DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(72 products)
- DNA Alkylation(19 products)
- DNA Methyltransferase(460 products)
- DNA gyrase(6 products)
- DNA-PK(49 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,419 products)
- Reverse Transcriptase(42 products)
- Sirtuin(86 products)
- Telomerase(34 products)
- Topoisomerase(127 products)
Show 3 more subcategories
Found 894 products of "DNA Damage/DNA Repair"
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DNA crosslinker 4 dihydrochloride
CAS:DNA Crosslinker 4 binds DNA's minor groove, inhibits NCI-H460, A2780, MCF-7 cancer cells, and is used in cancer research.Formula:C16H24Cl2N8OColor and Shape:SolidMolecular weight:415.32Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H25N3O5Purity:98.47%Color and Shape:SolidMolecular weight:447.48L2H2-6OTD
CAS:L2H2-6OTD is a telomerase inhibitor with G-quadruplex loops; IC50: 15 nM.Formula:C30H30N10O8Color and Shape:SolidMolecular weight:658.62ATM Inhibitor-3
ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.Formula:C25H29FN6O3Color and Shape:SolidMolecular weight:480.53Atiratecan
CAS:Atiratecan (TP300), a CH0793076-based camptothecin prodrug, combats BCRP+/- tumors; doesn't affect AChE.Formula:C31H34N6O6Purity:98%Color and Shape:SolidMolecular weight:586.64DNA crosslinker 1 dihydrochloride
CAS:DNA Crosslinker 1 binds DNA minor groove with 1.1°C affinity increase; used in cancer research.Formula:C15H22Cl2N8OColor and Shape:SolidMolecular weight:401.29ATM Inhibitor-2
ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).Formula:C26H31N7O3Color and Shape:SolidMolecular weight:489.57Amrubicin HCl
CAS:Amrubicin (SM-5887), an anthracycline, treats lung cancer by inhibiting DNA replication and topoisomerase II, with less cardiac toxicity.Formula:C25H25NO9Color and Shape:SolidMolecular weight:483.47WSD0628
CAS:WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Formula:C23H23F2N5O2Color and Shape:SolidMolecular weight:439.46NBTI 5463
CAS:NBTI 5463 is a bacterial type II topoisomerase (topoisomerase II) inhibitor with antimicrobial properties. It effectively inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. By binding to topoisomerase II, NBTI 5463 prevents DNA cleavage and re-ligation, thereby impeding bacterial DNA replication and transcription. This compound shows potential for research into Gram-negative bacterial infections.Formula:C25H30N6O4Color and Shape:SolidMolecular weight:478.54S39625
CAS:S39625 is a stable, potent topoisomerase I inhibitor with anticancer properties, resistant to efflux transporters, inducing gamma-H2AX at nanomolar levels.Formula:C25H22N2O5Purity:98%Color and Shape:SolidMolecular weight:430.45Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Formula:C21H24N4OPurity:98%Color and Shape:SolidMolecular weight:348.44RU-0415529
CAS:RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.Formula:C21H29N3O4SColor and Shape:SolidMolecular weight:419.538Bizelesin
CAS:Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.Formula:C43H36Cl2N8O5Color and Shape:SolidMolecular weight:815.7Camptothecin-20(S)-O-propionate
CAS:CZ-48 is a DNA topoisomerase inhibitor.Formula:C23H20N2O5Color and Shape:SolidMolecular weight:404.42Aleglitazar
CAS:Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.Formula:C24H23NO5SPurity:99.03%Color and Shape:SolidMolecular weight:437.51Ref: TM-T14176
1mg233.00€5mg532.00€10mg718.00€25mg1,099.00€50mg1,485.00€100mg1,998.00€1mL*10mM (DMSO)538.00€VX-984
CAS:VX-984 (M9831) is an oral DNA-PK inhibitor, crossing the blood-brain barrier, targeting GBM and NSC-LC.Formula:C23H21D2N7OPurity:97.65% - 99.98%Color and Shape:SolidMolecular weight:415.49Ref: TM-T11067
1mg117.00€5mg248.00€10mg369.00€25mg575.00€50mg863.00€100mg1,305.00€200mg1,755.00€1mL*10mM (DMSO)271.00€KU-60019
CAS:KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).
Formula:C30H33N3O5SPurity:98.05% - 98.50%Color and Shape:SolidMolecular weight:547.67Simmitecan hydrochloride
CAS:Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.Formula:C34H39ClN4O6Purity:98.20% - 98.93%Color and Shape:SolidMolecular weight:635.15BAY-8400
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy inFormula:C21H17F2N5OPurity:99.53%Color and Shape:SolidMolecular weight:393.39Ref: TM-T9498
1mg80.00€5mg147.00€10mg215.00€25mg439.00€50mg750.00€100mg1,009.00€1mL*10mM (DMSO)161.00€
