Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 135 products of "Topoisomerase"
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Banoxantrone (D12)
CAS:Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.Formula:C22H28N4O6Purity:98%Color and Shape:SolidMolecular weight:456.55CH-0793076
CAS:CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).
Formula:C26H26N4O4Purity:98%Color and Shape:SolidMolecular weight:458.51Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formula:C21H21N3O2Color and Shape:SolidMolecular weight:347.41Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H26ClN3O5Purity:97.04%Color and Shape:SoildMolecular weight:483.94Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).Formula:C53H83FN6O15Color and Shape:SolidMolecular weight:1063.26TAK1 inhibitor
CAS:TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.
Formula:C22H19ClN6O2SPurity:98%Color and Shape:SoildMolecular weight:466.94Topo I/II-IN-1
Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.
Formula:C15H13N3S2Color and Shape:SolidMolecular weight:299.414CBX-12
CBX-12 is a peptide drug conjugate (PDC) that targets tumors in an antigen-independent manner and exhibits antitumor activity. Comprising a pH-sensitive peptide (pHLIP), an auto-cleavable linker, and the topoisomerase 1 (TOP1) inhibitor Exatecan, it effectively targets cancerous cells.Formula:C169H240FN35O49S2Color and Shape:SolidMolecular weight:3629.05DTS-108
CAS:DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.Formula:C145H233N43O33S2Color and Shape:SolidMolecular weight:3170.8(4-NH2)-Exatecan
CAS:(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).Formula:C23H21N3O4Purity:99.89%Color and Shape:SolidMolecular weight:403.43Belotecan hydrochloride
CAS:Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activityFormula:C25H28ClN3O4Purity:99.63% - ≥95%Color and Shape:SolidMolecular weight:469.96Ref: TM-T7551
1mg34.00€5mg66.00€10mg90.00€25mg144.00€50mg200.00€100mg280.00€200mg416.00€1mL*10mM (DMSO)69.00€Berberine hydrogen sulphate
CAS:Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.Formula:C20H19NO8SPurity:99% - 99.82%Color and Shape:Yellow Crystals Off-White To Yellow PowderMolecular weight:433.43Levofloxacin hydrochloride
CAS:Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Formula:C18H21ClFN3O4Purity:99.78% - 99.98%Color and Shape:SolidMolecular weight:397.8Pixantrone dimaleate
CAS:Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Formula:C25H27N5O10Purity:98.70% - 99.11%Color and Shape:SolidMolecular weight:557.211,4-Naphthoquinone
CAS:1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.Formula:C10H6O2Purity:99.24% - 99.56%Color and Shape:SolidMolecular weight:158.15SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formula:C22H20N2O5Purity:98% - 99.97%Color and Shape:Light-Yellow SolidMolecular weight:392.4Genz-644282
CAS:Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formula:C22H21N3O5Purity:97.49%Color and Shape:SolidMolecular weight:407.42Ref: TM-T4S0797
5mgTo inquire10mgTo inquire25mgTo inquire50mg93.00€100mg125.00€500mg266.00€1mL*10mM (DMSO)55.00€Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purity:97.47% - 99.97%Color and Shape:WhiteMolecular weight:1429.15Ref: TM-T2160
1mg39.00€5mg87.00€10mg115.00€25mg190.00€50mg285.00€100mg408.00€200mg620.00€1mL*10mM (DMSO)101.00€Voreloxin hydrochloride
CAS:Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Formula:C18H20ClN5O4SPurity:99.84%Color and Shape:SolidMolecular weight:437.9
