Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
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Oxaquin TEA
Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that …
Formula:
C37H48F2N5O11P
Purity:
99.79%
Color and Shape:
Liquid
Molecular weight:
807.77
Ref: TM-T12337L
| 1mg | 182.00 € | ||
| 5mg | 402.00 € | ||
| 10mg | 591.00 € | ||
| 25mg | 920.00 € | ||
| 50mg | 1,263.00 € | ||
| 100mg | 1,698.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Topoisomerase I inhibitor 10
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial …
Purity:
98%
Ref: TM-T80968
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Daun02
CAS:290304-24-4
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
Formula:
C41H44N2O20
Purity:
98%
Color and Shape:
Solid
Molecular weight:
884.79
Ref: TM-T15054
| 25mg | 705.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC)
Formula:
C26H24ClN3O6
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
509.94
Ref: TM-T77873
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Voreloxin
CAS:175414-77-4
Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
Formula:
C18H19N5O4S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
401.44
Ref: TM-T6724
| 1mg | 121.00 € | ||
| 5mg | 370.00 € | ||
| 25mg | 1,404.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Ac-Exatecan
CAS:2922852-48-8
Ac-Exatecan, the acetylated form of Exatecan (DX-8951), serves as a prevalent cytotoxic agent in antibody-drug …
Formula:
C26H24FN3O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
477.48
Ref: TM-T77901
| 5mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Doxorubicin
CAS:23214-92-8
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
Formula:
C27H29NO11
Purity:
98%
Color and Shape:
Red Crystalline Solid Solid
Molecular weight:
543.52
Ref: TM-T1456
| 10mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Topoisomerase II inhibitor 13
CAS:451515-89-2
WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.
Formula:
C22H23N9
Purity:
98.4%
Color and Shape:
Soild
Molecular weight:
413.48
Ref: TM-T67899
| 2mg | 36.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 84.00 € | ||
| 25mg | 127.00 € | ||
| 50mg | 184.00 € | ||
| 100mg | 274.00 € | ||
| 200mg | 389.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
CH-0793076
CAS:534605-78-2
CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).
Formula:
C26H26N4O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
458.51
Ref: TM-T14945
| 100mg | To inquire | ||
| 500mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Lurtotecan
CAS:149882-10-0
Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer …
Formula:
C28H30N4O6
Purity:
97.08%
Color and Shape:
Soild
Molecular weight:
518.56
Ref: TM-T60163
| 1mg | 295.00 € | ||
| 5mg | 722.00 € | ||
| 10mg | 1,003.00 € | ||
| 25mg | 1,466.00 € | ||
| 50mg | 2,005.00 € | ||
| 100mg | 2,711.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory …
Formula:
C53H83FN6O15
Color and Shape:
Liquid
Molecular weight:
1063.26
Ref: TM-T200217
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
AuM1Gly
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer …
Purity:
98%
Ref: TM-T82935
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Nifurpirinol
CAS:13411-16-0
Nifurpirinol (P-7138) is an antimicrobial compound that is acutely toxic to milkfish species.
Formula:
C12H10N2O4
Color and Shape:
Liquid
Molecular weight:
246.22
Ref: TM-T74065
| 1mg | 55.00 € | ||
| 5mg | 116.00 € | ||
| 10mg | 181.00 € | ||
| 25mg | 349.00 € | ||
| 50mg | 519.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered …
Formula:
C21H21N3O2
Color and Shape:
Liquid
Molecular weight:
347.41
Ref: TM-T200315
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 10 Dec 2024
TAK1 inhibitor
CAS:1326712-16-6
TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with …
Formula:
C22H19ClN6O2S
Purity:
98%
Color and Shape:
Soild
Molecular weight:
466.94
Ref: TM-T67909
| 5mg | 2,320.00 € | ||
| 50mg | 4,676.00 € | ||
| 100mg | 6,573.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
DRF-1042 HCl
DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, …
Formula:
C22H21ClN2O6
Purity:
99.212%
Color and Shape:
Liquid
Molecular weight:
444.87
Ref: TM-T15168L
| 1mg | 200.00 € | ||
| 5mg | 494.00 € | ||
| 10mg | 693.00 € | ||
| 25mg | 1,082.00 € | ||
| 50mg | 1,493.00 € | ||
| 100mg | 1,911.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Aclacinomycin A
CAS:57576-44-0
Aclacinomycin A has a wide range of applications in life science related research.
Formula:
C42H53NO15
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
811.87
Ref: TM-T21502
| 1mg | 279.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Garenoxacin
CAS:194804-75-6
Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative …
Formula:
C23H20F2N2O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
426.41
Ref: TM-T7179
| 5mg | 261.00 € | ||
| 10mg | 392.00 € | ||
| 25mg | 835.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
IndiMitecan
CAS:915360-05-3
IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].
Formula:
C25H21N3O6
Purity:
98.25%
Color and Shape:
Soild
Molecular weight:
459.45
Ref: TM-T60200
| 1mg | 93.00 € | ||
| 5mg | 194.00 € | ||
| 10mg | 299.00 € | ||
| 25mg | 490.00 € | ||
| 50mg | 686.00 € | ||
| 100mg | 965.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
(4-NH2)-Exatecan
CAS:2495742-21-5
(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug …
Formula:
C23H21N3O4
Purity:
99.89%
Color and Shape:
Solid
Molecular weight:
403.43
Ref: TM-T40159
| 1mg | 118.00 € | ||
| 5mg | 276.00 € | ||
| 10mg | 460.00 € | ||
| 25mg | 692.00 € | ||
| 50mg | 916.00 € | ||
| 100mg | 1,345.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
