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DNA Damage/DNA Repair

DNA Damage/DNA Repair

DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.

Subcategories of "DNA Damage/DNA Repair"

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Found 957 products of "DNA Damage/DNA Repair"

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  • CymitQuimica logo
    Targetmol
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    PPARγ phosphorylation inhibitor 1

    <p>PPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binding agent (IC50: 24 nM) with antidiabetic effects.</p>
    Formula:C22H14Cl2N2O4
    Color and Shape:Solid
    Molecular weight:441.26

    Ref: TM-T62554

  • E-3030 free acid
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    E-3030 free acid

    CAS:
    <p>E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.</p>
    Formula:C22H23ClFNO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:435.87

    Ref: TM-T27228

  • PPARγ modulator-2
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    PPARγ modulator-2

    CAS:
    <p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>
    Formula:C26H21NO7S3Se
    Color and Shape:Solid
    Molecular weight:634.6

    Ref: TM-T205068

  • (1S,2R,7S)-Sitafloxacin
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    (1S,2R,7S)-Sitafloxacin

    CAS:
    <p>(1S,2R,7S)-Sitafloxacin (DU-6856) is an enantiomer of Sitafloxacin and functions as a topoisomerase inhibitor. As an antibiotic, it demonstrates inhibitory activity against Escherichia coli DNA gyrase (IC50 0.18 μg/mL) and Staphylococcus aureus topoisomerase IV. (1S,2R,7S)-Sitafloxacin exhibits antibacterial properties and is utilized in the study of various bacterial infections.</p>
    Formula:C19H18ClF2N3O3
    Color and Shape:Solid
    Molecular weight:409.81

    Ref: TM-T207616

  • (S)-WSD0628
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    (S)-WSD0628

    CAS:
    <p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>
    Formula:C23H23F2N5O2
    Color and Shape:Solid
    Molecular weight:439.458

    Ref: TM-T205268

  • (1R,2S,7R)-Sitafloxacin
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    (1R,2S,7R)-Sitafloxacin

    CAS:
    <p>(R)-Sitafloxacin (DU-6857) is an enantiomer of Sitafloxacin (DU-6859a) and functions as a topoisomerase inhibitor, demonstrating an IC50 of 0.18 μg/mL against DNA gyrase.</p>
    Formula:C19H18ClF2N3O3
    Color and Shape:Solid
    Molecular weight:409.814

    Ref: TM-T206262

  • Amezalpat
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    Amezalpat

    CAS:
    <p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>
    Formula:C34H41N3O4
    Color and Shape:Solid
    Molecular weight:555.707

    Ref: TM-T205015

  • ATR-IN-19
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    ATR-IN-19

    CAS:
    <p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>
    Formula:C18H19N7OS
    Color and Shape:Solid
    Molecular weight:381.45

    Ref: TM-T61636

  • Topotecan acetate
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    Topotecan acetate

    CAS:
    <p>Topotecan acetate is an inhibitor of topoisomerase.</p>
    Formula:C25H27N3O7
    Color and Shape:Solid
    Molecular weight:481.498

    Ref: TM-T204761

  • RU-0415529
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    RU-0415529

    CAS:
    <p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>
    Formula:C21H29N3O4S
    Color and Shape:Solid
    Molecular weight:419.538

    Ref: TM-T204295

  • CymitQuimica logo
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    ATR-IN-12

    <p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>
    Formula:C22H27N5O3S
    Color and Shape:Solid
    Molecular weight:441.55

    Ref: TM-T62563

  • O6BTG-C8-αGlu
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    O6BTG-C8-αGlu

    CAS:
    <p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>
    Formula:C24H34BrN5O7S
    Color and Shape:Solid
    Molecular weight:616.525

    Ref: TM-T205643

  • PPARγ-IN-5
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    PPARγ-IN-5

    CAS:
    <p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>
    Formula:C22H23ClO7
    Color and Shape:Solid
    Molecular weight:434.867

    Ref: TM-T205246

  • PPARα/δ agonist 3
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    PPARα/δ agonist 3

    CAS:
    <p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>
    Formula:C23H25F3N2O4
    Color and Shape:Solid
    Molecular weight:450.451

    Ref: TM-T205373

  • Topoisomerase I inhibitor 8
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    Topoisomerase I inhibitor 8

    CAS:
    <p>Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.</p>
    Formula:C24H21FN2O4
    Color and Shape:Solid
    Molecular weight:420.43

    Ref: TM-T62225

  • CymitQuimica logo
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    ATR-IN-11

    <p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>
    Formula:C25H30N6O2
    Color and Shape:Solid
    Molecular weight:446.54

    Ref: TM-T62651

  • CymitQuimica logo
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    Topoisomerase I/II inhibitor 2

    <p>Compound 1a inhibits Topoisomerase I/II, shrinks mouse liver tumors, IC50: 6.83/9.82 μM for LM9/Huh7 cells.</p>
    Formula:C19H16N2O4
    Color and Shape:Solid
    Molecular weight:336.34

    Ref: TM-T61045

  • SIRT6 activator 2
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    SIRT6 activator 2

    CAS:
    <p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>
    Formula:C23H23N3O6
    Color and Shape:Solid
    Molecular weight:437.45

    Ref: TM-T200625

  • TP3011
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    TP3011

    CAS:
    <p>TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.</p>
    Formula:C26H26N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.51

    Ref: TM-T13191

  • (Rac)-RG108
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    (Rac)-RG108

    CAS:
    <p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>
    Formula:C19H14N2O4
    Color and Shape:Solid
    Molecular weight:334.326

    Ref: TM-T206761