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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • STAT3 degrader-2
    Targetmol
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    STAT3 degrader-2

    CAS:
    <p>STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various</p>
    Formula:C59H62N9O13P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1136.15

    Ref: TM-T78983

  • TCJL37
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    TCJL37

    CAS:
    <p>TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.</p>
    Formula:C17H11ClF2N4O2
    Color and Shape:Solid
    Molecular weight:376.74

    Ref: TM-T4666

  • JAK-IN-31
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    JAK-IN-31

    CAS:
    <p>JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,</p>
    Formula:C21H19N7O2S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:465.55

    Ref: TM-T79882

  • QL-1200186
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    QL-1200186

    CAS:
    <p>QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following</p>
    Formula:C26H27N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:485.54

    Ref: TM-T81331

  • Itacnosertib (hydrocholide)
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    Itacnosertib (hydrocholide)

    CAS:
    <p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>
    Formula:C26H29ClN8O
    Color and Shape:Solid
    Molecular weight:505.01

    Ref: TM-T84696

  • FM-479
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    FM-479

    CAS:
    <p>FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.</p>
    Formula:C25H26N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:442.523

    Ref: TM-T22333

  • JAK-IN-17
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    JAK-IN-17

    <p>"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."</p>
    Formula:C33H38F2N6O8
    Color and Shape:Solid
    Molecular weight:684.69

    Ref: TM-T73250

  • ABBV-712
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    ABBV-712

    CAS:
    <p>ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases</p>
    Formula:C24H28N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:452.5

    Ref: TM-T83218

  • PIM-IN-2
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    PIM-IN-2

    CAS:
    <p>PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .</p>
    Formula:C19H22N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:338.4

    Ref: TM-T81460

  • STAT6-IN-1
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    STAT6-IN-1

    CAS:
    <p>STAT6-IN-1: STAT6 inhibitor, IC50=0.028 µM, targets SH2 domain, for allergy and cancer research.</p>
    Formula:C33H37IN3O7P
    Color and Shape:Solid
    Molecular weight:745.54

    Ref: TM-T73129

  • FD1024
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    FD1024

    CAS:
    <p>FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.</p>
    Formula:C21H20F2N4O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.47

    Ref: TM-T79456

  • HS94
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    HS94

    CAS:
    <p>HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.</p>
    Formula:C15H15N5O2S
    Purity:95.04%
    Color and Shape:Solid
    Molecular weight:329.38

    Ref: TM-T77777

  • JAK-IN-3
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    JAK-IN-3

    CAS:
    <p>JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.</p>
    Formula:C18H20N4O3
    Purity:98.04% - 98.19%
    Color and Shape:Solid
    Molecular weight:340.38

    Ref: TM-T11704

  • JAK1-IN-9
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    JAK1-IN-9

    CAS:
    <p>JAK1-IN-9 (compound 23a) is a potent, selective inhibitor of JAK1, demonstrating an IC50 of 72 nM.</p>
    Formula:C16H13IN6
    Color and Shape:Solid
    Molecular weight:416.22

    Ref: TM-T62155

  • GDC-9918
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    GDC-9918

    CAS:
    <p>GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.</p>
    Formula:C20H18F2N6O5S
    Color and Shape:Solid
    Molecular weight:492.46

    Ref: TM-T201178

  • Cenacitinib
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    Cenacitinib

    CAS:
    <p>Cenacitinib is an effective inhibitor of Janus kinase (Janus kinase) and possesses anti-inflammatory activity.</p>
    Formula:C19H19F2N7O3
    Color and Shape:Solid
    Molecular weight:431.40

    Ref: TM-T201149

  • YLIU-4-105-1
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    YLIU-4-105-1

    CAS:
    <p>YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.</p>
    Formula:C32H34F3N7O2
    Color and Shape:Solid
    Molecular weight:605.65

    Ref: TM-T201176

  • JAK2 JH2 binder-1
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    JAK2 JH2 binder-1

    CAS:
    <p>JAK2 JH2 binder-1: potent, selective, Ki=37.1 nM, potential for studying myeloproliferative neoplasms.</p>
    Formula:C29H25N7O6S
    Color and Shape:Solid
    Molecular weight:599.62

    Ref: TM-T64227

  • CymitQuimica logo
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    Ten01

    <p>Ten01 exhibits a 5.0 nM inhibition of JAK1 kinase.</p>
    Formula:C18H20F6N4O
    Color and Shape:Solid
    Molecular weight:422.37

    Ref: TM-T62257

  • STAT3-IN-7
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    STAT3-IN-7

    CAS:
    <p>STAT3-IN-7, an orally active aryl sulfonamido azetidine compound, serves as a STAT3 inhibitor with anticancer activities.</p>
    Formula:C30H26F5N5O4S
    Color and Shape:Solid
    Molecular weight:647.62

    Ref: TM-T73114