Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Found 86 products of "Sirtuin"
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SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formula:C22H12FN3O4Purity:98%Color and Shape:SolidMolecular weight:401.35Dihydrocoumarin
CAS:Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).Formula:C9H8O2Purity:98.46%Color and Shape:Leaflets Room Temperature (Ntp 1992)Molecular weight:148.16YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purity:99.47%Color and Shape:SolidMolecular weight:372.18Ref: TM-T9320
2mg38.00€5mg57.00€10mg93.00€25mg170.00€50mg289.00€100mg507.00€200mg655.00€500mg1,018.00€1mL*10mM (DMSO)63.00€Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Formula:C20H23N3O2SPurity:99.33%Color and Shape:SolidMolecular weight:369.483-TYP
CAS:3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.Formula:C7H6N4Purity:99.16% - >99.99%Color and Shape:SolidMolecular weight:146.15Ref: TM-T4108
2mg39.00€5mg52.00€10mg93.00€25mg166.00€50mg248.00€100mg393.00€200mg560.00€1mL*10mM (DMSO)52.00€SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Formula:C22H20N4OS2Purity:99.52% - 99.75%Color and Shape:SolidMolecular weight:420.55Ref: TM-T6984
1mg39.00€2mg50.00€5mg79.00€10mg107.00€25mg197.00€50mg311.00€100mg505.00€1mL*10mM (DMSO)90.00€Selisistat S-enantiomer
CAS:Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.
Formula:C13H13ClN2OPurity:99.86%Color and Shape:SolidMolecular weight:248.71Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Formula:C20H24O11Purity:99.71% - 99.98%Color and Shape:White PowderMolecular weight:440.40Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Formula:C30H42O7Purity:98.06% - 99.98%Color and Shape:SolidMolecular weight:514.65AGK2
CAS:AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.
Formula:C23H13Cl2N3O2Purity:98.68% - 99.17%Color and Shape:SolidMolecular weight:434.27AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Formula:C19H21N3O5SPurity:98.32% - 99.44%Color and Shape:SolidMolecular weight:403.45Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Formula:C13H13ClN2OPurity:99.8%Color and Shape:SolidMolecular weight:248.71Ref: TM-T15263
1mg106.00€2mg159.00€5mg259.00€10mg376.00€25mg630.00€50mg880.00€100mg1,169.00€1mL*10mM (DMSO)284.00€Agrimol B
CAS:1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Formula:C37H46O12Purity:99.06% - ≥95%Color and Shape:SolidMolecular weight:682.75SRT 1720 dihydrochloride
CAS:SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).Formula:C25H25Cl2N7OSPurity:98.58%Color and Shape:SolidMolecular weight:542.48Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Formula:C34H51N3O3SPurity:99.16%Color and Shape:SolidMolecular weight:581.85Ref: TM-T3447
1mg54.00€2mg73.00€5mg92.00€10mg117.00€25mg215.00€50mg360.00€100mg537.00€1mL*10mM (DMSO)117.00€SRT1720 hydrochloride
CAS:SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).Formula:C25H24ClN7OSPurity:98% - 99.93%Color and Shape:SolidMolecular weight:506.22Ref: TM-T2412
1mg69.00€2mg89.00€5mg139.00€10mg250.00€25mg394.00€50mg562.00€100mg800.00€200mg1,103.00€500mg1,634.00€1mL*10mM (DMSO)221.00€Nicotinamide riboside chloride
CAS:NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Formula:C11H15ClN2O5Purity:98.92% - 99.86%Color and Shape:SolidMolecular weight:290.7SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Formula:C25H23N7OSPurity:98.84%Color and Shape:SolidMolecular weight:469.56Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Formula:C13H13ClN2OPurity:98.53% - 99.94%Color and Shape:SolidMolecular weight:248.71Ref: TM-T6111
5mg48.00€10mg54.00€25mg87.00€50mg133.00€100mg222.00€200mg330.00€500mg535.00€1mL*10mM (DMSO)50.00€Scopolin
CAS:Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.Formula:C16H18O9Purity:98.97% - ≥95%Color and Shape:SolidMolecular weight:354.31
