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IκB/IKK

IκB/IKK

The IκB/IKK complex is a key regulator of the NF-κB signaling pathway, which controls the expression of genes involved in immune responses, inflammation, and cell survival. IκB proteins inhibit NF-κB activity by sequestering it in the cytoplasm, while IKKs phosphorylate IκB, leading to its degradation and the activation of NF-κB. Dysregulation of the IκB/IKK pathway is linked to chronic inflammation, cancer, and autoimmune diseases. At CymitQuimica, we provide a selection of high-quality IκB/IKK modulators to support your research in signal transduction, inflammation, and therapeutic development.

Found 61 products of "IκB/IKK"

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  • IMD-0560
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    IMD-0560

    CAS:
    <p>IMD-0560 is a novel inhibitor of IκB kinase β.</p>
    Formula:C15H8BrF6NO2
    Purity:99.51%
    Color and Shape:Solid
    Molecular weight:428.12

    Ref: TM-T15564

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    Ac2-26 ammonium

    <p>Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.</p>
    Formula:C141H210N32O44S·xNH3
    Purity:95.58%
    Color and Shape:Solid
    Molecular weight:3089.43 (free base)

    Ref: TM-T78371

  • TBK1/IKKε-IN-2
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    TBK1/IKKε-IN-2

    CAS:
    <p>TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.</p>
    Formula:C26H27N5O3
    Purity:98.89%
    Color and Shape:Solid
    Molecular weight:457.52

    Ref: TM-T15559

  • BAY-985
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    BAY-985

    CAS:
    <p>BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.</p>
    Formula:C27H30F3N9O
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:553.58

    Ref: TM-T10477

  • Vinpocetine
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    Vinpocetine

    CAS:
    <p>Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).</p>
    Formula:C22H26N2O2
    Purity:99.85% - 99.98%
    Color and Shape:White Crystalline Solid
    Molecular weight:350.45

    Ref: TM-T0167

  • MRT67307
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    MRT67307

    CAS:
    <p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>
    Formula:C26H36N6O2
    Purity:99.25% - 99.84%
    Color and Shape:Solid
    Molecular weight:464.6

    Ref: TM-T0097

  • Siegesbeckialide I
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    Siegesbeckialide I

    <p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>
    Formula:C20H28O6
    Color and Shape:Solid
    Molecular weight:364.43

    Ref: TM-T72578

  • Verproside
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    Verproside

    CAS:
    <p>Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.</p>
    Formula:C22H26O13
    Color and Shape:Solid
    Molecular weight:498.437

    Ref: TM-T124745

  • TBK1/IKKε-IN-6
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    TBK1/IKKε-IN-6

    CAS:
    <p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>
    Formula:C31H36F2N8O4
    Color and Shape:Solid
    Molecular weight:622.678

    Ref: TM-T39841

  • IKK-IN-3
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    IKK-IN-3

    CAS:
    <p>IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).</p>
    Formula:C17H17N5S
    Color and Shape:Solid
    Molecular weight:323.42

    Ref: TM-T40700

  • HOIPIN-1
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    HOIPIN-1

    CAS:
    <p>HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 &gt;2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-</p>
    Formula:C17H13NaO4
    Purity:98.83%
    Color and Shape:Soild
    Molecular weight:304.27

    Ref: TM-T78557

  • LY2409881
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    LY2409881

    CAS:
    <p>LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.</p>
    Formula:C24H29ClN6OS
    Color and Shape:Solid
    Molecular weight:485.05

    Ref: TM-T41101

  • PS 1145 dihydrochloride
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    PS 1145 dihydrochloride

    CAS:
    <p>IκB kinase (IKK) inhibitor</p>
    Formula:C17H13Cl3N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:395.67

    Ref: TM-T23191

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    SU1261

    <p>SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200684

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    PROTAC STING degrader-4

    <p>PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).</p>
    Formula:C39H42Cl2N8O9
    Color and Shape:Solid
    Molecular weight:836.24518

    Ref: TM-T207609

  • ML 120B dihydrochloride
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    ML 120B dihydrochloride

    CAS:
    <p>MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.</p>
    Formula:C19H17Cl3N4O2
    Color and Shape:Solid
    Molecular weight:439.72

    Ref: TM-T39199

  • IKK 16 hydrochloride
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    IKK 16 hydrochloride

    CAS:
    <p>IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.</p>
    Formula:C28H30ClN5OS
    Color and Shape:Solid
    Molecular weight:520.09

    Ref: TM-T15557

  • GSK8612
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    GSK8612

    CAS:
    <p>GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .</p>
    Formula:C17H17BrF3N7O2S
    Purity:99.46% - 99.8%
    Color and Shape:Solid
    Molecular weight:520.33

    Ref: TM-T5540

  • AZD3264
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    AZD3264

    CAS:
    <p>AZD3264 is a new type IKK2 inhibitor.</p>
    Formula:C21H23N5O4S
    Purity:98.98% - 99.17%
    Color and Shape:Solid
    Molecular weight:441.5

    Ref: TM-T6771

  • MLN120B
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    MLN120B

    CAS:
    <p>MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).</p>
    Formula:C19H15ClN4O2
    Purity:98.92%
    Color and Shape:Solid
    Molecular weight:366.8

    Ref: TM-TQ0306