Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
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Irinotecan hydrochloride trihydrate
CAS:136572-09-3
Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.
Formula:
C33H45ClN4O9
Purity:
98.37% - 99.79%
Color and Shape:
Pale Yellow To Yellow Crystalline Powder
Molecular weight:
677.18
Ref: TM-T0486
| 25mg | 42.00 € | ||
| 50mg | 56.00 € | ||
| 100mg | 78.00 € | ||
| 200mg | 93.00 € | ||
| 500mg | 156.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Hycanthone
CAS:3105-97-3
Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.
Formula:
C20H24N2O2S
Purity:
98.78%
Color and Shape:
Yellow-Orange Powder (Ntp 1992)
Molecular weight:
356.48
Ref: TM-T15507
| 5mg | 38.00 € | ||
| 10mg | 54.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Lomefloxacin
CAS:98079-51-7
Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
Formula:
C17H19F2N3O3
Purity:
99.26%
Color and Shape:
Off-White To Yellow Crystals
Molecular weight:
351.35
Ref: TM-T1444
| 25mg | 45.00 € | ||
| 100mg | 59.00 € | ||
| 200mg | 73.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Lomefloxacin hydrochloride
CAS:98079-52-8
Lomefloxacin hydrochloride (Okacyn) is a fluoroquinolone that inhibits DNA replication in bacteria, causing cell death.
Formula:
C17H20ClF2N3O3
Purity:
99.43% - 99.75%
Color and Shape:
White Powder
Molecular weight:
387.81
Ref: TM-T1625
| 100mg | 57.00 € | ||
| 500mg | 93.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Gatifloxacin
CAS:112811-59-3
Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.
Formula:
C19H22FN3O4
Purity:
99.96%
Color and Shape:
White Powder
Molecular weight:
375.39
Ref: TM-T1293
| 1g | 52.00 € | ||
| 500mg | 48.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Epirubicin hydrochloride
CAS:56390-09-1
Epirubicin hydrochloride (Pharmorubicin) is a Topo and Foxp3 inhibitor. Epirubicin hydrochloride has antitumor activity. Cost-effective …
Formula:
C27H30ClNO11
Purity:
99.59% - 99.79%
Color and Shape:
Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)
Molecular weight:
579.98
Ref: TM-T0125
| 2mg | 39.00 € | ||
| 5mg | 55.00 € | ||
| 10mg | 88.00 € | ||
| 25mg | 147.00 € | ||
| 50mg | 235.00 € | ||
| 100mg | 319.00 € | ||
| 500mg | 768.00 € | ||
| 1mL*10mM (DMSO) | 73.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Ciprofloxacin monohydrochloride
CAS:93107-08-5
Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.
Formula:
C17H18FN3O3·HCl
Purity:
100% - 99.5%
Color and Shape:
White Or Light Yellow Crystalline Powder
Molecular weight:
367.8
Ref: TM-T0250
| 1g | 64.00 € | ||
| 500mg | 48.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Nalidixic acid sodium salt
CAS:3374-05-8
Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.
Formula:
C12H11N2NaO3
Purity:
100% - 99.94%
Color and Shape:
White To Off-White Powder
Molecular weight:
254.22
Ref: TM-T0909L
| 100mg | 41.00 € | ||
| 200mg | 52.00 € | ||
| 500mg | 91.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Aldoxorubicin hydrochloride
CAS:1361563-03-2
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor.
Formula:
C37H43ClN4O13
Purity:
100%
Color and Shape:
Soild
Molecular weight:
787.21
Ref: TM-T11090L1
| 1mg | 62.00 € | ||
| 2mg | 83.00 € | ||
| 5mg | 113.00 € | ||
| 10mg | 149.00 € | ||
| 25mg | 292.00 € | ||
| 50mg | 433.00 € | ||
| 100mg | 637.00 € | ||
| 500mg | 1,346.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
AuM1Phe
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin …
Purity:
98%
Ref: TM-T82934
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Chimmitecan
CAS:185425-25-6
Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro …
Formula:
C23H20N2O5
Purity:
98.5%
Color and Shape:
Soild
Molecular weight:
404.42
Ref: TM-T60123
| 1mg | 90.00 € | ||
| 5mg | 200.00 € | ||
| 10mg | 283.00 € | ||
| 25mg | 436.00 € | ||
| 50mg | 621.00 € | ||
| 100mg | 858.00 € | ||
| 200mg | 1,154.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Topixantrone 2HCl
CAS:2514569-86-7
Topixantrone 2HCl is a DNA topoisomerase inhibitor with antitumor activity for the study of gastric …
Formula:
C21H28Cl2N6O2
Purity:
98.18% - 99.96%
Color and Shape:
Soild
Molecular weight:
467.39
Ref: TM-T28994L
| 1mg | 182.00 € | ||
| 5mg | 452.00 € | ||
| 10mg | 647.00 € | ||
| 25mg | 1,009.00 € | ||
| 50mg | 1,392.00 € | ||
| 100mg | 1,841.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Rebeccamycin
CAS:93908-02-2
Rebeccamycin: an antitumor antibiotic; targets DNA topoisomerase I; minor effect on kinase C and topo …
Formula:
C27H21Cl2N3O7
Purity:
98%
Color and Shape:
Solid
Molecular weight:
570.38
Ref: TM-T16726
| 500µg | 422.00 € | ||
| 2500µg | 1,878.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
(rac)-Exatecan Intermediate 1
CAS:102978-40-5
(rac)-Exatecan Intermediate 1 is a camptothecin derivative, a potential topoisomerase I inhibitor, used in tumor …
Formula:
C13H13NO5
Color and Shape:
Liquid
Molecular weight:
263.25
Ref: TM-T88858
| 5mg | 35.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 79.00 € | ||
| 50mg | 112.00 € | ||
| 100mg | 175.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
DiPT-4
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and …
Formula:
C32H22FN5O4S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
591.61
Ref: TM-T78747
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Ledoxantrone trihydrochloride
CAS:119221-49-7
Ledoxantrone trihydrochloride is a Top II inhibitor with anticancer activity and is used in the …
Formula:
C21H30Cl3N5OS
Purity:
98.13%
Color and Shape:
Soild
Molecular weight:
506.92
Ref: TM-T68091L
| 1mg | 269.00 € | ||
| 5mg | 592.00 € | ||
| 10mg | 887.00 € | ||
| 25mg | 1,510.00 € | ||
| 50mg | 2,265.00 € | ||
| 100mg | 3,397.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
XR-11576 HCl
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor …
Formula:
C23H25ClN4O2
Purity:
98.89%
Color and Shape:
Soild
Molecular weight:
424.92
Ref: TM-T26339L
| 1mg | 181.00 € | ||
| 5mg | 400.00 € | ||
| 10mg | 591.00 € | ||
| 25mg | 922.00 € | ||
| 50mg | 1,271.00 € | ||
| 100mg | 1,705.00 € | ||
| 500mg | 3,428.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Pyronaridine tetraphosphate
CAS:76748-86-2
Pyronaridine tetraphosphate is a DNA topoisomerase 2 inhibitor with antimalarial and antitumor activity for the …
Formula:
C29H44ClN5O18P4
Purity:
99.82%
Color and Shape:
Solid
Molecular weight:
910.03
Ref: TM-T16697
| 10mg | 35.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Antitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose …
Formula:
C70H82N8O18S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
1355.51
Ref: TM-T79263
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable …
Formula:
C25H26ClN3O5
Purity:
97.04%
Color and Shape:
Soild
Molecular weight:
483.94
Ref: TM-T21319L
| 1mg | 46.00 € | ||
| 2mg | 57.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 187.00 € | ||
| 50mg | 280.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
