DNA Damage/DNA Repair

<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>

<p>RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).</p>

<p>ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).</p>

<p>Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir.</p>

<p>Neobavaisoflavone: DNA polymerase inhibitor, potential for treating bone loss, anti-inflammatory, reduces ROS, RNS, cytokines in macrophages.</p>

<p>MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.</p>

<p>CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.</p>

<p>Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used in</p>

CHDI-390576 is an HDAC inhibitor that inhibits class IIa HDAC 4, HDAC 5, HDAC 7, and HDAC 9, and can be used in cancer research.

<p>RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits &gt; 200-fold selectivity over other HDAC.</p>

<p>Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PARP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PARP2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse PARP2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PARP2 in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].</p>

<p>PF-3882845 is an MR antagonist that binds to the progesterone receptor (PR) and is used in the study of endocrine disorders and urogenital disorders.</p>

<p>Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.</p>

<p>Cyclophosphamide-d4 is a deuterated compound of Cyclophosphamide. Cyclophosphamide has a CAS number of 50-18-0. Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.</p>

<p>BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).</p>

<p>PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.</p>

<p>ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.</p>

<p>MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.</p>

<p>7-Methyladenine (NSC-7857) can be used as a marker of exposure to exogenous and carcinogenic methylating agents.</p>

<p>ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces</p>

<p>A-20832 blocks strand cleavage in resolvase-driven recombination; doesn't prevent resolvase-res binding or synapse formation, only binds at res site I.</p>

<p>GSK-7227 is a novel PPARδ partial agonist that upregulates target genes in muscle cells, indicating its potential role in modulating muscle metabolism and energy.</p>

<p>LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.</p>

<p>A-1062, a resolvase-binding inhibitor, inhibits resolvase binding to the res site.</p>

<p>L-764406 is a partial agonist of human PPAR gamma.</p>

<p>A 9387 is an inhibitor of resolvase protein.</p>

<p>SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.</p>

<p>Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.</p>

<p>BVT.13 is used as a selective PPAR-gamma activator.</p>

<p>promotes the reprogramming of human somatic cells to pluripotent stem cells</p>

<p>Aldoxorubicin, an albumin-binding prodrug of Doxorubicin, exhibits potent antitumor effects in cancer lines and mouse models.</p>

<p>Cas9-IN-3 is a potent inhibitor of Cas9 with IC50 of 28 μM. CRISPR/Cas systems have revolutionized gene editing in several species [1].</p>

<p>Exifone (NSC-680919) is a mixed, nonessential activator of HDAC1 that is capable of binding to both free and substrate-bound enzyme, resulting in an increased</p>

<p>BRD0539 is a cell-permeable spCas9 inhibitor that blocks the binding of spCas9 to DNA and inhibits Streptococcus pyogenes Cas9 (SpCas9).</p>

<p>Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.</p>

<p>Naveglitazar racemate is the racemate of Naveglitazar.</p>

<p>Chlornaphazine is an antineoplastic and has been identified as a human carcinogen.</p>

<p>Arazine, a cell-permeable G protein modulator, is an isoprenylcysteine methyltransferase substrate.</p>

<p>NU/ICRF 500 is a novel anthracenyl-amino acid catalytic inhibitor of topoisomerase II.</p>

<p>S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.</p>

<p>GW0072 is a partial agonist of PPARγ.</p>

<p>PPARγ agonist 3, also known as Compound 18a, is a potent and selective agonist of PPARγ.</p>

XR-11576 is a DNA topoisomerase I and II inhibitor for the treatment of solid tumors.

<p>NC182 is a topo II inhibitor that shows selective and potent topo II inhibition on the induction of topo II-dependent DNA fragmentation.</p>

<p>GW2433 is an agonist of PPAR receptor.</p>

<p>Leurubicin is used as a prodrug of doxorubicin.</p>

<p>ICRF-193 is a DNA topoisomerase II inhibitor.</p>

<p>2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].</p>