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JAK

JAK

JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.

Found 245 products of "JAK"

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  • JAK-IN-15
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    JAK-IN-15

    CAS:
    <p>JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).</p>
    Formula:C22H23FN4O3S
    Color and Shape:Solid
    Molecular weight:442.51

    Ref: TM-T39400

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    TYD-68

    <p>TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206972

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    LH168

    <p>LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.</p>
    Formula:C29H31F3N6O2S
    Color and Shape:Solid
    Molecular weight:584.66

    Ref: TM-T205103

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    HAT-SIL-TG-1&AT

    <p>HAT-SIL-TG-1&amp;AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth &amp; STAT3/5 phosphorylation in tumors.</p>
    Formula:C60H69N17O11S
    Color and Shape:Solid
    Molecular weight:1236.36

    Ref: TM-T74800

  • Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
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    Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)

    CAS:
    <p>Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.</p>
    Formula:C88H138N20O34P2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2082.1

    Ref: TM-TP1269

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    JAK3-IN-15

    <p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200631

  • PROTAC TYK2 degradation agent1
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    PROTAC TYK2 degradation agent1

    CAS:
    <p>PROTAC TYK2 Agent1 selectively degrades TYK2, with a 14 nM DC50, for autoimmune research.</p>
    Formula:C55H69N13O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1056.28

    Ref: TM-T75026

  • AS2553627
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    AS2553627

    CAS:
    <p>AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.</p>
    Formula:C18H19N5O
    Color and Shape:Solid
    Molecular weight:321.38

    Ref: TM-T26664

  • Deuruxolitinib
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    Deuruxolitinib

    CAS:
    <p>Deuruxolitinib functions as an inhibitor of JAK1/2.</p>
    Formula:C17H18N6
    Color and Shape:Solid
    Molecular weight:314.41

    Ref: TM-T203715

  • SJ10542
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    SJ10542

    CAS:
    <p>SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.</p>
    Formula:C41H46N12O5S
    Color and Shape:Solid
    Molecular weight:818.95

    Ref: TM-T74429

  • Axltide
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    Axltide

    CAS:
    <p>Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.</p>
    Formula:C63H107N19O20S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1514.77

    Ref: TM-TP1713

  • SJ1008030
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    SJ1008030

    CAS:
    <p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>
    Formula:C42H43N13O7S
    Color and Shape:Solid
    Molecular weight:873.94

    Ref: TM-T74580

  • Tyrosine Kinase Inhibitor Library
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    Tyrosine Kinase Inhibitor Library

    <p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>
    Color and Shape:Odour Solid

    Ref: TM-L2200

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    TYK2 activator-1

    <p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>
    Formula:C23H21FN4O2
    Color and Shape:Solid
    Molecular weight:404.16485

    Ref: TM-T207637

  • JAK-STAT Compound Library
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    JAK-STAT Compound Library

    <p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>
    Color and Shape:Odour Solid

    Ref: TM-L3700

  • Pumecitinib
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    Pumecitinib

    CAS:
    <p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>
    Formula:C17H20N8O2S
    Purity:99.94%
    Color and Shape:Soild
    Molecular weight:400.46

    Ref: TM-T67758

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    SJ1008030 formic

    <p>SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an</p>
    Formula:C43H45N13O9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:919.96

    Ref: TM-T77944

  • SJ988497
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    SJ988497

    CAS:
    <p>SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.</p>
    Formula:C36H36N10O5
    Color and Shape:Solid
    Molecular weight:688.74

    Ref: TM-T74994

  • Kinase Inhibitor Library
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    Kinase Inhibitor Library

    <p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>
    Color and Shape:Odour Solid

    Ref: TM-L1600

  • FDA-Approved Kinase Inhibitor Library
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    FDA-Approved Kinase Inhibitor Library

    <p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>
    Color and Shape:Liquid

    Ref: TM-L1610