DNA-PK

LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative …

STL127705 is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 …

Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest …

(R)-(-)-Rolipram is an R-enantiomer of Rolipram which is a PDE4 inhibitor.

Nedisertib (M3814) is a specific inhibitor of DNA-dependent Protein Kinase (DNA-PK, IC50: <3 nM).

IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of …

PIK-75 Hydrochloride is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than …

LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and …

PI-3065 is a novel potent and selective PI3K p110δ inhibitor.

LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It …

NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for …

Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR …

XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.

PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) …

PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for …

Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold …

Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity …

AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM …

Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of …

Voxtalisib (SAR245409, XL765)Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits …

AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM and …

ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).

CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity …

CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).

KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 …

PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).

Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).

PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα …

6-Nitroveratraldehyde is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved …

Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity …

SF2523 is a highly selective and potent inhibitor.

KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.

LY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more …

OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of …

YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining …

BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor …

NU7441 (KU-57788) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).

ETP 45658 is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 …

NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 …