Nrf2
Nrf2 is a transcription factor that regulates the expression of antioxidant proteins and detoxification enzymes, playing a pivotal role in cellular defense against oxidative stress and inflammation. Activation of Nrf2 signaling provides protection against various diseases, including cancer, neurodegeneration, and cardiovascular disorders. Nrf2 modulators are being explored for their potential therapeutic applications in reducing oxidative damage and inflammation. At CymitQuimica, we provide a range of high-quality Nrf2 pathway modulators to support your research in oxidative stress, inflammation, and disease prevention.
Found 84 products for "Nrf2".
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BPK-29
CAS:BPK-29 disrupts NR0B1 binding and modifies C274, inhibiting growth in KEAP1-mutant cancers.Formula:C26H32ClN3O3Purity:98%Color and Shape:SolidMolecular weight:470AI-3
CAS:Nrf2/Keap1 and Keap1/Cul3 interaction inhibitorFormula:C11H13ClO3S2Purity:98%Color and Shape:SolidMolecular weight:292.8WN1316
CAS:WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS).Formula:C20H26Cl3N5OColor and Shape:SolidMolecular weight:458.81Dihydrolipoic acid
CAS:Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.Formula:C8H16O2S2Purity:97.51%Color and Shape:Yellow To Orange LiquidMolecular weight:208.34K67
CAS:K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.Formula:C29H30N2O7S2Purity:98.43%Color and Shape:Yellow SolidMolecular weight:582.688DDO-7263
CAS:DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.Formula:C14H9F2N3OPurity:99.85%Color and Shape:White SolidMolecular weight:273.2376Nrf2 activator-7
CAS:Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.Formula:C35H32N2O11S2Color and Shape:SolidMolecular weight:720.77Nrf2-IN-1
CAS:Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Formula:C21H22ClN3O2Purity:95.00% - 99.68%Color and Shape:SolidMolecular weight:383.871WRR139
CAS:WRR139 is an NGLY1 inhibitor that impairs Nrf1 processing and sensitizes cancer cells to proteasome inhibitors.Formula:C25H32N2O4SPurity:99.90%Color and Shape:White SolidMolecular weight:456.6Keap1-Nrf2-IN-16
CAS:Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.Formula:C73H114N16O26Color and Shape:SolidMolecular weight:1631.78Keap1-Nrf2-IN-15
CAS:Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescenceFormula:C39H35N3O12S2Color and Shape:SolidMolecular weight:801.84Keap1-IN-1
Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.Formula:C17H21Cl2N2O5PS3Color and Shape:SolidMolecular weight:531.434Nrf2-IN-3
CAS:Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.Formula:C22H26N4O4SPurity:97.75%Color and Shape:SolidMolecular weight:442.53Nrf2 degrader 1
CAS:Nrf2 degrader 1 is a PROTAC degrading Nrf2, inhibiting A549 and LK-2 cells (IC₅₀ = 100 nM and 40 nM).Formula:C45H42N6O8SColor and Shape:SolidMolecular weight:826.92CPDT
CAS:CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Formula:C6H6S3Color and Shape:SolidMolecular weight:174.307Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Formula:C20H17BrO3Color and Shape:SolidMolecular weight:385.25Keap1-Nrf2-IN-3
CAS:Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.Formula:C31H34N6O3Color and Shape:SolidMolecular weight:538.652Keap1-Nrf2-IN-5
CAS:Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Formula:C23H30N4O6SColor and Shape:SolidMolecular weight:490.57NFE2L2 activator 3
CAS:NFE2L2 activator 3 (Compound 3) is an activator of NFE2L2/NRF2, specifically enhancing the activity of NAD(P)H:quinone oxidoreductase (NQO1), with an EC50 of less than 1 nM. It is useful for researching respiratory diseases such as chronic obstructive pulmonary disease.Formula:C29H33ClN4O5S2Molecular weight:617.18CYP2E1-IN-1
CAS:CYP2E1-IN-1 (Compound 10) is an orally active inhibitor of cytochrome P450 2E1 (CYP2E1) with a dissociation constant (Kd) of 7.02 μM, an IC50 of 1.64 μM, and a Ki of 0.897 μM. It alleviates pancreatic damage by activating the Nrf2/HO-1 signaling pathway and inhibiting ROS production. CYP2E1-IN-1 demonstrates significant anti-inflammatory and antioxidant properties, effectively reducing inflammation and oxidative stress in severe acute pancreatitis (SAP). It is suitable for the study of SAP and other inflammation-related conditions.Formula:C6H7NOSMolecular weight:141.191
