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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • CX-6258
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    CX-6258

    CAS:
    <p>CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.</p>
    Formula:C26H24ClN3O3
    Purity:97.46%
    Color and Shape:Solid
    Molecular weight:461.94

    Ref: TM-T1834

  • JAK-IN-20
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    JAK-IN-20

    CAS:
    <p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>
    Formula:C28H30FN7O2
    Color and Shape:Solid
    Molecular weight:515.58

    Ref: TM-T63581

  • Niclosamide monohydrate
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    Niclosamide monohydrate

    CAS:
    <p>Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication.</p>
    Formula:C13H10Cl2N2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:345.14

    Ref: TM-T23068

  • Peficitinib hydrochloride
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    Peficitinib hydrochloride

    CAS:
    <p>Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).</p>
    Formula:C18H23ClN4O2
    Color and Shape:Solid
    Molecular weight:362.86

    Ref: TM-T61365

  • TK4b
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    TK4b

    CAS:
    <p>TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) &amp; 19.40 nM (JAK2).</p>
    Formula:C21H22N2O2
    Color and Shape:Solid
    Molecular weight:334.41

    Ref: TM-T61020

  • TK4g
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    TK4g

    CAS:
    <p>TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) &amp; 15.80 nM (JAK3); promising for lymphoid diseases &amp; leukemia research.</p>
    Formula:C19H19N3O4S
    Color and Shape:Solid
    Molecular weight:385.44

    Ref: TM-T61698

  • JAK-2/3-IN-2
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    JAK-2/3-IN-2

    CAS:
    <p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 &amp; JAK3 inhibitor with IC50s of 23.85 nM (JAK2) &amp; 18.9 nM (JAK3).</p>
    Formula:C19H19ClN2OS
    Color and Shape:Solid
    Molecular weight:358.89

    Ref: TM-T61323

  • XZH-5
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    XZH-5

    CAS:
    <p>XZH-5 is an inhibitor of STAT3.</p>
    Formula:C22H25F6N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:537.46

    Ref: TM-T26340

  • JAK-IN-14
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    JAK-IN-14

    CAS:
    <p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>
    Formula:C19H15FN4O
    Purity:98.27%
    Color and Shape:Solid
    Molecular weight:334.35

    Ref: TM-T9764

  • TyK2-IN-2
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    TyK2-IN-2

    CAS:
    <p>TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).</p>
    Formula:C16H18N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:310.35

    Ref: TM-T13232

  • JAK-IN-18
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    JAK-IN-18

    CAS:
    <p>"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."</p>
    Formula:C27H28F2N6O3
    Color and Shape:Solid
    Molecular weight:522.55

    Ref: TM-T63658

  • JAK3-IN-12
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    JAK3-IN-12

    CAS:
    <p>JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.</p>
    Formula:C19H19N5O4S
    Color and Shape:Solid
    Molecular weight:413.45

    Ref: TM-T62114

  • Tyk2-IN-5
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    Tyk2-IN-5

    CAS:
    <p>Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).</p>
    Formula:C21H19FN8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:434.43

    Ref: TM-T13234

  • Tyk2-IN-7
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    Tyk2-IN-7

    CAS:
    <p>Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).</p>
    Formula:C18H15D3N6O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T13235

  • MS-1020
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    MS-1020

    CAS:
    <p>MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.</p>
    Formula:C21H18N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:346.38

    Ref: TM-T28113

  • 1,2,3,4,5,6-Hexabromocyclohexane
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    1,2,3,4,5,6-Hexabromocyclohexane

    CAS:
    <p>Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.</p>
    Formula:C6H6Br6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.54

    Ref: TM-T22462

  • OICR-0547
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    OICR-0547

    CAS:
    <p>OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.</p>
    Formula:C28H29F3N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:542.55

    Ref: TM-T12290

  • JAK3-IN-9
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    JAK3-IN-9

    CAS:
    <p>JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.</p>
    Formula:C17H23N5O4S
    Color and Shape:Solid
    Molecular weight:393.46

    Ref: TM-T61814

  • EP009
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    EP009

    CAS:
    <p>EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.</p>
    Formula:C14H24O2
    Color and Shape:Solid
    Molecular weight:224.34

    Ref: TM-T27274

  • INCB16562
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    INCB16562

    CAS:
    <p>INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.</p>
    Formula:C19H11Cl2N5
    Color and Shape:Solid
    Molecular weight:380.23

    Ref: TM-T68306