Endocrinology/Hormones
Endocrinology/hormone inhibitors are compounds that block the action of hormones or interfere with hormone signaling pathways. These inhibitors are essential for studying the regulation of endocrine systems and for developing treatments for hormone-related diseases, such as diabetes, thyroid disorders, and hormone-dependent cancers. By modulating hormone activity, these inhibitors can help elucidate the complex interactions within the endocrine system. At CymitQuimica, we offer a wide range of high-quality endocrinology/hormone inhibitors to support your research in endocrinology, pharmacology, and medical sciences.
Subcategories of "Endocrinology/Hormones"
- Androgen Receptor(207 products)
- Annexin A(11 products)
- Aromatase(20 products)
- Estrogen/progestogen Receptor(49 products)
- GPR(1 products)
- Glucocorticoid Receptor(153 products)
- LHRH(1 products)
- Opioid Receptor(296 products)
- Prostaglandin Receptor(119 products)
- RAAS(86 products)
- Reductase(52 products)
- Somatostatin(46 products)
- Thyroid hormone receptor(THR)(26 products)
- Vasopressin Receptor(44 products)
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Found 3178 products of "Endocrinology/Hormones"
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Androgen receptor-IN-5
CAS:<p>Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties.</p>Formula:C22H10Cl2F4N4OSPurity:98%Color and Shape:SolidMolecular weight:525.31A81988
CAS:<p>A81988 is an antagonist of angiotensin AT1 receptors.</p>Formula:C23H22N6O2Purity:98%Color and Shape:SolidMolecular weight:414.46Trimegestone
CAS:<p>Trimegestone, a highly effective oral progestogen, is used for endometrial protection, all doses inducing secretory endometrial transformation.</p>Formula:C22H30O3Purity:98%Color and Shape:SolidMolecular weight:342.47RU 59063
CAS:<p>RU 59063 is a prototype of a new class of high-affinity nonsteroidal androgen receptor (AR) ligands.</p>Formula:C17H18F3N3O2SPurity:99.09%Color and Shape:SolidMolecular weight:385.4GW-803430
CAS:<p>GW-803430: potent MCH R1 antagonist, pIC50=9.3, orally effective against obesity in animals.</p>Formula:C25H24ClN3O3SPurity:98.07%Color and Shape:SolidMolecular weight:481.99MB-07811
CAS:<p>MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity.</p>Formula:C28H32ClO5PPurity:99.74% - 99.94%Color and Shape:SolidMolecular weight:514.98CO23
CAS:<p>CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.</p>Formula:C19H18I2N2O4Purity:98.08%Color and Shape:SolidMolecular weight:592.17Rovatirelin
CAS:<p>Rovatirelin (S-0373) is a TRH analog that improves motor dysfunction in a rat model of cytosine arabinoside-induced spinal cerebellar degeneration.</p>Formula:C16H22N4O4SPurity:99.59%Color and Shape:SolidMolecular weight:366.43Giredestrant tartrate
CAS:<p>Giredestrant tartrate: a new oral, selective non-steroidal ER antagonist, inhibits ER-mediated gene activation and degrades ER protein, treating tumors.</p>Formula:C31H37F5N4O7Purity:>99.99%Color and Shape:SolidMolecular weight:672.64Baxdrostat
CAS:<p>Baxdrostat is an aldosterone synthase inhibitor.</p>Formula:C22H25N3O2Purity:99.8%Color and Shape:SolidMolecular weight:363.45DS08210767
CAS:<p>DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.</p>Formula:C31H39N5O2Purity:98.79%Color and Shape:SolidMolecular weight:513.67AMG 837 calcium hydrate
CAS:<p>AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM.</p>Formula:C52H44CaF6O8Purity:98.07%Color and Shape:SolidMolecular weight:950.97OSU-ERb-12
CAS:<p>OSU-ERb-12 is an ERβ agonist that suppresses ovarian cancer cell proliferation both in vitro and in vivo, and decreases the expression of Snail [1] [2].</p>Formula:C15H30B10O2Color and Shape:SolidMolecular weight:350.51Opioid receptor antagonist 1
CAS:<p>Opioid receptor antagonist 1 (Compound 10) is an Orvinol-based antagonist of opioid receptors. It exhibits activity as an antagonist against the analgesic properties of morphine.</p>Formula:C24H29ClF3NO4Color and Shape:SolidMolecular weight:487.94Isotodesnitazene
CAS:<p>Isotodesnitazene is an opioid compound that primarily targets the μ-opioid receptor (MOR). It exhibits EC50 values of 34.8 nM and 142 nM for MOR-βarr2 and MOR-mini-Gi, respectively. Isotodesnitazene can be utilized for research in opioid drugs.</p>Formula:C23H31N3OColor and Shape:SolidMolecular weight:365.51LIT-001 free base
CAS:<p>LIT-001, a nonpeptide OT-R agonist, enhances mouse autism-like behavior, with EC50=55 nM and Ki=226 nM.</p>Formula:C28H33N7O2SPurity:98%Color and Shape:SolidMolecular weight:531.67GC 14
CAS:<p>GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively.</p>Formula:C26H27NO6Purity:98%Color and Shape:SolidMolecular weight:449.5Metahexestrol
CAS:<p>Metahexestrol is an inhibitor of the estrogen receptor (E2R) with antitumor activity. It significantly inhibits the proliferation of estrogen receptor-positive MCF-7 human breast cancer cell line with an ED50 of 1.0 μM. Additionally, Metahexestrol shows inhibitory activity in estrogen receptor-negative MDA-MB-231 cell lines, and its antiproliferative effect is not reversed by estrogen, suggesting that its mechanism may be partially independent of the E2R pathway. Metahexestrol is applicable in research on estrogen-dependent breast cancer.</p>Formula:C18H22O2Color and Shape:SolidMolecular weight:270.366BMS-248360
CAS:<p>BMS-248360: Oral dual hAT1/hETA antagonist with Kis of 10nM & 1.9nM, respectively; treats hypertension.</p>Formula:C36H45N5O5SPurity:98%Color and Shape:SolidMolecular weight:659.84GDC-0927 Racemate
CAS:<p>GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM.</p>Formula:C28H28FNO4Purity:98%Color and Shape:SolidMolecular weight:461.52ID11916
CAS:<p>ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.</p>Formula:C29H27F3N8O3SColor and Shape:SolidMolecular weight:624.637ERRα antagonist-2
CAS:<p>ERRα antagonist-2 is an estrogen-related receptor α inverse agonist, inhibiting migration and invasion in ER-negative MDA-MB-231,breast cancer.</p>Formula:C19H16N2O6SPurity:99.26%Color and Shape:SolidMolecular weight:400.41BU72
CAS:<p>BU72 is a potent, long-lasting agonist for μ and κ opioid receptors, with partial agonistic activity at the δ opioid receptor (EC50 values of 0.054, 0.033, and 0.58 nM, respectively). It provides strong, enduring analgesic effects primarily mediated through μ opioid receptors. BU72 also exhibits a prolonged duration of activity and can partially reverse morphine-induced analgesia. It is applicable in studies of opioid dependence.</p>Formula:C28H32N2O2Color and Shape:SolidMolecular weight:428.57CH5447240
CAS:<p>CH5447240: potent hPTHR1 agonist, treats Hypoparathyroidism, EC50 12 nM, 55% oral bioavailability, raises rat serum calcium.</p>Formula:C26H39N5O4SPurity:98%Color and Shape:SolidMolecular weight:517.6822-Thiocyanatosalvinorin A
CAS:<p>22-Thiocyanatosalvinorin A (RB-64) is a potent selective agonist for the kappa-opioid receptor, exhibiting an EC50 value of 0.077 nM.</p>Formula:C24H27NO8SColor and Shape:SolidMolecular weight:489.54Novokinin
CAS:<p>Angiotensin AT2 receptor agonist</p>Formula:C39H61N11O7Purity:98%Color and Shape:SolidMolecular weight:795.97Anilopam
CAS:<p>Anilopam is an opioid analgesic belonging to the benzazepine class and acts as an agonist at opioid receptors.</p>Formula:C20H26N2OColor and Shape:SolidMolecular weight:310.435′-Guanidinonaltrindole
CAS:<p>5′-Guanidinonaltrindole (GNTI) is a selective antagonist of the kappa opioid receptor.</p>Formula:C27H29N5O3Color and Shape:SolidMolecular weight:471.551Naldemedine tosylate
CAS:<p>Naldemedine (S-297995) tosylate, a PAMORA, targets μ-, δ-, κ-opioid receptors, aiding OIC research, may bind to SARS-CoV2's 3CL pro.</p>Formula:C39H42N4O9SColor and Shape:SolidMolecular weight:742.84DS34942424
<p>DS34942424 is an orally potent analgesic which did not exhibit mu opioid receptor agonist activity.</p>Formula:C15H17FN2OColor and Shape:SolidMolecular weight:260.31KR31173
CAS:<p>KR31173 is an AT1 antagonist with an IC50 of 3.27 nM. When labeled with the 11C isotope, KR31173 can be used as a tracer for positron emission tomography (PET). In mice, KR31173 exhibits favorable biodistribution and pharmacological characteristics. It selectively binds to organs in CD-1 mice known to have a high density of AT1 angiotensin receptors.</p>Formula:C31H30N8O2Color and Shape:SolidMolecular weight:546.626β-Naltrexol
CAS:<p>6β-Naltrexol is a peripherally selective opioid antagonist that reduces constipation from opioids while minimizing central nervous system effects.</p>Formula:C20H25NO4Purity:99.933%Color and Shape:SolidMolecular weight:343.42Mu opioid receptor antagonist 8
CAS:<p>Muopioid Receptor Antagonist 8 (368) serves as an antagonist to the μ-opioid receptor, significantly inhibiting the activation of Gi induced by met-enkephalin at the µOR.</p>Formula:C36H35N3O4SColor and Shape:SolidMolecular weight:605.75Riminkefon
CAS:<p>Riminkefon is a kappa opioid receptor agonist .</p>Formula:C38H57N7O6Color and Shape:SolidMolecular weight:707.9(Rac)-Fidarestat
CAS:<p>(Rac)-Fidarestat ((Rac)-SNK 860) is the racemic form of Fidarestat, functioning as a potent inhibitor of the enzyme aldose reductase.</p>Formula:C12H10FN3O4Color and Shape:SolidMolecular weight:279.224EN171
CAS:<p>EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.</p>Formula:C17H22N2OColor and Shape:SolidMolecular weight:270.37Bromadoline
CAS:<p>Bromadoline is an opioid compound that exhibits anti-nociceptive properties in rodents.</p>Formula:C15H21BrN2OColor and Shape:SolidMolecular weight:325.244Estrogen receptor modulator 11
CAS:<p>Estrogen receptor modulator11 (Compound 27) is a tetrahydroisoquinoline derivative. It exhibits affinity for the estrogen receptor (ER), with IC50 values of 285 nM for ERα and 421 nM for ERβ. Estrogen receptor modulator11 does not demonstrate antagonist activity in MCF-7 cell assays.</p>Formula:C21H18FNOColor and Shape:SolidMolecular weight:319.372Triisopropyl phosphate
CAS:<p>Triisopropyl phosphate inhibits TFF1 and EGR3 gene expression and exhibits anti-estrogenic activity by suppressing Estradiol-induced proliferation of MCF-7 cells, with an EC50 of 341 μM. Additionally, Triisopropyl phosphate reduces estrogen response element (ERE)-stimulated luciferase activity in MVLN cells, with an EC50 of 900 μM.</p>Formula:C9H21O4PColor and Shape:SolidMolecular weight:224.234PBPE hydrochloride
CAS:<p>PBPE hydrochloride is a derivative of tamoxifen and functions as a selective ligand for antiestrogen binding sites (AEBS). The binding affinity (Ki) of PBPE hydrochloride and MBPE to AEBS is 8.79 nM and 17.57 nM, respectively.</p>Formula:C19H24ClNOColor and Shape:SolidMolecular weight:317.853AR antagonist 10
CAS:<p>AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.</p>Formula:C18H17ClN4O3SColor and Shape:SolidMolecular weight:404.871KNT-127
CAS:<p>KNT-127 is an agonist of δ-Opioid receptor.</p>Formula:C24H24N2O2Purity:98%Color and Shape:SolidMolecular weight:372.46EN1441
CAS:<p>EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.</p>Formula:C13H13ClN2O2Color and Shape:SolidMolecular weight:264.708AP5
CAS:<p>AP5: GPR40 agonist, positive allosteric modulator; rat hIP1 EC50: 0.49 nM.</p>Formula:C28H28FNO4Purity:98%Color and Shape:SolidMolecular weight:461.52Glucocorticoid receptor activator 1
CAS:<p>Glucocorticoid Receptor Activator 1, a phenyl nitrogen-heterocyclic precursor, acts as an activator of the glucocorticoid receptor (GR). By activating GR, it downregulates the expression of pro-inflammatory genes stimulated by TNF, making it useful for inflammation research.</p>Formula:C11H15Cl2NO2Color and Shape:SolidMolecular weight:264.15Androgen receptor antagonist 12
CAS:<p>Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.</p>Formula:C12H8F3N3O2Color and Shape:SolidMolecular weight:283.21Naltrindole 5′-isothiocyanate
CAS:<p>Naltrindole 5′-isothiocyanate (5'-NTII) is an irreversible delta opioid receptor antagonist that counters the analgesic effects induced by DSLET without altering the effects caused by DPDPE.</p>Formula:C27H25N3O3SColor and Shape:SolidMolecular weight:471.571LEO 134310
CAS:<p>LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.</p>Formula:C34H40N2O8Color and Shape:SolidMolecular weight:604.696:2 Cl-PFAES
CAS:<p>6:2 Cl-PFAES exhibits reproductive toxicity by elevating the levels of serum estradiol and vitellogenin in adult males, which can harm the embryonic development of offspring.</p>Formula:C8ClF16KO4SColor and Shape:SolidMolecular weight:570.67Urotensin-II receptor antagonist-1
CAS:<p>Urotensin-II receptor antagonist-1 (compound 1) is a human Urotensin II receptor antagonist with low oral bioavailability (F=0-3% in rats) and a Ki of 16 nM in HEK293 cells expressing human recombinant UT receptors. It inhibits cytochrome P450 enzymes (IC50=0.75 μM for CYP2D6; 1.4 μM for CYP3A4), suppresses κ opioid receptors (EC50=3.2 μM), and targets cardiac sodium channels (Ki=2.5 μM).</p>Formula:C25H31Cl2N3OColor and Shape:SolidMolecular weight:460.439SJ1008066
CAS:<p>SJ1008066 is a MAGE-A11 inhibitor with an IC50 of 0.13 μM. It binds to the MAGE homology domain (MHD) and disrupts the MAGE-A11:PCF11 interaction.</p>Formula:C21H22N4Color and Shape:SolidMolecular weight:330.43Glucocorticoid receptor agonist-5
CAS:<p>Glucocorticoid Receptoragonist-5 (compound 4) is an effective glucocorticoid molecule acting as a potent agonist for glucocorticoid receptors. It exhibits anti-inflammatory and immunosuppressive activities and serves as an ADC cytotoxin.</p>Formula:C36H40O7Color and Shape:SolidMolecular weight:584.722-Hydroxy mifepristone
CAS:<p>22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcohol metabolite that exhibits both anti-progestational and anti-glucocorticoid activities. This compound contains an alkyne group and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Furthermore, 22-Hydroxy Mifepristone demonstrates a relative binding affinity of 48% to the human glucocorticoid receptor.</p>Formula:C29H35NO3Color and Shape:SolidMolecular weight:445.59Galaxolide
CAS:<p>Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), oxidative stress, and genotoxicity. It also stimulates the enzymatic activities of EROD and GST (Glutathione S-transferase).</p>Formula:C18H26OColor and Shape:SolidMolecular weight:258.40Erα-IN-1
<p>Erα-IN-1 (compound 3c) is an inhibitor of the estrogen receptor α (ERα), effectively blocking ERα activity in MCF7/ERE-LUC cells.</p>Formula:C16H11FN2Color and Shape:SolidMolecular weight:250.27Estrogen receptor antagonist 7
CAS:<p>ER antagonist 7, compound 13, inhibits ERs, halts breast/ovarian cancer cell growth, has anticancer properties.</p>Formula:C23H17N3O4Color and Shape:SolidMolecular weight:399.4Amoitone B
CAS:<p>Amoitone B, a cystosporone B derivative, functions as an NR4A1 agonist and exhibits anticancer activity [1].</p>Formula:C22H34O5Color and Shape:SolidMolecular weight:378.5JDTic Dihydrochloride
CAS:<p>JDTic Dihydrochloride is a high-affinity and selective κ-opioid receptor (KOR) antagonist that blocks dynorphin-KOR signalling,antidepressant.</p>Formula:C28H41Cl2N3O3Purity:98%Color and Shape:SolidMolecular weight:538.55AR antagonist 11
CAS:<p>AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.</p>Formula:C20H17ClN2OColor and Shape:SolidMolecular weight:336.815ERβ agonist-1
CAS:<p>ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.</p>Formula:C25H36O2Color and Shape:SolidMolecular weight:368.55Androstatrione
CAS:<p>Androstatrione is an androgenic compound.</p>Formula:C19H26O3Color and Shape:SolidMolecular weight:302.41BNTX
CAS:<p>BNTX (7-Benzylidenenaltrexone) is a selective δ1-opioid receptor antagonist. It competitively counteracts the antisecretory effects of DPDPE, Deltorphin 2, and DAMGO. BNTX is applicable in research focused on antinociceptive effects.</p>Formula:C27H27NO4Color and Shape:SolidMolecular weight:429.508Estrogen receptor antagonist 4
CAS:<p>Estrogen receptor antagonist 4 blocks ER, impacting cell growth and cancer research potential.</p>Formula:C23H29BF4N4O2Color and Shape:SolidMolecular weight:480.31ORIC-101
CAS:<p>ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity.</p>Formula:C34H47NO2Purity:98%Color and Shape:SolidMolecular weight:501.74Estrone acetate
CAS:<p>Estrone acetate (Hogival) is an estrogen derivative and an activator of estrogen receptors (ER). This compound can enhance breast development, stimulate the secretion of pituitary prolactin, and induce both the proliferation and activation of lactotrophs, evidenced by the reduction in prolactin storage granule size and the increase in the volume density of the rough endoplasmic reticulum and Golgi apparatus. Estrone acetate holds potential for endocrinological research and for investigating the mechanisms by which estrogen influences pituitary function, prolactin regulation, and breast tumor models.</p>Formula:C20H24O3Color and Shape:SolidMolecular weight:312.403AP5 sodium
CAS:<p>AP5 sodium: potent oral GPR40 agonist, enhances ligands, may aid type II diabetes research.</p>Formula:C28H27FNNaO4Color and Shape:SolidMolecular weight:483.515AVE 0991
CAS:<p>AVE 0991 is a nonpeptide analog of angiotensin-(1-7), a Mas agonist with inhibitory effects on [125I]-Ang-(1-7) and on neuroinflammation in Alzheimer's disease.</p>Formula:C29H32N4O5S2Purity:98.69%Color and Shape:SolidMolecular weight:580.72BMS-986118
CAS:<p>BMS-986118 is a GPR40 full agonist targeting type II diabetes, prompting insulin release without hypoglycemia risk.</p>Formula:C25H28ClF3N4O4Purity:98%Color and Shape:SolidMolecular weight:540.96(±)-J 113397
CAS:<p>(±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist (K(i): cloned human ORL1=1.8 nM).</p>Formula:C24H37N3O2Color and Shape:SolidMolecular weight:399.57LX1
CAS:<p>LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.</p>Formula:C22H15F6NO2Color and Shape:SolidMolecular weight:439.35GLPG0492 (R enantiomer)
CAS:<p>GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator.</p>Formula:C19H14F3N3O3Color and Shape:SolidMolecular weight:389.33GPR81 agonist 2
CAS:<p>GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.</p>Formula:C26H27ClN6O5S2Color and Shape:SolidMolecular weight:603.11Dazucorilant
CAS:<p>Dazucorilant (CORT113176), a selective non-steroidal GR modulator, has high affinity with a K i <1 nM, useful for neurological research.</p>Formula:C29H22F4N4O3SColor and Shape:SolidMolecular weight:582.57TD-0212
CAS:<p>TD-0212: Oral dual antagonist for AT1 (pKi 8.9) & NEP inhibitor (pIC50 9.2).</p>Formula:C28H34FN3O4SPurity:98%Color and Shape:SolidMolecular weight:527.65LNS8801
CAS:<p>LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.</p>Formula:C21H18BrNO3Color and Shape:SolidMolecular weight:412.277C108297
CAS:<p>C108297: glucocorticoid modulator, combats diet obesity/inflammation, reduces appetite/lipid storage, boosts fat burn.</p>Formula:C30H36FN3O4SPurity:98%Color and Shape:SolidMolecular weight:553.69FSH receptor antagonist 1
CAS:<p>FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G(s) protein-coupled human follicle-stimulating hormone (FSH) receptor. It exhibits an IC50 value of 28 nM in cell lines expressing the human FSH receptor. This compound significantly inhibits follicle growth and ovulation in in vitro mouse models.</p>Formula:C33H32N2O2Color and Shape:SolidMolecular weight:488.619SDM25N hydrochloride
CAS:<p>δ receptor antagonist</p>Formula:C26H27ClN2O3Purity:98%Color and Shape:SolidMolecular weight:450.96Estrogen receptor-agonist-1
CAS:<p>Estrogen receptor-agonist-1 (compound 4e) is an estrogen receptor (ER) agonist that binds to ERα with high affinity.</p>Formula:C24H22N2O2Color and Shape:SolidMolecular weight:370.444ERRγ agonist-1
<p>ERRγ agonist-1 can be used in neuropsychological disorders research.</p>Formula:C17H21N5OColor and Shape:SolidMolecular weight:311.38TRβ agonist 1
CAS:<p>TRβ Agonist 1, a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, demonstrates an EC50 value of 21 nM.</p>Formula:C29H25FN2O8Color and Shape:SolidMolecular weight:548.52PD 134922
CAS:<p>PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.</p>Formula:C37H61N5O7SPurity:98%Color and Shape:SolidMolecular weight:719.97rel-SB-612111 hydrochloride
CAS:<p>NOP receptor antagonist</p>Formula:C24H30Cl3NOPurity:98%Color and Shape:SolidMolecular weight:454.86JNJ-1250132
CAS:<p>JNJ-1250132 is a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro.</p>Formula:C33H41NO4Color and Shape:SolidMolecular weight:515.68GPR84 antagonist 3
CAS:<p>Potent GPR84 antagonist 3 (compound 42), pIC50 8.28, inhibits GTPγS, with good pharmacokinetics.</p>Formula:C29H27N5OColor and Shape:SolidMolecular weight:461.56Androgen receptor degrader-5
CAS:<p>Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.</p>Formula:C29H25F4N5O2Color and Shape:SolidMolecular weight:551.53Sunobinop
CAS:<p>Sunobinop (S 117957) is an opioid receptor-like orphan receptor (ORL1) modulator.</p>Formula:C26H33N3O3Color and Shape:SolidMolecular weight:435.56Norbinaltorphimine dihydrochloride
CAS:<p>Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.</p>Formula:C40H45Cl2N3O6Purity:98.17% - 99.88%Color and Shape:SolidMolecular weight:734.71SC13
CAS:<p>SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects.</p>Formula:C26H30N2O5Color and Shape:SolidMolecular weight:450.53FL442
CAS:<p>FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).</p>Formula:C15H13F3N2OColor and Shape:SolidMolecular weight:294.27LY2066948
CAS:<p>LY2066948 is a selective oral estrogen receptor modulator (SERM) with high affinity for estrogen receptors ERα and ERβ (Ki of 0.51 and 1.36 nM, respectively) and displays potent anti-estrogenic activity. It effectively blocks the increase in uterine weight induced by ethinylestradiol in immature rats. LY2066948 is utilized in the research of uterine fibroids and myomas.</p>Formula:C30H31NO5SColor and Shape:SolidMolecular weight:517.64CCG258747
CAS:<p>CCG258747 is a novel, selective inhibitor of the GRK2 subfamily.</p>Formula:C28H27FN4O4Color and Shape:SolidMolecular weight:502.54MK-6913
CAS:<p>MK-6913 is a potent and selective agonist of estrogen receptor β.</p>Formula:C25H27N3O2Purity:98%Color and Shape:SolidMolecular weight:401.5Elacestrant S enantiomer dihydrochloride
<p>Elacestrant (RAD1901) dihydrochloride, an oral ERR degrader, has IC50 of 48 nM (ERα) and 870 nM (ERβ). Its S enantiomer has low activity.</p>Formula:C30H40Cl2N2O2Purity:98%Color and Shape:SolidMolecular weight:531.56A 74273
CAS:<p>A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition.</p>Formula:C44H74N4O8Purity:98%Color and Shape:SolidMolecular weight:787.08Estrogen receptor antagonist 6
CAS:<p>Estrogen receptor antagonist 6 is a potent blocker of estrogen signaling, regulating various biological effects. (Compound 166)</p>Formula:C25H31F3N2O3Color and Shape:SolidMolecular weight:464.52(+)-JJ-74-138
CAS:<p>(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).</p>Formula:C22H22F8N2OSColor and Shape:SolidMolecular weight:514.48Mu opioid receptor antagonist 4
<p>Compound 31: Potent, selective MOR antagonist; crosses blood-brain barrier; Ki & EC50: 0.38 nM; useful for OUD research.</p>Formula:C25H28N2O4SColor and Shape:SolidMolecular weight:452.57σ1 Receptor/μ Opioid receptor modulator 2
CAS:<p>Compound 4x, also known as σ1 Receptor/μOpioid receptormodulator 2, acts as a μOR agonist and a σ1R antagonist, exhibiting a potent μOR EC50 of 0.6 nM and strong σ1R inhibitory activity (Ki: 363.7 nM). It demonstrates significant analgesic effects in various pain models.</p>Formula:C23H31N3OMolecular weight:365.51RJG-2051
CAS:<p>RJG-2051 is a selective covalent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), with an IC50 value of 13 nM. It interferes with the metabolism of substrates such as androgens, estrogens, and prostaglandins through AKR1C3. RJG-2051 holds potential for cancer research.</p>Formula:C26H31N5O4SColor and Shape:SolidMolecular weight:509.62
