Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
TP-3654
CAS:<p>TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).</p>Formula:C22H25F3N4OPurity:99.8% - 99.95%Color and Shape:SolidMolecular weight:418.46E7449
CAS:<p>E7449 is a potent inhibitor of PARP1, PARP2, TNKS1, and TNKS2 with IC50s of 2, 1, ~50, and ~50 nM respectively.</p>Formula:C18H15N5OPurity:97.13%Color and Shape:SolidMolecular weight:317.34Protosappanin A
CAS:<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Formula:C15H12O5Purity:99.42% - 99.82%Color and Shape:SolidMolecular weight:272.25Molibresib
CAS:<p>Molibresib (GSK525762) is an inhibitor of BET proteins (IC50: about 35 nM).</p>Formula:C22H22ClN5O2Purity:97.70% - 99.08%Color and Shape:SolidMolecular weight:423.9(+)-JQ1 PA
CAS:<p>(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).</p>Formula:C22H20ClN5OSPurity:98.36%Color and Shape:SolidMolecular weight:437.95WM-1119
CAS:<p>WM-1119 is a highly potent, selective KAT6A/B inhibitor</p>Formula:C18H13F2N3O3SPurity:96.59% - 99.58%Color and Shape:SolidMolecular weight:389.38XD14
CAS:<p>XD14 inhibits BET bromodomains with Kd: BRD4(1) 160nM, BRD2(1) 170nM, BRD3(1) 380nM, BRD3(2) 490nM, BRD2(2) 830nM, BRD4(2) 850nM.</p>Formula:C20H27N3O5SPurity:97.46%Color and Shape:SolidMolecular weight:421.51FL-411
CAS:<p>FL-411 (BRD4-IN-1) is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.</p>Formula:C18H19N3O2SPurity:98.19%Color and Shape:SolidMolecular weight:341.43GSK3685032
CAS:<p>GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).</p>Formula:C22H24N6OSPurity:98.56% - 99.49%Color and Shape:SolidMolecular weight:420.53Daminozide
CAS:<p>Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.</p>Formula:C6H12N2O3Purity:99.86%Color and Shape:White Crystalline Solid Physical Description Odorless White Crystals Or Powder (Ntp 1992)Molecular weight:160.17GSK-5959
CAS:<p>GSK-5959 is a selective BRPF1 inhibitor with IC50 ~80 nM, 100-fold more specific than 35 other bromodomains.</p>Formula:C22H26N4O3Purity:98.35% - 98.65%Color and Shape:SolidMolecular weight:394.47Deucravacitinib
CAS:<p>Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.</p>Formula:C20H19D3N8O3Purity:98.52% - >99.99%Color and Shape:SolidMolecular weight:425.46Momelotinib
CAS:<p>Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.</p>Formula:C23H22N6O2Purity:97.47% - 99.56%Color and Shape:SolidMolecular weight:414.46MS436
CAS:<p>MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.</p>Formula:C18H17N5O3SPurity:97.95% - 98.92%Color and Shape:SolidMolecular weight:383.42SNS-314 Mesylate
CAS:<p>SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.</p>Formula:C18H15ClN6OS2·CH4O3SPurity:99.44% - 99.92%Color and Shape:SolidMolecular weight:527.04BAY-598
CAS:<p>BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.</p>Formula:C22H20Cl2F2N6O3Purity:99.18% - 99.78%Color and Shape:SolidMolecular weight:525.342',3',5'-triacetyl-5-Azacytidine
CAS:<p>2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.</p>Formula:C14H18N4O8Purity:98.34%Color and Shape:SolidMolecular weight:370.31GSK046
CAS:<p>GSK046 (iBET-BD2), potent oral BET BD2 inhibitor; IC50: BRD2 (264 nM), BRD3 (98 nM), BRD4 (49 nM), BRDT (214 nM); immunomodulatory.</p>Formula:C23H27FN2O4Purity:99.97%Color and Shape:SolidMolecular weight:414.47RO495
CAS:<p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>Formula:C17H14Cl2N6OPurity:97.94%Color and Shape:SolidMolecular weight:389.24GSK6853
CAS:<p>GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.</p>Formula:C22H27N5O3Purity:98.71% - 99.21%Color and Shape:SolidMolecular weight:409.48(Z)-LFM-A13
CAS:<p>(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.</p>Formula:C11H8Br2N2O2Purity:99.88%Color and Shape:SolidMolecular weight:360Niraparib
CAS:<p>Niraparib (MK-4827) inhibits PARP1/PARP2 (IC50: 3.8/2.1 nM), effective on BRCA mutant cancers, 330x less effective on PARP3, V-PARP, Tank1.</p>Formula:C19H20N4OPurity:98% - 99.91%Color and Shape:SolidMolecular weight:320.39AKBA
CAS:<p>AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.</p>Formula:C32H48O5Purity:97.85% - 99.77%Color and Shape:SolidMolecular weight:512.72MN-64
CAS:<p>MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.</p>Formula:C18H16O2Purity:99.5% - 99.93%Color and Shape:SolidMolecular weight:264.32SGC0946
CAS:<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>Formula:C28H40BrN7O4Purity:98% - 99.82%Color and Shape:SolidMolecular weight:618.57SMI-16a
CAS:<p>SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (</p>Formula:C13H13NO3SPurity:99.99%Color and Shape:SolidMolecular weight:263.31OF-1
CAS:<p>OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.</p>Formula:C17H18BrN3O4SPurity:98.55% - ≥95%Color and Shape:SolidMolecular weight:440.31AT9283
CAS:<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Formula:C19H23N7O2Purity:99.83% - 99.98%Color and Shape:SolidMolecular weight:381.43SETDB1-TTD-IN-1
CAS:<p>SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.</p>Formula:C28H31N5O2Purity:98.26% - 99.96%Color and Shape:SolidMolecular weight:469.58JMJD7-IN-1
CAS:<p>JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM.</p>Formula:C16H8Cl2N2O4Purity:99.66%Color and Shape:SolidMolecular weight:363.15PF-9366
CAS:<p>PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).</p>Formula:C20H19ClN4Purity:97.28% - 99.88%Color and Shape:SolidMolecular weight:350.84AG-270
CAS:<p>AG-270 is an allosteric and orally active inhibitor of MAT2A.</p>Formula:C30H27N5O2Purity:98.28% - 98.87%Color and Shape:SolidMolecular weight:489.57C-82
CAS:<p>C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.</p>Formula:C33H34N6O4Purity:98.86% - 99.66%Color and Shape:SolidMolecular weight:578.66Itacitinib
CAS:<p>Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.</p>Formula:C26H23F4N9OPurity:96.4% - 99.5%Color and Shape:SolidMolecular weight:553.51A-966492
CAS:<p>A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.</p>Formula:C18H17FN4OPurity:98.53% - 99.27%Color and Shape:SolidMolecular weight:324.35GSK503
CAS:<p>GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.</p>Formula:C31H38N6O2Purity:98% - 99.89%Color and Shape:SolidMolecular weight:526.67PFI-4
CAS:<p>PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.</p>Formula:C21H24N4O3Purity:99.53% - ≥95%Color and Shape:SolidMolecular weight:380.44NI-57
CAS:<p>NI-57 inhibits BRPF family proteins: BRPF1 (IC50=3.1nM), BRPF2 (IC50=46nM), BRPF3 (IC50=140nM).</p>Formula:C19H17N3O4SPurity:99.88% - >99.99%Color and Shape:SolidMolecular weight:383.42Menin-MLL inhibitor MI-2
CAS:<p>Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.</p>Formula:C18H25N5S2Purity:97.46%Color and Shape:SolidMolecular weight:375.55Molibresib besylate
CAS:<p>Molibresib besylate (GSK 525762C) is a BET protein family inhibitor used in the study of refractory hematologic malignant diseases.</p>Formula:C28H28ClN5O5SPurity:99.64% - 99.64%Color and Shape:SolidMolecular weight:582.07Oroxylin A
CAS:<p>Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.</p>Formula:C16H12O5Purity:98.72% - 99.55%Color and Shape:SolidMolecular weight:284.26Tofacitinib
CAS:<p>Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of rheumatoid arthritis. Cost effective and quality assured.</p>Formula:C16H20N6OPurity:99% - >99.99%Color and Shape:SolidMolecular weight:312.37GSK126
CAS:<p>GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).</p>Formula:C31H38N6O2Purity:98% - 99.67%Color and Shape:SolidMolecular weight:526.67Seclidemstat
CAS:<p>Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.</p>Formula:C20H23ClN4O4SPurity:98.28% - 99.76%Color and Shape:SolidMolecular weight:450.94Veliparib dihydrochloride
CAS:<p>Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.</p>Formula:C13H18Cl2N4OPurity:98% - 99.81%Color and Shape:SolidMolecular weight:317.21Remodelin
CAS:<p>Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.</p>Formula:C15H14N4SPurity:99.39% - 99.83%Color and Shape:SolidMolecular weight:282.363PT-2385
CAS:<p>PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).</p>Formula:C17H12F3NO4SPurity:98.91% - 99.55%Color and Shape:SolidMolecular weight:383.34Venadaparib
CAS:<p>Venadaparib, a PARP inhibitor (IC50: 1.4/1.0 nM for PARP1/2), is orally active, selective, not affecting PARP-5, used in tumor studies.</p>Formula:C23H23FN4O2Purity:99.86%Color and Shape:SolidMolecular weight:406.45RN-1 dihydrochloride
CAS:<p>RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).</p>Formula:C23H31Cl2N3O2Purity:99.64%Color and Shape:SolidMolecular weight:452.42Ruxolitinib
CAS:<p>Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.</p>Formula:C17H18N6Purity:99.4% - >99.99%Color and Shape:SolidMolecular weight:306.36
