Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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Momelotinib
CAS:Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formula:C23H22N6O2Purity:97.07% - 99.56%Color and Shape:SolidMolecular weight:414.46Ref: TM-T1849
1mg35.00€2mg50.00€5mg77.00€10mg89.00€25mg158.00€50mg245.00€100mg385.00€200mg592.00€1mL*10mM (DMSO)84.00€MS436
CAS:MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.Formula:C18H17N5O3SPurity:97.95% - 98.92%Color and Shape:SolidMolecular weight:383.42Ref: TM-T1854
2mg42.00€5mg62.00€10mg95.00€25mg172.00€50mg268.00€100mg429.00€200mg615.00€1mL*10mM (DMSO)69.00€SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Formula:C18H15ClN6OS2·CH4O3SPurity:99.44% - 99.92%Color and Shape:SolidMolecular weight:527.04BAY-598
CAS:BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.Formula:C22H20Cl2F2N6O3Purity:99.18% - 99.78%Color and Shape:SolidMolecular weight:525.342',3',5'-triacetyl-5-Azacytidine
CAS:2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.Formula:C14H18N4O8Purity:98.34%Color and Shape:SolidMolecular weight:370.31Ref: TM-T7840
2mg38.00€5mg50.00€10mg75.00€25mg122.00€50mg177.00€100mg266.00€200mg385.00€1mL*10mM (DMSO)60.00€GSK046
CAS:GSK046 (iBET-BD2), potent oral BET BD2 inhibitor; IC50: BRD2 (264 nM), BRD3 (98 nM), BRD4 (49 nM), BRDT (214 nM); immunomodulatory.Formula:C23H27FN2O4Purity:99.97%Color and Shape:SolidMolecular weight:414.47Ref: TM-T8932
1mg57.00€5mg120.00€10mg200.00€25mg447.00€50mg715.00€100mg1,108.00€200mg1,485.00€1mL*10mM (DMSO)133.00€RO495
CAS:RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assaysFormula:C17H14Cl2N6OPurity:97.94%Color and Shape:SolidMolecular weight:389.24Ref: TM-T22416
1mg46.00€5mg86.00€10mg126.00€25mg235.00€50mg344.00€100mg465.00€200mg625.00€1mL*10mM (DMSO)94.00€GSK6853
CAS:GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.Formula:C22H27N5O3Purity:98.71% - 99.21%Color and Shape:SolidMolecular weight:409.48(Z)-LFM-A13
CAS:(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.Formula:C11H8Br2N2O2Purity:99.88%Color and Shape:SolidMolecular weight:360Niraparib
CAS:Niraparib (MK-4827) inhibits PARP1/PARP2 (IC50: 3.8/2.1 nM), effective on BRCA mutant cancers, 330x less effective on PARP3, V-PARP, Tank1.Formula:C19H20N4OPurity:98% - 99.91%Color and Shape:SolidMolecular weight:320.39Ref: TM-T3231
5mg57.00€10mg84.00€25mg105.00€50mg137.00€100mg205.00€200mg304.00€500mg515.00€1mL*10mM (DMSO)63.00€AKBA
CAS:AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.Formula:C32H48O5Purity:97.85% - 99.77%Color and Shape:SolidMolecular weight:512.72MN-64
CAS:MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.Formula:C18H16O2Purity:99.5% - 99.93%Color and Shape:SolidMolecular weight:264.32SGC0946
CAS:SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.Formula:C28H40BrN7O4Purity:98% - 99.82%Color and Shape:SolidMolecular weight:618.57SMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Formula:C13H13NO3SPurity:99.99%Color and Shape:SolidMolecular weight:263.31Ref: TM-T3989
1mg34.00€2mg46.00€5mg66.00€10mg93.00€25mg152.00€50mg222.00€100mg334.00€1mL*10mM (DMSO)87.00€OF-1
CAS:OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.Formula:C17H18BrN3O4SPurity:98.55% - ≥95%Color and Shape:SolidMolecular weight:440.31Ref: TM-T2127
1mg35.00€5mg74.00€10mg123.00€25mg240.00€50mg385.00€100mg595.00€200mg833.00€1mL*10mM (DMSO)74.00€AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
Formula:C19H23N7O2Purity:99.83% - 99.98%Color and Shape:SolidMolecular weight:381.43SETDB1-TTD-IN-1
CAS:SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.Formula:C28H31N5O2Purity:98.26% - 99.96%Color and Shape:SolidMolecular weight:469.58JMJD7-IN-1
CAS:JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM.Formula:C16H8Cl2N2O4Purity:99.66%Color and Shape:SolidMolecular weight:363.15PF-9366
CAS:PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).Formula:C20H19ClN4Purity:97.28% - 99.88%Color and Shape:SolidMolecular weight:350.84Ref: TM-T5191
1mg46.00€5mg96.00€10mg130.00€25mg227.00€50mg321.00€100mg442.00€200mg642.00€1mL*10mM (DMSO)92.00€AG-270
CAS:AG-270 is an allosteric and orally active inhibitor of MAT2A.Formula:C30H27N5O2Purity:98.28% - 98.87%Color and Shape:SolidMolecular weight:489.57Ref: TM-T9050
1mg110.00€2mgTo inquire5mg256.00€10mg378.00€25mg628.00€50mg882.00€100mg1,225.00€200mg1,673.00€C-82
CAS:C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.Formula:C33H34N6O4Purity:98.86% - 99.66%Color and Shape:SolidMolecular weight:578.66Itacitinib
CAS:Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.Formula:C26H23F4N9OPurity:96.4% - 99.5%Color and Shape:SolidMolecular weight:553.51A-966492
CAS:A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.Formula:C18H17FN4OPurity:98.53% - 99.27%Color and Shape:SolidMolecular weight:324.35Ref: TM-T6366
2mg34.00€5mg52.00€10mg94.00€25mg163.00€50mg261.00€100mg374.00€200mg530.00€1mL*10mM (DMSO)52.00€GSK503
CAS:GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.Formula:C31H38N6O2Purity:98% - 99.89%Color and Shape:SolidMolecular weight:526.67PFI-4
CAS:PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.Formula:C21H24N4O3Purity:99.53% - ≥95%Color and Shape:SolidMolecular weight:380.44NI-57
CAS:NI-57 inhibits BRPF family proteins: BRPF1 (IC50=3.1nM), BRPF2 (IC50=46nM), BRPF3 (IC50=140nM).Formula:C19H17N3O4SPurity:99.88% - >99.99%Color and Shape:SolidMolecular weight:383.42Menin-MLL inhibitor MI-2
CAS:Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.Formula:C18H25N5S2Purity:97.46%Color and Shape:SolidMolecular weight:375.55Ref: TM-T2649
2mg39.00€5mg58.00€10mg84.00€25mg160.00€50mg230.00€100mg356.00€200mg522.00€1mL*10mM (DMSO)64.00€Molibresib besylate
CAS:Molibresib besylate (GSK 525762C) is a BET protein family inhibitor used in the study of refractory hematologic malignant diseases.Formula:C28H28ClN5O5SPurity:99.64% - 99.64%Color and Shape:SolidMolecular weight:582.07Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Formula:C16H12O5Purity:98.72% - 99.55%Color and Shape:SolidMolecular weight:284.26Ref: TM-T6S1315
1mg37.00€5mg71.00€10mg90.00€25mg147.00€50mg208.00€100mg309.00€200mg447.00€1mL*10mM (DMSO)84.00€Tofacitinib
CAS:Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of rheumatoid arthritis. Cost effective and quality assured.Formula:C16H20N6OPurity:99% - >99.99%Color and Shape:SolidMolecular weight:312.37BRD9539
CAS:BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μMFormula:C24H21N3O3Purity:98% - 99.57%Color and Shape:SolidMolecular weight:399.44Seclidemstat
CAS:Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.Formula:C20H23ClN4O4SPurity:98.28% - 99.76%Color and Shape:SolidMolecular weight:450.94Ref: TM-T4527
5mg46.00€10mg69.00€25mg114.00€50mg177.00€100mg335.00€200mg500.00€500mg807.00€1mL*10mM (DMSO)50.00€Veliparib dihydrochloride
CAS:Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.Formula:C13H18Cl2N4OPurity:98% - 99.81%Color and Shape:SolidMolecular weight:317.21Remodelin
CAS:Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.Formula:C15H14N4SPurity:99.39% - 99.83%Color and Shape:SolidMolecular weight:282.363Ref: TM-T3499
2mg37.00€5mg52.00€10mg73.00€25mg123.00€50mg175.00€100mg236.00€200mg353.00€1mL*10mM (DMSO)56.00€PT-2385
CAS:PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).Formula:C17H12F3NO4SPurity:98.91% - 99.55%Color and Shape:SolidMolecular weight:383.34Ref: TM-T7848
1mg63.00€2mg93.00€5mg144.00€10mg222.00€25mg379.00€50mg532.00€100mg740.00€200mg982.00€1mL*10mM (DMSO)119.00€Venadaparib
CAS:Venadaparib, a PARP inhibitor (IC50: 1.4/1.0 nM for PARP1/2), is orally active, selective, not affecting PARP-5, used in tumor studies.Formula:C23H23FN4O2Purity:99.86%Color and Shape:SolidMolecular weight:406.45Ref: TM-T9430
1mg46.00€2mg59.00€5mg90.00€10mg137.00€25mg268.00€50mg439.00€100mg645.00€1mL*10mM (DMSO)90.00€RN-1 dihydrochloride
CAS:RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).Formula:C23H31Cl2N3O2Purity:99.64%Color and Shape:SolidMolecular weight:452.42Ruxolitinib
CAS:Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.Formula:C17H18N6Purity:99.4% - >99.99%Color and Shape:SolidMolecular weight:306.36Ref: TM-T1829
5mg55.00€10mg71.00€25mg96.00€50mg110.00€100mg146.00€200mg231.00€500mg393.00€1mL*10mM (DMSO)62.00€GSK2801
CAS:GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.Formula:C20H21NO4SPurity:97.78% - 99.45%Color and Shape:SolidMolecular weight:371.455-Methyl-2'-deoxycytidine
CAS:5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.Formula:C10H15N3O4Purity:99.18% - 99.69%Color and Shape:SolidMolecular weight:241.242-methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one
CAS:2-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one is ligand of CBP.Formula:C10H11NOSPurity:99.68%Color and Shape:SolidMolecular weight:193.275-Fluoro-2'-deoxycytidine
CAS:5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .Formula:C9H12FN3O4Purity:97.91%Color and Shape:Fine White PowderMolecular weight:245.21Ref: TM-T7718
2mg34.00€5mg48.00€10mg64.00€25mg90.00€50mg138.00€100mg200.00€200mg296.00€500mg497.00€1mL*10mM (DMSO)50.00€A-366
CAS:A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.Formula:C19H27N3O2Purity:97.28% - 99.8%Color and Shape:SolidMolecular weight:329.44Ref: TM-T3624
1mg35.00€2mg50.00€5mg74.00€10mg90.00€25mg208.00€50mg359.00€100mg530.00€1mL*10mM (DMSO)82.00€UNC3866 TFA(1872382-47-2 free base)
CAS:UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Formula:C45H67F3N6O10Purity:98.43%Color and Shape:SolidMolecular weight:909.046-Thioguanine
CAS:6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.Formula:C5H5N5SPurity:98.75% - >99.99%Color and Shape:Odorless Or Almost Odorless Pale Yellow Crystalline PowderMolecular weight:167.19IOX4
CAS:IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Formula:C15H16N6O3Purity:99.97%Color and Shape:SolidMolecular weight:328.33NEO2734
CAS:NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).Formula:C22H24F3N3O3Purity:98.72% - 98.8%Color and Shape:SolidMolecular weight:435.44Ref: TM-T8658
1mg108.00€5mg260.00€10mg430.00€25mg710.00€50mg973.00€100mg1,333.00€500mg2,673.00€1mL*10mM (DMSO)286.00€Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Formula:C30H52O3Purity:98% - 99.9%Color and Shape:SolidMolecular weight:460.73XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54Ref: TM-T17267
1mg52.00€2mg73.00€5mg94.00€10mg141.00€25mg244.00€50mg371.00€100mg552.00€1mL*10mM (DMSO)104.00€Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formula:C23H28N8OSPurity:99.99%Color and Shape:SolidMolecular weight:464.59
