TGF-beta/Smad
TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.
Found 58 products of "TGF-beta/Smad"
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Garetosmab
CAS:<p>Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.</p>Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:146 kDaOxymatrine
CAS:<p>Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.</p>Formula:C15H24N2O2Purity:98.72% - 99.72%Color and Shape:SolidMolecular weight:264.36Ponsegromab
CAS:<p>Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.</p>Purity:100% (SEC-HPLC) - > 95%Color and Shape:LiquidMolecular weight:146.08 kDaHydrochlorothiazide
CAS:<p>Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。</p>Formula:C7H8ClN3O4S2Purity:99.43% - 99.50%Color and Shape:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Molecular weight:297.74Isoviolanthin
CAS:<p>Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal cells, potential HCC therapy.</p>Formula:C27H30O14Purity:99.25% - 99.66%Color and Shape:SolidMolecular weight:578.52Tubastatin
CAS:<p>Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.</p>Formula:C21H22N2O2Purity:98.23%Color and Shape:SolidMolecular weight:334.41Emugrobart
<p>Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Color and Shape:Odour LiquidCBT-295
<p>CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and IL-6, along with the bile duct proliferation marker CK-19, and ameliorates liver fibrosis. The compound's ability to reverse liver fibrosis contributes to lowered ammonia levels in the blood and brain, which in turn reduces ammonia-induced neuroinflammation. CBT-295 shows potential for the study of liver cirrhosis and related encephalopathy.</p>Formula:C18H20ClN3OColor and Shape:SolidMolecular weight:329.82Linavonkibart
CAS:<p>Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.</p>Purity:97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Color and Shape:LiquidSotatercept
CAS:<p>Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.</p>Purity:97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Color and Shape:LiquidFresolimumab
CAS:<p>Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.</p>Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:144.4 kDaALK5-IN-83
<p>ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.</p>Formula:C20H23N7O2SColor and Shape:SolidMolecular weight:425.51TGFβRI-IN-7
<p>TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.</p>Formula:C27H32N6O2Color and Shape:SolidMolecular weight:472.582Cirevetmab
CAS:<p>Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.</p>Color and Shape:LiquidSLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:<p>SLLK is a control peptide for LSKL.</p>Formula:C21H41N5O6Purity:98%Color and Shape:SolidMolecular weight:459.58Rilogrotug
<p>Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Color and Shape:Odour LiquidLerdelimumab
CAS:<p>Lerdelimumab (CAT-152) is an IgG4 monoclonal antibody targeting TGF-β2, used in glaucoma scarring research.</p>Color and Shape:LiquidBintrafusp alfa
CAS:<p>Bintrafusp alfa (M7824) is a protein consisting of the extracellular structural domain of TGF-βRII with a monoclonal antibody to human immunoglobulin G1.</p>Purity:96.1% (SDS-PAGE); 99.2% (SEC-HPLC) - 96.1% (SDS-PAGE); 99.2% (SEC-HPLC)Color and Shape:LiquidSD-208
CAS:<p>SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.</p>Formula:C17H10ClFN6Purity:98.72% - 99.65%Color and Shape:SolidMolecular weight:352.75SRI-011381 hydrochloride
CAS:<p>SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Formula:C20H32ClN3OPurity:99.32% - 99.41%Color and Shape:SolidMolecular weight:365.94Asiaticoside
CAS:<p>Asiaticoside, in Centella asiatica, may treat wounds/burns.</p>Formula:C48H78O19Purity:98% - 99.96%Color and Shape:PowderMolecular weight:959.12Chebulinic acid
CAS:<p>Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.</p>Formula:C41H32O27Purity:98.91% - 99.71%Color and Shape:SolidMolecular weight:956.68(E)-SIS3
CAS:<p>(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!</p>Formula:C28H27N3O3·HClPurity:95.64% - 98%Color and Shape:SolidMolecular weight:489.99R-268712
CAS:<p>R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.</p>Formula:C20H18FN5OPurity:99.61%Color and Shape:SolidMolecular weight:363.39SJ000291942
CAS:<p>SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.</p>Formula:C16H15FN2O4Purity:99.66%Color and Shape:SolidMolecular weight:318.3LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Formula:C25H44F6N6O9Purity:99.75%Color and Shape:SolidMolecular weight:686.64Kartogenin
CAS:<p>Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.</p>Formula:C20H15NO3Purity:96.25% - 97.79%Color and Shape:SolidMolecular weight:317.34ITD-1
CAS:<p>ITD-1 is a potent and highly selective TGFβ pathway inhibitor.</p>Formula:C27H29NO3Purity:99.89% - >99.99%Color and Shape:SolidMolecular weight:415.52Galunisertib
CAS:<p>Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C22H19N5OPurity:97.09% - 99.98%Color and Shape:SolidMolecular weight:369.42Alantolactone
CAS:<p>Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.</p>Formula:C15H20O2Purity:99.02% - 99.66%Color and Shape:Crystalline PowderMolecular weight:232.32BMP signaling agonist sb4
CAS:<p>BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)</p>Formula:C14H10BrNOSPurity:99.48% - 99.805%Color and Shape:SolidMolecular weight:320.2BMS986260
CAS:<p>BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).</p>Formula:C18H12ClFN6OPurity:97.67%Color and Shape:SolidMolecular weight:382.78BIO-013077-01
CAS:<p>BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.</p>Formula:C17H13N5Purity:99.87%Color and Shape:SolidMolecular weight:287.32Trimethylamine N-oxide dihydrate
CAS:<p>TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.</p>Formula:C3H13NO3Purity:98.75%Color and Shape:White CrystalMolecular weight:111.14LY3200882
CAS:<p>LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).</p>Formula:C24H29N5O3Purity:99.46% - 99.63%Color and Shape:SolidMolecular weight:435.52SRI-011381
CAS:<p>SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Formula:C20H31N3OPurity:98.64%Color and Shape:SolidMolecular weight:329.48Trevogrumab
CAS:<p>Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).</p>Purity:95% - 95%Color and Shape:LiquidNisevokitug
CAS:<p>Nisevokitug (anti-TGF-β mAb) neutralizes TGF-β and is being studied for its ability to modulate the immunosuppressive tumor microenvironment.</p>Purity:95%Color and Shape:LiquidMetelimumab
CAS:<p>Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).</p>Purity:95%Color and Shape:LiquidLivmoniplimab
CAS:<p>Livmoniplimab (ABBV-151; ARGX-115) is a humanised monoclonal antibody targeting LRRC32 (GARP)/TGFβ1, which blocks TGFβ1 release mediated by LRRC32</p>Purity:95%Color and Shape:LiquidHalofuginone
CAS:<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Formula:C16H17BrClN3O3Purity:99.53%Color and Shape:Off-White SolidMolecular weight:414.68Chromenone 1
CAS:<p>Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).</p>Formula:C18H10F3N3O2Purity:99.83% - 99.93%Color and Shape:SolidMolecular weight:357.29Halofuginone hydrobromide
CAS:<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Formula:C16H17BrClN3O3·HBrPurity:97.01% - 99.73%Color and Shape:SolidMolecular weight:495.59CJJ300
CAS:<p>CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.</p>Formula:C30H33N3Purity:99.80%Color and Shape:SolidMolecular weight:435.6(Rac)-SIS3 free base
CAS:<p>SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.</p>Formula:C28H27N3O3Purity:98%Color and Shape:SolidMolecular weight:453.53TGFβRI-IN-1
CAS:<p>TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,</p>Formula:C20H14D3N5O2Purity:98%Color and Shape:SolidMolecular weight:362.4SJ000063181
CAS:<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Formula:C14H14ClFN2O2Purity:99.94%Color and Shape:SolidMolecular weight:296.723,7-DMF
CAS:3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formula:C17H14O4Purity:98%Color and Shape:SolidMolecular weight:282.29DT-6
CAS:<p>DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing</p>Formula:C89H130N20O29S2Purity:98%Color and Shape:SolidMolecular weight:2008.23TGFβ-IN-5
CAS:<p>TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.</p>Formula:C20H16N4Purity:99.29% - 99.5%Color and Shape:SolidMolecular weight:312.37Myristoyl tetrapeptide-12
CAS:<p>Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].</p>Formula:C32H63N7O5Purity:98%Color and Shape:SolidMolecular weight:625.89TP0427736
CAS:<p>TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.</p>Formula:C14H10N4S2Purity:97.26%Color and Shape:SolidMolecular weight:298.39(+)-ITD-1
CAS:<p>(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).</p>Formula:C27H29NO3Color and Shape:SolidMolecular weight:415.52CDD-1431
CAS:<p>CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.</p>Formula:C33H38N8O5SColor and Shape:SolidMolecular weight:658.77TGFβ1-IN-1
CAS:<p>TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.</p>Formula:C22H24N2O3Purity:99.89% - 99.89%Color and Shape:SolidMolecular weight:364.438TGFβRI-IN-3
CAS:<p>TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4.</p>Formula:C28H23N3O2SPurity:99.85%Color and Shape:SoildMolecular weight:465.57Luspatercept
CAS:<p>Luspatercept (ACE-536), a recombinant modified ActRIIB fusion protein, selectively binds to transforming growth factor β superfamily ligands, thereby enhancing erythrocyte production and advancing the maturation of erythroid precursors. Moreover, by binding with GDF11, it inhibits Smad2/3 signaling. This compound is instrumental in anemia research [1].</p>Color and Shape:LiquidDCN1-IN-2
CAS:<p>DCN1-IN-2, a DCN1 inhibitor, exhibits potent activity with an IC 50 of 2.96 nM. It effectively mitigates Ang II/TGFβ-induced activation of cardiac fibroblasts and diminishes ISO-induced cardiac fibrosis and remodeling in mice through the selective inhibition of cullin 3.</p>Formula:C18H14ClF3N4OSColor and Shape:SolidMolecular weight:426.84
