IκB/IKK
The IκB/IKK complex is a key regulator of the NF-κB signaling pathway, which controls the expression of genes involved in immune responses, inflammation, and cell survival. IκB proteins inhibit NF-κB activity by sequestering it in the cytoplasm, while IKKs phosphorylate IκB, leading to its degradation and the activation of NF-κB. Dysregulation of the IκB/IKK pathway is linked to chronic inflammation, cancer, and autoimmune diseases. At CymitQuimica, we provide a selection of high-quality IκB/IKK modulators to support your research in signal transduction, inflammation, and therapeutic development.
Found 58 products of "IκB/IKK"
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Ac2-26 ammonium
Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.Formula:C141H210N32O44S·xNH3Purity:95.58%Color and Shape:SolidMolecular weight:3089.43 (free base)BAY-985
CAS:BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Formula:C27H30F3N9OPurity:99.62%Color and Shape:SolidMolecular weight:553.58Ref: TM-T10477
1mg163.00€5mg334.00€10mg502.00€25mg853.00€50mg1,161.00€100mg1,558.00€1mL*10mM (DMSO)408.00€TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Formula:C26H27N5O3Purity:98.89%Color and Shape:SolidMolecular weight:457.52Ref: TM-T15559
1mg87.00€5mg178.00€10mg289.00€25mg462.00€50mg625.00€100mg802.00€1mL*10mM (DMSO)178.00€IMD-0560
CAS:IMD-0560 is a novel inhibitor of IκB kinase β.Formula:C15H8BrF6NO2Purity:99.51%Color and Shape:SolidMolecular weight:428.12Vinpocetine
CAS:Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Formula:C22H26N2O2Purity:99.85% - 99.98%Color and Shape:White Crystalline SolidMolecular weight:350.45LY2409881
CAS:LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.Formula:C24H29ClN6OSColor and Shape:SolidMolecular weight:485.05PS 1145 dihydrochloride
CAS:IκB kinase (IKK) inhibitorFormula:C17H13Cl3N4OPurity:98%Color and Shape:SolidMolecular weight:395.67Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.Formula:C20H28O6Color and Shape:SolidMolecular weight:364.43SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Color and Shape:Odour SolidIKK-IN-3
CAS:IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).Formula:C17H17N5SColor and Shape:SolidMolecular weight:323.42TBK1/IKKε-IN-6
CAS:TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Formula:C31H36F2N8O4Color and Shape:SolidMolecular weight:622.678PROTAC STING degrader-4
PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).Formula:C39H42Cl2N8O9Color and Shape:SolidMolecular weight:836.24518Verproside
CAS:Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.Formula:C22H26O13Color and Shape:SolidMolecular weight:498.437MRT67307
CAS:Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Formula:C26H36N6O2Purity:99.25% - 99.84%Color and Shape:SolidMolecular weight:464.6HOIPIN-1
CAS:HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Formula:C17H13NaO4Purity:98.65%Color and Shape:SoildMolecular weight:304.27IKK 16 hydrochloride
CAS:IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.Formula:C28H30ClN5OSColor and Shape:SolidMolecular weight:520.09ML 120B dihydrochloride
CAS:MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.Formula:C19H17Cl3N4O2Color and Shape:SolidMolecular weight:439.72MLN120B
CAS:MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Formula:C19H15ClN4O2Purity:98.92%Color and Shape:SolidMolecular weight:366.8Ref: TM-TQ0306
1mg49.00€2mg70.00€5mg96.00€10mg160.00€25mg329.00€50mg567.00€100mg777.00€1mL*10mM (DMSO)116.00€AZD3264
CAS:AZD3264 is a new type IKK2 inhibitor.Formula:C21H23N5O4SPurity:98.98% - 99.17%Color and Shape:SolidMolecular weight:441.5Ref: TM-T6771
1mg52.00€2mg70.00€5mg103.00€10mg160.00€25mg311.00€50mg502.00€100mg805.00€500mg1,605.00€1mL*10mM (DMSO)114.00€GSK8612
CAS:GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .Formula:C17H17BrF3N7O2SPurity:99.68% - 99.99%Color and Shape:SolidMolecular weight:520.33SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Formula:C9H8N2OS2Purity:99.88% - >99.99%Color and Shape:SolidMolecular weight:224.3BMS-345541
CAS:BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Formula:C14H17N5Purity:99.36% - 99.74%Color and Shape:SolidMolecular weight:255.32TBK1/IKKε-IN-5
CAS:TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).Formula:C28H31N7O3Purity:98.77%Color and Shape:SolidMolecular weight:513.59Ref: TM-T7951
1mg88.00€5mg182.00€10mg269.00€25mg429.00€50mg587.00€100mg837.00€200mg1,125.00€1mL*10mM (DMSO)224.00€JTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Formula:C17H13NaO4Purity:99.95%Color and Shape:SolidMolecular weight:304.27Ref: TM-T8951
1mg37.00€2mg50.00€5mg65.00€10mg95.00€25mg210.00€50mg339.00€100mg495.00€500mg1,099.00€1mL*10mM (DMSO)77.00€2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
Formula:C11H10N2OSPurity:99.48%Color and Shape:SolidMolecular weight:218.27BMS-345541 hydrochloride
CAS:BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Formula:C14H18ClN5Purity:99.13%Color and Shape:SolidMolecular weight:291.78Ref: TM-T8542
1mg38.00€2mg50.00€5mg82.00€10mg119.00€25mg212.00€50mg356.00€100mg533.00€1mL*10mM (DMSO)52.00€BOT-64
CAS:BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFormula:C15H15NO2SPurity:99.73%Color and Shape:SolidMolecular weight:273.35Ref: TM-T8705
1mg50.00€5mg110.00€10mg170.00€25mg323.00€50mg494.00€100mg665.00€200mg893.00€1mL*10mM (DMSO)102.00€IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Formula:C15H8ClF6NO2Purity:99.65% - 99.98%Color and Shape:SolidMolecular weight:383.67Ref: TM-T6141
2mg46.00€5mg63.00€10mg87.00€25mg155.00€50mg210.00€100mg294.00€500mg713.00€1mL*10mM (DMSO)65.00€NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFormula:C31H30O8Purity:99.03%Color and Shape:SolidMolecular weight:530.57Ref: TM-T9105
1mg166.00€5mg341.00€10mg550.00€25mg898.00€50mg1,216.00€100mg1,644.00€1mL*10mM (DMSO)398.00€INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Formula:C15H16N2OPurity:95.41%Color and Shape:SolidMolecular weight:240.3GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formula:C22H19N3O5S2Purity:98.42%Color and Shape:SolidMolecular weight:469.53BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Formula:C10H7NO3Purity:96.48% - 97%Color and Shape:Yellow Crystalline PowderMolecular weight:189.17Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H25N3O4Purity:98%Color and Shape:SolidMolecular weight:395.45Ertiprotafib
CAS:Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.
Formula:C31H27BrO3SPurity:98.70%Color and Shape:SolidMolecular weight:559.51TBK1/IKKε-IN-4
CAS:TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nMFormula:C28H35N7O4Color and Shape:SolidMolecular weight:533.62PHA-408
CAS:PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.Formula:C29H27ClFN7O2Purity:98%Color and Shape:SolidMolecular weight:560.02DMX-129
CAS:DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Formula:C19H17FN8Color and Shape:SolidMolecular weight:376.39IKK2-IN-4
CAS:IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Formula:C12H11N3O2SPurity:99.83%Color and Shape:SolidMolecular weight:261.3Ref: TM-T36524
1mg108.00€5mg261.00€10mg401.00€25mg622.00€50mg837.00€100mg1,125.00€200mg1,504.00€500µg82.00€1-Dehydro-[10]-gingerdione
CAS:1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.Formula:C21H30O4Color and Shape:SolidMolecular weight:346.46CS12192
CAS:CS12192 enhances survival, boosts weight, and shows promise in GVHD research per patent CN112773802A.Formula:C25H23ClFN7O2Color and Shape:SolidMolecular weight:507.95HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Formula:C19H16ClN3O3SPurity:98.07% - 98.17%Color and Shape:SolidMolecular weight:401.87Ref: TM-T11573
2mg137.00€5mg222.00€10mg356.00€25mg708.00€50mg1,063.00€100mg1,603.00€200mg2,187.00€1mL*10mM (DMSO)245.00€CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formula:C22H21N3O6S2Color and Shape:SolidMolecular weight:487.55Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H26ClN3O4Color and Shape:SolidMolecular weight:431.91IKKβ-IN-1
CAS:IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).Formula:C31H30N4O4SColor and Shape:SolidMolecular weight:554.66CGA-JK3
CAS:CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.Formula:C15H19NO3Purity:98%Color and Shape:SolidMolecular weight:261.32(Rac)-BAY-985
CAS:(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Formula:C27H30F3N9OPurity:98%Color and Shape:SolidMolecular weight:553.58Bay 65-1942 (R form)
CAS:Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.Formula:C22H25N3O4Purity:98%Color and Shape:SolidMolecular weight:395.45IKK-IN-1
CAS:IKK-IN-1 is an inhibitor of IKK.Formula:C22H26ClN3O4Purity:98%Color and Shape:SolidMolecular weight:431.91ACHP Hydrochloride
CAS:ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Formula:C21H25ClN4O2Purity:99.83%Color and Shape:SolidMolecular weight:400.9Ref: TM-T10237
1mg66.00€5mg144.00€10mg227.00€25mg375.00€50mg540.00€100mg777.00€500mg1,549.00€1mL*10mM (DMSO)159.00€IKK-IN-4
CAS:IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].Formula:C18H19N5SColor and Shape:SolidMolecular weight:337.44PF-184
PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.Formula:C32H32ClFN6O4Color and Shape:SolidMolecular weight:619.09Glabrescone C
CAS:Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.
Formula:C19H22O7Color and Shape:SolidMolecular weight:362.37TBK1-IN-1
CAS:TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formula:C27H37N7O2Purity:99.81% - >99.99%Color and Shape:SolidMolecular weight:491.63Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.Formula:C22H20O12Color and Shape:SolidMolecular weight:476.39BMS-066
CAS:BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.Formula:C19H21N7O2Purity:98%Color and Shape:SolidMolecular weight:379.42GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formula:C22H20O8Color and Shape:SolidMolecular weight:412.39TBK1/IKKε-IN-1
CAS:TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Formula:C28H26N4O5Purity:98%Color and Shape:SolidMolecular weight:498.53
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