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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • BP-5-087
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    BP-5-087

    CAS:
    <p>BP-5-087 is a STAT3 inhibitor, combining with BCR-ABL1 inhibition to overcome kinase-independent resistance in chronic myeloid leukemia.</p>
    Formula:C36H30F8N2O6S
    Color and Shape:Solid
    Molecular weight:770.69

    Ref: TM-T70167

  • Galiellalactone
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    Galiellalactone

    CAS:
    <p>inhibits IL-6-mediated JAK/STAT signal transduction</p>
    Formula:C11H14O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:194.23

    Ref: TM-T22796

  • CP-690550A
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    CP-690550A

    CAS:
    <p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>
    Formula:C15H21N5O2
    Color and Shape:Solid
    Molecular weight:303.36

    Ref: TM-T31074

  • GDC-4379
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    GDC-4379

    CAS:
    <p>GDC-4379 is a JAK1 inhibitor that can be used to study asthma.</p>
    Formula:C21H18ClF2N7O3
    Color and Shape:Solid
    Molecular weight:489.86

    Ref: TM-T63280

  • Peficitinib hydrobromide
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    Peficitinib hydrobromide

    CAS:
    <p>Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.</p>
    Formula:C18H23BrN4O2
    Color and Shape:Solid
    Molecular weight:407.312

    Ref: TM-T33905

  • Povorcitinib
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    Povorcitinib

    CAS:
    <p>Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).</p>
    Formula:C23H22F5N7O
    Color and Shape:Solid
    Molecular weight:507.469

    Ref: TM-T39113

  • (2R,5S)-Ritlecitinib
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    (2R,5S)-Ritlecitinib

    CAS:
    <p>(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].</p>
    Formula:C15H19N5O
    Color and Shape:Solid
    Molecular weight:285.34

    Ref: TM-T60565

  • YM-341619
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    YM-341619

    CAS:
    <p>YM-341619 (AS1617612), potent STAT6 inhibitor; IC50: 0.70 nM; hinders IL-4-induced Th2 in mice; may aid allergic disease research.</p>
    Formula:C22H21F3N6O2
    Color and Shape:Solid
    Molecular weight:458.44

    Ref: TM-T62860

  • TUL01101
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    TUL01101

    CAS:
    <p>TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.</p>
    Formula:C22H25F2N5O2
    Color and Shape:Solid
    Molecular weight:429.46

    Ref: TM-T73392

  • Stafia-1-dipivaloyloxymethyl ester
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    Stafia-1-dipivaloyloxymethyl ester

    CAS:
    <p>Stafia-1 suppresses pSTAT5a in a dose-dependent manner (0-200 μM) without affecting pSTAT5b.</p>
    Formula:C37H48FO13P
    Color and Shape:Solid
    Molecular weight:750.74

    Ref: TM-T35917

  • MM-206
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    MM-206

    CAS:
    <p>MM-206, a cell-permeable, non-cytotoxic naphthalene sulfonamide compound, it effectively inhibits STAT3 DNA-binding activity.</p>
    Formula:C22H12F5NO3S2
    Color and Shape:Solid
    Molecular weight:497.46

    Ref: TM-T28075

  • MC0704
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    MC0704

    <p>MC0704: STAT3 inhibitor, IC50=2.13μM, promotes apoptosis &amp; cell arrest, anti-breast cancer, for mTNBC research.</p>
    Formula:C29H21BrN4O2
    Color and Shape:Solid
    Molecular weight:537.41

    Ref: TM-T73501

  • STAT3-IN-15
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    STAT3-IN-15

    <p>STAT3-IN-15: Potent, oral STAT3 inhibitor for IPF, blocks STAT3 phosphorylation, cell migration, and EMT.</p>
    Formula:C20H17F3N2O3S
    Color and Shape:Solid
    Molecular weight:422.42

    Ref: TM-T73035

  • Thi-DPPY
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    Thi-DPPY

    CAS:
    <p>Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.</p>
    Formula:C28H28ClN5O4S
    Color and Shape:Solid
    Molecular weight:566.07

    Ref: TM-T64008

  • HJC0149
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    HJC0149

    CAS:
    <p>HJC0149 is a potent orally bioavailable signal transducer and activator of transcription 3 inhibitor.</p>
    Formula:C15H10ClNO4S
    Color and Shape:Solid
    Molecular weight:335.76

    Ref: TM-T24142

  • TYK2-IN-11
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    TYK2-IN-11

    CAS:
    <p>TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.</p>
    Formula:C18H17N5O3S
    Color and Shape:Solid
    Molecular weight:383.42

    Ref: TM-T61658

  • SYK/JAK-IN-1
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    SYK/JAK-IN-1

    CAS:
    <p>SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.</p>
    Formula:C24H26N8O3
    Color and Shape:Solid
    Molecular weight:474.52

    Ref: TM-T63086

  • PF-00956980
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    PF-00956980

    CAS:
    <p>PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.</p>
    Formula:C18H26N6O
    Color and Shape:Solid
    Molecular weight:342.44

    Ref: TM-T71089

  • LLL12
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    LLL12

    CAS:
    <p>LLL12 inhibits STAT3 phosphorylation, boosting Cisplatin and Paclitaxel effects against ovarian cancer cell activities.</p>
    Formula:C14H9NO5S
    Color and Shape:Solid
    Molecular weight:303.29

    Ref: TM-T71099

  • JAK-IN-10
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    JAK-IN-10

    CAS:
    <p>JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.</p>
    Formula:C20H18FN5O3S
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:427.45

    Ref: TM-T13571