IκB/IKK
The IκB/IKK complex is a key regulator of the NF-κB signaling pathway, which controls the expression of genes involved in immune responses, inflammation, and cell survival. IκB proteins inhibit NF-κB activity by sequestering it in the cytoplasm, while IKKs phosphorylate IκB, leading to its degradation and the activation of NF-κB. Dysregulation of the IκB/IKK pathway is linked to chronic inflammation, cancer, and autoimmune diseases. At CymitQuimica, we provide a selection of high-quality IκB/IKK modulators to support your research in signal transduction, inflammation, and therapeutic development.
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BAY-985
CAS:2409479-29-2
BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.
Formula:
C27H30F3N9O
Purity:
99.62%
Color and Shape:
Solid
Molecular weight:
553.58
Ref: TM-T10477
| 1mg | 169.00 € | ||
| 5mg | 346.00 € | ||
| 10mg | 554.00 € | ||
| 25mg | 889.00 € | ||
| 50mg | 1,198.00 € | ||
| 100mg | 1,613.00 € | ||
| 1mL*10mM (DMSO) | 428.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
TBK1/IKKε-IN-2
CAS:1292310-49-6
TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.
Formula:
C26H27N5O3
Purity:
98.89%
Color and Shape:
Solid
Molecular weight:
457.52
Ref: TM-T15559
| 1mg | 90.00 € | ||
| 5mg | 184.00 € | ||
| 10mg | 299.00 € | ||
| 25mg | 476.00 € | ||
| 50mg | 645.00 € | ||
| 100mg | 827.00 € | ||
| 1mL*10mM (DMSO) | 187.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Vinpocetine
CAS:42971-09-5
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
Formula:
C22H26N2O2
Purity:
100%
Color and Shape:
White Crystalline Solid
Molecular weight:
350.45
Ref: TM-T0167
| 25mg | 35.00 € | ||
| 50mg | 47.00 € | ||
| 100mg | 59.00 € | ||
| 200mg | 79.00 € | ||
| 500mg | 142.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
IMD-0560
CAS:439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
Formula:
C15H8BrF6NO2
Purity:
99.51%
Color and Shape:
Solid
Molecular weight:
428.12
Ref: TM-T15564
| 1mg | 43.00 € | ||
| 5mg | 93.00 € | ||
| 10mg | 135.00 € | ||
| 25mg | 236.00 € | ||
| 50mg | 354.00 € | ||
| 100mg | 485.00 € | ||
| 200mg | 667.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
MRT67307
CAS:1190378-57-4
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.
Formula:
C26H36N6O2
Purity:
99.25% - 99.79%
Color and Shape:
Solid
Molecular weight:
464.6
Ref: TM-T0097
| 1mg | 40.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 123.00 € | ||
| 25mg | 235.00 € | ||
| 50mg | 451.00 € | ||
| 100mg | 643.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
ACHP
CAS:406208-42-2
ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects …
Formula:
C21H24N4O2
Purity:
98.66%
Color and Shape:
Solid
Molecular weight:
364.44
Ref: TM-T22021
| 1mg | 52.00 € | ||
| 5mg | 105.00 € | ||
| 10mg | 157.00 € | ||
| 25mg | 251.00 € | ||
| 50mg | 367.00 € | ||
| 100mg | 625.00 € | ||
| 200mg | 1,019.00 € | ||
| 500mg | 2,037.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Cudraflavone B
CAS:19275-49-1
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in …
Formula:
C25H24O6
Purity:
98%
Color and Shape:
Solid
Molecular weight:
420.45
Ref: TM-TN3726
| 1mg | To inquire | ||
| 5mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
Physalin O
CAS:120849-18-5
Physalin O has anti-inflammatory properties, binds with GSH, and inhibits NO production.
Formula:
C28H32O10
Purity:
98%
Color and Shape:
Solid
Molecular weight:
528.554
Ref: TM-TN4779
| 5mg | 850.00 € | ||
| 1mL*10mM (DMSO) | 1,293.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Goshonoside F5
CAS:90851-28-8
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both …
Formula:
C32H54O13
Purity:
98%
Color and Shape:
Solid
Molecular weight:
646.771
Ref: TM-TN4162
| 1mg | 357.00 € | ||
| 5mg | 1,756.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Isophysalin A
CAS:1363398-67-7
Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant …
Formula:
C28H30O10
Purity:
98%
Color and Shape:
Solid
Molecular weight:
526.53
Ref: TM-TN4318
| 5mg | 812.00 € | ||
| 1mL*10mM (DMSO) | 1,227.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Selinidin
CAS:19427-82-8
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
Formula:
C19H20O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
328.364
Ref: TM-TN4986
| 5mg | 510.00 € | ||
| 1mL*10mM (DMSO) | 519.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
TBK1/IKKε-IN-5
CAS:1893397-65-3
TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).
Formula:
C28H31N7O3
Purity:
98.77%
Color and Shape:
Solid
Molecular weight:
513.59
Ref: TM-T7951
| 1mg | 90.00 € | ||
| 5mg | 186.00 € | ||
| 10mg | 273.00 € | ||
| 25mg | 437.00 € | ||
| 50mg | 598.00 € | ||
| 100mg | 851.00 € | ||
| 200mg | 1,144.00 € | ||
| 1mL*10mM (DMSO) | 227.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
BX795
CAS:702675-74-9
BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over …
Formula:
C23H26IN7O2S
Purity:
98% - 99.57%
Color and Shape:
Solid
Molecular weight:
591.47
Ref: TM-T1830
| 5mg | 58.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 206.00 € | ||
| 50mg | 335.00 € | ||
| 100mg | 502.00 € | ||
| 200mg | 727.00 € | ||
| 500mg | 1,096.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:4815-35-4
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
Formula:
C11H10N2OS
Purity:
99.48%
Color and Shape:
Solid
Molecular weight:
218.27
Ref: TM-T8910
| 5mg | 35.00 € | ||
| 10mg | 52.00 € | ||
| 25mg | 82.00 € | ||
| 50mg | 109.00 € | ||
| 100mg | 163.00 € | ||
| 200mg | 237.00 € | ||
| 1mL*10mM (DMSO) | 41.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
MLN120B
CAS:783348-36-7
MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).
Formula:
C19H15ClN4O2
Purity:
98.92%
Color and Shape:
Solid
Molecular weight:
366.8
Ref: TM-TQ0306
| 1mg | 49.00 € | ||
| 2mg | 69.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 157.00 € | ||
| 25mg | 323.00 € | ||
| 50mg | 557.00 € | ||
| 100mg | 759.00 € | ||
| 1mL*10mM (DMSO) | 116.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
AZD3264
CAS:1609281-86-8
AZD3264 is a new type IKK2 inhibitor.
Formula:
C21H23N5O4S
Purity:
98.98% - 99.17%
Color and Shape:
Solid
Molecular weight:
441.5
Ref: TM-T6771
| 1mg | 52.00 € | ||
| 2mg | 70.00 € | ||
| 5mg | 102.00 € | ||
| 10mg | 159.00 € | ||
| 25mg | 308.00 € | ||
| 50mg | 496.00 € | ||
| 100mg | 795.00 € | ||
| 500mg | 1,569.00 € | ||
| 1mL*10mM (DMSO) | 113.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Dehydrocostus Lactone
CAS:477-43-0
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.
Formula:
C15H18O2
Purity:
98.15% - 99.86%
Color and Shape:
Solid
Molecular weight:
230.3
Ref: TM-T2833
| 5mg | 46.00 € | ||
| 10mg | 69.00 € | ||
| 25mg | 123.00 € | ||
| 50mg | 198.00 € | ||
| 100mg | 305.00 € | ||
| 500mg | 733.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
INH14
CAS:200134-22-1
INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for …
Formula:
C15H16N2O
Purity:
95.41%
Color and Shape:
Solid
Molecular weight:
240.3
Ref: TM-T5209
| 2mg | 37.00 € | ||
| 5mg | 54.00 € | ||
| 10mg | 81.00 € | ||
| 25mg | 117.00 € | ||
| 50mg | 203.00 € | ||
| 100mg | 302.00 € | ||
| 200mg | 435.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
GSK8612
CAS:2361659-62-1
GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .
Formula:
C17H17BrF3N7O2S
Purity:
99.46% - ≥98%
Color and Shape:
Solid
Molecular weight:
520.33
Ref: TM-T5540
| 1mg | 46.00 € | ||
| 2mg | 59.00 € | ||
| 5mg | 91.00 € | ||
| 10mg | 128.00 € | ||
| 25mg | 210.00 € | ||
| 50mg | 369.00 € | ||
| 100mg | 555.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SC-514
CAS:354812-17-2
SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent …
Formula:
C9H8N2OS2
Purity:
100% - 99.88%
Color and Shape:
Solid
Molecular weight:
224.3
Ref: TM-T2118
| 5mg | 40.00 € | ||
| 10mg | 53.00 € | ||
| 25mg | 87.00 € | ||
| 50mg | 114.00 € | ||
| 100mg | 169.00 € | ||
| 500mg | 430.00 € | ||
| 1mL*10mM (DMSO) | 37.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
