DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(72 products)
- DNA Alkylation(13 products)
- DNA Methyltransferase(455 products)
- DNA gyrase(11 products)
- DNA-PK(48 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,421 products)
- Reverse Transcriptase(42 products)
- Sirtuin(88 products)
- Telomerase(33 products)
- Topoisomerase(140 products)
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Found 1032 products of "DNA Damage/DNA Repair"
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DNMT2-IN-2
DNMT2-IN-2 is a selective inhibitor of DNA methyltransferase 2 (DNMT2) with a KD value of 3.04 μM. It targets a concealed allosteric binding site of DNMT2 and reduces m5C levels in tRNA of MOLM-13 cells. This compound works synergistically with Doxorubicin to impair cell viability and is applicable in cancer research, including studies of cervical cancer and leukemia.Color and Shape:Odour SolidTAS-103
CAS:TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.Formula:C20H19N3O2Color and Shape:SolidMolecular weight:333.38Tet1 peptide
CAS:Tet1peptide is a neuron-specific ligand for GT1B ganglioside. It can serve as a ligand for the targeted delivery of functionalized polymers.Formula:C73H114N20O17Color and Shape:SolidMolecular weight:1543.81WAY-620472
CAS:WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.Formula:C23H21N5OSPurity:98.99%Color and Shape:SolidMolecular weight:415.51Mca-VDQVDGW-Lys(Dnp)-NH2
Mca-VDQVDGW-Lys(Dnp)-NH2, a fluorogenic substrate specific to caspase-7, facilitates the quantification of caspase-7 activity.Formula:C60H74N14O21Color and Shape:SolidMolecular weight:1327.31Macrocalin B
CAS:Macrocalin B is a diterpenoid against tumor cell proliferation and telomerase activity.Formula:C20H26O6Color and Shape:SolidMolecular weight:362.42Abd110
CAS:Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].Formula:C41H42N8O7SColor and Shape:SolidMolecular weight:790.89Pericosine A
CAS:<p>Pericosine A, a fungal metabolite from P. byssoides, shows anticancer effects (GI50s = 0.05-24.55 μM) and EGFR inhibition (40-70% at 100 μg/ml).</p>Formula:C8H11ClO5Color and Shape:SolidMolecular weight:222.62PPARγ agonist 16
CAS:PPARγ agonist16 (Compound 4G) is a PPARγ agonist that competitively binds to the ligand-binding domain (LBD) of PPARγ with an IC50 of 1790 nM. It reduces ear swelling in mouse models and exhibits antihyperglycemic activity in mice with Streptozotocin-induced diabetes.Formula:C19H14BrNO4SColor and Shape:SolidMolecular weight:432.29AsCas12a Nuclease
AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.Topoisomerase IIα-IN-9
CAS:Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C14H14O4SColor and Shape:SolidMolecular weight:278.32SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColor and Shape:SolidMolecular weight:492.5MCC-555
CAS:MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.Formula:C21H16FNO3SPurity:99.07% - 99.82%Color and Shape:SolidMolecular weight:381.42Ref: TM-T21764
5mg70.00€10mg111.00€25mg226.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)77.00€Way 120744
CAS:Way 120744 is a new naphthyl 3h -1,2,3,5-oxadiazole 2-oxide.Formula:C12H9ClN2O2SColor and Shape:SolidMolecular weight:280.73Topo I/II-IN-1
<p>Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.</p>Formula:C15H13N3S2Color and Shape:SolidMolecular weight:299.414HDAC-IN-76
HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.Formula:C27H26N4O4Color and Shape:SolidMolecular weight:470.5220-carboxy Arachidonic Acid
CAS:20-COOH-AA, 20-HETE metabolite, inhibits kidney ion transport, relaxes constricted vessels, and activates PPARα/γ.Formula:C20H30O4Color and Shape:SolidMolecular weight:334.456HDAC6-IN-50
<p>HDAC6-IN-50 (Compound 4) is an effective inhibitor of HDAC6 with an IC50 value of 35 nM. It is utilized in the study of Parkinson's disease (PD) and Alzheimer's disease (AD).</p>Color and Shape:Odour SolidElafibranor sulfoxide
Elafibranor (GFT505) sulfoxide is a sulfoxide metabolite of Elafibranor, which acts as an agonist for PPARα/δ with EC50 values of 45 nM and 175 nM, respectively. Elafibranor is utilized in research related to primary biliary cholangitis.Color and Shape:Odour SolidISX-3
CAS:ISX-3 boosts bone growth, reduces fat formation, affects PPARγ, and is studied for osteopenia and osteoporosis.Formula:C16H15ClN4O2Purity:99.47%Color and Shape:SolidMolecular weight:330.77Ref: TM-T67855
5mg50.00€10mg80.00€25mg140.00€50mg221.00€100mg329.00€200mg472.00€1mL*10mM (DMSO)64.00€Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formula:C27H49NO5SPurity:>99.99% - >99.99%Color and Shape:SoildMolecular weight:499.75DNA gyrase/Topo IV-IN-1
DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV with antibacterial properties. It exhibits IC50 values of 11 and 17 nM against the DNA gyrase of Escherichia coli and methicillin-resistant Staphylococcus aureus, respectively, and IC50 values of 83 and 21 nM against topoisomerase IV of the same organisms. DNA gyrase/Topo IV-IN-1 is applicable in anti-infective research.Formula:C44H59NO8Color and Shape:SolidMolecular weight:729.941PPARγ agonist 15
PPARγ agonist15 (Compound 7c) functions as an agonist of PPARγ, inhibiting the expression of α-amylase (HPA) and α-glucosidase (HLAG) with IC50 values of 28.35 µM and 26.21 µM, respectively. It enhances glucose uptake in L6 myotubes and improves glucose homeostasis, insulin sensitivity, and lipid metabolism in a rat model of Streptozotocin-induced diabetes.Formula:C21H16N4O3S2Color and Shape:SolidMolecular weight:436.51AuL1
<p>AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.</p>Formula:C29H50AuCl2N5Color and Shape:SolidMolecular weight:736.61Elomotecan
CAS:Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II.Cost-effective and quality-assured.Formula:C29H32ClN3O4Color and Shape:SolidMolecular weight:522.04IC 86621
CAS:IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formula:C12H15NO3Purity:99.68%Color and Shape:SolidMolecular weight:221.25Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
CAS:Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM.Formula:C24H23NO5SPurity:99.59%Color and Shape:SoildMolecular weight:437.51Ref: TM-T63898
1mg185.00€5mg426.00€10mg627.00€25mg938.00€50mg1,320.00€100mg1,786.00€1mL*10mM (DMSO)472.00€Carboxyphosphamide
CAS:Carboxyphosphamide, an inactive byproduct, forms from cyclophosphamide via aldophosphamide oxidation.Formula:C7H15Cl2N2O4PColor and Shape:SolidMolecular weight:293.08NHC-diphosphate
CAS:NHC-diphosphate, a phosphorylated β-d-N4-Hydroxycytidine metabolite, is a potent antiviral against VEEV, CHIKV, and HCV.Formula:C9H15N3O12P2Color and Shape:SolidMolecular weight:419.18HDAC6-IN-19
HDAC6-IN-19 (Compound 14g), an HDAC6 inhibitor with an IC50 of 2.68 nM, additionally inhibits HDAC1, HDAC2, and HDAC3, with IC50 values of 61.6 nM, 98.7 nM, andFormula:C26H23ClN4O3Purity:98%Color and Shape:SolidMolecular weight:474.94GK718
GK718, a selective HDAC1/3 inhibitor with IC50 values of 259 nM and 139 nM, respectively, elevates acetylated histone H3 levels in cells and mitigates BleomycinPurity:98%Color and Shape:Odour SolidAuM1Gly
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the lowPurity:98%Color and Shape:Odour SolidHDAC-IN-78
HDAC-IN-78 (compound 66a) is an HDAC inhibitor utilized for cancer research.Color and Shape:Odour Solid(iso)-BRD20322
CAS:(iso)-BRD20322 is an isomer of BRD20322, a novel potent inhibitor of spCas9，disrupts the binding of spCas9 to DNA and reduces non-specific DNA editing events.Formula:C27H31N3O2Purity:99.60% - 99.60%Color and Shape:SoildMolecular weight:429.55Ref: TM-T69645L
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€200mg2,555.00€HDAC-IN-64
HDAC-IN-64 (Compound 13), an HDAC inhibitor, demonstrates potent inhibition of HDAC4/5/6/7/9 with IC50 values of 24, 45, 85, 31, and 37 nM, respectively.Formula:C15H8ClF4N7OPurity:98%Color and Shape:SolidMolecular weight:413.72Colibactin 742
CAS:Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leadsFormula:C37H42N8O5S2Color and Shape:SolidMolecular weight:742.91Carboxy-pyridostatin 2HCl
Carboxy-pyridostatin 2HCl has potential antitumor activity with high affinity for DNA at DNA G4s.Formula:C35H36Cl2N10O7Purity:97.12% - 99.98%Color and Shape:SoildMolecular weight:779.63MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Color and Shape:Odour SolidNH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC)Formula:C26H24ClN3O6Purity:98%Color and Shape:SolidMolecular weight:509.94nTZDpa
CAS:nTZDpa is an antibiotic with antimicrobial activity.Formula:C22H15Cl2NO2SColor and Shape:SolidMolecular weight:428.33Berzosertib
CAS:Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.Formula:C24H25N5O3SPurity:97.34% - >99.99%Color and Shape:SolidMolecular weight:463.55Ref: TM-T2669
1mg35.00€5mg74.00€10mg92.00€25mg155.00€50mg225.00€100mg359.00€200mg525.00€500mg833.00€1mL*10mM (DMSO)77.00€SIRT1 activator 1
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.Purity:98%Color and Shape:Odour SolidTertomotide hydrochloride
CAS:<p>Tertomotide (GV1001) hydrochloride is a peptide vaccine composed of a 16-amino acid sequence from human telomerase reverse transcriptase (hTERT). It exhibits neuroprotective properties and has potential for research in Alzheimer's disease.</p>Formula:C85H147ClN26O21Color and Shape:SolidMolecular weight:1904.69Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).Formula:C53H83FN6O15Color and Shape:SolidMolecular weight:1063.26METTL16-IN-1
METTL16-IN-1 is a potent inhibitor of METTL16, with an IC50 value of 1.7 μM and a Kd value of 1.35 μM. It effectively suppresses the binding of U6 snRNA deletion to the METTL16 MTD, with an IC50 value of 2.5 μM. METTL16-IN-1 also exhibits antitumor activity.Formula:C19H12BrN3O6S2Molecular weight:520.93509HDAC6-IN-18
HDAC6-IN-18 (Compound 4), an irreversible and selective HDAC6 isoform inhibitor, exhibits potent anti-multiple myeloma effects.Formula:C16H13N3O7SPurity:98%Color and Shape:SolidMolecular weight:391.36Topoisomerase I/II inhibitor 5
TopoisomeraseI/II inhibitor 5 (compound 1) stabilizes G4 structures through binding and concurrently inhibits the relaxation activities of TopoI and II.Color and Shape:Odour SolidHDAC6-IN-25
HDAC6-IN-25 (compound 8) is a potent and selective HDAC6 inhibitor, exhibiting an IC50 value of 0.6 nM [1].Purity:98%Color and Shape:Odour SolidDTS-108
CAS:DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.Formula:C145H233N43O33S2Color and Shape:SolidMolecular weight:3170.8Martinostat
CAS:Martinostat is an HDAC inhibitor that can be radiolabeled for quantitative imaging of HDACs within the central nervous system and major peripheral organs.Formula:C22H30N2O2Color and Shape:SolidMolecular weight:354.491-Methyladenosine-d3
1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium-labeled 1-Methyladenosine. This compound is a modification of RNA that serves as a biomarker for tumors, with elevated levels in the body linked to cancer development. Upon methylation, 1-Methyladenosine upregulates the expression of PPARδ, regulates cholesterol metabolism, and activates the Hedgehog signaling pathway, thereby driving the onset of liver tumors.Color and Shape:Odour SolidFKB04
<p>FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanisms in hepatocellular carcinoma cells. This leads to T-loop defects, inducing telomere shortening and cellular senescence. Additionally, FKB04 inhibits tumor growth in a human liver cancer xenograft mouse model (by implanting Huh-7 cells in BALB/c mice). This compound is utilized in research focused on liver cancer.</p>Color and Shape:Odour SolidNU-PRO-1
NU-PRO-1 is a covalent telomerase reverse transcriptase (TERT) PROTAC degrader. While NU-PRO-1 on its own does not cause DNA damage, it significantly delays DNA repair following radiation exposure.Color and Shape:Odour SolidSMPB Crosslinker
CAS:SMPB crosslinker reacts with sulfhydryl/amino groups, has a longer chain than MBS, and a non-cleavable spacer arm.Formula:C18H16N2O6Purity:98%Color and Shape:SolidMolecular weight:356.33Banoxantrone (D12)
CAS:Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.Formula:C22H28N4O6Purity:98%Color and Shape:SolidMolecular weight:456.55PR-104 sodium
CAS:PR-104 sodium: hypoxia-activated, tumor-targeting pre-prodrug; turns into PR-104A for research.Formula:C14H19BrN4NaO12PSColor and Shape:SolidMolecular weight:601.25Tibesaikosaponin V
CAS:TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.Formula:C42H68O15Color and Shape:SolidMolecular weight:812.98Elinafide
CAS:Elinafide, a dinaphthylimide cytotoxic agent, is a DNA-targeted anticancer agent that has shown antitumor activity in in vitro and in vivo assays.Formula:C31H28N4O4Purity:97.67%Color and Shape:SolidMolecular weight:520.58CC618
CAS:CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.Formula:C20H15F6N3O3S2Purity:99.94%Color and Shape:SolidMolecular weight:523.47Ref: TM-T9767
1mg115.00€5mg249.00€10mg369.00€25mg562.00€50mg787.00€100mg1,054.00€200mg1,406.00€1mL*10mM (DMSO)314.00€Antitumor agent-63
CAS:Compound 40, a non-toxic 20(S)-O-CPT glycoconjugate, is stable, with low Topo I inhibition.Formula:C38H46N4O18Color and Shape:SolidMolecular weight:846.79DMT-dG(ib) Phosphoramidite
CAS:<p>DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.</p>Formula:C44H54N7O8PPurity:99.21%Color and Shape:SolidMolecular weight:839.92Hippeastrine
CAS:<p>Hippeastrine is an alkaloid that inhibits Top I dose-dependently with a 7.25 μg/mL IC50 and has anticancer properties.</p>Formula:C17H17NO5Color and Shape:SolidMolecular weight:315.32Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formula:C21H21N3O2Color and Shape:SolidMolecular weight:347.41SJ-106C
SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.Color and Shape:Odour SolidNanaomycin A
CAS:Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).Formula:C16H14O6Purity:98%Color and Shape:SolidMolecular weight:302.28Silatecan
CAS:Silatecan is a useful organic compound for research related to life sciences. The catalog number is T67968 and the CAS number is 220913-32-6.Formula:C26H30N2O5SiColor and Shape:SoildMolecular weight:478.61Melphalan
CAS:Melphalan is an orally bioavailable DNA alkylating agent exhibiting antitumour activity, commonly employed in cancer chemotherapy.Formula:C13H18Cl2N2O2Molecular weight:305.21CP 84364
CAS:CP 84364 is a metabolite of CP-80794.Formula:C14H18N2O4Color and Shape:SolidMolecular weight:278.30SP4e
SP4e is a PPAR-γ activator.SP4e was effective in decreasing blood glucose, total cholesterol, triglycerides and LDL levels and increasing HDL levels.Formula:C22H17ClN2O2S2Purity:99.79%Color and Shape:SoildMolecular weight:440.97(±)9-HEPE
CAS:<p>(±)9-HEPE is produced by non-enzymatic oxidation of EPA.</p>Formula:C20H30O3Color and Shape:SolidMolecular weight:318.457Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Formula:C21H22N2O6Color and Shape:SolidMolecular weight:398.409NSC 370284
CAS:NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formula:C21H25NO6Purity:99.74%Color and Shape:SolidMolecular weight:387.43Hippeastrine Hydrobromide
CAS:Hippeastrine hydrobromide is a natural alkaloid which demonstrates significant cytotoxicity against a panel of human and murine tumor cell lines.Formula:C17H18BrNO5Color and Shape:SolidMolecular weight:396.237ACT-387042
CAS:ACT-387042 is a Bacterial Topoisomerase Inhibitor, it has broad-spectrum activity against Gram-positive and Gram-negative bacteria.Formula:C23H26FN5O4SColor and Shape:SolidMolecular weight:487.55CAY10599
CAS:<p>CAY10599 has a wide range of applications in life science related research.</p>Formula:C38H41NO5Color and Shape:SolidMolecular weight:591.748NHC-triphosphate tetrasodium
NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.Formula:C9H12N3Na4O15P3Color and Shape:SolidMolecular weight:587.08(R)-VX-984
CAS:(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.Formula:C23H21D2N7OPurity:98%Color and Shape:SolidMolecular weight:415.49PDPH Crosslinker
CAS:PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.Formula:C8H11N3OS2Color and Shape:SolidMolecular weight:229.32Topoisomerase I inhibitor 10
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity.Purity:98%Color and Shape:Odour SolidSibiromycin
CAS:Sibiromycin: natural, potent antitumor PBD that binds DNA's minor groove at guanine NH2.Formula:C24H33N3O7Color and Shape:SolidMolecular weight:475.542N-desmethyl Rosiglitazone
CAS:N-desmethyl Rosiglitazone, a major rosiglitazone metabolite by CYP2C8, treats type 2 diabetes as a selective PPARγ ligand.Formula:C17H17N3O3SColor and Shape:SolidMolecular weight:343.4Amorfrutin B
CAS:Amorfrutin B is a useful organic compound for research related to life sciences. The catalog number is T124211 and the CAS number is 78916-42-4.Formula:C26H32O4Color and Shape:SolidMolecular weight:408.538HDAC1/6-IN-2
HDAC1/6-IN-2 (I-c4), a dual inhibitor of HDAC1 and HDAC6, exhibits potent activity with IC50 values of 3.1 nM for HDAC1 and 2.95 nM for HDAC6. This compound demonstrates notable antitumor activity.Formula:C22H17FN4O3Color and Shape:SolidMolecular weight:404.39CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formula:C26H26N4O4Purity:98%Color and Shape:SolidMolecular weight:458.51Sulotroban
CAS:sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.Formula:C16H17NO5SPurity:98.86% - 99.98%Color and Shape:SolidMolecular weight:335.37GJ071 oxalate
CAS:GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.Formula:C20H29N3O7SPurity:99.97%Color and Shape:SolidMolecular weight:455.53Ref: TM-T31932
1mg77.00€5mg158.00€10mg225.00€25mg338.00€50mg475.00€100mg638.00€200mg845.00€1mL*10mM (DMSO)170.00€ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value ofFormula:C26H34N6O2Purity:98%Color and Shape:SolidMolecular weight:462.5925-Hydroxytachysterol3
CAS:25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.Formula:C27H44O2Color and Shape:SolidMolecular weight:400.64N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
CAS:<p>N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide: binds CB1 (Ki=365 nM), activates PPARα (EC50=698 nM), reduces rat food intake, no FAAH inhibition.</p>Formula:C27H45NO3Color and Shape:SolidMolecular weight:431.661CUDA disodium
CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.Color and Shape:Odour SolidAntitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targetsFormula:C70H82N8O18SPurity:98%Color and Shape:SolidMolecular weight:1355.5117-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.Formula:C22H30O3Color and Shape:SolidMolecular weight:342.479Saroglitazar Magnesium
CAS:<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Formula:C50H56MgN2O8S2Purity:98.1%Color and Shape:SolidMolecular weight:901.43(±)4(5)-DiHDPA lactone
CAS:(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5Formula:C22H32O3Color and Shape:SolidMolecular weight:344.495HDAC6-IN-24
HDAC6-IN-24 (compound N1) is an inhibitor of histone deacetylase 6 (HDAC6) [1].Purity:98%Color and Shape:Odour SolidMulti-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Color and Shape:Odour SolidLeriglitazone
CAS:Leriglitazone, pioglitazone's metabolite, is a PPARγ agonist (Ki:1.2μM, EC50:680nM), enhancing transcription and stabilizing AF-2.Formula:C19H20N2O4SPurity:98%Color and Shape:SolidMolecular weight:372.44Telomerase-IN-3
CAS:Telomerase-IN-3 is an inhibitor of telomerase.Formula:C19H16ClN5O3Purity:98%Color and Shape:SolidMolecular weight:397.825'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
CAS:5'-O-DMT-dU, a dUTPase inhibitor (Ki > 1 mM) for E. coli, is used in DNA synthesis.Formula:C30H30N2O7Color and Shape:SolidMolecular weight:530.57Gatifloxacin sesquihydrate
CAS:Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia.Formula:C19H24FN3O5Color and Shape:SolidMolecular weight:393.41
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