Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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MS31 trihydrochloride
MS31 trihydrochloride: a selective SPIN1 inhibitor, binds H3K4me3 (IC50: 77-243 nM), non-toxic to healthy cells.Formula:C20H30Cl3N3O2Color and Shape:SolidMolecular weight:450.83SC-43
CAS:SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).Formula:C21H13ClF3N3O2Purity:98.44%Color and Shape:SolidMolecular weight:431.8Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Formula:C9H10O4Purity:99.88%Color and Shape:White Crystal Or PowderMolecular weight:182.17AMG-47a
CAS:AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formula:C29H28F3N5O2Purity:98%Color and Shape:SolidMolecular weight:535.56(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formula:C23H24N4OPurity:97.75% - 99.92%Color and Shape:SolidMolecular weight:372.46Ref: TM-T21503
1mg43.00€2mg56.00€5mg93.00€10mg113.00€25mg200.00€50mg330.00€100mg480.00€1mL*10mM (DMSO)90.00€Menin-MLL inhibitor 20
CAS:Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities.Formula:C33H40N8O4Purity:97.77%Color and Shape:SolidMolecular weight:612.72Ref: TM-T9399
1mg38.00€5mg86.00€10mg128.00€25mg250.00€50mg369.00€100mg527.00€200mg712.00€1mL*10mM (DMSO)95.00€WM-8014
CAS:WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.Formula:C20H17FN2O3SPurity:99.64%Color and Shape:SolidMolecular weight:384.42Ref: TM-T4362
1mg54.00€2mg78.00€5mg109.00€10mg166.00€25mg316.00€50mg470.00€100mg682.00€1mL*10mM (DMSO)129.00€Abrocitinib
CAS:Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formula:C14H21N5O2SPurity:99.09% - 99.91%Color and Shape:SolidMolecular weight:323.41RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:98% - 99.91%Color and Shape:SolidMolecular weight:545.63Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14PHD-1-IN-1
CAS:PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Formula:C13H8N4Purity:99.74%Color and Shape:SolidMolecular weight:220.23Ref: TM-T9627
1mg42.00€5mg92.00€10mg132.00€25mg231.00€50mg349.00€100mg522.00€200mg710.00€1mL*10mM (DMSO)90.00€FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formula:C28H32O6Purity:97% - 97.90%Color and Shape:SolidMolecular weight:464.55Ref: TM-T6838
2mg43.00€5mg63.00€10mg88.00€25mg117.00€50mg187.00€100mg333.00€500mg797.00€1mL*10mM (DMSO)69.00€3-methyl-1,2,3,4-tetrahydroquinazolin-2-one
CAS:3-methyl-1,2,3,4-tetrahydroquinazolin-2-one is a inhibitor of BRD4 .Formula:C9H10N2OPurity:99.3% - 99.64%Color and Shape:SolidMolecular weight:162.19Ref: TM-T50006
2mg37.00€5mg52.00€10mg78.00€25mg119.00€50mg172.00€100mg259.00€500mg642.00€1mL*10mM (DMSO)56.00€Alobresib
CAS:Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.Formula:C26H23N5O2Purity:97.63%Color and Shape:SolidMolecular weight:437.49Ref: TM-T8495
1mg70.00€2mg87.00€5mg137.00€10mg260.00€25mg507.00€50mg713.00€100mg982.00€1mL*10mM (DMSO)150.00€C-82
CAS:C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.Formula:C33H34N6O4Purity:98.86% - 99.66%Color and Shape:SolidMolecular weight:578.66Tubacin
CAS:Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.Formula:C41H43N3O7SPurity:97.62% - 98.75%Color and Shape:SolidMolecular weight:721.86Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurity:98% - 99.45%Color and Shape:SolidMolecular weight:393.49Ref: TM-T1825
1mg35.00€2mg50.00€5mg66.00€10mg84.00€25mg156.00€50mg212.00€100mg371.00€1mL*10mM (DMSO)66.00€J-147
CAS:J-147, a curcumin derivative, is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging.Formula:C18H17F3N2O2Purity:99.61% - >99.99%Color and Shape:SolidMolecular weight:350.33PLX51107
CAS:PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).Formula:C26H22N4O3Purity:99.75%Color and Shape:SolidMolecular weight:438.48Ref: TM-TQ0253
1mg52.00€2mg77.00€5mg113.00€10mg178.00€25mg313.00€50mg464.00€100mg672.00€1mL*10mM (DMSO)124.00€SHR0302
CAS:SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formula:C18H22N8O2SPurity:99.11%Color and Shape:SolidMolecular weight:414.48Ref: TM-T9195
1mg80.00€5mg183.00€10mg298.00€25mg512.00€50mg817.00€100mg1,311.00€1mL*10mM (DMSO)167.00€OUL35
CAS:OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.Formula:C14H12N2O3Purity:99.2%Color and Shape:SolidMolecular weight:256.26EPZ005687
CAS:EPZ005687 is a potent and selective inhibitor of EZH2.Formula:C32H37N5O3Purity:97.06% - 99.64%Color and Shape:SolidMolecular weight:539.67Rucaparib Phosphate
CAS:Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.Formula:C19H18FN3O·H3PO4Purity:99.37%Color and Shape:SolidMolecular weight:421.36Ref: TM-T6127
1mg35.00€2mg50.00€5mg74.00€10mg109.00€25mg178.00€50mg235.00€100mg371.00€200mg553.00€1mL*10mM (DMSO)74.00€JAK3-IN-6
CAS:JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormula:C19H18N4O3Purity:99.94% - 99.94%Color and Shape:SolidMolecular weight:350.37Ruxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Formula:C17H18N6Purity:99.37% - 99.79%Color and Shape:SolidMolecular weight:306.36Momelotinib HCl
CAS:Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.Formula:C23H24Cl2N6O2Color and Shape:SolidMolecular weight:487.38BRD4770
CAS:BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.Formula:C25H23N3O3Purity:99.53% - 99.82%Color and Shape:SolidMolecular weight:413.47XAV-939
CAS:XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assay).Formula:C14H11F3N2OSPurity:97.47% - 99.67%Color and Shape:SolidMolecular weight:312.31GSK2879552 2HCl (1401966-69-5(free base))
GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
Formula:C23H30Cl2N2O2Purity:99.87% - ≥95%Color and Shape:SolidMolecular weight:437.41Ref: TM-T4418
1mg59.00€2mg86.00€5mg109.00€10mg175.00€25mg293.00€50mg411.00€100mg610.00€500mg1,301.00€WZ4003
CAS:WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.Formula:C25H29ClN6O3Purity:99.65% - >99.99%Color and Shape:SolidMolecular weight:496.99Ref: TM-T6291
5mg48.00€10mg73.00€25mg111.00€50mg166.00€100mg241.00€200mg358.00€500mg590.00€1mL*10mM (DMSO)50.00€Iso-H7 dihydrochloride
CAS:Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.Formula:C14H19Cl2N3O2SPurity:99.53%Color and Shape:White Crystalline SolidMolecular weight:364.29ABBV-744
CAS:ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.Formula:C28H30FN3O4Purity:97.03% - >99.99%Color and Shape:SolidMolecular weight:491.55Ref: TM-T4697
1mg44.00€2mg56.00€5mg90.00€10mg142.00€25mg284.00€50mg409.00€100mg500.00€200mg718.00€1mL*10mM (DMSO)90.00€Menin-MLL inhibitor MI-2
CAS:Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.Formula:C18H25N5S2Purity:97.46%Color and Shape:SolidMolecular weight:375.55Ref: TM-T2649
2mg39.00€5mg58.00€10mg84.00€25mg160.00€50mg230.00€100mg356.00€200mg522.00€1mL*10mM (DMSO)64.00€UMB298
CAS:UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.Formula:C27H31ClN4O2Purity:99.76%Color and Shape:SolidMolecular weight:479.01Ref: TM-T9194
1mg46.00€5mg94.00€10mg149.00€25mg250.00€50mg351.00€100mg480.00€200mg622.00€1mL*10mM (DMSO)99.00€(S)-CPI203
CAS:CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formula:C19H18ClN5OSPurity:99.01% - 99.92%Color and Shape:SolidMolecular weight:399.9Ref: TM-T6026
2mg34.00€5mg55.00€10mg89.00€25mg170.00€50mg269.00€100mg424.00€200mg593.00€1mL*10mM (DMSO)58.00€C646
CAS:C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).Formula:C24H19N3O6Purity:98% - 99.21%Color and Shape:SolidMolecular weight:445.42Ref: TM-T2452
2mg46.00€5mg65.00€10mg92.00€25mg185.00€50mg360.00€100mg532.00€500mg1,144.00€1mL*10mM (DMSO)65.00€PF-CBP1 hydrochloride
CAS:PF-CBP1 HCl selectively inhibits CREBBP bromodomain (IC50: 125 nM) and p300 (IC50: 363 nM).Formula:C29H37ClN4O3Purity:97.11% - 99.02%Color and Shape:SolidMolecular weight:525.08BCI-121
CAS:BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.Formula:C14H18BrN3O2Purity:99.67%Color and Shape:SolidMolecular weight:340.22RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formula:C14H5F6N5OPurity:98% - 98.85%Color and Shape:SolidMolecular weight:373.21Ref: TM-T22142
1mg43.00€2mg55.00€5mg93.00€10mg137.00€25mg254.00€50mg380.00€100mg573.00€500mg1,189.00€GLPG0634 analog
CAS:GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.Formula:C23H18N6O2Purity:99.52% - >99.99%Color and Shape:SolidMolecular weight:410.43Ref: TM-T3076
1mg38.00€2mg50.00€5mg84.00€10mg137.00€25mg250.00€50mg442.00€100mg623.00€500mg1,305.00€1mL*10mM (DMSO)93.00€Tofacitinib Citrate
CAS:Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Formula:C22H28N6O8Purity:99.19% - 99.75%Color and Shape:SolidMolecular weight:504.49MI-463
CAS:MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).Formula:C24H23F3N6SPurity:99.18% - >99.99%Color and Shape:SolidMolecular weight:484.54SGC2085 HCl
CAS:SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.Formula:C19H24N2O2·HClPurity:99.91%Color and Shape:SolidMolecular weight:348.87Ref: TM-T4013
1mg93.00€2mg150.00€5mg190.00€10mg343.00€25mg567.00€50mg825.00€100mg1,130.00€1mL*10mM (DMSO)244.00€KC7F2
CAS:KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.Formula:C16H16Cl4N2O4S4Purity:98% - 99.11%Color and Shape:SolidMolecular weight:570.38DDP-38003 trihydrochloride
DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.Formula:C21H29Cl3N4OPurity:98%Color and Shape:SolidMolecular weight:459.84BYK204165
CAS:BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)Formula:C15H12N2O2Purity:99.61%Color and Shape:SolidMolecular weight:252.27Ref: TM-T7896
1mg44.00€5mg66.00€10mg90.00€25mg167.00€50mg236.00€100mg349.00€200mg512.00€1mL*10mM (DMSO)73.00€Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formula:C15H18O2Purity:97.55% - 99.92%Color and Shape:SolidMolecular weight:230.30Bempedoic acid
CAS:Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C.Formula:C19H36O5Purity:99.85% - 99.94%Color and Shape:SolidMolecular weight:344.49Ref: TM-T3625
2mg34.00€5mg50.00€10mg70.00€25mg118.00€50mg207.00€100mg333.00€500mg797.00€1mL*10mM (DMSO)52.00€GSK6853
CAS:GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.Formula:C22H27N5O3Purity:98.71% - 99.21%Color and Shape:SolidMolecular weight:409.48
