Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
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Aldoxorubicin hydrochloride
CAS:1361563-03-2
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor.
Formula:
C37H43ClN4O13
Purity:
100%
Color and Shape:
Soild
Molecular weight:
787.21
Ref: TM-T11090L1
| 1mg | 62.00 € | ||
| 2mg | 83.00 € | ||
| 5mg | 113.00 € | ||
| 10mg | 149.00 € | ||
| 25mg | 292.00 € | ||
| 50mg | 433.00 € | ||
| 100mg | 637.00 € | ||
| 500mg | 1,346.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Lurtotecan
CAS:149882-10-0
Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer …
Formula:
C28H30N4O6
Purity:
97.08%
Color and Shape:
Soild
Molecular weight:
518.56
Ref: TM-T60163
| 1mg | 295.00 € | ||
| 5mg | 722.00 € | ||
| 10mg | 1,003.00 € | ||
| 25mg | 1,466.00 € | ||
| 50mg | 2,005.00 € | ||
| 100mg | 2,711.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Doxorubicin
CAS:23214-92-8
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
Formula:
C27H29NO11
Purity:
98%
Color and Shape:
Red Crystalline Solid Solid
Molecular weight:
543.52
Ref: TM-T1456
| 10mg | To inquire |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Ac-Exatecan
CAS:2922852-48-8
Ac-Exatecan, the acetylated form of Exatecan (DX-8951), serves as a prevalent cytotoxic agent in antibody-drug …
Formula:
C26H24FN3O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
477.48
Ref: TM-T77901
| 5mg | To inquire |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Voreloxin
CAS:175414-77-4
Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
Formula:
C18H19N5O4S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
401.44
Ref: TM-T6724
| 1mg | 121.00 € | ||
| 5mg | 370.00 € | ||
| 25mg | 1,404.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
XR-11576 HCl
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor …
Formula:
C23H25ClN4O2
Purity:
98.89%
Color and Shape:
Soild
Molecular weight:
424.92
Ref: TM-T26339L
| 1mg | 181.00 € | ||
| 5mg | 400.00 € | ||
| 10mg | 591.00 € | ||
| 25mg | 922.00 € | ||
| 50mg | 1,271.00 € | ||
| 100mg | 1,705.00 € | ||
| 500mg | 3,428.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
AuM1Phe
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin …
Purity:
98%
Ref: TM-T82934
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 6 Nov 2024
AuM1Gly
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer …
Purity:
98%
Ref: TM-T82935
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 6 Nov 2024
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC)
Formula:
C26H24ClN3O6
Purity:
98%
Color and Shape:
Solid
Molecular weight:
509.94
Ref: TM-T77873
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Topoisomerase I inhibitor 10
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial …
Purity:
98%
Ref: TM-T80968
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Antitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose …
Formula:
C70H82N8O18S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
1355.51
Ref: TM-T79263
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 6 Nov 2024
DiPT-4
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and …
Formula:
C32H22FN5O4S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
591.61
Ref: TM-T78747
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Aclacinomycin A
CAS:57576-44-0
Aclacinomycin A has a wide range of applications in life science related research.
Formula:
C42H53NO15
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
811.87
Ref: TM-T21502
| 1mg | 279.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Nifurpirinol
CAS:13411-16-0
Nifurpirinol (P-7138) is an antimicrobial compound that is acutely toxic to milkfish species.
Formula:
C12H10N2O4
Color and Shape:
Solid
Molecular weight:
246.22
Ref: TM-T74065
| 1mg | 55.00 € | ||
| 5mg | 116.00 € | ||
| 10mg | 181.00 € | ||
| 25mg | 349.00 € | ||
| 50mg | 519.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
Ledoxantrone trihydrochloride
CAS:119221-49-7
Ledoxantrone trihydrochloride is a Top II inhibitor with anticancer activity and is used in the …
Formula:
C21H30Cl3N5OS
Purity:
98.13%
Color and Shape:
Soild
Molecular weight:
506.92
Ref: TM-T68091L
| 1mg | 269.00 € | ||
| 5mg | 592.00 € | ||
| 10mg | 887.00 € | ||
| 25mg | 1,510.00 € | ||
| 50mg | 2,265.00 € | ||
| 100mg | 3,397.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
DRF-1042 HCl
DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, …
Formula:
C22H21ClN2O6
Purity:
99.212%
Color and Shape:
Solid
Molecular weight:
444.87
Ref: TM-T15168L
| 1mg | 200.00 € | ||
| 5mg | 494.00 € | ||
| 10mg | 693.00 € | ||
| 25mg | 1,082.00 € | ||
| 50mg | 1,493.00 € | ||
| 100mg | 1,911.00 € |
Estimated delivery in United States, on Wednesday 6 Nov 2024
IndiMitecan
CAS:915360-05-3
IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].
Formula:
C25H21N3O6
Purity:
98.25%
Color and Shape:
Soild
Molecular weight:
459.45
Ref: TM-T60200
| 1mg | 93.00 € | ||
| 5mg | 194.00 € | ||
| 10mg | 299.00 € | ||
| 25mg | 490.00 € | ||
| 50mg | 686.00 € | ||
| 100mg | 965.00 € |
Estimated delivery in United States, on Friday 8 Nov 2024
(4-NH2)-Exatecan
CAS:2495742-21-5
(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug …
Formula:
C23H21N3O4
Purity:
99.89%
Color and Shape:
Solid
Molecular weight:
403.43
Ref: TM-T40159
| 1mg | 118.00 € | ||
| 5mg | 276.00 € | ||
| 10mg | 460.00 € | ||
| 25mg | 692.00 € | ||
| 50mg | 916.00 € | ||
| 100mg | 1,345.00 € |
Estimated delivery in United States, on Friday 8 Nov 2024
Exatecan
CAS:171335-80-1
Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 …
Formula:
C24H22FN3O4
Purity:
99.64% - 99.84%
Color and Shape:
Solid
Molecular weight:
435.45
Ref: TM-T11249
| 10mg | 35.00 € | ||
| 25mg | 69.00 € | ||
| 50mg | 90.00 € | ||
| 100mg | 133.00 € | ||
| 500mg | 316.00 € |
Estimated delivery in United States, on Friday 8 Nov 2024
(S)-10-Hydroxycamptothecin
CAS:19685-09-7
(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against …
Formula:
C20H16N2O5
Purity:
99.09% - 99.81%
Color and Shape:
Solid
Molecular weight:
364.35
Ref: TM-T2764
| 25mg | 57.00 € | ||
| 50mg | 70.00 € | ||
| 100mg | 95.00 € | ||
| 500mg | 183.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Tuesday 12 Nov 2024
