
DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(71 products)
- DNA Alkylation(11 products)
- DNA Methyltransferase(421 products)
- DNA gyrase(11 products)
- DNA-PK(51 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,388 products)
- Reverse Transcriptase(43 products)
- Sirtuin(88 products)
- Telomerase(33 products)
- Topoisomerase(136 products)
Show 3 more subcategories
Found 958 products of "DNA Damage/DNA Repair"
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Epigenetic factor-IN-1
CAS:<p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>Formula:C32H34FN5O6S2Purity:98%Color and Shape:SolidMolecular weight:667.77PR-104A
CAS:<p>PR-104A is a hypoxia-targeted anticancer agent.</p>Formula:C14H19BrN4O9SColor and Shape:SolidMolecular weight:499.29ATM-IN-1
CAS:<p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>Formula:C30H36N6O3Color and Shape:SolidMolecular weight:528.65Pradofloxacin
CAS:<p>Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.</p>Formula:C21H21FN4O3Purity:98.76%Color and Shape:SolidMolecular weight:396.41DNMT-IN-3
CAS:<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Formula:C37H39N7OColor and Shape:SolidMolecular weight:597.75MPI_5a
CAS:<p>MPI_5a selectively inhibits HDAC6 (IC50=36 nM), slightly affects other HDACs, and blocks acyl-tubulin build-up (IC50=210 nM).</p>Formula:C16H17N3O3Purity:99.62%Color and Shape:SolidMolecular weight:299.32DNA-PK-IN-10
CAS:<p>DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].</p>Formula:C25H28N6O2Purity:98%Color and Shape:SolidMolecular weight:444.539-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:<p>9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential</p>Formula:C22H18ClFN2O4Purity:98%Color and Shape:SolidMolecular weight:428.84SRT3657
CAS:<p>SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.</p>Formula:C40H54N8O6SPurity:98%Color and Shape:SolidMolecular weight:774.97NH2-methylpropanamide-Exatecan TFA
CAS:<p>Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.</p>Formula:C30H30F4N4O7Purity:98%Color and Shape:SolidMolecular weight:634.58DY-46-2
CAS:<p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>Formula:C19H22N6O5SPurity:99.12% - 99.12%Color and Shape:SolidMolecular weight:446.48HDAC/BET-IN-1
CAS:<p>HDAC/BET-IN-1 inhibits HDAC1 (IC50: 0.163 μM), HDAC6 (IC50: 0.067 μM), BRD4 (Ki: 0.076 μM), and fights leukemia.</p>Formula:C29H40N4O8SPurity:98%Color and Shape:SolidMolecular weight:604.71Trovafloxacin mesylate
CAS:<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Formula:C21H19F3N4O6SPurity:99.18%Color and Shape:SolidMolecular weight:512.46NT160
CAS:<p>NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases.</p>Formula:C21H21F3N4O2Purity:99.3%Color and Shape:SolidMolecular weight:418.41Antipsychotic agent 54
CAS:<p>Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM).</p>Formula:C21H23FN2O4Purity:98.10%Color and Shape:SolidMolecular weight:386.42HDAC6-IN-8
CAS:<p>Compound 12C, with altered cap groups, shows wide-range enzyme inhibition; 9m and 9q target HDAC6 specifically.</p>Formula:C23H17BrFN5O3Purity:98%Color and Shape:SolidMolecular weight:510.32Bocodepsin
CAS:<p>Bocodepsin (OKI-179) is a selective, orally active inhibitor of histone deacetylases (HDAC) with demonstrated antitumor efficacy.</p>Formula:C26H39N5O6S2Purity:98%Color and Shape:SolidMolecular weight:581.75ATR-IN-29
CAS:<p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>Formula:C19H22N8OPurity:98%Color and Shape:SolidMolecular weight:378.43Zabofloxacin
CAS:<p>Zabofloxacin inhibits bacterial topoisomerases II/IV, effectively targeting gram-positive pathogens like S. aureus and S. pneumoniae.</p>Formula:C19H20FN5O4Purity:98%Color and Shape:SolidMolecular weight:401.3910-Nitrolinoleic acid
CAS:<p>10-Nitrolinoleate, a nitration product of linoleate, modulates PPARγ, enhancing glucose uptake, and aids in muscle relaxation via NO/cGMP pathway.</p>Formula:C18H31NO4Color and Shape:SolidMolecular weight:325.44WAY-354574
CAS:<p>WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].</p>Formula:C20H23ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:406.93PARP7-IN-16
CAS:<p>PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.</p>Formula:C25H26FN4NaO4Purity:98%Color and Shape:SolidMolecular weight:488.49SDOX
CAS:<p>SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.</p>Formula:C69H97NO20S2Purity:98%Color and Shape:SolidMolecular weight:1324.63Furegrelate sodium
CAS:<p>Furegrelate sodium (U-63557A) is an orally active thromboxane synthase inhibitor with an IC50 of 15 nM in platelets.</p>Formula:C15H10NNaO3Purity:99.92%Color and Shape:SolidMolecular weight:275.23Lexitropsin 1
CAS:<p>Lexitropsin 1 is a new anticancer drug.</p>Formula:C15H19N7O3SPurity:98%Color and Shape:SolidMolecular weight:377.427-Deaza-2′-deoxyguanosine 5′-triphosphate
CAS:<p>7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].</p>Formula:C11H17N4O13P3Purity:98%Color and Shape:SolidMolecular weight:506.19(S)-Ceralasertib
CAS:<p>(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.</p>Formula:C20H24N6O2SColor and Shape:SolidMolecular weight:412.51ATR-IN-18
CAS:<p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>Formula:C19H22F3N7O5SColor and Shape:SolidMolecular weight:517.48Prostaglandin B3
CAS:<p>Prostaglandin B3 (PGB3) is a secondary alcohol belonging to the prostaglandin B class, characterized by its relatively low affinity for human PPARγ, exhibiting a K_i value greater than 1 mM, in contrast to PGB1 and PGB2, which have K_i values of 26.28 ± 8.7 μM and 77 ± 37.7 μM, respectively [1].</p>Formula:C20H28O4Color and Shape:SolidMolecular weight:332.43Ambamustine
CAS:<p>Ambamustine (PTT 119): a tripeptide nitrogen mustard, DNA inhibitor/alkylator with antitumor properties, researched for various disorders.</p>Formula:C29H39Cl2FN4O4SPurity:98%Color and Shape:SolidMolecular weight:629.61ATR-IN-8
CAS:<p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>Formula:C20H22N6O2SColor and Shape:SolidMolecular weight:410.49Oxamflatin
CAS:<p>Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor with an alkyne group capable of azide-alkyne cycloaddition reactions (CuAAc).</p>Formula:C17H14N2O4SPurity:98.25%Color and Shape:SolidMolecular weight:342.37KD-3010
CAS:<p>KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.</p>Formula:C30H33F3N2O8S2Purity:99.61%Color and Shape:SolidMolecular weight:670.72Nesuparib
CAS:<p>Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.</p>Formula:C23H24N6OPurity:99.71%Color and Shape:SolidMolecular weight:400.48KPZ560
CAS:<p>KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively.</p>Formula:C26H21N5O3S2Purity:98%Color and Shape:SolidMolecular weight:515.61AZD4619
CAS:<p>AZD4619 is a potent, selective and reversible orally bioavailable agonist of PPARα receptor.</p>Formula:C25H26O8S2Color and Shape:SolidMolecular weight:518.6BM152054
CAS:<p>BM152054 is a potent PPARγ ligand that induces glucose utilization in peripheral tissues by enhancing insulin action.</p>Formula:C22H18N2O4S3Purity:99.56%Color and Shape:SolidMolecular weight:470.58Sipoglitazar
CAS:<p>Sipoglitazar, a PPARγ agonist, is used potentially for the treatment of diabetes.</p>Formula:C25H25N3O4SPurity:98%Color and Shape:SolidMolecular weight:463.55Sirtuin modulator 1
CAS:<p>Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.</p>Formula:C31H32ClN5O2S2Purity:99.63%Color and Shape:SolidMolecular weight:606.2SIRT-IN-1
CAS:<p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>Formula:C19H27N5O2SPurity:99.29%Color and Shape:SolidMolecular weight:389.52Ac-Exatecan
CAS:<p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>Formula:C26H24FN3O5Purity:97.09%Color and Shape:SolidMolecular weight:477.48ZL-2201
CAS:<p>ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.</p>Formula:C20H25N9O5SPurity:98%Color and Shape:SolidMolecular weight:503.54PARP7-IN-15
CAS:<p>PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].</p>Formula:C23H24F6N6O4Purity:98%Color and Shape:SolidMolecular weight:562.46ATR-IN-6
CAS:<p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>Formula:C28H28FN7O2Color and Shape:SolidMolecular weight:513.57E7016
CAS:<p>E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.</p>Formula:C20H19N3O3Purity:99.02%Color and Shape:SolidMolecular weight:349.38IACS-52825
CAS:<p>IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model and can be used to study neurological disorders.</p>Formula:C16H13F7N4O2Purity:99.77%Color and Shape:SolidMolecular weight:426.29CGS 15435
CAS:<p>CGS 15435: potent TxA2 synthase inhibitor, IC50=1 nM; less selective for PGI2 synthase, COX, and liposynthase.</p>Formula:C20H21ClN2O2Purity:99.86%Color and Shape:SolidMolecular weight:356.85PARP-1-IN-4
CAS:<p>PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.</p>Formula:C22H15Cl2N3O2Purity:99.82%Color and Shape:SolidMolecular weight:424.28Lartesertib
CAS:<p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>Formula:C23H21FN6O3Purity:99.9%Color and Shape:SolidMolecular weight:448.45AZ31
CAS:<p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,</p>Formula:C24H28N4O3Purity:98.01%Color and Shape:SolidMolecular weight:420.5

