DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(71 products)
- DNA Alkylation(11 products)
- DNA Methyltransferase(422 products)
- DNA gyrase(11 products)
- DNA-PK(51 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,388 products)
- Reverse Transcriptase(43 products)
- Sirtuin(88 products)
- Telomerase(33 products)
- Topoisomerase(136 products)
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Found 958 products of "DNA Damage/DNA Repair"
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15-LOX-IN-2
<p>15-LOX-IN-2 (Compound 2a) is an orally active inhibitor of COX-2/15-LOX and a partial agonist of PPARγ. It exhibits anti-inflammatory activity by inhibiting levels of 20-HETE, IL-1β, and TNF-α in LPS-treated RAW 264.7 cells. Additionally, it significantly enhances glucose uptake without the presence of insulin and is applicable in metabolic disease research.</p>Color and Shape:Odour SolidBanoxantrone-d12 dihydrochloride
CAS:<p>Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.</p>Formula:C22H30Cl2N4O6Purity:98%Color and Shape:SolidMolecular weight:529.48N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
CAS:<p>N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide: binds CB1 (Ki=365 nM), activates PPARα (EC50=698 nM), reduces rat food intake, no FAAH inhibition.</p>Formula:C27H45NO3Color and Shape:SolidMolecular weight:431.661HDAC-IN-76
HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.Formula:C27H26N4O4Color and Shape:SolidMolecular weight:470.52SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColor and Shape:SolidMolecular weight:492.5Leriglitazone
CAS:<p>Leriglitazone, pioglitazone's metabolite, is a PPARγ agonist (Ki:1.2μM, EC50:680nM), enhancing transcription and stabilizing AF-2.</p>Formula:C19H20N2O4SPurity:98%Color and Shape:SolidMolecular weight:372.44Larsucosterol Ammonium salt
CAS:<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Formula:C27H49NO5SPurity:>99.99% - >99.99%Color and Shape:SoildMolecular weight:499.75NHC-diphosphate triammonium
<p>NHC-triphosphate triammonium is a phosphorylated metabolite of NHC, incorporated into HCV RNA by viral polymerase.</p>Color and Shape:SolidSTAT3/HDAC-IN-2
<p>STAT3/HDAC-IN-2 (compound 18), a dual inhibitor of STAT3 and HDAC, promotes autophagy and apoptosis. This compound features an amphiphilic hydroxamic acid hybrid structure, derived from the natural product isopropanol lactone (IAL), and functions as a nanoscale anticancer agent. It has the ability to self-assemble into nanoparticles in aqueous environments, leading to enhanced tumor tissue accumulation, increased cellular uptake, and improved anticancer efficacy compared to its free state.</p>Formula:C28H32N2O7Color and Shape:SolidMolecular weight:508.56Amrubicin
CAS:<p>The compound is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II.</p>Formula:C25H25NO9Purity:98%Color and Shape:SolidMolecular weight:483.47CL2-MMT-SN38
CAS:<p>CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.</p>Formula:C102H122N12O24Color and Shape:SolidMolecular weight:1900.158Top1/2-IN-1
<p>Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.</p>Formula:C21H21N3O2Color and Shape:SolidMolecular weight:347.4120-carboxy Arachidonic Acid
CAS:<p>20-COOH-AA, 20-HETE metabolite, inhibits kidney ion transport, relaxes constricted vessels, and activates PPARα/γ.</p>Formula:C20H30O4Color and Shape:SolidMolecular weight:334.45615-deoxy-Δ-12,14-Prostaglandin J2
CAS:<p>15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.</p>Formula:C20H28O3Purity:98%Color and Shape:Neat OilMolecular weight:316.43(±)9-HEPE
CAS:<p>(±)9-HEPE is produced by non-enzymatic oxidation of EPA.</p>Formula:C20H30O3Color and Shape:SolidMolecular weight:318.457SP4e
<p>SP4e is a PPAR-γ activator.SP4e was effective in decreasing blood glucose, total cholesterol, triglycerides and LDL levels and increasing HDL levels.</p>Formula:C22H17ClN2O2S2Purity:99.79%Color and Shape:SoildMolecular weight:440.97NSC 370284
CAS:<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Formula:C21H25NO6Purity:99.74%Color and Shape:SolidMolecular weight:387.43VH 032 amide-PEG1-acid
CAS:<p>VHL ligand for PROTAC R&D; E3 ligase with PEG1 linker and carboxylic acid for target conjugation.</p>Formula:C28H38N4O7SColor and Shape:SolidMolecular weight:574.69Gemfibrozil 1-O-β-glucuronide
CAS:<p>Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil , is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.</p>Formula:C21H30O9Purity:98%Color and Shape:SolidMolecular weight:426.46MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Color and Shape:Odour Solid
