TLR
Toll-like receptors (TLRs) are a class of proteins that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. TLRs are involved in detecting a wide range of pathogens, including bacteria, viruses, and fungi, and are essential for the activation of inflammatory signaling pathways. Dysregulation of TLR signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. At CymitQuimica, we offer a variety of high-quality TLR modulators to support your research in innate immunity, inflammation, and infectious disease.
Found 88 products for "TLR".
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BMS-905
CAS:BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Formula:C23H29N3Purity:99.94%Color and Shape:White SolidMolecular weight:347.5CU-CPT22
CAS:CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Formula:C19H22O7Purity:98.66% - 99.80%Color and Shape:Red SolidMolecular weight:362.37Ref: TM-T15020
1mg49.00€2mg66.00€5mg94.00€1mL*10mM (DMSO)108.00€10mg159.00€25mg296.00€50mg444.00€100mg647.00€200mg888.00€CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Formula:C17H13F3N4O2Purity:99.84%Color and Shape:SolidMolecular weight:362.31Ref: TM-T15017
1mg50.00€5mg105.00€1mL*10mM (DMSO)117.00€10mg160.00€25mg268.00€50mg409.00€100mg583.00€TLR7/8 agonist 3
CAS:TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.Formula:C17H23N5OPurity:99.84%Color and Shape:SolidMolecular weight:313.4Ref: TM-T13167
1mg60.00€5mg133.00€1mL*10mM (DMSO)147.00€10mg215.00€25mg349.00€50mg482.00€100mg665.00€200mg893.00€CU-CPT17e
CAS:CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Formula:C27H24N2O8Purity:98.49%Color and Shape:White SolidMolecular weight:504.49TLR8 agonist 8
CAS:TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.Formula:C53H63N11O10Color and Shape:SolidMolecular weight:1014.14Pam2CSK4
CAS:TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.Formula:C65H126N10O12SPurity:98%Color and Shape:SolidMolecular weight:1271.83TLR8 agonist 7
CAS:TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.Formula:C54H63N9O16Color and Shape:SolidMolecular weight:1094.13TLR2 antagonist-1
TLR2antagonist-1 is a selective antagonist of Toll-like receptor 2 (TLR2). It effectively inhibits excessive activation of TLR2, with an IC50 value of 11.41 μM, and reduces the production of inflammatory factors. TLR2antagonist-1 exhibits metabolic stability, with a half-life (T1/2) of 16.67 minutes in mouse liver microsomes. This compound is useful for research in inflammation, immunology, and neurological disorders.TLR7 agonist 21
TLR7 agonist21 (Compound 27B) is a selective activator of Toll-like receptor 7 (TLR7), with an EC50 of 17.53 nM for human TLR7 and 41.7 nM for mouse TLR7. It induces the secretion of pro-inflammatory cytokines, including IL-6, TNF-α, IFN-α1, and IL-4. Acting as a vaccine adjuvant, TLR7 agonist21 enhances IgG and IgA levels, offering protection for mice against influenza virus infection.Formula:C22H33N7OMolecular weight:411.27466Pam3CSK4
CAS:Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.Formula:C81H156N10O13SPurity:98%Color and Shape:SolidMolecular weight:1510.23TLR7 agonist 20 hydrochloride
TLR7 agonist20 hydrochloride is an imidazoquinoline analog that functions as a potent and specific agonist for TLR7, with an EC50 value of 0.23 μM against hTLR7. It demonstrates strong adjuvant activity in enhancing spike antibody levels and induces a robust T helper cell 1 (Th1) response. Additionally, it increases levels of IgG2b and IgG2c, aside from IgG1.Formula:C22H25ClN4OMolecular weight:396.91PTD-N5-1
CAS:PTD-N5-1 (N5-1) is an IRF5 inhibitory peptide. It can block the production of IL-12 induced by β-glucan in both wild-type and Clec2d-deficient bone marrow-derived dendritic cells (BMDC) that are activated by IFN-γ. PTD-N5-1 modulates antifungal immunity by inhibiting IRF5-mediated IL-12 production.Formula:C148H248N52O30SColor and Shape:SolidMolecular weight:3267.95Pam3CSK4-Biotin
CAS:Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.Formula:C103H192N14O17S2Purity:98%Color and Shape:SolidMolecular weight:1962.85CRX 527
CAS:CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.Formula:C81H151N2O19PColor and Shape:SolidMolecular weight:1488.04Ezeprogind
CAS:Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can TrustFormula:C25H44N6Purity:99.28%Color and Shape:White SolidMolecular weight:428.66MTT5
MTT5, a toll-like receptor 7 (TLR7) agonist, can be conjugated with Deruxtecan to exert antitumor activity in HER2-positive solid tumors through tumor cell killing and immune activation.Formula:C22H27N7O4Color and Shape:SolidMolecular weight:453.49TLR7/8 agonist 11
TLR7/8 agonist 11 (compound 30) serves as a powerful agonist for hTLR7 and hTLR8, exhibiting EC50 values of 31.1 nM and 13.1 nM, respectively. This compound is crucial in the functioning of both adaptive and innate immune responses.Formula:C28H38N8O2Molecular weight:518.65TLR7 agonist 26
CAS:TLR7 agonist26 (Compound 4) serves as an effective Toll-like receptor7 (TLR7) agonist with an EC50 value of 225.5 nM. It exhibits immunopotentiating effects.Formula:C17H19N5O4Molecular weight:357.36MTvkPABC-P5 TFA
MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).Color and Shape:Odour Solid
