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DNA Damage/DNA Repair

DNA Damage/DNA Repair

DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.

Subcategories of "DNA Damage/DNA Repair"

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Found 958 products of "DNA Damage/DNA Repair"

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  • Epigenetic factor-IN-1

    CAS:
    <p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>
    Formula:C32H34FN5O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:667.77
  • PR-104A

    CAS:
    <p>PR-104A is a hypoxia-targeted anticancer agent.</p>
    Formula:C14H19BrN4O9S
    Color and Shape:Solid
    Molecular weight:499.29
  • ATM-IN-1

    CAS:
    <p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>
    Formula:C30H36N6O3
    Color and Shape:Solid
    Molecular weight:528.65
  • Pradofloxacin

    CAS:
    <p>Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.</p>
    Formula:C21H21FN4O3
    Purity:98.76%
    Color and Shape:Solid
    Molecular weight:396.41
  • DNMT-IN-3

    CAS:
    <p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>
    Formula:C37H39N7O
    Color and Shape:Solid
    Molecular weight:597.75
  • MPI_5a

    CAS:
    <p>MPI_5a selectively inhibits HDAC6 (IC50=36 nM), slightly affects other HDACs, and blocks acyl-tubulin build-up (IC50=210 nM).</p>
    Formula:C16H17N3O3
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:299.32
  • DNA-PK-IN-10

    CAS:
    <p>DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].</p>
    Formula:C25H28N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:444.53
  • 9-Chloromethyl-10-hydroxy-11-F-Camptothecin

    CAS:
    <p>9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential</p>
    Formula:C22H18ClFN2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:428.84
  • SRT3657

    CAS:
    <p>SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.</p>
    Formula:C40H54N8O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:774.97
  • NH2-methylpropanamide-Exatecan TFA

    CAS:
    <p>Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.</p>
    Formula:C30H30F4N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:634.58
  • DY-46-2

    CAS:
    <p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>
    Formula:C19H22N6O5S
    Purity:99.12% - 99.12%
    Color and Shape:Solid
    Molecular weight:446.48
  • HDAC/BET-IN-1

    CAS:
    <p>HDAC/BET-IN-1 inhibits HDAC1 (IC50: 0.163 μM), HDAC6 (IC50: 0.067 μM), BRD4 (Ki: 0.076 μM), and fights leukemia.</p>
    Formula:C29H40N4O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:604.71
  • Trovafloxacin mesylate

    CAS:
    <p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>
    Formula:C21H19F3N4O6S
    Purity:99.18%
    Color and Shape:Solid
    Molecular weight:512.46
  • NT160

    CAS:
    <p>NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases.</p>
    Formula:C21H21F3N4O2
    Purity:99.3%
    Color and Shape:Solid
    Molecular weight:418.41
  • Antipsychotic agent 54

    CAS:
    <p>Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM).</p>
    Formula:C21H23FN2O4
    Purity:98.10%
    Color and Shape:Solid
    Molecular weight:386.42
  • HDAC6-IN-8

    CAS:
    <p>Compound 12C, with altered cap groups, shows wide-range enzyme inhibition; 9m and 9q target HDAC6 specifically.</p>
    Formula:C23H17BrFN5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:510.32
  • Bocodepsin

    CAS:
    <p>Bocodepsin (OKI-179) is a selective, orally active inhibitor of histone deacetylases (HDAC) with demonstrated antitumor efficacy.</p>
    Formula:C26H39N5O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:581.75
  • ATR-IN-29

    CAS:
    <p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>
    Formula:C19H22N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:378.43
  • Zabofloxacin

    CAS:
    <p>Zabofloxacin inhibits bacterial topoisomerases II/IV, effectively targeting gram-positive pathogens like S. aureus and S. pneumoniae.</p>
    Formula:C19H20FN5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:401.39
  • 10-Nitrolinoleic acid

    CAS:
    <p>10-Nitrolinoleate, a nitration product of linoleate, modulates PPARγ, enhancing glucose uptake, and aids in muscle relaxation via NO/cGMP pathway.</p>
    Formula:C18H31NO4
    Color and Shape:Solid
    Molecular weight:325.44
  • WAY-354574

    CAS:
    <p>WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].</p>
    Formula:C20H23ClN2O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:406.93
  • PARP7-IN-16

    CAS:
    <p>PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.</p>
    Formula:C25H26FN4NaO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:488.49
  • SDOX

    CAS:
    <p>SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.</p>
    Formula:C69H97NO20S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1324.63
  • Furegrelate sodium

    CAS:
    <p>Furegrelate sodium (U-63557A) is an orally active thromboxane synthase inhibitor with an IC50 of 15 nM in platelets.</p>
    Formula:C15H10NNaO3
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:275.23
  • Lexitropsin 1

    CAS:
    <p>Lexitropsin 1 is a new anticancer drug.</p>
    Formula:C15H19N7O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:377.42
  • 7-Deaza-2′-deoxyguanosine 5′-triphosphate

    CAS:
    <p>7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].</p>
    Formula:C11H17N4O13P3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:506.19
  • (S)-Ceralasertib

    CAS:
    <p>(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.</p>
    Formula:C20H24N6O2S
    Color and Shape:Solid
    Molecular weight:412.51
  • ATR-IN-18

    CAS:
    <p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>
    Formula:C19H22F3N7O5S
    Color and Shape:Solid
    Molecular weight:517.48
  • Prostaglandin B3

    CAS:
    <p>Prostaglandin B3 (PGB3) is a secondary alcohol belonging to the prostaglandin B class, characterized by its relatively low affinity for human PPARγ, exhibiting a K_i value greater than 1 mM, in contrast to PGB1 and PGB2, which have K_i values of 26.28 ± 8.7 μM and 77 ± 37.7 μM, respectively [1].</p>
    Formula:C20H28O4
    Color and Shape:Solid
    Molecular weight:332.43
  • Ambamustine

    CAS:
    <p>Ambamustine (PTT 119): a tripeptide nitrogen mustard, DNA inhibitor/alkylator with antitumor properties, researched for various disorders.</p>
    Formula:C29H39Cl2FN4O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:629.61
  • ATR-IN-8

    CAS:
    <p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>
    Formula:C20H22N6O2S
    Color and Shape:Solid
    Molecular weight:410.49
  • Oxamflatin

    CAS:
    <p>Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor with an alkyne group capable of azide-alkyne cycloaddition reactions (CuAAc).</p>
    Formula:C17H14N2O4S
    Purity:98.25%
    Color and Shape:Solid
    Molecular weight:342.37
  • KD-3010

    CAS:
    <p>KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.</p>
    Formula:C30H33F3N2O8S2
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:670.72
  • Nesuparib

    CAS:
    <p>Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.</p>
    Formula:C23H24N6O
    Purity:99.71%
    Color and Shape:Solid
    Molecular weight:400.48
  • KPZ560

    CAS:
    <p>KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively.</p>
    Formula:C26H21N5O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:515.61
  • AZD4619

    CAS:
    <p>AZD4619 is a potent, selective and reversible orally bioavailable agonist of PPARα receptor.</p>
    Formula:C25H26O8S2
    Color and Shape:Solid
    Molecular weight:518.6
  • BM152054

    CAS:
    <p>BM152054 is a potent PPARγ ligand that induces glucose utilization in peripheral tissues by enhancing insulin action.</p>
    Formula:C22H18N2O4S3
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:470.58
  • Sipoglitazar

    CAS:
    <p>Sipoglitazar, a PPARγ agonist, is used potentially for the treatment of diabetes.</p>
    Formula:C25H25N3O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:463.55
  • Sirtuin modulator 1

    CAS:
    <p>Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of &lt; 1 μM.</p>
    Formula:C31H32ClN5O2S2
    Purity:99.63%
    Color and Shape:Solid
    Molecular weight:606.2
  • SIRT-IN-1

    CAS:
    <p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>
    Formula:C19H27N5O2S
    Purity:99.29%
    Color and Shape:Solid
    Molecular weight:389.52
  • Ac-Exatecan

    CAS:
    <p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>
    Formula:C26H24FN3O5
    Purity:97.09%
    Color and Shape:Solid
    Molecular weight:477.48
  • ZL-2201

    CAS:
    <p>ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.</p>
    Formula:C20H25N9O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:503.54
  • PARP7-IN-15

    CAS:
    <p>PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].</p>
    Formula:C23H24F6N6O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:562.46
  • ATR-IN-6

    CAS:
    <p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>
    Formula:C28H28FN7O2
    Color and Shape:Solid
    Molecular weight:513.57
  • E7016

    CAS:
    <p>E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.</p>
    Formula:C20H19N3O3
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:349.38
  • IACS-52825

    CAS:
    <p>IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model and can be used to study neurological disorders.</p>
    Formula:C16H13F7N4O2
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:426.29
  • CGS 15435

    CAS:
    <p>CGS 15435: potent TxA2 synthase inhibitor, IC50=1 nM; less selective for PGI2 synthase, COX, and liposynthase.</p>
    Formula:C20H21ClN2O2
    Purity:99.86%
    Color and Shape:Solid
    Molecular weight:356.85
  • PARP-1-IN-4

    CAS:
    <p>PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.</p>
    Formula:C22H15Cl2N3O2
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:424.28
  • Lartesertib

    CAS:
    <p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>
    Formula:C23H21FN6O3
    Purity:99.9%
    Color and Shape:Solid
    Molecular weight:448.45
  • AZ31

    CAS:
    <p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of &lt;1.2 nM and 46 nM,</p>
    Formula:C24H28N4O3
    Purity:98.01%
    Color and Shape:Solid
    Molecular weight:420.5