Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
(Z)-SMI-4a
CAS:<p>(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.</p>Formula:C11H6F3NO2SPurity:97.66% - 99.93%Color and Shape:SolidMolecular weight:273.23Oclacitinib
CAS:<p>Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000</p>Formula:C15H23N5O2SPurity:98% - 98.45%Color and Shape:White To Off-White SolidMolecular weight:337.44lutidinic acid
CAS:<p>lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.</p>Formula:C7H5NO4Purity:98.06%Color and Shape:White To Off-White Crystalline PowderMolecular weight:167.12RG108
CAS:<p>RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).</p>Formula:C19H14N2O4Purity:98% - 99.43%Color and Shape:SolidMolecular weight:334.33SGC-CBP30
CAS:<p>SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).</p>Formula:C28H33ClN4O3Purity:99.05% - >99.99%Color and Shape:SolidMolecular weight:509.04AZD-1480
CAS:<p>AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in solid tumors, PPV, PMF, ET trials.</p>Formula:C14H14ClFN8Purity:98.25% - 99.47%Color and Shape:SolidMolecular weight:348.77JAK-IN-5 hydrochloride
CAS:<p>JAK-IN-5 hydrochloride is a JAK inhibitor [1].</p>Formula:C27H32ClFN6OColor and Shape:SolidMolecular weight:511.03Barasertib-HQPA
CAS:<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Formula:C26H30FN7O3Purity:98.43% - 99.29%Color and Shape:SolidMolecular weight:507.56ARV-825
CAS:<p>ARV-825: PROTAC recruits BRD4 to cereblon for rapid BRD4 degradation in all tested BL cells.</p>Formula:C46H47ClN8O9SPurity:97.15% - 98%Color and Shape:SolidMolecular weight:923.43UNC6934
CAS:<p>UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.</p>Formula:C24H21N5O4Purity:98.67%Color and Shape:SolidMolecular weight:443.45Annaosanchun
CAS:<p>Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).</p>Formula:C19H32O3Purity:99.58%Color and Shape:SolidMolecular weight:308.46GS-829845
CAS:<p>GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life</p>Formula:C17H19N5O2SPurity:99.93%Color and Shape:SolidMolecular weight:357.43CX-6258 hydrochloride
CAS:<p>CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).</p>Formula:C26H24ClN3O3·HClPurity:96.03% - 98.60%Color and Shape:SolidMolecular weight:498.4CBHcy
CAS:<p>CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.</p>Formula:C9H17NO4SPurity:>99.99% - >99.99%Color and Shape:SolidMolecular weight:235.3TNG-462
CAS:<p>TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).</p>Formula:C28H36N6O2SPurity:98.7%Color and Shape:SolidMolecular weight:520.69MIV-6R
CAS:<p>MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.</p>Formula:C27H35N3OPurity:99.81% - 99.88%Color and Shape:SolidMolecular weight:417.59Talazoparib tosylate
CAS:<p>PF-3882845 is an MR antagonist that binds to the progesterone receptor (PR) and is used in the study of endocrine disorders and urogenital disorders.</p>Formula:C26H22F2N6O4SPurity:99.79%Color and Shape:SolidMolecular weight:552.55Zavondemstat
CAS:<p>Zavondemstat (QC8222 free base) is a KDM4 inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.</p>Formula:C26H29N3O3Purity:99.43% - 99.53%Color and Shape:SolidMolecular weight:431.53MS023 dihydrochloride
CAS:<p>MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.</p>Formula:C17H27Cl2N3OPurity:99.52%Color and Shape:SolidMolecular weight:360.32Cerdulatinib hydrochloride
CAS:<p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.</p>Formula:C20H28ClN7O3SPurity:99.85%Color and Shape:SolidMolecular weight:482Chromium(III) acetate
CAS:<p>Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.</p>Formula:C2H3O2CrPurity:99.9%Color and Shape:Blue-Green Powder Environment Immediate Steps Should Be Taken To Limit Its Spread To The Environment It Is Used InMolecular weight:76.37(S)-HH2853
CAS:<p>(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.</p>Formula:C31H36F3N7O3Purity:97.18% - 99.74%Color and Shape:SolidMolecular weight:611.66MRK-740
CAS:<p>MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.</p>Formula:C25H32N6O3Purity:99.66%Color and Shape:SolidMolecular weight:464.56BI-9321 trihydrochloride
CAS:<p>BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.</p>Formula:C22H24Cl3FN4Purity:99.12% - 99.34%Color and Shape:SolidMolecular weight:469.81R 59-022
CAS:<p>R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.</p>Formula:C27H26FN3OSPurity:98.55%Color and Shape:SolidMolecular weight:459.58PFI-2
CAS:<p>PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other</p>Formula:C23H25F4N3O3SPurity:99.38%Color and Shape:SolidMolecular weight:499.52NVP-BSK805
CAS:<p>NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.</p>Formula:C27H28F2N6OPurity:98%Color and Shape:SolidMolecular weight:490.55MK-5108
CAS:<p>MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.</p>Formula:C22H21ClFN3O3SPurity:99.22%Color and Shape:SolidMolecular weight:461.94Dehydrocorydaline nitrate
CAS:<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Formula:C22H24N2O7Purity:99.79% - 99.92%Color and Shape:SolidMolecular weight:428.44SCH-1473759 hydrochloride
CAS:<p>SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).</p>Formula:C20H27ClN8OSPurity:98.29%Color and Shape:SolidMolecular weight:463GSK2807 Trifluoroacetate
CAS:<p>GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).</p>Formula:C21H33F3N8O7Purity:99.95%Color and Shape:SolidMolecular weight:566.53(R)-Dihydrolipoic acid
CAS:<p>(R)-Dihydrolipoic acid, the biochemically significant R-enantiomer, partakes in biochemical transformations.</p>Formula:C8H16O2S2Purity:98%Color and Shape:SolidMolecular weight:208.33Solrikitug
CAS:<p>Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.</p>Purity:95%Color and Shape:LiquidTazemetostat trihydrochloride
CAS:<p>Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.</p>Formula:C34H47Cl3N4O4Purity:98%Color and Shape:SolidMolecular weight:682.12Acedapsone
CAS:<p>Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.</p>Formula:C16H16N2O4SPurity:98%Color and Shape:SolidMolecular weight:332.37Diethyl bipy55'DC
CAS:<p>"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."</p>Formula:C16H16N2O4Purity:98%Color and Shape:SolidMolecular weight:300.312-PADQZ
CAS:<p>DPQ is an antiviral compound.</p>Formula:C14H19N5O2Purity:98%Color and Shape:White PowderMolecular weight:289.33Nicotinamide-d4
CAS:<p>Nicotinamide-d4 is a deuterium-labelled compound of nicotinamide for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.</p>Formula:C6H2D4N2OPurity:99.746%Color and Shape:SolidMolecular weight:126.15193 D7
CAS:<p>193 D7 is an inhibitor of histone demethylase JMJD1C (IC50= 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumors by targeting intratumoral Treg cells in mouse tumor models.</p>Formula:C16H15NO4SColor and Shape:SolidMolecular weight:317.36GSK 4027
CAS:<p>GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for PCAF.</p>Formula:C17H21BrN4OColor and Shape:SolidMolecular weight:377.28I-BET787
CAS:<p>I-BET787, an orally active pan-BET bromodomain inhibitor, has demonstrated efficacy in murine inflammation models.</p>Formula:C16H20ClN3O2Color and Shape:SolidMolecular weight:321.80CrBKA
CAS:<p>CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity [1] .</p>Formula:C28H31N3O6Color and Shape:SolidMolecular weight:505.56AdipoR agonist 1
CAS:<p>AdipoR agonist 1 (Compound 112254), acting as an agonist for the adiponectin receptor (AdipoR), stimulates transcriptional regulators including peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). It is employed in the field of preventive doping research.</p>Formula:C26H35N3O3Color and Shape:SolidMolecular weight:437.57HDAC6-IN-27
CAS:<p>HDAC6-IN-27 (compound 8C), an HDAC inhibitor, exhibits IC 50 values of 15.9 nM, 136.5 nM, and 6180.2 nM against HDAC6, HDAC8, and HDAC1, respectively. It also demonstrates potent antiparasitic effects [1].</p>Formula:C15H15N3O4Color and Shape:SolidMolecular weight:301.3BG47
CAS:<p>BG47: a COMET probe for precise optical epigenetic control, inhibits histone deacetylases with light.</p>Formula:C25H22N4O2SColor and Shape:SolidMolecular weight:442.54Guanosine-5'-triphosphate disodium salt
CAS:<p>5'-GTP disodium salt boosts myogenic differentiation and fuels cellular processes.</p>Formula:C10H14N5Na2O14P3Purity:95.69% - 99.96%Color and Shape:Odorless White SolidMolecular weight:567.14GSK-J1 lithium salt
CAS:<p>GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B.</p>Formula:C22H22LiN5O2Purity:98%Color and Shape:SolidMolecular weight:395.38BG14
CAS:<p>BG14: High-res optical epigenetic control; photo-inhibits human histone deacetylases with visible light.</p>Formula:C21H21N5OColor and Shape:SolidMolecular weight:359.433KAT6-IN-1
CAS:<p>KAT6-IN-1 is a potent KAT6 inhibitor. KAT6-IN-1 can be used in research of cancer [1] .</p>Formula:C19H18N4O5SColor and Shape:SolidMolecular weight:414.43ZM39923
CAS:<p>ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).</p>Formula:C23H25NOPurity:98%Color and Shape:SolidMolecular weight:331.45
