Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Found 86 products of "Sirtuin"
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Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Formula:C13H13ClN2OPurity:98.53% - 99.94%Color and Shape:SolidMolecular weight:248.71Ref: TM-T6111
5mg48.00€10mg54.00€25mg87.00€50mg133.00€100mg222.00€200mg330.00€500mg535.00€1mL*10mM (DMSO)50.00€Selisistat S-enantiomer
CAS:Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.
Formula:C13H13ClN2OPurity:99.86%Color and Shape:SolidMolecular weight:248.71Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purity:97.47% - 99.97%Color and Shape:WhiteMolecular weight:1429.15Scopolin
CAS:Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.Formula:C16H18O9Purity:98.97% - ≥95%Color and Shape:SolidMolecular weight:354.31AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Formula:C19H21N3O5SPurity:98.32% - 99.44%Color and Shape:SolidMolecular weight:403.45Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Formula:C25H34N4O2SPurity:98.89% - >99.99%Color and Shape:SolidMolecular weight:454.63Ref: TM-T1818
1mg43.00€2mg56.00€5mg77.00€10mg87.00€25mg157.00€50mg230.00€100mg393.00€500mg930.00€1mL*10mM (DMSO)79.00€YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purity:99.47%Color and Shape:SolidMolecular weight:372.18Ref: TM-T9320
2mg38.00€5mg57.00€10mg93.00€25mg170.00€50mg289.00€100mg507.00€200mg655.00€500mg1,018.00€1mL*10mM (DMSO)63.00€Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Formula:C13H13ClN2OPurity:99.8%Color and Shape:SolidMolecular weight:248.71Ref: TM-T15263
1mg101.00€2mg150.00€5mg245.00€10mg356.00€25mg597.00€50mg835.00€100mg1,108.00€1mL*10mM (DMSO)269.00€Ophiopogonin D'
CAS:Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.
Formula:C44H70O16Purity:99.77%Color and Shape:SolidMolecular weight:855.02SRT 2104
CAS:SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.Formula:C26H24N6O2S2Purity:98.34% - 99.82%Color and Shape:SolidMolecular weight:516.64Ref: TM-T6679
1g1,558.00€1mg43.00€5mg93.00€10mg124.00€25mg219.00€50mg358.00€100mg533.00€200mg763.00€500mg1,161.00€SRT1720 hydrochloride
CAS:SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).Formula:C25H24ClN7OSPurity:98% - 99.93%Color and Shape:SolidMolecular weight:506.22Ref: TM-T2412
1mg69.00€2mg89.00€5mg139.00€10mg250.00€25mg394.00€50mg562.00€100mg800.00€200mg1,103.00€500mg1,634.00€1mL*10mM (DMSO)221.00€OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Formula:C19H14N2O6Purity:97.47% - 98.6%Color and Shape:SolidMolecular weight:366.32AGK7
CAS:AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Formula:C23H13Cl2N3O2Purity:98.31%Color and Shape:SolidMolecular weight:434.27Gardenia yellow
CAS:Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.Formula:C44H64O24Purity:98.24% - 98.82%Color and Shape:Orange Yellow To Reddish Yellow PowderMolecular weight:976.96SRT 1460
CAS:SRT 1460 is a SIRT1 activator.
Formula:C26H29N5O4SPurity:98.25%Color and Shape:SolidMolecular weight:507.6CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formula:C22H15FN4O2SPurity:98.92%Color and Shape:SolidMolecular weight:418.44SRT 2183
CAS:SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Formula:C27H24N4O2SPurity:97.86%Color and Shape:SolidMolecular weight:468.57Ref: TM-T16932
1mg50.00€2mg72.00€5mg107.00€10mg165.00€25mg283.00€50mg430.00€100mg622.00€1mL*10mM (DMSO)111.00€Sirtinol
CAS:Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Formula:C26H22N2O2Purity:97.12% - 99.96%Color and Shape:SolidMolecular weight:394.47Ref: TM-T6671
2mg43.00€5mg58.00€10mg93.00€25mg178.00€50mg343.00€100mg509.00€500mg1,121.00€1mL*10mM (DMSO)58.00€AK-7
CAS:AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.Formula:C19H21BrN2O3SPurity:98.43% - 99.34%Color and Shape:SolidMolecular weight:437.35Ref: TM-T5490
1mg34.00€2mg47.00€5mg71.00€10mg100.00€25mg177.00€50mg313.00€100mg512.00€1mL*10mM (DMSO)89.00€Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Formula:C15H10O6Purity:94.14% - 99.05%Color and Shape:Yellow To Brown Crystalline PowderMolecular weight:286.24
