DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
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5-Methyl-2'-deoxycytidine
CAS:838-07-3
5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in …
Formula:
C10H15N3O4
Purity:
99.18% - 99.69%
Color and Shape:
Solid
Molecular weight:
241.24
Ref: TM-T7457
| 1g | 54.00 € | ||
| 500mg | 41.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
EPZ015666
CAS:1616391-65-1
EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.
Formula:
C20H25N5O3
Purity:
98% - 99.92%
Color and Shape:
Solid
Molecular weight:
383.44
Ref: TM-T6076
| 1mg | 49.00 € | ||
| 2mg | 61.00 € | ||
| 5mg | 91.00 € | ||
| 10mg | 122.00 € | ||
| 50mg | 343.00 € | ||
| 100mg | 493.00 € | ||
| 1mL*10mM (DMSO) | 91.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
EI1
CAS:1418308-27-6
EI1 (Ezh2 inhibitor) is a potent and selective EZH2 inhibitor with IC50 of 15 nM …
Formula:
C23H26N4O2
Purity:
99.98%
Color and Shape:
Solid
Molecular weight:
390.48
Ref: TM-T6484
| 2mg | 43.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 181.00 € | ||
| 50mg | 269.00 € | ||
| 100mg | 397.00 € | ||
| 200mg | 590.00 € | ||
| 1mL*10mM (DMSO) | 77.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
Bobcat339
CAS:2280037-51-4
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not …
Formula:
C16H12ClN3O
Purity:
97.79% - 98.76%
Color and Shape:
Solid
Molecular weight:
297.74
Ref: TM-T5198
| 5mg | 51.00 € | ||
| 10mg | 82.00 € | ||
| 25mg | 158.00 € | ||
| 50mg | 246.00 € | ||
| 100mg | 360.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
MM-102 TFA
CAS:1883545-52-5
MM-102 TFA is a potent WDR5/MLL inhibitor with IC50 of 2.4 nM; it disrupts MLL1-WDR5 …
Formula:
C37H50F5N7O6
Purity:
99.3% - 99.4%
Color and Shape:
Solid
Molecular weight:
783.83
Ref: TM-T8768
| 1mg | 39.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 104.00 € | ||
| 10mg | 171.00 € | ||
| 25mg | 278.00 € | ||
| 50mg | 412.00 € | ||
| 100mg | 610.00 € | ||
| 1mL*10mM (DMSO) | 149.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
GSK2807 Trifluoroacetate
CAS:2245255-66-5
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 …
Formula:
C21H33F3N8O7
Purity:
99.95%
Color and Shape:
Solid
Molecular weight:
566.53
Ref: TM-T11486
| 1mg | 90.00 € | ||
| 5mg | 183.00 € | ||
| 10mg | 269.00 € | ||
| 25mg | 455.00 € | ||
| 50mg | To inquire |
Estimated delivery in United States, on Friday 27 Dec 2024
Tetrahydrouridine
CAS:18771-50-1
Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.
Formula:
C9H16N2O6
Purity:
98%
Color and Shape:
Solid
Molecular weight:
248.23
Ref: TM-T17059
| 1mg | To inquire | ||
| 2mg | To inquire | ||
| 5mg | To inquire | ||
| 10mg | To inquire | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 100mg | To inquire | ||
| 1mL*10mM (DMSO) | To inquire |
Estimated delivery in United States, on Friday 27 Dec 2024
UNC0224
CAS:1197196-48-7
UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 …
Formula:
C26H43N7O2
Purity:
97.61%
Color and Shape:
Solid
Molecular weight:
485.67
Ref: TM-T17203
| 1mg | 51.00 € | ||
| 2mg | 72.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 156.00 € | ||
| 25mg | 347.00 € | ||
| 50mg | 546.00 € | ||
| 100mg | 779.00 € | ||
| 500mg | 1,598.00 € | ||
| 1mL*10mM (DMSO) | 107.00 € |
Estimated delivery in United States, on Thursday 9 Jan 2025
GSK-1268997
CAS:1414375-50-0
GSK-1268997 is a bio-active chemical.
Formula:
C21H23N7O3S
Purity:
99.78% - 99.81%
Color and Shape:
Solid
Molecular weight:
453.52
Ref: TM-T32003
| 1mg | 272.00 € | ||
| 5mg | 671.00 € | ||
| 10mg | 917.00 € | ||
| 25mg | 1,428.00 € | ||
| 50mg | 1,838.00 € |
Estimated delivery in United States, on Thursday 9 Jan 2025
Cedazuridine
CAS:1141397-80-9
Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.
Formula:
C9H14F2N2O5
Purity:
99.46%
Color and Shape:
Solid
Molecular weight:
268.21
Ref: TM-T26972
| 1mg | 54.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 150.00 € | ||
| 25mg | 295.00 € | ||
| 50mg | 445.00 € | ||
| 1mL*10mM (DMSO) | 117.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
SW155246
CAS:420092-79-1
SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 …
Formula:
C16H11ClN2O5S
Purity:
97.79%
Color and Shape:
Solid
Molecular weight:
378.79
Ref: TM-T8967
| 5mg | 51.00 € | ||
| 10mg | 74.00 € | ||
| 25mg | 137.00 € | ||
| 50mg | 211.00 € | ||
| 100mg | 334.00 € | ||
| 500mg | 716.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
Procainamide
CAS:51-06-9
Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.
Formula:
C13H21N3O
Purity:
98.86%
Color and Shape:
Solid
Molecular weight:
235.33
Ref: TM-T60322
| 200mg | 39.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
TFMB-(S)-2-HG
CAS:1445703-64-9
TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.
Formula:
C13H11F3O4
Purity:
98.88%
Color and Shape:
Solid
Molecular weight:
288.22
Ref: TM-T24871
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 82.00 € | ||
| 25mg | 152.00 € | ||
| 50mg | 236.00 € | ||
| 100mg | 350.00 € | ||
| 500mg | 738.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
WDR5-0102
CAS:824960-50-1
WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 …
Formula:
C18H19ClN4O3
Purity:
97.16%
Color and Shape:
Solid
Molecular weight:
374.82
Ref: TM-T67947
| 1mg | 75.00 € | ||
| 5mg | 167.00 € | ||
| 10mg | 270.00 € | ||
| 25mg | 540.00 € | ||
| 50mg | 779.00 € | ||
| 100mg | 1,067.00 € | ||
| 500mg | 2,125.00 € | ||
| 1mL*10mM (DMSO) | 213.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
CM-579
CAS:1846570-40-8
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a …
Formula:
C29H40N4O3
Purity:
99.62%
Color and Shape:
Solid
Molecular weight:
492.65
Ref: TM-T10840L
| 1mg | 55.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 137.00 € | ||
| 25mg | 215.00 € | ||
| 50mg | 316.00 € | ||
| 100mg | 466.00 € | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
LEM-14-1189
CAS:2987501-17-5
LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood …
Formula:
C35H34N6O5S2
Purity:
97.98%
Color and Shape:
Liquid
Molecular weight:
682.81
Ref: TM-T72979
| 1mg | 325.00 € | ||
| 5mg | 905.00 € | ||
| 10mg | 1,115.00 € | ||
| 25mg | 1,476.00 € | ||
| 50mg | 1,838.00 € | ||
| 100mg | 2,336.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
CPUY074020
CAS:902279-44-1
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) …
Formula:
C25H28N4O2
Purity:
99.07%
Color and Shape:
Solid
Molecular weight:
416.52
Ref: TM-T10882
| 1mg | 110.00 € | ||
| 5mg | 247.00 € | ||
| 10mg | 355.00 € | ||
| 25mg | 551.00 € | ||
| 50mg | 781.00 € | ||
| 100mg | 1,021.00 € | ||
| 200mg | 1,396.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
Valemetostat tosylate
CAS:1809336-93-3
Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory …
Formula:
C33H42ClN3O7S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
660.22
Ref: TM-T13279
| 25mg | 850.00 € | ||
| 50mg | 1,113.00 € | ||
| 100mg | 1,542.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
CARM1-IN-1
CAS:1020399-49-8
CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows …
Formula:
C26H21Br2NO3
Purity:
97.35%
Color and Shape:
Solid
Molecular weight:
555.26
Ref: TM-T10682L
| 1mg | 37.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 123.00 € | ||
| 25mg | 241.00 € | ||
| 50mg | 392.00 € | ||
| 100mg | 610.00 € | ||
| 200mg | 871.00 € | ||
| 1mL*10mM (DMSO) | 93.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
MM-102
CAS:1417329-24-8
MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction with IC50 of 2.4 …
Formula:
C35H49F2N7O4
Purity:
98.77% - 99.08%
Color and Shape:
Solid
Molecular weight:
669.8
Ref: TM-T6333
| 1mg | 39.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 104.00 € | ||
| 10mg | 171.00 € | ||
| 25mg | 344.00 € | ||
| 50mg | 531.00 € | ||
| 100mg | 760.00 € | ||
| 1mL*10mM (DMSO) | 155.00 € |
Estimated delivery in United States, on Thursday 23 Jan 2025
