Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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HDAC/NAMPT-IN-1
CAS:<p>HDAC/NAMPT-IN-1 (compound 39h) simultaneously inhibits HDAC and NAMPT, exhibiting IC 50 values ranging from 0.72 to 37081 nM for HDAC and 1618 nM for NAMPT [1].</p>Formula:C19H21N5O2Color and Shape:SolidMolecular weight:351.4IACS-9571 hydrochloride
CAS:<p>IACS-9571 hydrochloride: potent TRIM24/BRPF1 inhibitor; IC50 = 8 nM (TRIM24); Kd = 31 nM (TRIM24), 14 nM (BRPF1).</p>Formula:C32H43ClN4O8SColor and Shape:SolidMolecular weight:679.22KDM2B-IN-4
CAS:<p>KDM2B-IN-4, from patent WO2016112284A1 as 182b, is a potent KDM2B inhibitor used in cancer research.</p>Formula:C24H28N2O2Color and Shape:SolidMolecular weight:376.49CEP-8983
CAS:<p>CEP-8983 is a PARP inhibitor potentially for the treatment of solid tumours.</p>Formula:C18H14N2O3Purity:98%Color and Shape:SolidMolecular weight:306.32BRM/BRG1 ATP Inhibitor-4
CAS:<p>BRM/BRG1 ATP Inhibitor-4, a potent inhibitor of BRG1/BRM, is utilized in the research of cancers and BAF complex-related disorders.</p>Formula:C25H32N6O3SColor and Shape:SolidMolecular weight:496.62MAT2A-IN-7
CAS:<p>MAT2A-IN-7 inhibits MAT2A in various cancers, especially MTAP-deficient cancer cells, with potential for research use.</p>Formula:C17H13ClF3N3O2Color and Shape:SolidMolecular weight:383.75Dihydro-5-azacytidine acetate
CAS:<p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>Formula:C10H18N4O7Purity:98%Color and Shape:SolidMolecular weight:306.27LT052
CAS:<p>LT052 is a BET BD1 inhibitor with anti-inflammatory activity. It mediates the BRD4/NF-κB/NLRP3 signaling inflammatory pathway.</p>Formula:C22H19N5O4SPurity:98.82%Color and Shape:SolidMolecular weight:449.48Sirt2-IN-6
CAS:<p>Sirt2-IN-6 is a potent and selective inhibitor of SIRT2 (IC50: 0.815 μM) and can be used to study cancer.</p>Formula:C26H26N6O3SColor and Shape:SolidMolecular weight:502.59BRD4884
CAS:<p>BRD4884 is a highly selective and efficient HDAC1 and HDAC2 inhibitor that also inhibits HDAC3, used in research on neurological disorders.</p>Formula:C18H19FN2O2Purity:99.19% - 99.21%Color and Shape:SolidMolecular weight:314.35Lorpucitinib
CAS:<p>Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.</p>Formula:C22H28N6O2Purity:99.72%Color and Shape:SolidMolecular weight:408.5KDM2/7-IN-1
CAS:<p>KDM2/7-IN-1 is a selective histone demethylase inhibitor (IC50s: 0.2–>120 μM) that inhibits HeLa and KYSE-150 cell proliferation, epigenetic and cancer.</p>Formula:C15H27NO4Purity:99.87%Color and Shape:SolidMolecular weight:285.38BETi-211
CAS:<p>BETi-211 is a selective inhibitor BET bromodomain.</p>Formula:C26H29N7O3Color and Shape:SolidMolecular weight:487.55ZYJ-25e
CAS:<p>ZYJ-25e is an oral histone deacetylase inhibitor (HDACi) with potent antitumor activities.</p>Formula:C30H40N4O8Purity:98%Color and Shape:SolidMolecular weight:584.66IND 1316
CAS:<p>IND 1316 is an activator of AMP-activated protein kinase (AMPK).</p>Formula:C22H17NO3Color and Shape:SolidMolecular weight:343.38CCT077791
CAS:<p>CCT077791 is a potent inhibitor of p300 and PCAF histone acetyltransferase activity for cancer research.</p>Formula:C9H5ClN2O3SPurity:98.60%Color and Shape:SolidMolecular weight:256.67ZIKV-IN-2
CAS:<p>ZIKV-IN-2 blocks ZIKV replication, is a strong NS5 MTase inhibitor (IC50: 38.86 μM), and aids Zika virus research.</p>Formula:C39H42O4Color and Shape:SolidMolecular weight:574.75KU-0058684
CAS:<p>KU-0058684 is a potent PARP and DNA-PK inhibitors.</p>Formula:C19H14FN3O3Color and Shape:SolidMolecular weight:351.33ML753286
CAS:<p>ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.</p>Formula:C20H25N3O3Purity:98%Color and Shape:SolidMolecular weight:355.43Trotabresib
CAS:<p>Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.</p>Formula:C21H21NO4SPurity:99.86%Color and Shape:SolidMolecular weight:383.46JAK1-IN-4
CAS:<p>JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).</p>Formula:C26H32FN9O2Purity:98%Color and Shape:SolidMolecular weight:521.59Y02224
CAS:<p>Y02224 is a BET inhibitor. It shows the reasonable antiproliferative effect on leukemia cells.</p>Formula:C20H17BrN2O4SPurity:98%Color and Shape:SolidMolecular weight:461.33Dot1L-IN-5
CAS:<p>Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].</p>Formula:C23H19ClF2N8O5SColor and Shape:SolidMolecular weight:592.96HAT-IN-1
CAS:<p>HAT-IN-1 is an inhibitor of HAT used in the research of cancer.</p>Formula:C23H18BrF4N3O4Purity:98%Color and Shape:SolidMolecular weight:556.3Helenalin Acetate
CAS:<p>Helenalin Acetate: anti-inflammatory, anti-cancer, hinders C/EBPß and p300 cooperation.</p>Formula:C17H20O5Purity:98%Color and Shape:SolidMolecular weight:304.34HDAC-IN-45
CAS:<p>HDAC-IN-45, a small HDAC blocker, forms H-bonds with Y303 and shows anticancer properties; IC50 for HDAC1/2/3: 0.108/0.585/0.563 μM.</p>Formula:C25H20ClFN8OColor and Shape:SolidMolecular weight:502.93DM-01
CAS:<p>DM-01 is a potent and selective inhibitor of EZH2.</p>Formula:C23H24F3N3O2Color and Shape:SolidMolecular weight:431.45dBRD9-A
CAS:<p>Potent BRD9 degrader that binds selectively, fully degrades BRD9 at low doses, and hinders synovial sarcoma growth in vitro and in mice.</p>Formula:C42H49N7O8Color and Shape:SolidMolecular weight:779.88PB118
<p>PB118 clears Aβ, boosts phagocytosis, enhances tubulin networks, reduces p-tau & inflammation in AD; HDAC6 IC50: 5.6 nM.</p>Formula:C18H19FN2O2Color and Shape:SoildMolecular weight:314.35Dot1L-IN-7
CAS:<p>Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.</p>Formula:C23H27N9O2Color and Shape:SolidMolecular weight:461.52CeMMEC2
CAS:<p>CeMMEC2, a novel inhibitor of BRD4, binds both the first and the second bromodomain of BRD4.</p>Formula:C14H19N5Color and Shape:SolidMolecular weight:257.33(1S,2R)-Tranylcypromine hydrochloride
CAS:<p>(1S,2R)-Tranylcypromine hydrochloride ((1S,2R)-SKF 385), a potent antidepressant, functions by inhibiting both MAO and LSD1.</p>Formula:C9H12ClNColor and Shape:SolidMolecular weight:169.651Guadecitabine sodium
CAS:<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Formula:C18H24N9NaO10PPurity:98%Color and Shape:SolidMolecular weight:580.407HDAC6-IN-46
CAS:<p>HDAC6-IN-46 (compound 12) is a selective inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 of 6.2 nM. It is utilized in research related to Alzheimer's disease.</p>Formula:C26H21N3O4Color and Shape:SolidMolecular weight:439.46HDAC3-IN-T326
CAS:<p>HDAC3-IN-T326: potent, selective HDAC3 inhibitor, boosts NF-κB acetylation, activates latent HIV gene expression.</p>Formula:C21H18N6O3SPurity:98%Color and Shape:SolidMolecular weight:434.47Gue1654
CAS:<p>Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.</p>Formula:C23H17N3OS3Purity:98.02% - 98.04%Color and Shape:SolidMolecular weight:447.6LSD1-IN-6
CAS:<p>LSD1-IN-6, a potent LSD1 inhibitor (IC50: 123 nM), enhances H3K4me2 without altering LSD1 expression. Reversible.</p>Formula:C15H13BrN2O3Purity:98%Color and Shape:SolidMolecular weight:349.18SC-9
CAS:<p>SC-9 is a protein kinase C activator.</p>Formula:C22H24ClNO2SPurity:98%Color and Shape:SolidMolecular weight:401.95PS432
CAS:<p>PS432 inhibits atypical PKCs, targets PIF-pocket, reduces tumors in mice sans side effects.</p>Formula:C25H19ClN2O5SPurity:98%Color and Shape:SolidMolecular weight:494.95SMYD2-IN-1
CAS:<p>SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).</p>Formula:C25H25Cl2F2N7O2Purity:98%Color and Shape:SolidMolecular weight:564.41Piribedil dihydrochloride
CAS:<p>dopamine agonist</p>Formula:C16H20Cl2N4O2Purity:98%Color and Shape:SolidMolecular weight:371.26Akt Inhibitor X
CAS:<p>Akt Inhibitor X is a cell-permeable and reversible inhibitor of Akt phosphorylation.</p>Formula:C20H25ClN2OPurity:98%Color and Shape:SolidMolecular weight:344.88KDM5B-IN-3
CAS:<p>KDM5B-IN-3 inhibits KDM5B/JARID1B with IC50 of 9.32 μM, useful in gastric cancer studies.</p>Formula:C19H25ClN4O2Color and Shape:SolidMolecular weight:376.88DDP-38003 dihydrochloride
CAS:<p>DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).</p>Formula:C21H28Cl2N4OPurity:99.76%Color and Shape:SolidMolecular weight:423.38CID-4785700
CAS:<p>CID-4785700 is a potent pan-GTPase inhibitor that inhibits Rab7 and inhibits the fungal histone acetyltransferase Rtt109 that binds to Asf1 and Vps75</p>Formula:C22H23ClFN3O3Purity:98.16%Color and Shape:SolidMolecular weight:431.89Kgp-IN-1
CAS:<p>Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.</p>Formula:C19H24F4N4O3Purity:98%Color and Shape:SolidMolecular weight:432.41PARP-1/2-IN-1
CAS:<p>PARP-1-/2-IN-1 is a potent inhibitor of PARP-1 (IC50: 0.51 nM) and PARP-2 (IC50: 23.11 nM).</p>Formula:C24H27FN4O3Color and Shape:SolidMolecular weight:438.49NSC-636819
CAS:<p>NSC-636819 is a novel inhibitor of KDM4A/KDM4B.</p>Formula:C22H12Cl4N2O4Purity:98%Color and Shape:SolidMolecular weight:510.15M-110
CAS:<p>M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).</p>Formula:C22H28ClN5O3Purity:99.55%Color and Shape:SolidMolecular weight:445.94MI-1
CAS:<p>MI-1 inhibits Menin-MLL interaction with an IC 50 of 1.9 μM [1].</p>Formula:C19H25N5S2Color and Shape:SolidMolecular weight:387.57
