecular weight:371.43Ref: TM-T9568
1mg44.00€5mg66.00€10mg101.00€25mg222.00€50mg356.00€100mg530.00€500mg1,153.00€1mL*10mM (DMSO)54.00€Hispidulin
CAS:Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Formula:C16H12O6Purity:98.53% - 99.87%Color and Shape:SolidMolecular weight:300.26RK-287107
CAS:RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).Formula:C22H26F2N4O2Purity:99.64%Color and Shape:SolidMolecular weight:416.46C-7280948
CAS:C-7280948 is a PRMT1 inhibitor.Formula:C14H16N2O2SPurity:99.55% - ≥95%Color and Shape:SolidMolecular weight:276.35Ref: TM-T2097
5mg46.00€10mg66.00€25mg109.00€50mg178.00€100mg268.00€200mg414.00€500mg667.00€1mL*10mM (DMSO)49.00€Cucurbitacin I
CAS:Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Formula:C30H42O7Purity:96.69% - 99.8%Color and Shape:SolidMolecular weight:514.65γ-Oryzanol
CAS:γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in theFormula:C40H58O4Purity:mixture - mixtureColor and Shape:White Or White Crystalline Powder OdourlessMolecular weight:602.9EED226
CAS:EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.Formula:C17H15N5O3SPurity:98.14% - 99.33%Color and Shape:SolidMolecular weight:369.4Fucosterol
CAS:Fucosterol, from E. stolonifera, has anti-diabetic, anti-adipogenic, anti-cancer properties; it affects PPARα and C/EBPα to control fat cell formation.Formula:C29H48OPurity:98% - 99.68%Color and Shape:White PowderMolecular weight:412.69Iniparib
CAS:Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).Formula:C7H5IN2O3Purity:98.93%Color and Shape:SolidMolecular weight:292.03Ref: TM-T6224
5mg52.00€10mg73.00€25mg119.00€50mg216.00€100mg340.00€200mg540.00€500mg863.00€1mL*10mM (DMSO)52.00€Anacardic Acid
CAS:Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases.Formula:C22H36O3Purity:97.47% - 99.87%Color and Shape:SolidMolecular weight:348.52EDO-S101
CAS:EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.Formula:C19H28Cl2N4O2Purity:98.02% - 99.44%Color and Shape:SolidMolecular weight:415.36Buformin hydrochloride
CAS:Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Formula:C6H16ClN5Purity:97.83%Color and Shape:SolidMolecular weight:193.68MLN8054
CAS:MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Formula:C25H15ClF2N4O2Purity:98.07% - 98.26%Color and Shape:SolidMolecular weight:476.86Ref: TM-T6315
1mg50.00€2mg67.00€5mg84.00€10mg120.00€25mg220.00€50mg356.00€100mg537.00€1mL*10mM (DMSO)88.00€Nudifloramide
CAS:Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).Formula:C7H8N2O2Purity:99.7% - ≥95%Color and Shape:SolidMolecular weight:152.15AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
Formula:C21H21N3O2SPurity:97.24% - 99.83%Color and Shape:SolidMolecular weight:379.48Ruboxistaurin mesylate
CAS:Ruboxistaurin: PKC beta inhibitor, eases oxidative stress, heart issues & nephropathy in diabetic rats, halts retinal neovascularization.Formula:C29H32N4O6SPurity:98%Color and Shape:SolidMolecular weight:564.65AZ505
CAS:AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).Formula:C29H38Cl2N4O4Purity:98.18%Color and Shape:SolidMolecular weight:577.54Ref: TM-TQ0100
1mg60.00€5mg130.00€10mg178.00€25mg295.00€50mg462.00€100mg623.00€1mL*10mM (DMSO)165.00€MI-503
CAS:MI-503 is an efficient and selective Menin-MLL inhibitor. MI-503 has a significant inhibitory effect on human MLL leukemia cell line. Cost-effective and quality-assured.Formula:C28H27F3N8SPurity:99.87% - 99.99%Color and Shape:SolidMolecular weight:564.63Ref: TM-TQ0069
1mg50.00€5mg114.00€10mg178.00€25mg334.00€50mg557.00€100mg888.00€1mL*10mM (DMSO)141.00€Niraparib hydrochloride
CAS:Niraparib hydrochloride (MK-4827) is a PARP inhibitor with potential cancer treatment effects, causing DNA damage and apoptosis.Formula:C19H21ClN4OPurity:99.26%Color and Shape:SolidMolecular weight:356.85Bromosporine
CAS:Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.Formula:C17H20N6O4SPurity:99.65% - 99.79%Color and Shape:SolidMolecular weight:404.44Ref: TM-T6255
1mg44.00€2mg57.00€5mg93.00€10mg133.00€25mg260.00€50mg416.00€100mg665.00€200mg888.00€1mL*10mM (DMSO)92.00€8-CHLOROQUINAZOLIN-4(1H)-ONE
CAS:8-CHLOROQUINAZOLIN-4(1H)-ONE is inhibitor of Poly [ADP-ribose] polymerase 1 (human)Formula:C8H5ClN2OPurity:98.79%Color and Shape:SolidMolecular weight:180.59(R)-(-)-JQ1 Enantiomer
CAS:(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
Formula:C23H25ClN4O2SPurity:99.38%Color and Shape:SolidMolecular weight:456.99ICG001
CAS:ICG001 antagonizes Wnt signaling, binds CBP with 3 μM IC50, not p300.Formula:C33H32N4O4Purity:99.06% - 99.95%Color and Shape:SolidMolecular weight:548.63Ref: TM-T2237
1mg34.00€5mg66.00€10mg101.00€25mg197.00€50mg341.00€100mg530.00€500mg1,134.00€1mL*10mM (DMSO)81.00€Rucaparib hydrochloride
CAS:Rucaparib hydrochloride (AG014699) is an oral PARP inhibitor with Ki 1.4 nM for PARP1 and hinders H6PD, studied in CRPC research.Formula:C19H19ClFN3OColor and Shape:SolidMolecular weight:359.83GSK1379725A
CAS:GSK1379725A is a selective BPTF ligand (Kd = 2.8 μM).
Formula:C23H23FN6O3Purity:99.51%Color and Shape:SolidMolecular weight:450.47Nicotinamide riboside chloride
CAS:NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Formula:C11H15ClN2O5Purity:98.92% - 99.86%Color and Shape:SolidMolecular weight:290.7Rucaparib acetate
CAS:Rucaparib acetate, an oral PARP-1, -2, -3 inhibitor (Ki 1.4 nM for PARP1), also moderately inhibits H6PD; promising for CRPC research.Formula:C21H22FN3O3Color and Shape:SolidMolecular weight:383.423PF-9363
CAS:PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.Formula:C20H20N4O6SPurity:99.03% - 99.7%Color and Shape:SolidMolecular weight:444.46JQEZ5
CAS:JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).Formula:C30H38N8O2Purity:98.14% - ≥98%Color and Shape:SolidMolecular weight:542.68EB-47 dihydrochloride
CAS:EB 47 is an effective inhibitor of PARP-1 (IC50: 45 nM).Formula:C24H29Cl2N9O6Color and Shape:SolidMolecular weight:610.45
