Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 136 products for "Topoisomerase".
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AuM1Phe
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization.Purity:98%Color and Shape:Odour SolidTopoisomerase II inhibitor 19
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and a topoisomerase II inhibitor with an IC50 of 0.34 μM. It induces damage in ctDNA.Formula:C27H16ClN3OSMolecular weight:465.070263-Fluoro-14-methyl-10-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
CAS:3-Fluoro-14-methyl-10-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one (conjugate 8) inhibits TOP1/II with anti-tumor effects.Formula:C25H26FN3O7Molecular weight:499.50DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Color and Shape:Odour SolidF-14512 Hydrochloride
CAS:F-14512 Hydrochloride is a highly potent and tumor-selective inhibitor of DNA topoisomerase II.Formula:C33H51Cl4N5O8Molecular weight:787.60CBX-12
CBX-12 is a peptide drug conjugate (PDC) that targets tumors in an antigen-independent manner and exhibits antitumor activity. Comprising a pH-sensitive peptide (pHLIP), an auto-cleavable linker, and the topoisomerase 1 (TOP1) inhibitor Exatecan, it effectively targets cancerous cells.Formula:C169H240FN35O49S2Color and Shape:SolidMolecular weight:3629.05AuM1Gly
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the lowPurity:98%Color and Shape:Odour SolidBWC0977
CAS:BWC0977 is a dual topoisomerase inhibitor used in antibacterial research against multidrug-resistant Gram-negative bacteria.Formula:C22H21FN6O5Purity:99.53%Color and Shape:SolidMolecular weight:468.44Merbarone
CAS:Merbarone is a Type II DNA topoisomerase inhibitor that suppresses the catalytic activity of human topoisomerase IIα by blocking DNA cleavage, subsequently inducing activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix, Merbarone triggers apoptosis in CEM cells through activation of ICE/CED-3-like proteases, making it a mechanistically informative compound for studying DNA damage responses and apoptosis pathways.Formula:C11H9N3O3SPurity:99.51%Color and Shape:SolidMolecular weight:263.272Topotecan
CAS:Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.Formula:C23H23N3O5Purity:96.14% - 98.23%Color and Shape:Yellow SolidMolecular weight:421.4458Pixantrone dimaleate
CAS:Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Formula:C25H27N5O10Purity:98.70% - 99.11%Color and Shape:Blue SolidMolecular weight:557.5094Razoxane
CAS:Razoxane is used as an antimitotic agent with immunosuppressive properties.Formula:C11H16N4O4Purity:99.75%Color and Shape:SolidMolecular weight:268.26919-amino-CPT
CAS:9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.Formula:C20H17N3O4Purity:99.13% - 99.82%Color and Shape:Yellow SolidMolecular weight:363.3667Gatifloxacin hydrochloride
CAS:Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.Formula:C19H23ClFN3O4Purity:99.85% - 99.89%Color and Shape:SolidMolecular weight:411.855Topovale
CAS:Topovale (ARC111) is a potent inhibitor of topoisomerase I.Formula:C23H23N3O5Purity:99.94%Color and Shape:SolidMolecular weight:421.4458Artemisitene
CAS:Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.Formula:C15H20O5Purity:99.58%Color and Shape:SolidMolecular weight:280.3163Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formula:C15H12O3Purity:98.07% - 99.18%Color and Shape:White SolidMolecular weight:240.254Indotecan
CAS:Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).Formula:C26H26N2O7Purity:97% - 98%Color and Shape:Yellow SolidMolecular weight:478.4938Rubitecan
CAS:Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.Formula:C20H15N3O6Purity:97.54%Color and Shape:SolidMolecular weight:393.3496
