Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Found 91 products for "Sirtuin".
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SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Formula:C22H20N4OS2Purity:99.52% - 99.75%Color and Shape:SolidMolecular weight:420.55Ref: TM-T6984
1mg37.00€2mg52.00€5mg74.00€1mL*10mM (DMSO)86.00€10mg102.00€25mg187.00€50mg295.00€100mg477.00€Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Formula:C30H42O7Purity:98.06% - 99.98%Color and Shape:White SolidMolecular weight:514.65AGK2
CAS:AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.Formula:C23H13Cl2N3O2Purity:98.68% - 99.17%Color and Shape:SolidMolecular weight:434.27Ref: TM-T6371
1mg34.00€2mg46.00€5mg70.00€1mL*10mM (DMSO)77.00€10mg90.00€25mg177.00€50mg281.00€100mg444.00€500mg982.00€Salermide
CAS:Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.Formula:C26H22N2O2Purity:97.09% - 99.55%Color and Shape:SolidMolecular weight:394.47Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Formula:C25H19N5OS2Purity:98% - 99.36%Color and Shape:SolidMolecular weight:469.58UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Formula:C16H13N3Purity:98.31%Color and Shape:SolidMolecular weight:247.29Ref: TM-T7679
1mg38.00€5mg77.00€1mL*10mM (DMSO)95.00€10mg110.00€25mg215.00€50mg306.00€100mg429.00€200mg600.00€SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Formula:C25H23N7OSPurity:98.84%Color and Shape:SolidMolecular weight:469.56Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Formula:C34H51N3O3SPurity:99.16%Color and Shape:SolidMolecular weight:581.85Ref: TM-T3447
1mg54.00€2mg73.00€5mg92.00€10mg117.00€1mL*10mM (DMSO)117.00€25mg215.00€50mg360.00€100mg537.00€Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Formula:C13H13ClN2OPurity:99.8%Color and Shape:White SolidMolecular weight:248.71Ref: TM-T15263
1mg101.00€2mg150.00€5mg245.00€1mL*10mM (DMSO)269.00€10mg356.00€25mg597.00€50mg835.00€100mg1,108.00€Ophiopogonin D'
CAS:Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.Formula:C44H70O16Purity:99.69% - 99.77%Color and Shape:White SolidMolecular weight:855.02Ref: TM-TN1071
1mg114.00€5mg289.00€10mg432.00€1mL*10mM (DMSO)533.00€25mg692.00€50mg945.00€100mg1,251.00€SRT 2104
CAS:SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.Formula:C26H24N6O2S2Purity:98.34% - 99.82%Color and Shape:Yellow SolidMolecular weight:516.64Ref: TM-T6679
1mg43.00€5mg93.00€10mg124.00€25mg219.00€50mg358.00€100mg533.00€200mg763.00€500mg1,161.00€1g1,558.00€OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Formula:C19H14N2O6Purity:97.47% - 98.6%Color and Shape:SolidMolecular weight:366.32AGK7
CAS:AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Formula:C23H13Cl2N3O2Purity:98.31%Color and Shape:SolidMolecular weight:434.27SRT 2183
CAS:SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Formula:C27H24N4O2SPurity:97.86%Color and Shape:SolidMolecular weight:468.57Ref: TM-T16932
1mg52.00€2mg69.00€5mg102.00€1mL*10mM (DMSO)105.00€10mg157.00€25mg268.00€50mg408.00€100mg590.00€AK-7
CAS:AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.Formula:C19H21BrN2O3SPurity:98.43% - 99.34%Color and Shape:White SolidMolecular weight:437.35Ref: TM-T5490
1mg34.00€2mg47.00€5mg71.00€1mL*10mM (DMSO)89.00€10mg100.00€25mg177.00€50mg313.00€100mg512.00€Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Formula:C15H10O6Purity:94.14% - 99.05%Color and Shape:Yellow To Brown Crystalline PowderMolecular weight:286.244'-bromo-Resveratrol
CAS:4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)Formula:C14H11BrO2Purity:99.00%Color and Shape:SolidMolecular weight:291.14CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formula:C22H15FN4O2SPurity:98.92%Color and Shape:SolidMolecular weight:418.44SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Formula:C15H12ClN3OPurity:99.79%Color and Shape:SolidMolecular weight:285.73Ref: TM-T39233
1mg90.00€5mg222.00€1mL*10mM (DMSO)245.00€10mg334.00€25mg567.00€50mg807.00€100mg1,099.00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurity:99.36%Color and Shape:SolidMolecular weight:491.09Ref: TM-T8480
1mg37.00€2mg49.00€5mg66.00€1mL*10mM (DMSO)70.00€10mg84.00€25mg133.00€50mg215.00€100mg356.00€
